Abstract: A controller for use in a power converter including a jitter generator circuit coupled to receive a drive signal from a switch controller and generate a jitter signal. The jitter signal is a modulated jitter signal when the drive signal is below a first threshold frequency. The switch controller is coupled to a power switch coupled to an energy transfer element. The switch controller is coupled to receive a current sense signal representative of a current through the power switch. The switch controller is coupled to generate the drive signal to control switching of the power switch in response to the current sense signal and the jitter signal to control a transfer of energy from an input of the power converter to an output of the power converter.

Abstract: This disclosure provides compounds and compositions and methods of using those compounds and compositions to treat diseases and disorders associated with excessive transforming growth factor-beta (TGF?) activity. This disclosure also provides methods of using the compounds in combination with one or more cancer immunotherapies.

Abstract: A method, non-transitory computer readable medium, and device that assists with proactive prediction of disk failure in a RAID group includes obtaining performance data for a plurality of storage drives. The obtained performance data is compared with a stored classification data to predict one or more storage drives of the plurality of storage drives failing within a time period. The data present in the one or more storage drives predicted to fail based on the comparison is copied on to one or more secondary storage drives. A notification including a list of the one or more storage drives predicted to fail is sent upon the copying the data on to the one or more secondary storage drives.

Abstract: A method and system for controlling a data transmission for a network-based service over limited network connectivity are described. A computing device detects that it has insufficient network connectivity to transmit a data message from a service requester application executing on the computing device to a server using a data communications channel. The computing device receives user input for a request for service and transmits the request for service to the server via an alternate communications channel. The server receives and processes the request to arrange for service for the user and transmits data corresponding to a service arrangement to the computing device over the alternate communications channel.

Abstract: A controller includes a current limit generator that generates a current limit threshold. A switch controller receives the current limit threshold, an enable signal, and a current sense signal representative of a current through a power switch. The switch controller generates a drive signal to control switching of the power switch to control the transfer of energy from an input of the power converter to an output of the power converter in response to the enable signal and the current sense signal. The switch controller outputs the drive signal to turn on the power switch in response to the enable signal and turns off the power switch when the current sense signal reaches the current limit threshold. A jitter generator generates a jitter signal for jittering a switching period of the drive signal. The current limit threshold is modulated by the jitter signal.

Abstract: This disclosure provides compounds and compositions and methods of using those compounds and compositions to treat diseases and disorders associated with excessive transforming growth factor-beta (TGF?) activity. This disclosure also provides methods of using the compounds in combination with one or more cancer immunotherapies.

Abstract: There are provided inter alia pyrazolyl-substituted pyridone compounds, which exhibit biological activity, e.g., inhibitory action, against serine proteases, including thrombin and various kallikreins. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of serine proteases, including thrombin and various kallikreins.

Abstract: A switched mode power converter has an energy transfer element that delivers an output signal to a load. A power switching device coupled to the primary side of the energy transfer element regulates a transfer of energy to the load. A secondary controller is coupled to receive a feedback signal and output a pulsed signal in response thereto. A primary controller is coupled to receive the pulsed signal and output a drive signal in response thereto, the drive signal being coupled to control switching of the power switching device. A compensation circuit generates an adaptively compensated signal synchronous with the pulsed signal. The adaptively compensated signal has a parameter that is adaptively adjusted in response to a comparison of the feedback signal with a threshold reference signal. The parameter converges towards a final value that produces a desired level of the output signal.

Abstract: A method and system for controlling a data transmission for a network-based service over limited network connectivity are described. A computing device detects that it has insufficient network connectivity to transmit a data message from a service requester application executing on the computing device to a server using a data communications channel. The computing device receives user input for a request for service and transmits the request for service to the server via an alternate communications channel. The server receives and processes the request to arrange for service for the user and transmits data corresponding to a service arrangement to the computing device over the alternate communications channel.

Abstract: A controller includes a switch controller, a current limit generator, a jitter modulator, and an arithmetic operator circuit. The switch controller is coupled to generate a drive signal to control switching of a power switch in response to a current sense signal and a modulated current limit signal to control a transfer of energy from an input of a power converter to an output of the power converter. The current limit generator is coupled to generate a current limit signal. The jitter modulator is coupled to generate a jitter signal for jittering a switching period of the drive signal without an oscillator. The arithmetic operator circuit is coupled to receive the current limit signal and the jitter signal and is coupled to generate a modulated current limit signal in response to the current limit signal and the jitter signal.

Abstract: A computing system can detect a session trigger corresponding to execution of a service application on a computing device of a user, the session trigger initiating a user session of an application-based service. The system can execute one or more of a plurality of models corresponding to a unique objective for the application-based service, wherein each model runs real-time session data corresponding to the user session. The system can generate, from each model of the plurality of models, a session score indicating a priority level for the unique objective corresponding to the model. Based on the session score from each of the plurality of models, the system can transmit treatment data to the computing device of the user, the treatment data causing treatment content to be displayed on the computing device of the user.

