Abstract: The present invention provides for a process for preparing liposomes, lipid discs, and other lipid nanoparticles using a multi-port manifold, wherein the lipid solution stream, containing an organic solvent, is mixed with two or more streams of aqueous solution (e.g., buffer). In some aspects, at least some of the streams of the lipid and aqueous solutions are not directly opposite of each other. Thus, the process does not require dilution of the organic solvent as an additional step. In some embodiments, one of the solutions may also contain an active pharmaceutical ingredient (API). This invention provides a robust process of liposome manufacturing with different lipid formulations and different payloads. Particle size, morphology, and the manufacturing scale can be controlled by altering the port size and number of the manifold ports, and by selecting the flow rate or flow velocity of the lipid and aqueous solutions.

Abstract: The invention discloses a novel four-direction headrest, which comprises a headrest housing, a U-shaped headrest bar, a Z-direction sliding fixing socket, an unlocking mechanism bracket, a tab, a tab return spring, an X-direction sliding fixing socket, an X-direction sliding guide, an unlocking steel wire, an unlocking button, wherein the locking and unlocking among the X-direction sliding fixing socket, the unlocking mechanism bracket, and the U-shaped headrest bar is realized by the unlocking steel wire, and the locking and unlocking between the tab and the X-direction sliding guide is realized by the tab movement driven by the unlocking steel wire. The locking and unlocking mechanism of the invention is simple, efficient and controllable.

Abstract: Adipose derived regenerative cells are used to treat patients, including patients with cardiovascular conditions, diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells, e.g., stem and/or progenitor cells, obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, adipose derived regenerative cells are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic cardiovascular benefit.

Abstract: In one embodiment, a method includes receiving at a location related failure identification device, failure data for a plurality of components within a system, mapping at the device, the failure data to location data comprising a location of each of the components within the system, identifying at the device, location related failures based on the mapping, and outputting from the device, information on the location related failures. An apparatus and logic are also disclosed herein.

Abstract: Disclosed are various embodiments for increasing distributed database capacity by adding new nodes while minimizing downtime. A database is partitioned among multiple nodes in a cluster. Each node stores a respective portion of the database. The portions of the database are replicated to corresponding physical standbys. For each portion, a first portion is mapped to an existing node, while a remaining portion is mapped to a physical standby. The cluster is updated to include the physical standbys as additional nodes among which the database is partitioned.

Abstract: A technique includes determining a first set of intra-node port weights for a first switch of a first routing node, determining a set of inter-node port weights including a first inter-node port weight for routing traffic to a second routing node, determining a first inter-node weighted port group for the first switch for traffic directed to the second routing node, the first inter-node weighted port group including a first total port weight based on a first intra-node port weight and the first inter-node port weight and which is applied to a first port of the first switch, and a second total port weight based on a second intra-node port weight and the first inter-node port weight and which is applied to the second port of the first switch, and routing traffic to an output port of the first switch based on the first inter-node weighted port group.

Abstract: A technique for load balancing in a multi-topology network selects a network path having a favorable bandwidth*hop count product. Accordingly, shorter paths are prioritized while longer paths are used for traffic load balancing when appropriate. For example, a telecommunications network may employ a Clos-style topology in which hosts are connected to each other through multiple hierarchical levels of forwarding devices. One or more high level switches may be removed, creating isolated blocks of forwarding devices. The blocks may be connected by the remaining original high level Clos-style topology switch(es) and a second type of network topology. In an exemplary embodiment, traffic may be scheduled over routes with the following decreasing priorities: (1) the shortest path, using either or both network topologies; (2) a path using only a single network topology type; (3) non-shortest paths between directly-connected blocks; and (4) non-shortest paths between indirectly-connected blocks.

Abstract: Embodiments of vehicles including wheel well reinforcement members are discussed and disclosed herein. In one embodiment, a vehicle includes a wheel well, a rocker coupled to the wheel well, where the rocker extends rearward from the wheel well in a vehicle longitudinal direction, a torque box coupled to the rocker, and a reinforcement member positioned at least partially within the wheel well, the reinforcement member including a forward face that is coupled the radially inward facing side of the wheel well, and at least one of a downward face that is coupled to and extends along the torque box and that is oriented to face downward in a vehicle vertical direction and an outboard face that is coupled to and extends along the rocker and that is oriented to face outboard in the vehicle lateral direction.

Abstract: A file transmitting system and method can deliver a file to other directories according to a user's operation. The system and method record status information corresponding to different user interfaces, and are configured to detect a user interface and a file that the user is operating. The system and method further deliver the file to a designated directory from the record without changing a current user interface to the user interface with the designated directory.

Abstract: Docetaxel and doxorubicin can be formulated in liposomal pharmaceutical compositions. In various embodiments, the pharmaceutical compositions include (i) a first liposome type comprising a first lipid layer comprising an unsaturated phospholipid, cholesterol or a cholesterol derivative, DC-cholesterol, a cationic lipid, and preferably a pegylated phospholipid, and a first active pharmaceutical ingredient (API) comprising docetaxel in the first lipid layer; and (ii) a second liposome type comprising a second lipid layer, an aqueous interior, and a second API comprising doxorubicin crystallized in the aqueous interior, (iii) where the first liposome type does not comprise doxorubicin and the second liposome type does not comprise docetaxel. The pharmaceutical composition can be used to treat a subject, for example, a human subject having cancer.

