Abstract: Disclosed is a Mobile Edge Computing (MEC) server device (100) and use of method thereof. Proposed design of the MEC server device (100) works with a 5G network for edge computing and analysis. The proposed server device (100) has multiple elements integrated on a single board and uses a passive thermal cooling approach. The proposed MEC server device (100) enables equal heat dissipation. Further, the device has a high processing speed and computing functionality.

Abstract: The invention, in general, relates to the field of Adeno-associated virus (AAV). More particularly, the present invention relates to bioengineered AAV9 vector carrying optimised transgene for Duchenne muscular dystrophy gene therapy. The present invention particularly provides an engineered AAV9 vector containing a microdystrophin therapeutic gene optimized for codon usage, under the control of a ubiquitous promoter and a Kozak sequence, aimed at gene therapy for Duchenne muscular dystrophy. The improved AAV9 vector amplifies the therapeutic efficacy of DMD gene therapy.

Abstract: Present disclosure generally relates to computing and wireless communications, particularly, to mobile edge computing (MEC) server and method for MEC. The MEC server includes casing. The casing includes scalable processor comprising external Platform controller Hub (PCH) is configured to perform edge computing of network data associated with telecommunication network. Further, MEC server in casing includes Board Management Controller (BMC) communicatively coupled to PCH is configured to manage functions of motherboard and manage access to remote monitoring function of MEC server. Furthermore, MEC server in casing includes ethernet controllers configured to perform fronthaul connectivity with radio unit associated with telecommunication network, or Backhaul connectivity for optical ethernet associated with telecommunication network.

Abstract: A method for fabricating a multianalyte detection device. The multianalyte detection device includes a substrate having a plurality of graphene field effect transistor devices each having a source, a drain, and a side gate located thereon. A graphene layer deposited on the substrate to form a plurality of graphene active regions between the source electrode and the drain electrode of each of the plurality of graphene field effect transistors for detection of an analyte therein. A plurality of graphene windows are located on the graphene active regions for receiving a liquid for detecting of the analyte therein. One or more passivation layers are positioned on the substrate to protect the source electrode and the drain electrode for each of the plurality of graphene field effect transistor devices from the liquid received in the plurality of graphene windows.

Abstract: A method and system for label-free detection of pathogenic and antibiotic resistant bacteria is disclosed. The method includes fabricating a G-FET/peptide device having a synthesized peptide probe capable of recognizing and binding to a bacterial target; performing electric-field assisted binding of at least one bacterial cell of the bacterial target to the G-FET/peptide device; and electrically detecting the binding of the at least one bacterial cell to the G-FET/peptide device.

Abstract: A method and system for label-free detection of pathogenic and antibiotic resistant bacteria is disclosed. The method includes fabricating a G-FET/peptide device having a synthesized peptide probe capable of recognizing and binding to a bacterial target; performing electric-field assisted binding of at least one bacterial cell of the bacterial target to the G-FET/peptide device; and electrically detecting the binding of the at least one bacterial cell to the G-FET/peptide device.

Abstract: Methods, apparatus, and processor-readable storage media for implementing extensible upgrade and modification as a service are provided herein. An example computer-implemented method includes processing one or more modifiers, wherein each modifier includes an independent processing unit having a given canonical structure and is configured to execute one or more automated actions related to at least one of application modification and application migration; obtaining data pertaining to multiple applications across multiple computing environments; determining, based at least in part on processing at least a portion of the obtained data, at least one of the one or more modifiers applicable for use in executing at least one of the one or more automated actions in connection with at least a portion of the multiple applications; and executing the at least one of the one or more automated actions using the at least one determined modifier.

