Abstract: An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74) is disclosed. The epitope within the domain 3 of the VEGFR2 is located between amino acid residues 250 and 270 of SEQ ID NO: 74. Use of the antibody or antigen-binding fragment thereof in the manufacture of a medicament for inhibiting tumor growth, tumor angiogenesis, and/or inducing cancer cell cytotoxicity in a subject in need thereof is also disclosed. Also disclosed is a method of detecting the presence of VEGFR2 in a tumor vascular endothelial cell or a cancer cell in a biological sample.

Abstract: An LCD device includes a TFT array substrate, a liquid crystal layer, and a plurality of photo spacers. The photo spacers are located inside the liquid crystal layer. The TFT array substrate includes a pixel electrode layer and an alignment layer. The alignment layer is arranged on the of TFT array substrate on the side near the liquid crystal layer. The pixel electrode layer is arranged on the alignment layer on the side far away from liquid crystal layer; the alignment layer includes a plurality of contact portion. The bottom of the photo spacers are holding with the contact portions. A plurality of block portion is adjacent to the contact portions. The block portion is a protrusion formed toward the color filter substrate with respect to the contact portion, so that the displacement of the photo spacers on the TFT array substrate can be limited.

Abstract: Compounds of general formula (Ia), compounds of general formula (Ia?), compounds of general formula (Ib), compounds of general formula (Ib?), compounds of general formula (I), compounds of general formula (I?), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.

Abstract: A presence-based capability discovery mechanism for in-call services in the rich communication services (RCS) release 6 suite of services is provided. A method can comprise receiving a unique identifier representing a communication between a first user device and a second user device, the unique identifier comprising a concatenation of a first string, a second string, and a third string, as a function of the second string, performing a look up of a first presence tuple associated with the first user device; and associating the unique identifier to first presence tuple.

Abstract: In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.

Abstract: The present invention provides implementation and communication methods, an apparatus and a system of a virtual subscriber identity module. The implementation method includes: receiving a VSIM application request sent by a terminal, where the VSIM application request carries an identifier of a VSIM desired by the terminal; obtaining corresponding VSIM installation information according to the identifier of the desired VSIM; and sending the VSIM installation information to the terminal, so that the terminal installs the VSIM according to the VSIM installation information. The embodiments of the present invention effectively solve a problem where an existing mobile operator network does not support the VSIM, and provide an effective and convenient operation scheme for an existing domestic or international roaming service.

Abstract: A lock structure includes a case, a first latch, a second latch, a transmission member, a transmission module, a swaying plate and a driving plate, wherein the transmission module is rotated to drive the swaying plate and the transmission member to perform swing action for making the swaying plate driving the first latch being hidden into the case. In addition, the driving plate moves upwardly by swing action of the transmission member, and the driving plate drives the second latch in operation for making the second latch being hidden into the case.

Abstract: A system and method for facilitating characterizing data to enable dynamic generation of a user interface feature based on the data. An example method includes maintaining data in accordance with a data model accessible to webpage computer code, wherein the data model is adapted to be populated with data associated with one or more data attributes in the data model; and providing a signal, identifying a data attribute, from the data model to webpage computer code to facilitate dynamic construction of one or more user interface features characterizing a rendering of a webpage. Data in the data model is characterized by one or more data attributes, each of which is associated with an attribute definition. The example method may further include organizing one or more attribute definitions in the data model as computing objects containing characterizations of the one or more data attributes.

Abstract: Described herein are methods of evaluating metastatic potential of a cancer based on the phosphorylation state and/or intracellular localization of iASPP. Therapeutic regimens designed based on the results of the diagnostic methods are also provided.

Abstract: A system that incorporates teachings of the subject disclosure may include, for example, capturing images that are associated with a video conference communication session, obtaining a video conference policy associated with the video conference communication session, applying object pattern recognition to the images to detect an object in the images, and retrieve first replacement image content according to the video conference policy. The images can be adjusted by replacing a first portion of the images other than the detected object with the first replacement image content to generate first adjusted video content. The first adjusted video content can be provided to the first recipient communication device via the video conference communication session. Non-adjusted video content can be provided according to the video conference policy to the second recipient communication device via the video conference communication session. Other embodiments are disclosed.

