Abstract: A drug delivery device comprises a medication container containing medication for delivery and a detachable unit having an electronic circuit with a microprocessor. The electronic circuit is open and non-operational when the detachable component is assembled on the drug delivery device; and the electronic circuit is closed and operational when the detachable component is detached from the drug delivery device. The detachment of the detachable unit is an essential step to operate the drug delivery device. The detachable unit can be an activation protection cap or a needle shield remover for an autoinjector device. Alternatively, the detachable unit can be a needle shield remover for a pre-filled syringe.

Abstract: A method for treating autoimmune and/or inflammatory disease includes a step of identifying a subject exhibiting symptoms of autoimmune and/or inflammatory disease administering a fasting mimicking diet. A probiotic composition for gastrointestinal autoimmune and/or inflammatory disease Bacteroides acidifaciens, Bifidobacterium choerinum, and combinations thereof is also provided.

Abstract: A scheduling method applied in an industrial heterogeneous network in which a TSN and a non-TSN are interconnected is provided. The TSSDN controller classifies data flows according to the delay requirements, and calculates the scheduling priorities of the data flows in the industrial heterogeneous network. The TSSDN controller adopts an improved CSPF algorithm to determine a shortest path in the heterogeneous network, and marks the scheduling priorities of the data flows which are transmitted from the subnet of the heterogeneous network and arrive at the switch for the first time. Flow table matching is performed at the SDN switch. In a case of performing flow table matching successfully, the counter is updated and the instruction included in the flow table is executed. In a case of performing flow table matching unsuccessfully, a PacketIn message is transmitted to the TSSDN controller, and the TSSDN controller performs analysis and makes a decision.

Abstract: The present invention relates to a DDoS attack detection and mitigation method for an industrial SDN network, and belongs to the field of network security. According to the method, by means of the cooperation between an east-west interface of an SDN controller in an industrial backhaul network and a system manager of an industrial access network, in conjunction with the features of the industrial backhaul network and an industrial access network data packet, a flow entry matching field of an OpenFlow switch is extended, and a flow table 0 is set to be a “flow table dedicated to DDoS attack mitigation” for defending against an attacking data flow in a timely manner. By using the SDN controller of an industrial backhaul network and a DDoS attack detection and mitigation system, an attacking data flow is identified and a DDoS attack source is found, and the policy of mitigating a DDoS attack is implemented by means of scheduling a system manager of the industrial access network.

Abstract: The present invention relates to a judgment method for edge node computing result trustworthiness based on trust evaluation, and belongs to the technical field of data processing. By means of the present invention, a security mechanism for trustworthiness of a computing result output by an industrial edge node is guaranteed, the industrial edge node is prevented from outputting error data, and attacks of false data of malicious edge nodes are resisted, it is guaranteed that trustworthy computing results not be tampered are input in the industrial cloud, and a site device is made to receive correct computing results rather than malicious or meaningless messages, thereby improving efficiency and security of industrial production.

Abstract: An injection device is provided herein comprising a container body for holding medication content having a distal end and a proximal end, the container body providing an outward flange at the distal end and a ledge at the proximal end; a piston placed at the proximal end of the container body for sealing and displacing medication content; a push rod placed inside the container body for moving the piston distally; and a connector providing an orifice for medication content delivery, placed at said distal end of said container body. The orifice in the connector provides medication content injection fluid pathway. With modification of the fundamental structure, a number of innovative device designs are created.

Abstract: Provided are antibodies that specifically bind to TIGIT (T cell immunoreceptor with Ig and ITIM domains, WUCAM or Vstm3) and inhibit Tigit-mediated cellular signaling and activities in immune cells. The anti-TIGIT antibodies can be used to treat or diagnose cancer, infectious diseases or other pathological disorders that may be modulated by Tigit-mediated functions.

Abstract: Disclosed herein is a building assembly for assembling building panels. The building assembly includes a supporting member, a pair of a first sealing member, an elastically deformable gasket, and a second sealing member. The supporting member has a base, a channel disposed at the center of the base, and a pair of rails independently disposed next to the channel. The pair of a first sealing members independently includes a first base portion and two retention tongues independently extending outwardly from the first base portion. The elastically deformable gasket has a U- or V-shaped space in cross section and two flanges independently extending laterally from one edge of the U- or V-shaped space. The second sealing member has a second base portion and a rib disposed at the center of the second base portion.

Abstract: The present invention provides a factory power management and control method based on edge-cloud coordination, including: 1) forming an industrial field network by a field node, a routing node and a device executing production tasks; 2) parsing production task information data and sending; 3) issuing an STN model in production field to an edge node; 4) sending to the edge node; 5) computing, required to complete the production tasks; 6) computing values of comprehensive ranks; 7) executing, by the edge node, the higher rank, and executing, by the cloud power management center, the lower rank; 8) executing, by the edge node, a demand response algorithm; 9) executing, by the production device, the production tasks based on computing results; and executing, by a power generation station in factory, a power storage station in factory and a power supply station outside factory, corresponding schemes based on the results.

