Abstract: Thienopyridinone compounds of Formula (I) and pharmaceutically acceptable salts thereof are described. In these compounds, one of X1; X2, and X3 is S and the other two are each independently CR, wherein R and all other variables are as defined herein. The compounds are shown to inhibit HPK1 kinase activity and to have in vivo antitumor activity. The compounds can be effectively combined with pharmaceutically acceptable carriers and also with other immunomodulatory approaches, such as checkpoint inhibition or inhibitors of tryptophan oxidation. Formula (I).

Abstract: Apparatus and associated methods relate to a consolidated power-on-reset system (PORS) at a system-on-chip (SoC) level. In an illustrative example, an integrated circuit may include a first power domain and a second power region. A level shifter circuit may be coupled to translate data from the first power domain to the second power domain. A PORS including a voltage detection circuit, a glitch filter circuit, and logic gates may be configured to generate isolation signals between the first power domain and the second power domain. The level shifter circuit may be enabled in response to the generated isolation signals. By using the isolation signals, multiple power domains on IC may be managed comprehensively during power-up to avoid unstable operation.

Abstract: One or more embodiments provide techniques for migrating virtual machines (VMs) from a private data center to a cloud data center. A hybrid cloud manager determines a scope of migration from the private data center to the cloud data center. The hybrid cloud manager groups each VM included in the scope of migration into one or more clusters. The hybrid cloud manager defines one or more migration phases. Each migration phase comprises a subset of the one or more clusters. The hybrid cloud manager generates a migration schedule based on at least the one or more migration phases. The hybrid cloud manager migrates the VMs from the private data center to the cloud data center in accordance with the migration schedule.

Abstract: The present teachings provide a compound represented by structural formula (1-0), or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

Abstract: The invention relates to improved method of synthesis for Treprostinil comprising condensation reaction of the carbonyl compound having allyl, alkyl, crotyl or MEM-protected phenolic hydroxyl group, compound (4) with a hydroxyl-protected alkynol (5) to give the condensation product, compound (6). Subjecting compound (6) to oxidation, reduction, hydroxyl protection and carbonylation, cyclization reactions gave the tricyclic derivative (10). Further reactions comprising reduction, hydrogenation and deprotection of the phenolic and side-chain hydroxyl groups, wherein the sequence and choice of reagents was governed by protecting groups, gave the triol intermediate, compound (14). Cyanoalkylation at phenolic hydroxyl functionality and further hydrolysis yielded the prostacyclin compound, Treprostinil (1) and its pharmaceutically acceptable salts, having desired purity.

Abstract: In an embodiment, a method of payload matching via a single pass transformation of an HTTP payload includes receiving a payload packet destined for a recipient and parsing the payload packet in a single scan of the packet using a combined regular expression. The combined regular expression includes a plurality of regular expressions that correspond to a set of replacement rules.

Abstract: Systems and methods are disclosed herein that relate to automated measurement and analysis of end-to-end performance of Voice over Long Term Evolution (VoLTE) service and, in some embodiments, automated network optimization for VoLTE service performance improvement. In some embodiments, a method of operation of a network node to perform automated end-to-end analysis of VoLTE sessions is provided. In some embodiments, the method of operation of the network node comprises correlating control and data plane messages across a nodes and interfaces in a VoLTE network to thereby provide data representative of end-to-end message flows for a plurality of VoLTE sessions. The method of operation further comprises configuring one or more nodes in the VoLTE network based on the data representative of the end-to-end message flows for the plurality of VoLTE sessions. In this manner, automated network optimization for VoLTE service performance improvement can be provided.

Abstract: A combustion section for a gas turbine engine including an inner casing comprising a first material defining an inner diameter of a pressure vessel and a first heat transfer coefficient. A second material is extended at least partially over an outer diameter of the first material. The second material is disposed radially between the first material and a combustor liner. The second material defines a second heat transfer coefficient less than the first heat transfer coefficient.

Abstract: Thienopyridinone compounds of Formula (I) and pharmaceutically acceptable salts thereof are described. In these compounds, one of X1; X2, and X3 is S and the other two are each independently CR, wherein R and all other variables are as defined herein. The compounds are shown to inhibit HPK1 kinase activity and to have in vivo antitumor activity. The compounds can be effectively combined with pharmaceutically acceptable carriers and also with other immunomodulatory approaches, such as checkpoint inhibition or inhibitors of tryptophan oxidation. Formula (I).

