Abstract: Thienopyridinone compounds of Formula (I) and pharmaceutically acceptable salts thereof are described. In these compounds, one of X1; X2, and X3 is S and the other two are each independently CR, wherein R and all other variables are as defined herein. The compounds are shown to inhibit HPK1 kinase activity and to have in vivo antitumor activity. The compounds can be effectively combined with pharmaceutically acceptable carriers and also with other immunomodulatory approaches, such as checkpoint inhibition or inhibitors of tryptophan oxidation. Formula (I).

Abstract: A method of collecting and reporting inventory of resources deployed in a data center that includes hardware resources, a virtualization management software executed to provision virtual resources from the hardware resources, and a cloud management server executed to provision the virtual resources for tenants of the data center, includes the steps of: executing a first API call to the virtualization management software to collect first inventory of virtual resources deployed in the data center and a second API call to the cloud computing management software to collect second inventory of virtual resources deployed in the data center; storing the first and second inventory; and in response to an inventory request from a central orchestrator, initially sending a subset of the stored first and second inventory to the central orchestrator in accordance with parameters included in the inventory request, and thereafter sending updates to the subset to the central orchestrator periodically.

Abstract: The present invention relates generally to network communications, and more particularly to machine-to-machine (M2M) data communications. The present invention provides for a method, apparatus and computer program product for detecting performance event data across a machine-to-machine (M2M) network indicative of anomalous performance of data and thereafter alerting users of performance issues in real-time or near real-time.

Abstract: Some examples described herein relate to multi-chip devices. In an example, a multi-chip device includes first and second chips. The first chip includes a power supply circuit and a logic circuit. The first and second chips are coupled together. The second chip is configured to receive power from the power supply circuit. The second chip includes a programmable circuit, a pull-up circuit, and a detector circuit. The detector circuit is configured to detect a presence of a power voltage on the second chip and responsively output a presence signal. The power voltage on the second chip is based on the power from the power supply circuit. The logic circuit is configured to generate a pull-up signal based on the presence signal. The pull-up circuit is configured to receive the pull-up signal and configured to pull up a voltage of a node of the programmable circuit responsive to the pull-up signal.

Abstract: Examples described herein provide a method for disabling a defective portion of a fabric die of a stacked IC device. The method includes receiving a signal indicating that a portion of a fabric die of a stacked IC device including at least two fabric dies is defective. The method further includes, in response to the signal, pulling a source voltage rail of the defective portion to ground, thereby disabling the portion, and operating the remainder of the fabric die without interference from or contention with the disabled portion. In one example, the stacked IC device is an active on active (AoA) device, and the portion of the fabric die includes a configuration memory cell. In one example, the signal is received after power-up of the stacked IC device.

Abstract: A method and system for label-free detection of pathogenic and antibiotic resistant bacteria is disclosed. The method includes fabricating a G-FET/peptide device having a synthesized peptide probe capable of recognizing and binding to a bacterial target; performing electric-field assisted binding of at least one bacterial cell of the bacterial target to the G-FET/peptide device; and electrically detecting the binding of the at least one bacterial cell to the G-FET/peptide device.

Abstract: Various example embodiments relate to a filtration system. The filtration system includes a filter housing having a first housing end and a second housing end. The filter housing includes a housing cover defining an outlet. The housing cover includes a first guidance element extending from an internal portion of the housing cover axially away from the outlet. A second guidance element extends from the internal portion of the housing cover axially away from the outlet. A filter element has a first filter end and a second filter end. The filter element includes an end cap adjacent the first filter end and defining an end cap opening therethrough. The end cap includes a channel around the end cap opening. Filter media has a first media end and a second media end. The filter media extends axially from the first media end toward the second media end.

Abstract: A method of executing workflows in virtual machines that have been deployed to implement virtual network functions of a network service, wherein the virtual machines are running in a plurality of data centers each having a cloud management server running a cloud computing management software to provision virtual infrastructure resources thereof for a plurality of tenants, includes upon receiving a request to execute a workflow along with a plurality of parameters including first and second parameters at a data center, identifying a virtual machine deployed in the data center, in which the workflow is to be executed based on the first parameter, designating one of a plurality of methods by which the workflow is to be executed in the virtual machine according to the second parameter, and issuing a command to the virtual machine to execute the workflow according to the designated method.

Abstract: A filter assembly comprises a housing defining an internal volume. The housing defines an outlet. A housing ledge extends radially inwards from a rim of the outlet. An outlet conduit comprises an outlet elbow, and an outlet tube extending axially from the outlet elbow towards the housing. The outlet tube is positioned within the housing. A rib extends radially from an outer surface of the outlet tube proximate to the outlet elbow. The rib engages the housing ledge so as to couple the outlet conduit to the housing. A filter element is also positioned within the housing.

