Abstract: A method for providing a jitter signal for modulating a switching frequency of a power switch for a power converter. The method comprising receiving a drive signal representative of the switching frequency of the power switch, detecting the switching frequency from the drive signal, determining if the switching frequency is less than a first threshold frequency, and modulating a frequency of the jitter signal in response to determining if the switching frequency is less than the first threshold frequency.

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

Abstract: 5,6-disubstituted 2-aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

Abstract: Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: The present invention relates to a large-scale photosynthetic bioreactor in which transparent photobioreactors including a baffle are connected in parallel or in series by an adhesive element so that the reactor volume can be easily scaled up for scale-up culture of photosynthetic organisms, and to a fabrication method thereof. The large-scale photosynthetic bioreactor according to the present invention makes it possible to culture a larger amount of microalgae than a conventional photobioreactor in the same area. In addition, it has high light transmittance, produces a large amount of biomass per unit area due to smooth mixing, and has a significant effect of reducing carbon dioxide. Furthermore, the present invention has an advantage in that the number of photosynthetic bioreactors required to culture the same scale of photosynthetic organisms is significantly smaller than that in a conventional process for culture of photosynthetic organisms, and thus the operating costs can be reduced.

Abstract: Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: One or more implementations of a multi-film thermoplastic bag with a conjoined hem channel. For example, the multi-film thermoplastic bag includes a multi-film hem channel. Bonds secure the layers of the hem channel together so as to prevent a drawtape from inverting or bunching an inner layer of the hem channel during cinching. The bonds are thus located in a hem channel of a multi-film thermoplastic bag so as to reduce an amount of mechanical engagement between the films of the multi-film thermoplastic bag and another thermoplastic film such as a drawtape. In one or more implementations, a grab zone of the multi-film thermoplastic bag also includes bonds in the form of contact areas to provide tactile and visual cues of strength in the grab zone.

Abstract: Novel bromodomain and extraterminal domain (BET) inhibitors and to therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.

Abstract: 1,8-naphthyridinone compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

Abstract: Heterocyclic compounds as Weel inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: A controller to regulate a power converter includes a terminal that receives an enable signal including enable events representative of an output of the power converter. A drive circuit generates a drive signal to control switching of a power switch to control an energy transfer from an input to an output of the power converter. The drive circuit turns on the power switch when an enable event is received in the enable signal. A current limit threshold generator is coupled to the drive circuit to generate a threshold signal. The threshold signal increases in response to the power switch turning off and subsequently decreases. The threshold signal and a time between consecutive enable events are used to modulate the drive signal to regulate the output of the power converter.

Abstract: One or more implementations of a multi-film thermoplastic structure include a first film having a first appearance in contact with a second film having a second appearance at one or more visually-distinct contact areas. Wherein the one or more visually-distinct contact areas, cause the first film to take on the second appearance of the second film. The visually-distinct contact areas being of a uniform gauge and configured to separate before either of the first film or the second film fails when subjected to peel forces.

Abstract: Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: A switched mode power converter has an energy transfer element that delivers an output signal to a load. A power switching device coupled to the primary side of the energy transfer element regulates a transfer of energy to the load. A secondary controller is coupled to receive a feedback signal and output a pulsed signal in response thereto. A primary controller is coupled to receive the pulsed signal and output a drive signal in response thereto, the drive signal being coupled to control switching of the power switching device. A compensation circuit generates an adaptively compensated signal synchronous with the pulsed signal. The adaptively compensated signal has a parameter that is adaptively adjusted in response to a comparison of the feedback signal with a threshold reference signal. The parameter converges towards a final value that produces a desired level of the output signal.

Abstract: This invention provides for substituted pyrazolo[3,4-d]pyrimidine compounds of the Formula (I): as Wee1 inhibitors. The substituted pyrazolo[3,4-d]pyrimidine compounds may find use as therapeutic agents for the treatment of diseases. The substituted pyrazolo[3,4-d]pyrimidine compounds may also find particular use in oncology.

Abstract: Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

Abstract: 5,6-disubstituted 2-aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

Abstract: Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.