Abstract: Methods, apparatus, and processor-readable storage media for implementing extensible upgrade and modification as a service are provided herein. An example computer-implemented method includes processing one or more modifiers, wherein each modifier includes an independent processing unit having a given canonical structure and is configured to execute one or more automated actions related to at least one of application modification and application migration; obtaining data pertaining to multiple applications across multiple computing environments; determining, based at least in part on processing at least a portion of the obtained data, at least one of the one or more modifiers applicable for use in executing at least one of the one or more automated actions in connection with at least a portion of the multiple applications; and executing the at least one of the one or more automated actions using the at least one determined modifier.

Abstract: A system and method of identifying potential areas for mineral extraction is disclosed. The proposed systems and methods describe an autonomous mineral discovery platform that leverages robotics, X-Ray Florescence (XRF) technology, image analytics, smart devices, and IoT enabled devices to perform comprehensive field surveying and exploratory sampling. For example, by implementation of remote navigation and control, as well as field data capture and real-time data transmission capabilities, this platform can be configured to automatically identify rock types and their surface features and perform elemental composition analysis of surface while on-site and remote from the operator site.

Abstract: A system and method of identifying potential areas for mineral extraction is disclosed. The proposed systems and methods describe an autonomous mineral discovery platform that leverages robotics, X-Ray Florescence (XRF) technology, image analytics, smart devices, and IoT enabled devices to perform comprehensive field surveying and exploratory sampling. For example, by implementation of remote navigation and control, as well as field data capture and real-time data transmission capabilities, this platform can be configured to automatically identify rock types and their surface features and perform elemental composition analysis of surface while on-site and remote from the operator site.

Abstract: A method and system for label-free detection of pathogenic and antibiotic resistant bacteria is disclosed. The method includes fabricating a G-FET/peptide device having a synthesized peptide probe capable of recognizing and binding to a bacterial target; performing electric-field assisted binding of at least one bacterial cell of the bacterial target to the G-FET/peptide device; and electrically detecting the binding of the at least one bacterial cell to the G-FET/peptide device.

Abstract: The present invention provides a method for screening compounds for their ability to inhibit autophosphorylation of Janus kinase 3 in the absence of any additional substrate. The present invention also provides a method for screening compounds that bind to Janus kinase 3 domains other than the kinase domain, to identify synthetic or natural compounds including biomolecules, that modulate Janus kinase 3 activity. This invention also describes a multi-component screening kit composed of purified recombinant Janus kinase 3 proteins and recombinant phosphorylated Janus kinase 3 fusion proteins including, one or more phosphorylated or non-phosphorylated domain-deleted Janus kinase 3 fusion proteins.

Abstract: The present invention provides a method for screening compounds for their ability to inhibit autophosphorylation of Janus kinase 3 in the absence of any additional substrate. The present invention also provides a method for screening compounds that bind to Janus kinase 3 domains other than the kinase domain, to identify synthetic or natural compounds including biomolecules, that modulate Janus kinase 3 activity. This invention also describes a multi-component screening kit composed of purified recombinant Janus kinase 3 proteins and recombinant phosphorylated Janus kinase 3 fusion proteins including, one or more phosphorylated or non-phosphorylated domain-deleted Janus kinase 3 fusion proteins.

Abstract: Janus Kinase 3 is a non-receptor tyrosine kinase that mediates signals initiated by cytokines through interactions with the receptors of cytokines. Abnormal activation of Jak3 was associated with human hematologic and epithelial malignancies. Inhibitors of Jak3 have shown utility in many different disease such as autoimmune disorders, allograft rejection during transplantation, acute lymphoblastic leukemia, Type 1 diabetes, rheumatoid arthritis and allergy and asthma. Since these inhibitors make their way into clinical trials with profound effects, it is essential to develop a sensitive, precise, and rugged screening tool to screen synthetic compounds or other biomolecules that has the potential to modulate Jak3 functions and hence treat a wide variety of diseases. Present invention relates to novel high throughput system for finding previously unknown Jak3 interacting compounds, human biomolecule (e.g. proteins or others), and those compounds that can inhibit Jak3 activations.

