Abstract: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1? and human IL-1?. The dual specific antibodies of the invention also neutralize both human IL-1? and human IL-1?. The invention also provides domain antibodies (dAbs) specific for human IL-1? and human IL-1?.

Abstract: Proteins that bind sclerostin or sclerostin and TNF are described along with there use in composition and methods for treating, preventing, and diagnosing sclerostin related diseases and for detecting sclerostin or sclerostin and TNF in cells, tissues, samples, and compositions.

Abstract: Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-?), e.g., human TNF-?, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.

Abstract: The present invention features nucleic acids for recombinant protein expression in mammalian cell culture. The episomal vectors of the invention promote high protein production in mammalian cells expressing the SV40 T Ag or Epstein-Barr virus nuclear antigen (e.g., COS7 or HEK293-6E cells). The methods and systems are useful, for example, in pharmaceutical drug development and cloning, especially for the production of antibodies.

Abstract: According to various embodiments, a reagent fluid dispensing device may be provided. The reagent fluid dispensing device may include a chamber for receiving a reagent fluid, the chamber having a first opening and a second opening; a first fluid conduit connected to the first opening of the chamber; a reservoir connected to the first fluid conduit, the reservoir having a first opening, wherein the first opening of the reservoir is connected to the first fluid conduit to form a passive valve, wherein the reservoir is dimensionalized for storing a predetermined volume of the reagent fluid; and a pneumatic conduit connected to the second opening of the chamber, wherein selective application of pneumatic pressure to the chamber through the pneumatic conduit transfers the reagent fluid from the reservoir to the chamber through the first fluid conduit. According to various embodiments, a microfluidic device including the reagent fluid dispensing device, and a method of dispensing a reagent fluid may be provided.

Abstract: A method for controlling uninterruptible and parallel power modules has steps of parallelly and unloadably connecting multiple power modules to a load, acquiring a number and a load wattage of the power modules connected to the load and an instant load ratio, calculating a simulated load ratio in accordance with a simulated number of the power modules and the load wattage, if the simulated load ratio is closer to a half load and the redundancy requirement is met, unloading at least one of the power modules connected to the load so that other power modules connected to the load can share the additional load released from the unloaded power modules and the load ratio and output efficiency of each power module connected to the load can be enhanced.

Abstract: A method and device for determining a concentration of a biological target. The method and device include: capturing an image of a ticket including the biological target and information about the ticket; selecting pre-determined data corresponding to the ticket and the target responsive to the read information about the ticket; and determining the concentration of the biological target according to the pre-determined data. The method and device may further comprise selecting calibration data corresponding to the ticket, responsive to the read information about the ticket; and determining the concentration of the biological target according to the pre-determined data and the calibration data.

Abstract: The present invention features improved in vitro RNA display libraries to allow reliable expression and selection of scFv antibody molecules from expression libraries. The scFv antibody libraries of the invention contain an optimized, shortened inter-domain linker that improves expression scFv antibody expression. The scFv antibody libraries also include short nucleic acid barcodes that allow for identification of individual library clones, libraries or subsets thereof. Primers for generating, amplifying and spectratyping the scFv antibody libraries of the invention are also provided.

Abstract: The present invention describes IL-1? binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1?. Binding proteins of the invention have high affinity for IL-1? and neutralize IL-1? activity. A binding protein of the invention can be a full-length antibody or an IL-1?-binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1? binding proteins of the invention are useful for detecting IL-1? and for inhibiting IL-1? activity, including in a human subject suffering from a disease or disorder in which IL-1? activity is detrimental.

Abstract: Embodiments provide a security infrastructure that may be configured to run on top of an existing operating system to control what resources can be accessed by an applications and what APIs an application can call. Security decisions are made by taking into account both the current thread's identity and the current thread's call chain context to enable minimal privilege by default. The current thread context is captured and a copy of it is created to be used to perform security checks asynchronously. Every thread in the system has an associated identity. To obtain access to a particular resource, all the callers on the current thread are analyzed to make sure that each caller and thread has access to that resource. Only when each caller and thread has access to that resource is the caller given access to that resource.

Abstract: The present invention encompasses IL-1? binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Antibodies of the invention have high affinity for IL-1? and neutralize IL-1? activity. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting IL-1? and for inhibiting IL-1? activity, e.g., in a human subject suffering from a disorder in which IL-1? activity is detrimental.