Abstract: A smart fall arrest system is provided and includes a fall arrest device and an intelligent module fixed to the fall arrest device. The intelligent module includes a range finder, a user alert device, a processor and an accelerometer module. The processor is configured to determine a vertical clearance distance underlying a worksite based on signals from the range finder and the accelerometer module, the processor determines if the fall arrest device is appropriate and if the anchor point selected for connecting the fall arrest device is at an appropriate height.

Abstract: The present teachings provide a compound represented by the following structural formula: (Formula (I)); or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

Abstract: A method, apparatus, and non-transitory computer readable medium for performing joins on data from hierarchical databases are described. The method, apparatus, and non-transitory computer readable medium may provide for receiving one or more search results from each of a plurality of hierarchical databases, identifying one or more matching fields from each of the search results, joining the search results according to a set of rules for processing related fields to the matching fields, wherein the related fields comprise sibling fields, neighbor fields, ancestor fields, descendant fields, or any combination thereof, and generating one or more combined search results based on the joining.

Abstract: A method includes, responsive to identifying a user entering a terminal, identifying a role for the user. The method also includes providing a routing map to a mobile device associated with the user. The routing map identifies an allowable route for the user within the terminal, and the routing map is based on the role. The method further includes granting the user access to one or more restricted areas in the terminal, where the one or more restricted areas are located along the allowable route in the routing map. The method may also include monitoring a location of the user to identify a deviation of the user from the allowable route and, responsive to identifying the deviation, generating an alarm.

Abstract: A smart fall arrest system (30) is provided and includes a fall arrest device (32) and an intelligent module (34) fixed to the fall arrest device (32). The intelligent module includes a range finder (42), a user alert device (44), a processor (46) and an accelerometer module (50). The processor (46) is configured to determine a vertical clearance distance underlying a worksite based on signals from the range finder (42) and the accelerometer module (50), the processor determines if the fall arrest device (32) is appropriate and if the anchor point selected for connecting the fall arrest device (32) is at an appropriate height.

Abstract: Embodiments of the present disclosure relate to a method and a system for creating and managing a private, decentralized, secure peer-to-peer IP based mesh overlay network. In one embodiment, the mesh network is created comprising at least one gateway node capable of controlling one or more resources connected to the at least one gateway node. A mesh network management server authenticates and provisions the gateway node with a license and firmware for adding to the mesh overlay network and grants ownership of the gateway node to an authorized user. The owner may request for addition or removal of the gateway node or the resources.

Abstract: Embodiments of the present disclosure relate to method and a system for managing a decentralized access to a resource. A user of a client device having a third-party application installed therein request to join the mesh network based on invite received from the owner of the IoT gateway. The mesh network comprises one or more IoT gateway. One gateway is identified based on the topology of the client device, and an optimal connection between the client device and the identified gateway is determined. The third-party application may send a resource access request for accessing a resource of the mesh network and access the requested resource through the optimal connection route thus determined. Thus, the disclosure enables a peer-to-peer mesh network infrastructure that allows secure access to the resource by a third-party application without using a cloud server to route the resource access request from the client device to the gateway.

Abstract: In an embodiment, a method of payload matching via a single pass transformation of an HTTP payload includes receiving a payload packet destined for a recipient and parsing the payload packet in a single scan of the packet using a combined regular expression. The combined regular expression includes a plurality of regular expressions that correspond to a set of replacement rules. The method includes determining a scatter-gather list conforming to the rule, constructing a new payload packet based on the scatter-gather list, and sending the new payload packet to the recipient.

Abstract: Circuit designs and/or circuitry for integrated circuits (ICs) can be generated for radio-frequency (RF) applications by determining, using computer hardware, a value of a parameter of a super-sampling rate (SSR) block within a model of a circuit, wherein the value indicates a number of a plurality of data channels of the SSR block, automatically creating, using the computer hardware, a primary input port and a primary output port for the SSR block based on functionality of the SSR block, wherein vector size of the primary input port and the primary output port is determined from the value of the parameter, automatically creating, using the computer hardware, a plurality of scalar instances of the SSR block based on the value of the parameter, wherein the plurality of scalar instances are arranged in parallel, and configuring, using the computer hardware, each scalar instance of the plurality of scalar instances based on a parameterization of the SSR block.

Abstract: One or more examples provide techniques for providing a multi-site wide area network in a cloud computing system. In an example, a method of providing a multi-site wide area network (WAN) in a cloud computing system includes: creating a plurality of sites; creating a compute profile in each of the plurality of sites, each compute profile having a compute cluster of virtual machines (VMs); creating a service mesh having the compute profile of each of the plurality of sites; and deploying an application to the service mesh.

Abstract: One or more embodiments provide techniques for migrating a virtual machine (VM) from a private data center to a cloud data center. A hybridity manager receives a request at the cloud data center to replicate a VM from the private data center on the cloud data center. The hybridity manager identifies a source network associated with the VM. The hybridity manager identifies whether there exists a stretched network associated with the source network of the VM. Responsive to determining that there is a stretched network associated with the source network of the VM, the hybridity manager replicates the VM on the stretched network without reconfiguring internet-protocol (IP) settings of the VM.