Abstract: Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7, 8, 9, 10, 10a, 11-hexahydro-5, 6, 7a, 11-tetraazacyclohepta [def] cyclopenta [a] fluoren-4 (5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with temozolomide and/or radiation therapy. Also, disclosed a pharmaceutical combination comprising a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7, 8, 9, 10, 10a, 11-hexahydro-5, 6, 7a, 11-tetraazacyclohepta [def] cyclopenta [a] fluoren-4 (5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with temozolomide and the use thereof.

Abstract: An electric actuator includes a motor having a rotary shaft. The electric actuator further includes a vibration damping gasket mounted on the motor. The vibration damping gasket includes an annular body attached around the motor and an end wall formed on one end of the annular body, and the end wall defines a through hole allowing the rotary shaft to pass therethrough. The motor further includes an outer housing, and the annular body of the vibration damping gasket is attached around the outer housing. The end wall of the vibration damping gasket contacts with the end surface of the outer housing. The vibration damping gasket is made from a resilient material. The electric actuator can effectively reduce the mechanical vibration, improve a buffering effect thereof, and hence reduce the noise.

Abstract: A medication delivery device, for use with a container having a distal end and a needle being placed at the distal end of the container, including: a push rod which is movable with respect to at least a portion of the container; a resilient member configured to bias the push rod to move toward the distal end of the container; a releasable restraining means configured to releasably restrain the push rod in a locked state against the biasing of the resilient member; a means to adjust amount of movement of the push rod with respect to the container in order to deliver a predetermined dose of medication; and an activation means configured to release the releasable means. The means to adjust amount of movement of the push rod with respect to the container is bi-directional. The device can accommodate containers of different size or shape.

Abstract: An apparatus, method and computer-readable medium provide control of set top box volume based on mobile device events. The apparatus may execute a process that includes controlling a volume setting of an audio amplifier to output audio content to the one or more audio or audio/visual devices. A connection event signal from a mobile device is received via a wireless radio frequency receiver. The connection event signal indicates a call state of the mobile device. In response to receiving the connection event signal, a received signal strength indication associated with the connection event signal obtained. A volume setting that corresponds to the obtained received signal strength indication is determined. The volume setting output to the audio amplifier is adjusted according to the determined volume setting.

Abstract: A medication infusion device includes a medication container containing liquid medication; an infusion needle; and a reciprocating pump having a pump chamber. The liquid medication is withdrawn from the medication container into the pump chamber during suction operation of the reciprocating pump, and the liquid medication is dispensed out of the pump chamber through the infusion needle during dispensing operation of the reciprocating pump. There are also mechanisms preventing liquid from flowing through the infusion needle during suction operation of the reciprocating pump and preventing liquid from flowing back into the medication container during dispensing operation of the reciprocating pump. The medication infusion device may further include a microcontroller to control medication infusion volume and rate.

Abstract: Disclosed herein is a pharmaceutical combination for use in the prevention, delay of progression or treatment of cancer, wherein the pharmaceutical combination exhibits a synergistic efficacy. The pharmaceutical combination comprises a humanized antagonist monoclonal antibody against PD- and a RAF inhibitor. Also disclosed herein is a combination for use in the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject a therapeutically effective amount of a humanized antagonist monoclonal antibody against PD-1 and a therapeutically effective amount of a RAF inhibitor.

Abstract: A medical injection device used to deliver multiple doses of medication, including: a medication container having a movable piston; a push rod assembly having a plurality of spaced-apart position settings disposed along the length, the push rod assembly displacing the movable piston to dispense medication from the medication container; a spring to bias the push rod assembly to move toward the distal end of the medical injection device; a releasable restraining member configured to restrain the push rod assembly in a locked state against the biasing of the spring, upon release of the releasable restraining member, the push rod assembly moves toward the distal end of the medical injection device; and an arming mechanism configured to move the push rod assembly toward the proximal end of the medical injection device.

Abstract: Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a chemotherapeutic agent. Also, disclosed a pharmaceutical combination comprising a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor, or a chemotherapeutic agent and the use thereof.

Abstract: A wearable infusion device for delivering medication into body of a user, the infusion device comprising a medication container containing a volume of medication to be dispensed; an infusion needle that is fully enclosed in a sterile environment until the infusion needle is inserted into underlying tissue; an infusion needle insertion mechanism associated with the infusion needle, powered by one or more mechanical springs, that when activated, inserts the infusion needle through the skin into underlying tissue; means for delivering medication out of the medication container and into underlying tissue via the infusion needle; and a housing associated with the medication container, the infusion needle, the infusion needle insertion mechanism and the means for delivering medication.

Abstract: The present disclosure relates to a technical field of solar cells, and more particularly to an independently-driven film separation mechanism. The separation mechanism includes a mounting platform. A plurality of first suction components for sucking the bottom surfaces of wafers respectively are provided on one side of the mounting platform. Each of the first suction components is corresponding to one of the wafers. The mounting platform is provided with a plurality of second suction components for sucking films respectively, each of the films is provided on a top surface of the corresponding wafer. The first suction components and the second suction components are provided in a one to one correspondence, and a suction direction of each of the plurality of first suction components and a suction direction of each of the plurality of second suction components are opposite.

