Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

Abstract: 1,8-naphthyridinone compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

Abstract: This disclosure provides compounds and compositions and methods of using those compounds and compositions to treat diseases and disorders associated with excessive transforming growth factor-beta (TGF?) activity. This disclosure also provides methods of using the compounds in combination with one or more cancer immunotherapies.

Abstract: Novel bromodomain and extraterminal domain (BET) inhibitors contanining substituted 2-pyridones and therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.

Abstract: Heterocyclic compounds of Formula (J) as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: A method for providing a jitter signal for modulating a switching frequency of a power switch for a power converter. The method comprising receiving a drive signal representative of the switching frequency of the power switch, detecting the switching frequency from the drive signal, determining if the switching frequency is less than a first threshold frequency, and modulating a frequency of the jitter signal in response to determining if the switching frequency is less than the first threshold frequency.

Abstract: A control circuit comprising an output controller coupled to an output side of a power converter. The output controller comprises a switch control signal generator to receive a feedback signal representative of an output of the power controller and to communicate a control signal to an input controller coupled to an input side to control a turn ON of a power switch. The control signal is generated in response to the feedback signal and is communicated in response to an enable signal. The output controller comprises an extremum locator to generate the enable signal in response to a winding signal representative of an instantaneous voltage on an output terminal of an energy transfer element and the extremum locator enables the switch control signal generator such that the transition of the power switch from the OFF state to the ON state occurs substantially when the winding signal reaches an extremum.

Abstract: The present application discloses compounds that are inhibitors of Btk, compounds that are inhibitors of PI3K?, and compounds that are dual inhibitors of both Btk and PI3K?. Also described are methods for synthesizing such inhibitors and methods for using such inhibitors for the treatment of diseases wherein inhibition of Btk and PI3K? provides a therapeutic benefit to a patient having the disease.

Abstract: Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

Abstract: A method of providing an input switching request signal to an input side switch includes determining a switching request window indicative of relaxation ringing during a first switching cycle. It is determined that the input side switch is operating in a discontinuous conduction mode (DCM) mode of operation during a second switching cycle. It is determined that the switching request window is open during the second switching cycle. The input switching request signal is enabled in response to determining the switching request window is open.

Abstract: A controller for use in a power converter including a jitter generator circuit coupled to receive a drive signal from a switch controller and generate a jitter signal. The jitter signal is a modulated jitter signal when the drive signal is below a first threshold frequency. The switch controller is coupled to a power switch coupled to an energy transfer element. The switch controller is coupled to receive a current sense signal representative of a current through the power switch. The switch controller is coupled to generate the drive signal to control switching of the power switch in response to the current sense signal and the jitter signal to control a transfer of energy from an input of the power converter to an output of the power converter.

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

Abstract: This disclosure provides compounds and compositions and methods of using those compounds and compositions to treat diseases and disorders associated with excessive transforming growth factor-beta (TGF?) activity. This disclosure also provides methods of using the compounds in combination with one or more cancer immunotherapies.

Abstract: The present invention relates to a group of 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one (piperlongumine) derivatives, analogs and pharmaceutically acceptable salts thereof. The present invention also relates to processes for preparing the same; a pharmaceutical composition and formulation containing a derivative of piperlogumine; and use of the derivatives and analogs for treating cancer.

Abstract: A thermoplastic film which exhibits elastic-like behavior along at least one axis when stretched or elongated and then released. The thermoplastic film comprises a plurality of raised rib-like elements extending in a direction perpendicular to a main surface of the thermoplastic film. The thermoplastic film further includes a plurality of web areas positioned about the plurality of raised rib-like elements. The plurality of raised rib-like elements and plurality of web areas are arranged in a complex pattern. The complex pattern provides visual and tactile cues as the films are stretched or elongated. The complex pattern can cause the thermoplastic film to have a complex stretch profile.

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

Abstract: Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

Abstract: A method and apparatus for the production of air gases by the cryogenic separation of air with front end purification and air compression can include using an available compressed dry gas such as nitrogen, oxygen, stored purified air, or synthetic air to repressurize the adsorber without diverting any of the purified air just exiting the currently on-line adsorber or changing the flow rate of the main air compressor or air sent to the cold box. This enables the main air compressor (MAC) to operate at a relatively constant flow rate while also sending a relatively constant air flow to the cold box during this repressurization step, thereby reducing the risks of process upsets and minimizing capital expenditures related to the MAC and other warm-end equipments.

Abstract: A method and system for controlling a data transmission for a network-based service over limited network connectivity are described. A computing device detects that it has insufficient network connectivity to transmit a data message from a service requester application executing on the computing device to a server using a data communications channel. The computing device receives user input for a request for service and transmits the request for service to the server via an alternate communications channel. The server receives and processes the request to arrange for service for the user and transmits data corresponding to a service arrangement to the computing device over the alternate communications channel.

Abstract: A controller to regulate a power converter includes a terminal that receives an enable signal including enable events representative of an output of the power converter. A drive circuit generates a drive signal to control switching of a power switch to control an energy transfer from an input to an output of the power converter. The drive circuit turns on the power switch when an enable event is received in the enable signal. A current limit threshold generator is coupled to the drive circuit to generate a threshold signal. The threshold signal increases in response to the power switch turning off and subsequently decreases. The threshold signal and a time between consecutive enable events are used to modulate the drive signal to regulate the output of the power converter.