Abstract: A valve assembly with a valve shaft shiftable within a valve well from an off position blocking fluid communication between ports in the valve well, and an on position allowing fluid communication between such ports. The on position may be proximal to the off position. The length of the valve shaft is selected simply to block access to one of the ports of the valve well when in the off position, and thus may be shorter than prior valve shafts. The valve shaft is along a distal end of an actuatable member of the valve assembly, and a user-engagement element may be provided along the proximal end of the actuatable member. The user-engagement element may be movable towards the valve shaft to move the valve shaft from the off position to the on position.

Abstract: The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.

Abstract: An applicator for an analyte monitoring device may include an actuatable housing having a body defining a cavity therein and having a distal opening and a side opening. A cuff and a shuttle are received within the cavity and are separately translatable relative to the housing body. A base may removable engage the housing body at the distal opening. The housing body, the cuff, the shuttle, and/or the base may be engaged with one another with one or more releasable coupling features. The base may be removed from an engagement with the housing body, causing the cuff and the shuttle to be aligned and positioned in a configuration in which the analyte monitoring device, held by the shuttle, is ready for insertion into the skin.

Abstract: A trolley apparatus, system, and method of manufacture are described herein. The trolley apparatus may comprise one or more of a first side plate, a second side plate, a support axle, one or more roller components, and/or other components. The support axle may be mounted through and/or between the first side plate and the second side plate. The support axle may be mounted such that the first side plate and the second side plate are at opposite ends of the support axle. The support axle may be configured to support the one or more roller components. In some implementations, the trolley apparatus may be specifically configured to accommodate a slackline webbing which may have a width of about five centimeters.

Abstract: Disclosed are electric vertical take-off and landing (eVTOL) aircraft gaming apparatuses and methods. In one embodiment, a video game apparatus comprises a processor, a first inceptor, communicatively coupled to the processor, the first inceptor configured to accept longitudinal and lateral linear movements as manual input and provide corresponding signals to the processor, and a second inceptor, communicatively coupled to the processor, the second inceptor configured to accept longitudinal and lateral linear movements as manual input and provide corresponding signals to the processor, wherein the processor is configured to control a heading of an aircraft in a video game using a signal received from the second inceptor corresponding to lateral linear movement of the second inceptor. Some embodiments may additionally include at least one sensor and a thumb stick for each inceptor.

Abstract: Devices, systems, and methods for a valve for a medical device. The valve may include a valve stem. An elongate body of the valve stem may include a first opening and a second opening fluidly coupled to one another via a lumen. The valve stem may include a first seal and a second seal extending circumferentially around the elongate body. The elongate body, the first seal, and the second seal may be formed from a single material. The single material may be a thermoplastic elastomer or other suitable material. The valve stem may include recessed portion proximate the seals of the valve stem to facilitate bending or flexing of the seals as the valve stem translates within a valve well.

Abstract: Devices, systems, and methods for a valve for a medical device. The valve may include a valve stem. An elongate body of the valve stem may include a first opening and a second opening fluidly coupled to one another via a lumen. The valve stem may include one or more seals extending circumferentially around the elongate body. The one or more seals may include sealing surfaces that may be non-perpendicular with a longitudinal axis of the elongate body to selectively fluidly isolate openings or other features of a valve well in which the valve stem is configured to translate.

Abstract: This disclosure relates to a vehicle camera system. In some examples, the vehicle camera system includes one or more camera components, heat generating electronic components, and a shroud. The shroud is configured to provide structural support for the one or more camera components and configured to facilitate dissipation of heat generated by the heat generating electronic components. In some examples, the shroud includes boundaries at least partially surrounding the heat generating electronic components and defining a heat dissipation path for air flow from at least one air inlet to an air outlet of the shroud, and mounting features for mounting the one or more camera components, in which at least one of the mounting features is defined within a portion of the boundaries defining the heat dissipation path.

Abstract: A device includes a balloon configured for inflation with a light-diffusing fluid and configured, upon inflation, to expand a body lumen within which it is positioned and a flexible light-emitting device attached to the balloon having a light-emitting side facing radially inward toward the fluid so that, during a medical procedure, light emitted from the light-emitting side is diffused by the fluid and illuminates a treatment area within the body lumen proximal to the balloon.

