Abstract: An integrated circuit provides dynamic, on chip resistor trimming, including a digital control loop for stabilizing impedance matching among multiple devices communicatively linked over a data transmission line. The digital control loop stabilizes input/output impedance matching of various devices to within a precise ohmic range that is far narrower than standard process variations, such as sheet resistance, within the components themselves. The impedance matching circuit also overcomes EMI problems normally associated with digital control and thus provides dynamic on-chip digital control without non-linearity and with tighter tolerance than is presently possible. Accordingly, the circuit boosts performance of peripheral devices that communicate over a standard USB port, without the need for a computer as a go between or intermediate interface. This makes device to device communication possible as between USB On-the-Go capable devices.

Abstract: The invention provides a method of attenuating graft rejection in a patient undergoing an organ or tissue transplantation procedure. The inventive method involves administering FK778 using a dosing regimen that includes a period of customized administration to achieve or approximate a target whole blood trough level of FK778. The regimen optionally includes administration of a calcineurin inhibitor, such as Tacrolimus, and/or a steroid, and/or an antiviral. Specific preferred quantities of these pharmaceutically-active agents are provided as well as preferred timing and routes of administration. The invention also provides a medical kit for administering FK778. The kit includes printed instructions for administering FK778 to the patient undergoing a graft transplantation procedure according to a dosing regimen containing a period during which the dosage of FK778 is adjusted to deliver an amount of FK778 sufficient to maintain a target whole blood though level of FK778, such as described herein.