Abstract: Methods and apparatus to provide data network services to a non-registering endpoint are disclosed herein. A disclosed method includes, transmitting, by executing an instruction with a processor, information identifying the non-registering endpoint and a first list identifying a plurality of proxy-call session control functions to a plurality of serving-call session control functions, the plurality of proxy-call session control functions being statically assigned to process calls to the non-registering endpoint when selected by any of the plurality of serving-call session control functions. In the disclosed example method, the non-registering endpoint is unable to register with any data network. The first list can be provided to the plurality of serving-call session control functions in response to an event.

Abstract: This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics.

Abstract: In various example embodiments, a system and method for generating and routing notifications of content extracted from emails are presented. A member's interest in a specific email among a set of emails are determined based on a relevance score. Content from the specific email are extracted, the content being identified as primary information and secondary information. A notification is generated comprising of the vital content extracted from the specific email. Presentation of the primary information is caused, the primary information being associated with the notification according to a ranked order, the ranked order being based on the relevance score. In response to a member action, presentation of the secondary information is caused, the secondary information being associated with the notification.

Abstract: A system that incorporates teachings of the subject disclosure may include, for example, capturing images that are associated with a video conference communication session, obtaining a video conference policy associated with the video conference communication session, applying object pattern recognition to the images to detect an object in the images, and retrieve first replacement image content according to the video conference policy. The images can be adjusted by replacing a first portion of the images other than the detected object with the first replacement image content to generate first adjusted video content. The first adjusted video content can be provided to the first recipient communication device via the video conference communication session. Non-adjusted video content can be provided according to the video conference policy to the second recipient communication device via the video conference communication session. Other embodiments are disclosed.

Abstract: A semiconductor device comprises a multi-layered structure disposed over a substrate and defining a composite lateral etch profile. The multi-layered structure includes a lower sub-layer disposed over the substrate and comprising a metal oxide material that includes indium and zinc, the indium and zinc content in the bottom sub-layer substantially defining a first indium to zinc content ratio; a middle sub-layer disposed over the bottom sub-layer and comprising a metal material; an upper sub-layer disposed over the middle sub-layer and comprising a metal oxide material that includes indium and zinc, the indium to zinc content in the upper sub-layer substantially defining a second indium to zinc content ratio smaller than the first indium to zinc content ratio; and a lateral byproduct layer formed over the lateral etched surface, comprising substantially an metal oxide of the metal material in the middle sub-layer.

Abstract: In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).

Abstract: The present invention provides a door access management method applicable to a building. The building includes a plurality of areas. The door access management method includes setting access information of an access card, the access information marking accessible entrances of the access card in the building; arranging an electronic lock on a door for controlling access of an entrance of a corresponding area in the building; the electronic lock storing information of the entrance controlled by the electronic lock; the electronic lock sensing the access card for receiving the access information of the access card; the electronic lock comparing the access information with the information of the entrance controlled by the electronic lock; and unlocking the electronic lock when an accessible entrance marked by the access information corresponds to the information of the entrance controlled by the electronic lock.

Abstract: This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics.

Abstract: A thin film transistor array panel includes a first conductive layer including a gate electrode; a channel layer disposed over the gate; and a second conductive layer disposed over the channel layer. The second conductive layer includes a multi-layered portion defining a source electrode and a drain electrode, which includes a first sub-layer, a second sub-layer, and a third sub-layer sequentially disposed one over another. Both the third and the first sub-layers include indium and zinc oxide materials. An indium to zinc content ratio in the first sub-layer is greater than that in the third sub-layer. The content ratio differentiation between the first and the third sub-layers affects a lateral etch profile associated with a gap generated in the second conductive layer between the source and the drain electrodes, where the associated gap width in the third sub-layer is wider than that that in the first sub-layer.

Abstract: A thin film transistor array panel includes a first conductive layer including a gate electrode; a channel layer disposed over the gate; and a second conductive layer disposed over the channel layer. The second conductive layer includes a multi-layered portion defining a source electrode and a drain electrode, which includes a first sub-layer, a second sub-layer, and a third sub-layer sequentially disposed one over another. Both the third and the first sub-layers include indium and zinc oxide materials. An indium to zinc content ratio in the first sub-layer is greater than that in the third sub-layer. The content ratio differentiation between the first and the third sub-layers affects a lateral etch profile associated with a gap generated in the second conductive layer between the source and the drain electrodes, where the associated gap width in the third sub-layer is wider than that that in the first sub-layer.