Abstract: A flexible arm that is configured to be located between and physically and electrically connect an acoustic module of an open-ear headphone to a battery housing of the open-ear headphone. The flexible arm includes a flexible printed circuit that extends through the entire original resting length of the flexible arm and comprises a conductor that is configured to carry electrical energy between the acoustic module and the battery housing. A first interface structure is coupled to one of the acoustic module and the battery housing. At least one link member is pivotably coupled to the first interface structure. A flexible material encases at least some of the flexible printed circuit, at least some of the at least one link member, and at least some of the first interface structure.

Abstract: Methods and systems for refilling a container during an endoscopic procedure. An illustrative reservoir may be placed in selective fluid communication with a water bottle. The water bottle may form a fluid tight seal with the reservoir to transfer water from the water bottle to the reservoir.

Abstract: An applicator for an analyte monitoring device may include an actuatable housing having a body defining a cavity therein and having a distal opening and a side opening. A cuff and a shuttle are received within the cavity and are separately translatable relative to the housing body. A base may removable engage the housing body at the distal opening. The housing body, the cuff, the shuttle, and/or the base may be engaged with one another with one or more releasable coupling features. The base may be removed from an engagement with the housing body, causing the cuff and the shuttle to be aligned and positioned in a configuration in which the analyte monitoring device, held by the shuttle, is ready for insertion into the skin.

Abstract: Ultraviolet (UV) light emission devices and related methods of use. The UV light emission devices disclosed herein are particularly suited for use in disinfecting surfaces and air. The UV light emission devices disclosed herein can be provided in the form factor of a handheld device that is easily held and manipulated by a human user. The human user can manipulate the handheld UV light emission device to decontaminate surfaces, air, and other areas by orienting the handheld UV light emission device so that the UV light emitted from its light source is directed to the area of interest to be decontaminated.

Abstract: Provided herein are uses of chimeric antigen receptors (CARs) for treating a cancer (such as B cell related cancer, e.g., multiple myeloma).

Abstract: Methods and systems for refilling a container during an endoscopic procedure. An illustrative container may comprise a container extending from a first end to a second end and having a reduced diameter stem extending from the first end, the reduced diameter stem defining an opening for receiving a fluid, a water outlet, a gas inlet, and a port. The port may comprise a sealing ring defining an aperture extending from a first end to a second of the sealing ring, the aperture in fluid communication with the opening in the container, a cap positioned adjacent to the first end of the aperture of the sealing ring, and a biasing mechanism disposed between the container and the sealing ring.

Abstract: Disclosed are systems and methods for controlling an electric vertical take-off and landing (eVTOL) aircraft. In one embodiment, a system comprises a processor, a first inceptor, communicatively coupled to the processor, the first inceptor configured to accept longitudinal and lateral linear movements as manual input and provide corresponding signals to the processor, and a second inceptor, communicatively coupled to the processor, the second inceptor configured to accept longitudinal and lateral linear movements as manual input and provide corresponding signals to the processor, wherein the processor is configured to control a heading of an aircraft using a signal received from the second inceptor corresponding to lateral linear movement of the second inceptor. Some embodiments may additionally include at least one sensor and a thumb stick for each inceptor.

Abstract: A control system is provided that may include a controller for a vehicle system. The controller may include one or more processors configured to obtain at least one first operating parameter related to an operating system of the vehicle system, and determine an operating condition of the operating system based at least in part on the first operating parameter. The one or more processors may also be configured to communicate with an off-board sensor to obtain at least one auxiliary operating parameter related to the operating condition, and verify the operating condition based at least in part on the auxiliary operating parameter.

Abstract: A tent apparatus and method of manufacture are described herein. The tent apparatus may comprise a tent body, a frame, and/or other components. The tent body may include a first portion configured to be substantially enclosed within the bed of the pickup truck in an as-used mode of the tent apparatus, and a second portion that extends from the first portion such that the second portion is exposed to an environment above a bed of a pickup truck in the as-used mode. The frame may be integrally coupled to the tent body, and configured to articulate between a closed position and an open position. The frame may comprise a central hub coupled to the tent body at a central coupling point; and support members that extend from the central hub to coupling points on the tent body to integrate the frame with the tent body.

Abstract: A trolley apparatus, system, and method of manufacture are described herein. The trolley apparatus may comprise one or more of a first side plate, a second side plate, a support axle, one or more roller components, and/or other components. The support axle may be mounted through and/or between the first side plate and the second side plate. The support axle may be mounted such that the first side plate and the second side plate are at opposite ends of the support axle. The support axle may be configured to support the one or more roller components. In some implementations, the trolley apparatus may be specifically configured to accommodate a slackline webbing which may have a width of about five centimeters.