Abstract: Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: A method for the production of air gases by the cryogenic separation of air can include the steps of sending a purified and compressed air stream to a cold box under conditions effective for cryogenically separating the air stream into an oxygen product and nitrogen using a system of columns, wherein the purified and compressed air stream is at a feed pressure when entering the system of columns; withdrawing the oxygen product at a product pressure; delivering the oxygen product at a delivery pressure to an oxygen pipeline, wherein the oxygen pipeline has a pipeline pressure; wherein during the second mode of operation, the method can include monitoring the pipeline pressure; and reducing the difference between the pipeline pressure and the delivery pressure. By operating the method in a dynamic fashion, a power savings can be realized in instances in which the pipeline pressure deviates from its highest value.

Abstract: A switched mode power converter has an energy transfer element that delivers an output signal to a load. A power switching device coupled to the primary side of the energy transfer element regulates a transfer of energy to the load. A secondary controller is coupled to receive a feedback signal and output a pulsed signal in response thereto. A primary controller is coupled to receive the pulsed signal and output a drive signal in response thereto, the drive signal being coupled to control switching of the power switching device. A compensation circuit generates an adaptively compensated signal synchronous with the pulsed signal. The adaptively compensated signal has a parameter that is adaptively adjusted in response to a comparison of the feedback signal with a threshold reference signal. The parameter converges towards a final value that produces a desired level of the output signal.

Abstract: A controller includes a switch controller, a current limit generator, a jitter modulator, and an arithmetic operator circuit. The switch controller is coupled to generate a drive signal to control switching of a power switch in response to a current sense signal and a modulated current limit signal to control a transfer of energy from an input of a power converter to an output of the power converter. The current limit generator is coupled to generate a current limit signal. The jitter modulator is coupled to generate a jitter signal for jittering a switching period of the drive signal without an oscillator. The arithmetic operator circuit is coupled to receive the current limit signal and the jitter signal and is coupled to generate a modulated current limit signal in response to the current limit signal and the jitter signal.

Abstract: There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of kallikrein, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of kallikrein.

Abstract: An apparatus for the production of air gases by the cryogenic separation of air can include a cold box having a heat exchanger, and a system of columns; a pressure monitoring device; and a controller. The cold box can be configured to receive a purified and compressed air stream under conditions effective for cryogenically separating the air stream to form an air gas product. The apparatus may also include means for transferring the air gas product from the cold box to an air gas pipeline. The pressure monitoring device is configured to monitor the pipeline pressure, and the controller is configured to determine whether to operate in a power savings mode or a variable liquid production mode. By operating the apparatus in a dynamic fashion, a power savings and/or additional high value cryogenic liquids can be realized in instances in which the pipeline pressure deviates from its highest value.

Abstract: A method for the production of air gases by the cryogenic separation of air can include the steps of sending a purified and compressed air stream to a cold box under conditions effective for cryogenically separating the air stream into oxygen and nitrogen using a system of columns, wherein the purified and compressed air stream is at a feed pressure when entering the system of columns; withdrawing the oxygen at a product pressure; delivering the oxygen at a delivery pressure to an oxygen pipeline, wherein the oxygen pipeline has a pipeline pressure; and monitoring the pipeline pressure. The method can also include a controller configured to determine whether to operate in a power savings mode or a variable liquid production mode. By operating the method in a dynamic fashion, a power savings and/or additional high value cryogenic liquids can be realized in instances in which the pipeline pressure deviates from its highest value.

Abstract: An apparatus for the production of air gases by the cryogenic separation of air can include a cold box having a heat exchanger, and a system of columns; a pressure monitoring device; and a controller. The cold box can be configured to receive a purified and compressed air stream under conditions effective for cryogenically separating the air stream to form an air gas product. The apparatus may also include means for transferring the air gas product from the cold box to an air gas pipeline. The pressure monitoring device is configured to monitor the pipeline pressure, and the controller is configured to adjust the product pressure of the air gas product coming out of the cold box based upon the pipeline pressure.

Abstract: An apparatus for the production of air gases with variable liquid production by the cryogenic separation of air can include a cold box having a heat exchanger, and a system of columns; a pressure monitoring device; and a controller. The cold box can be configured to receive a purified and compressed air stream under conditions effective for cryogenically separating the air stream to form an air gas product. The apparatus may also include means for transferring the air gas product from the cold box to an air gas pipeline. The pressure monitoring device is configured to monitor the pipeline pressure, and the controller is configured to adjust the product pressure of the air gas product coming out of the cold box based upon the pipeline pressure and to further adjust liquid production from the cold box based on the adjusted product pressure.