Abstract: A single-source solid precursor matrix for semiconductor nanocrystals includes 45-55% by weight of zinc, 28-35% by weight of oxygen, 0.70-1.2% by weight of carbon, 1.5-2.5% by weight of hydrogen, 4-6% by weight of nitrogen, 5-7% by weight of sulphur and 1-5% by weight of dopant ions with respect to the weight of zinc atoms. Doped semiconductor nanocrystals for multicolor displays and bio markers include 60-65% by weight of zinc, 30-32% by weight of sulphur, 1.2-1.3% by weight of copper and 1.2-1.3% by weight of dopant ions.

Abstract: A single-source solid precursor matrix for semiconductor nanocrystals includes 45-55% by weight of zinc, 28-35% by weight of oxygen, 0.70-1.2% by weight of carbon, 1.5-2.5% by weight of hydrogen, 4-6% by weight of nitrogen, 5-7% by weight of sulphur and 1-5% by weight of dopant ions with respect to the weight of zinc atoms. Doped semiconductor nanocrystals for multicolor displays and bio markers include 60-65% by weight of zinc, 30-32% by weight of sulphur, 1.2-1.3% by weight of copper and 1.2-1.3% by weight of dopant ions.

Abstract: A process for preparing a single source solid precursor matrix for semiconductor nanocrystals having the steps of: mixing 0.1-1 Molar of an aqueous/non-aqueous (organic) solution containing the first component of the host matrix with 0.001-0.01 Molar of an aqueous/non-aqueous solution containing the first dopant ions, which needs in situ modification of valency state, dissolving 10-20 milligram of an inorganic salt for the in situ reduction of the first dopant ion in the solution, addition of 0.001-0.01 Molar of an aqueous/non-aqueous solution of an inorganic salt containing the dopant ions which do not need modifications of their valency state, addition of 0.1-1 Molar of an aqueous/non-aqueous solution of an inorganic salt containing the second component of the host material, addition of 5-10% by weight of an aqueous solution containing a pH modifying complexing agent, to obtain a mixture, and heating the mixture to obtain a solid layered micro-structural precursor compound.

Abstract: The invention is related to catalytic materials and particularly to mesoporous molecular sieves embedded with a zeolite, which are thermally stable at a temperature of at least 900° C., and to a method for the preparation of the catalytic materials. Said catalytic materials are suitable for applications in the field of hydrocarbon processing.

Abstract: The present invention relates to an active and selective zeolite catalyst having MTT structure that is useful in skeletal isomerisation of light olefins. The method for the manufacture of the zeolite catalyst having MTT structure comprises the steps of a) preparing of a gel mixture capable of forming crystalline material, and the mixture comprising sources of alkali or alkaline earth metal (M), of an oxide of a trivalent element (X), of an oxide of a tetravalent element (Y), water and a directing agent (R), and the mixture having a composition, in terms of molar ratios, within the given ranges; b) maintaining the mixture under sufficient conditions, including a temperature of from about 100° C. to about 250° C., under dynamic mode of stirring until crystals of the material are formed, recovering the material; and c) removing the directing agent (R) partly or totally with a calcination procedure.

Abstract: A process for preparing a single source solid precursor matrix for semiconductor nanocrystals having the steps of: mixing 0.1-1 Molar of an aqueous/non-aqueous (organic) solution containing the first component of the host matrix with 0.001-0.01 Molar of an aqueous/non-aqueous solution containing the first dopant ions, which needs in situ modification of valency state, dissolving 10-20 milligram of an inorganic salt for the in situ reduction of the first dopant ion in the solution, addition of 0.001-0.01 Molar of an aqueous/non-aqueous solution of an inorganic salt containing the dopant ions which do not need modifications of their valency state, addition of 0.1-1 Molar of an aqueous/non-aqueous solution of an inorganic salt containing the second component of the host material, addition of 5-10% by weight of an aqueous solution containing a pH modifying complexing agent, to obtain a mixture, and heating the mixture to obtain a solid layered micro-structural precursor compound.