Abstract: The disclosure provides a touch panel, including: a substrate, wherein the substrate includes a viewing region and a border region at an edge of the viewing region; a patterned transparent conductive layer formed on the substrate, wherein the patterned transparent conductive layer formed on the viewing region has a touch sensitive function; and a patterned metal layer formed on the patterned transparent conductive layer and on the border region, wherein the patterned metal layer includes a contact region and a trace region connecting to the contact region, and at least a portion of the contact region overlaps with the patterned transparent conductive layer, and a shift range between a formation position of the contact region of the patterned metal layer and a formation position of the patterned transparent conductive layer is smaller than about 150 ?m.

Abstract: A method for creating virtual environmental sensor on a power distribution unit is executed by a power distribution unit and has steps of connecting to a network and at least one power-consuming device, searching all environmental sensors through the network, receiving environmental condition messages sent from each environmental sensor, presenting at least one environmental condition range to determine if the environmental condition messages sent from each environmental sensor are out of one of the at least one environmental condition range, and powering on or off a corresponding power-consuming device when each environmental condition message is out of a corresponding environmental condition range. Using the method can create remote environmental sensors networked with the PDU and solve the expansion restriction, spatial limitation and intractable wiring arising from the environmental sensor embedded in the conventional PDU in the form of hardware.

Abstract: A touch display panel including a display panel and a touch panel is provided. The display panel includes a shielding pattern and a plurality of pixels separated by the shielding pattern and including multiple edge directions. The touch panel is disposed on the display panel and includes a plurality of first sensing series, a plurality of second sensing series and a plurality of dielectric patterns. Each dielectric pattern is disposed between each first sensing series and each second sensing series intersected therewith, and includes multiple edge direction non-parallel to the edge direction of the pixel.

Abstract: A method and system for matching two biometric images including receiving an input biometric image; generating an index table for the input biometric image, wherein the index table includes a quality quantity for each minutia of the input biometric image; receiving a second biometric image; generating a number of patterns for a first minutia of the second biometric image; associatively accessing the index table by the generated number of patterns; accumulating quality quantities accessed from the index table for each minutia of the input biometric image for the number of patterns of the first minutia of the second biometric image; and selecting a minutia candidate of the input biometric image responsive to the accumulated quality quantities.

Abstract: An uninterruptible power supply supporting active loads includes a charge and discharge module having a battery set and a charger charging the battery set with an input power, a switch circuit having at least two active switches connected to the battery set, a dynamic PWM control module connected with each of the active switches of the switch circuit, alternately outputting duty cycles composed of low-frequency square wave and high-frequency square wave and alternately controlling each of the active switches to turn on or off, and a transformer having a primary side connected with the switch circuit and a secondary side whose two terminals are connected with an output capacitor generating a filtering function in collaboration with an leakage inductor in the secondary side of the transformer. The uninterruptible power supply generates a quasi-continuous output satisfying the hold-up time demanded by an active load.

Abstract: A packaging box with easy tearing structure comprises a material box having: a seat; one side of the seat having a breakable portion; a receiving space formed at a lower side of the seat for receiving an object; an upper cover for covering the seat; a sealing film adhering on an upper side of the upper cover; the sealing film having at least one tearing line at the corresponding edge of the upper cover; the sealing film including an easy tearing portion which can be torn away from the other portion of the sealing film easily; and one end of the easy tearing portion adhering on the breakable portion. Moreover, the cover can be neglected.

Abstract: A method of remotely controlling power distribution units enables the power distribution units to automatically transmit messages to a server once connected to the server via a network. When a user logs into a server and requests to remotely control the associated power distribution units, the user only needs to enter the serial numbers or identification data thereof. The server then automatically searches for all power distribution units owned by the user, and provides a group management interface. The user can then group the power distribution units according to their locations or their properties in order to control the on and off thereof. Without knowing the IP addresses of the power distribution units, the user can readily control the power distribution units at different locations remotely.

Abstract: A semiconductor package includes a patterned metal foil, a chip, wires, a patterned dielectric layer, an adhesive layer, and a molding compound. The patterned metal foil has a first surface and a second surface opposite thereto. The patterned dielectric layer is disposed on the second surface and has openings exposing at least a portion of the patterned metal foil to form joints for external electrical connection. The chip is disposed on the first surface. The adhesive layer is disposed between the chip and the patterned metal foil. The wires respectively connect the chip and the patterned metal foil. The patterned dielectric layer is located below intersections between the wires and the patterned metal foil. The patterned dielectric layer, the wires, and the patterned metal foil overlap with one another on a plane. The molding compound is disposed on the first surface and covers the chip and the wires.