Abstract: A system for detecting an illuminance of the present invention includes a light source, a light sensor, and a signal output module. The light source includes a first A light-emitting diode, the first A light-emitting diode having a first color light; and the light source emits a first ray of light. The light sensor has a sensing face; the light sensor includes a first B light-emitting diode disposed on the sensing face, the first B light-emitting diode having the first color light; and the light sensor receives at least a portion of the first ray of light and generates a first sensing voltage. The signal output module is coupled to the light sensor to receive the first sensing voltage and output a sensing result signal according to the first sensing voltage.

Abstract: The present disclosure relates to the field of wafer processing, and discloses a wafer processing system. A wafer includes a substrate and a film on the substrate. The wafer processing system includes: an etching unit, configured to output a plurality of wafers to be separated; and a separation unit, including at least two first carrying platforms and a manipulator component, wherein the first carrying platforms are provided on a side of the etching unit, and are configured to carry the plurality of wafers to be separated, and the manipulator component is switched in turns at each position of all the first carrying platforms, and separates the films of the plurality of wafers on the first carrying platform from the substrates.

Abstract: Disclosed are systems for applying materials to components. The system comprises a tool operable for transferring a portion of a material from a supply of the material to a component. A first portion of the tool may be configured for cutting along a side or edge of the portion of the material. A second portion of the tool may be configured for tamping, pressing, or pushing against the portion of the material to cause uncut sides or edges of the portion of the material attached to the supply of the material to be torn, severed, detached, or separated from the supply of the material.

Abstract: In one aspect, a pen needle assembly is provided herein which includes a hub, and a needle fixed to the hub, the needle having proximal and distal ends with a lumen extending therebetween. The needle extends distally from the hub to define an exposed length between the distal end of the needle and the hub in the range of about 5.0 to 9.0 mm. The hub defines a post formed about the needle, the post having a distally-facing first skin engaging surface. The exposed length of the needle extends distally from the first skin engaging surface. The hub also defines a distally-facing second skin engaging surface which at least partially circumscribes the first skin engaging surface. The second skin engaging surface being located proximally of the first skin engaging surface. Advantageously, a pen needle assembly is provided having two skin engaging surfaces which provide stability in achieving subcutaneous injections.

Abstract: An apparatus, method and computer-readable medium provide control of set top box volume based on mobile device events. The apparatus may execute a process that includes controlling a volume setting of an audio amplifier to output audio content to the one or more audio or audio/visual devices. A connection event signal from a mobile device is received via a wireless radio frequency receiver. The connection event signal indicates a call state of the mobile device. In response to receiving the connection event signal, a received signal strength indication associated with the connection event signal obtained. A volume setting that corresponds to the obtained received signal strength indication is determined. The volume setting output to the audio amplifier is adjusted according to the determined volume setting.

Abstract: Provided are antibodies that specifically bind to T-cell immunoglobulin domain and mucin domain 3 (Tim-3). The anti-Tim-3 antibodies can be used to treat, prevent or diagnose immune, cancerous, infectious diseases or other pathological disorders that may be modulated by Tim-3-mediated functions.

Abstract: Compounds and methods for treating diseases or conditions affected by the activity or expression of genes/proteins related to human GH, GHR, STAT5, SOCS, IGF-1, insulin are provided. Monoclonal antibodies for treating diseases or conditions related to growth hormone and growth hormone receptor activity are also provided.

Abstract: An electronic device is provided. The electronic device comprises a display unit and a processing unit. The processing unit is electrically connected to the display unit and is configured to perform steps including: obtaining signal strength of connections between a plurality of nodes; and controlling the display unit to display the connections graphically according to the signal strength. An operation method adapted to an electronic device, and a non-transitory computer readable storage medium is also provided.

Abstract: An information processing method and an electronic apparatus are provided, for solving a technical problem of a weak capability of the electronic apparatus to process information. The method includes: acquiring M variation messages by monitoring variations of files in a file system of an electronic apparatus, where M is a positive integer; determining N files based on the M variation messages, where N is an integer less than or equal to M; identifying the N files respectively to determine at least one of the N files which meets a preset condition; and deleting the at least one file to reduce the amount of data stored in the electronic apparatus.

Abstract: The present disclosure relates to a technical field of solar cells, and more particularly to a separation device and a separation method for a film and a wafer. The separation device includes a base, a first suction plate, a driving mechanism, a swinging rod, and a clamping mechanism, wherein the first suction plate is horizontally provided on the base, and the first suction plate is fitted and sucked to a lower surface of a wafer; one end of the swinging rod is connected with the driving mechanism, and the other end of the swinging rod is connected with the clamping mechanism; the driving mechanism is used for driving the swinging rod and the clamping mechanism to swing in a vertical plane so that the swinging rod and the clamping mechanism get close to or away from the first suction plate.