Abstract: An electrically and thermally conductive gasket includes a resilient core including a plurality of sides, a heat spreader disposed along at least two sides of the plurality of sides of the resilient core, and an electrically conductive layer disposed along and/or covering at least a portion of the heat spreader, such that the portion of the heat spreader is between the resilient core and the electrically conductive layer. The gasket is positionable and/or compressible between first and second surfaces to thereby define an electrically conductive path and a thermally conductive path between the first and second surfaces.

Abstract: Provided are antibodies that specifically bind to TIGIT (T cell immunoreceptor with Ig and ITIM domains, WUCAM or Vstm3) and inhibit Tigit-mediated cellular signaling and activities in immune cells. The anti-TIGIT antibodies can be used to treat or diagnose cancer, infectious diseases or other pathological disorders that may be modulated by Tigit-mediated functions.

Abstract: A medication infusion device includes a pre-filled medication container containing sterile liquid medication. The medication infusion device also includes an infusion needle and the infusion needle has a distal end, wherein the distal end of the infusion needle is movable relative to the pre-filled medication container. There is a pierceable elastomeric component arranged at the distal end of the infusion needle to define a sterile environment, and this sterile environment is shared by the pre-filled medication container and the distal end of the infusion needle. The distal end of the infusion needle is embedded in a pierceable elastomeric component in order to keep the infusion needle enclosed in the sterile environment and prevent medication from flowing out of the infusion needle.

Abstract: Provided are antibodies that specifically bind to T-cell immunoglobulin domain and mucin domain 3 (Tim-3). The anti-Tim-3 antibodies can be used to treat, prevent or diagnose immune, cancerous, infectious diseases or other pathological disorders that may be modulated by Tim-3-mediated functions.

Abstract: A fasting mimicking diet package providing daily meal portions for a predetermined number of days is provided. The fasting mimicking diet package includes a kale cracker composition, a first vegetable broth composition, a mushroom soup composition, a tomato soup composition, a quinoa-containing minestrone soup composition, a bean-containing minestrone soup composition, and a pumpkin soup composition. Characteristically, the daily meal portions are packaged into meal servings or into a total daily serving to be divided into meals.

Abstract: A medication infusion device includes a medication container containing liquid medication; an infusion needle; and a reciprocating pump having a pump chamber. The liquid medication is withdrawn from the medication container into the pump chamber during suction operation of the reciprocating pump, and the liquid medication is dispensed out of the pump chamber through the infusion needle during dispensing operation of the reciprocating pump. There are also mechanisms preventing liquid from flowing through the infusion needle during suction operation of the reciprocating pump and preventing liquid from flowing back into the medication container during dispensing operation of the reciprocating pump. The medication infusion device may further include a microcontroller to control medication infusion volume and rate.

Abstract: The present application discloses a needle for repairing an alignment layer on a liquid crystal display substrate. The needle includes a needle tip; and a flexible material coating surrounding the needle tip.

Abstract: Disclosed are systems for applying materials to components. The system comprises a tool operable for transferring a portion of a material from a supply of the material to a component. A first portion of the tool may be configured for cutting along a side or edge of the portion of the material. A second portion of the tool may be configured for tamping, pressing, or pushing against the portion of the material to cause uncut sides or edges of the portion of the material attached to the supply of the material to be torn, severed, detached, or separated from the supply of the material.

Abstract: The invention proposes a method of separating hemicellulose through efficient pretreatment of fibrous biomass materials. Fibrous biomass materials are first pretreated by the slurry method: the fibrous biomass materials are milled through ball mills and sieved to obtain fibrous biomass material powder, and the powder is mixed with water at room temperature to obtain slurry premixed solution of the fibrous biomass material powder. Through regulation and control of the reaction temperature, the time and the water amount, efficient hydrothermal removal of hemicellulose from the fibrous biomass material powder is realized. After the mixed solution is filtered, the filtrate is subject to gradient sedimentation to separate hemicellulose with low dispersity, and the sediment is then dried before storage. After the filter residue is mixed with polar aprotic solvent and water, and heated and stirred in a pressurized reactor, high-purity cellulose is obtained through filtering and separation.

Abstract: Provided are antibodies that specifically bind to TIGIT (T cell immunoreceptor with Ig and ITIM domains, WUCAM or Vstm3) and inhibit Tigit-mediated cellular signaling and activities in immune cells. The anti-TIGIT antibodies can be used to treat or diagnose cancer, infectious diseases or other pathological disorders that may be modulated by Tigit-mediated functions.

Abstract: Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a chemotherapeutic agent. Also, disclosed a pharmaceutical combination comprising a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor, or a chemotherapeutic agent and the use thereof.