Abstract: The present disclosure is directed to allocating communication resources via information technology infrastructure. A system can provide a communication tag and an analytics tag for integration in a web site. The system can receive a request to allocate a phone number generated based on an interaction between the communication tag and the analytics tag. The request can include a first field comprising the communication endpoint identifier, a second field comprising the site identifier for the web site, and a third field comprising a session identifier for the computing device. The system can determine a virtual phone number to assign to a combination of the values of the fields provided in the request, and create a link between the assigned virtual number and the combination. The system can provide the assigned virtual phone number to the computing device that initiated the request.

Abstract: The present teachings provide a compound represented by the following structural formula: (Formula (I)); or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

Abstract: A method of migrating a virtualized computing instance between source and destination virtualized computing systems includes executing a first migration workflow in the source virtualized computing system between a source host computer and a first mobility agent simulating a destination host, executing a second migration workflow in the destination virtualized computing system between a second mobility agent simulating a source host and a destination host computer, sending, as part of the first migration workflow, a configuration of the migrated virtualized computing instance to the destination virtualized computing system, translating, as part of the second migration workflow, infrastructure-dependent information in the configuration of the migrated virtualized computing instance, and transferring, during execution of the first and second migration workflows, migration data including the virtualized computing instance between the source host and the destination host over a network.

Abstract: The invention relates to an improved method for a 5+3+2 solution phase syntheses of Icatibant acetate (1) comprising coupling of suitably protected peptide fragments which on deprotection followed by treatment with acetic acid provide Icatibant acetate (1) having desired purity.

Abstract: An example read address generation circuit for a static random access memory (SRAM) cell includes an operational amplifier having a non-inverting input coupled to a reference voltage, a memory emulation circuit having an output coupled to an inverting input of the operational amplifier and a control input coupled to an output of the operational amplifier, and a multiplexer having a first input coupled to receive a constant read voltage, a second input coupled to the output of the operational amplifier, and an output coupled to supply a read address voltage to the SRAM cell.

Abstract: Techniques for stateful connection optimization over stretched networks are disclosed. In one embodiment, traffic of virtual machines (VMs) that are live-migrated from a data center to a cloud is temporarily tromboned back to the data center to preserve active sessions. In such a case, a stretched network is created that includes a network in the data center and two stub networks in the cloud, one of which is route optimized such that traffic does not trombone back to the data center and the other which is not so optimized. A VM that is live migrated to the cloud is first attached to the unoptimized network so that traffic tromboning occurs. Thereafter, when the VM is powered off (e.g., during a reboot), in a maintenance mode, or in a quiet period, the VM is switched to the route optimized network.

Abstract: Techniques for upgrading virtual appliances in a hybrid cloud computing system are provided. In one embodiment, virtual appliances are upgraded by deploying the upgraded appliances in both a data center and a cloud, configuring the upgraded appliances to have the same IP addresses as original appliances, and disconnecting the original appliances from networks to which they are connected and connecting the upgraded appliances to those networks via the same ports previously used by the original appliances. In another embodiment, upgraded appliances are deployed in the data center and the cloud, but configured with new IP addresses that are different from those of the original appliances, and connections are switched from those of the original appliances to new connections with the new IP addresses. Embodiments disclosed herein permit virtual appliances to be upgraded or replaced with relatively little downtime so as to help minimize disruptions to existing traffic flows.

Abstract: Systems and methods are disclosed for improving Physical Downlink Control Channel (PDCCH) allocation for improved downlink scheduling. In some embodiments, a method of operation of a network node in a cellular communications network comprises transmitting a downlink assignment to a wireless device, the downlink assignment comprising an indication of whether the downlink assignment applies to a single Transmit Time Interval (TTI) or multiple consecutive TTIs, and transmitting a downlink data transmission to the wireless device during a single TTI or multiple downlink data transmissions to the wireless device during multiple consecutive TTIs according to the downlink assignment. In this manner, the network node does not need to transmit, and the wireless device does not need to receive/decode, a separate downlink assignment in each TTI. This may be beneficial to, e.g., mitigate PDCCH congestion.

Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.

Abstract: The present disclosure is directed to allocating communication resources via information technology infrastructure. A system can provide a communication tag and an analytics tag for integration in a web site. The system can receive a request to allocate a phone number generated based on an interaction between the communication tag and the analytics tag. The request can include a first field comprising the communication endpoint identifier, a second field comprising the site identifier for the web site, and a third field comprising a session identifier for the computing device. The system can determine a virtual phone number to assign to a combination of the values of the fields provided in the request, and create a link between the assigned virtual number and the combination. The system can provide the assigned virtual phone number to the computing device that initiated the request.

Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.