Abstract: A pharmaceutical composition can include a plurality of liposomes comprising docetaxel and doxorubicin. In various embodiments, a liposome can include (i) an active pharmaceutical ingredient (API) comprising docetaxel and doxorubicin; (ii) a lipid layer comprising an unsaturated phospholipid, a cholesterol, a cationic lipid, and preferably a pegylated phospholipid; and (iii) an aqueous interior, wherein the docetaxel is in the lipid layer and the doxorubicin is crystallized in the aqueous interior. The liposomes can be used to treat a subject, for example, a human subject having cancer. The cancer can be, for example, a lung cancer, preferably non-small cell lung cancer (NSCLC), colon cancer, breast cancer, or liver cancer.

Abstract: This disclosure provides an emergency handling method, comprising: receiving, by an emergency support function (ESF) entity, an emergency indicator indicating an emergency event from a network application server; handling the emergency indictor to derive related parameters including impacted network elements in a network; and triggering the impacted network elements to switch into a network emergency mode by sending an emergency command based on the related parameters. An emergency handling apparatus in a network is also provided. This improves efficiency of emergency handling in a network.

Abstract: A method for preparing a magnesium-based hydrogen storage material, includes: a Mg—Ce—Ni family amorphous alloy is prepared by a rapid cooling process; the amorphous alloy is pulverized, so as to obtain a amorphous powder; the amorphous alloy is activated, so as to obtain a MgH2—Mg2NiH4—CeH2.73 family nanocrystalline composite; the abovementioned composite is carried out a hydrogen absorption and desorption cycle, then the composite is placed in a pure Ar atmosphere for passivation, finally, the passivated composite is oxidized, so as to obtain a MgH2—Mg2NiH4—CeH2.73—CeO2 family nanocrystalline composite.

Abstract: Exemplary embodiments allocate network traffic among multiple paths in a network, which may include one or more preferred paths (e.g. shortest paths) and one or more alternative paths (e.g., non-shortest paths). In one embodiment, network traffic in form of flows may be allocated to the preferred paths until the allocation of additional network traffic would exceed a predetermined data rate. Additional flows may then be sent over the alternative paths, which may be longer than the preferred path. The paths to which each flow is assigned may be dynamically updated, and in some embodiments the path assignment for a particular flow may time out after a predetermined time. Accordingly, the flow traffic of each path may be balanced based on real-time traffic information.

Abstract: Described herein are devices for the transfer of tissue into tissue processing devices. In some embodiments, the devices provide for the transfer of tissue from a tissue collection vessel to a tissue processing vessel. In some embodiments, the devices and methods provide for direct harvest of the tissue into a tissue processing vessel. In some embodiments, the devices and methods provide for transfer of harvested tissue within a tissue collection container to a tissue processing container.

Abstract: Aspects and implementations of the present disclosure generally relate to use of a multi-chassis link aggregation for high performance and resilience in wide-area networking. In one aspect, the disclosure relates to a system that includes a switch fabric. The fabric includes at least a plurality of edge network devices, a set of internal switch devices, and a plurality of internal network links coupling each edge network device to at least a subset of the set of internal switch devices. The system includes a network controller coupled to the switch fabric, configured to maintain at least one link aggregation comprising a logical grouping of externally facing network interfaces of at least two of the plurality of edge devices. The network controller is configured to monitor internal link performance characteristics and determine throughput characteristics for each link aggregation over time based at least in part on current internal link performance characteristics.

Abstract: The disclosure relates to methods and nodes for reducing the signaling load in a communications network. One claim of the disclosure relates to a method in a first network node for handling of service requests. The method comprises the steps of: generating a service request message, transmitting the service request message to a second network node, establishing a radio access bearer, RAB, to the second network node, and transmitting uplink data via said RAB to the second network node.

Abstract: Disclosed are various embodiments for facilitating data redistribution in database sharding. A database is maintained that is horizontally partitioned into a set of first buckets using modulo-based assignments. A fixed number of the first buckets are stored in each of multiple physical data stores. The database is repartitioned into a set of second buckets using modulo-based assignments. The number of second buckets in the set is a multiple of the sum of a positive integer and the quantity of the physical data stores. The data in the database is unmoved between the physical data stores by repartitioning.

Abstract: An Sb—Te—Ti phase-change thin-film material applicable to a phase-change memory and preparation thereof. The Sb—Te—Ti phase-change memory material is formed by doping an Sb—Te phase-change material with Ti, Ti forms bonds with both Sb and Te, and the Sb—Te—Ti phase-change memory material has a chemical formula SbxTeyTi100-x-y, where 0<x<80 and 0<y<100?x. When the Sb—Te—Ti phase-change memory material is a Ti—Sb2Te3 phase-change memory material, Ti atoms replace Sb atoms, and phase separation does not occur. The crystallization temperature of the Sb—Te—Ti phase-change memory material is significantly risen, retention is improved, and thermal stability is enhanced; meanwhile, the amorphous state resistance decreases, and the crystalline state resistance increases; and the Sb—Te—Ti phase-change memory material has wide application in phase-change memories.

Abstract: The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue.