Abstract: A method for the production of air gases with variable liquid production by the cryogenic separation of air can include the steps of sending a purified and compressed air stream to a cold box under conditions effective for cryogenically separating the air stream into an oxygen product and nitrogen using a system of columns, wherein the purified and compressed air stream is at a feed pressure when entering the system of columns; withdrawing the oxygen product at a product pressure; delivering the oxygen product at a delivery pressure to an oxygen pipeline, wherein the oxygen pipeline has a pipeline pressure; wherein during the second mode of operation, the method can include monitoring the pipeline pressure; reducing the difference between the pipeline pressure and the delivery pressure; and adjusting liquid production from the cold box. By operating the method in a dynamic fashion, additional liquid production can be realized in instances in which the pipeline pressure deviates from its highest value.

Abstract: Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Abstract: There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of kallikrein, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of kallikrein.

Abstract: The present invention relates to a large-scale photosynthetic bioreactor in which transparent photobioreactors including a baffle are connected in parallel or in series by an adhesive element so that the reactor volume can be easily scaled up for scale-up culture of photosynthetic organisms, and to a fabrication method thereof. The large-scale photosynthetic bioreactor according to the present invention makes it possible to culture a larger amount of microalgae than a conventional photobioreactor in the same area. In addition, it has high light transmittance, produces a large amount of biomass per unit area due to smooth mixing, and has a significant effect of reducing carbon dioxide. Furthermore, the present invention has an advantage in that the number of photosynthetic bioreactors required to culture the same scale of photosynthetic organisms is significantly smaller than that in a conventional process for culture of photosynthetic organisms, and thus the operating costs can be reduced.

Abstract: A controller to regulate a power converter includes a terminal coupled to receive an enable signal including enable events representative of an output of the power converter. A drive circuit is coupled to generate a drive signal to control switching of a power switch to control a transfer of energy from an input of the power converter to the output of the power converter. The drive circuit is coupled to turn on the power switch when an enable event is received in the enable signal. A current limit threshold generator is coupled to the drive circuit to generate a current limit threshold signal. The current limit threshold signal varies each switching cycle of the power switch. A time between consecutive enable events in the enable signal is the switching cycle of the power switch.

Abstract: A controller includes a switch controller coupled to a power switch coupled to an energy transfer element. The switch controller is coupled to receive a current sense signal representative of a drain current through the power switch. The switch controller is coupled to generate a drive signal to control switching of the power switch in response to the current sense signal and a modulated current limit signal to control a transfer of energy from an input to an output of the power converter. A control modulator is coupled to generate a first signal. A jitter modulator is coupled to generate a second signal. The second signal is a periodic signal having a modulation time period that is greater than a switching period of the drive signal. An arithmetic operator circuit is coupled to generate the modulated current limit signal in response to the first signal and the second signal.

Abstract: A controller for use in a power converter includes a drive circuit coupled to generate a drive signal to control switching of a power switch to control a transfer of energy from a power converter input to a power converter output. An input is also included to receive an enable signal including enable events responsive to the power converter output. The drive circuit is coupled to turn ON the power switch in response to the enable events, and turn OFF the power switch in response to a power switch current reaching a current limit threshold. A current limit threshold generator is coupled to receive the drive signal from the drive circuit to vary the current limit threshold at a variable rate in response to the enable events of the enable signal.

Abstract: A method of providing an input switching request signal to an input side switch includes determining a switching request window indicative of relaxation ringing during a first switching cycle. It is determined that the input side switch is operating in a discontinuous conduction mode (DCM) mode of operation during a second switching cycle. It is determined that the switching request window is open during the second switching cycle. The input switching request signal is enabled in response to determining the switching request window is open.

Abstract: There are provided inter alia pyrazolyl-substituted pyridone compounds, which exhibit biological activity, e.g., inhibitory action, against serine proteases, including thrombin and various kallikreins. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of serine proteases, including thrombin and various kallikreins.

Abstract: This disclosure provides compounds and methods of using those compounds to treat metabolic disorders and hyperproliferative disorders, including administration of the compounds in conjunction with hormone receptor antagonists.

Abstract: Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

Abstract: 1,8-naphthyridinone compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

Abstract: A controller for use in a power converter including a jitter generator circuit coupled to receive a drive signal from a switch controller and generate a jitter signal. The jitter signal is a modulated jitter signal when the drive signal is below a first threshold frequency. The switch controller is coupled to a power switch coupled to an energy transfer element. The switch controller is coupled to receive a current sense signal representative of a current through the power switch. The switch controller is coupled to generate the drive signal to control switching of the power switch in response to the current sense signal and the jitter signal to control a transfer of energy from an input of the power converter to an output of the power converter.

Abstract: A power converter controller includes a drive circuit to generate a drive signal to control switching of a power switch. The drive circuit generates the drive signal in response to a current sense signal, a current limit signal, a frequency skip signal, and a hold signal. A current limit generator generates the current limit signal in response to a load. A frequency detection circuit generates the frequency skip signal in response to the drive signal to indicate when an intended frequency of the drive signal is within a frequency window. The current limit signal remains fixed for at least a switching cycle when the intended frequency is within the frequency window. A first latch generates the hold signal to control the current limit generator to hold the current limit signal. The first latch generates the hold signal in response to the frequency skip signal and a feedback signal.

Abstract: A power converter includes an energy transfer element that includes a primary winding and a secondary winding, and is coupled to transfer energy between the primary winding and the secondary winding. An enable circuit is coupled to generate an enable signal in response to a feedback signal falling below a threshold. A controller is coupled to control switching of a power switch coupled to the primary winding to regulate an output of the power converter. The controller includes a drive circuit coupled to output a drive signal in response to the enable signal, and a current limit threshold generator coupled to output a current limit threshold signal to the drive circuit in response to the drive signal. The current limit threshold signal varies in response to a time between events of the enable signal over a range of loads coupled to the output of the power converter.

Abstract: A method for regulating a power converter includes initiating a transition of a switch coupled to an input side of the power converter from an OFF to an ON state to regulate a transfer of energy from the input to an output side of the power converter after a switch control signal generator receives an enable signal and if a feedback signal representative of an output of the power converter indicates a change in an output of the power converter. The enable signal is generated to communicate a control signal from the output to the input side in response to a first signal representative of a voltage on an output terminal that oscillates in response to an ending of the transfer of energy. The transition of the switch from the OFF to the ON state occurs substantially at a time that the first signal reaches an extremum.

Abstract: A controller for use in a power converter includes a jitter generator circuit coupled to receive a drive signal from a switch controller and generate a jitter signal. The switch controller is coupled to a power switch coupled to an energy transfer element. The switch controller is coupled to receive a current sense signal representative of a drain current through the power switch. The switch controller is coupled to generate the drive signal to control switching of the power switch in response to the current sense signal and the jitter signal to control a transfer of energy from an input of the power converter to an output of the power converter.

Abstract: A power converter controller includes a drive circuit to generate a drive signal to control switching of a power switch. The drive circuit generates the drive signal in response to a current sense signal, a current limit signal, a frequency skip signal, and a hold signal. A current limit generator generates the current limit signal in response to a load. A frequency detection circuit generates the frequency skip signal in response to the drive signal to indicate when an intended frequency of the drive signal is within a frequency window. The current limit signal remains fixed for at least a switching cycle when the intended frequency is within the frequency window. A first latch generates the hold signal to control the current limit generator to hold the current limit signal. The first latch generates the hold signal in response to the frequency skip signal and a feedback signal.

Abstract: A switched mode power converter has an energy transfer element that delivers an output signal to a load. A power switching device coupled to the primary side of the energy transfer element regulates a transfer of energy to the load. A secondary controller is coupled to receive a feedback signal and output a pulsed signal in response thereto. A primary controller is coupled to receive the pulsed signal and output a drive signal in response thereto, the drive signal being coupled to control switching of the power switching device. A compensation circuit generates an adaptively compensated signal synchronous with the pulsed signal. The adaptively compensated signal has a parameter that is adaptively adjusted in response to a comparison of the feedback signal with a threshold reference signal. The parameter converges towards a final value that produces a desired level of the output signal.