Abstract: A device for treating hemorrhoids includes a first ligating member which moves between a first position in which the first member is tightened to a degree required to maintain a desired position of the first member around the first portion without significantly cutting off blood flow and a second configuration in which the first member is cinched down around the first portion to substantially cut off blood flow to the encircled first portion. Also, the device includes a first applicator having a proximal lumen and first and second opposed distal lumens open to the proximal lumen. The first member is extending from a proximal end distally through the proximal lumen into the first lumen to exit a distal end of the first lumen, loop around and enter the distal end of the second lumen. The first member is passing through the second lumen into the proximal lumen.

Abstract: A control system and method determine an energy demand associated with delivery of cargo in a trip. The energy demand represents how much electric energy is needed to move cargo vehicles that carry the cargo through the trip. Locations of energy tenders and states of charge of the energy tenders are determined. A schedule for the cargo vehicles to deliver the cargo to a delivery location within a delivery time slot is determined. This schedule is determined based on the energy demand, the locations of the energy tenders, and the states of charge of the energy tenders. The system and method direct which of the energy tenders that the cargo vehicles are to couple with, be powered by, and move with for powering the cargo along routes to the delivery location of the trip within the designated time slot.

Abstract: A dispensing device, comprising a plurality of microfluidic pumps, microfluidic valves, and a microfluidic mixer chip, for receiving and mixing microfluidic amounts of a plurality of fluids having differing viscosities, is disclosed. The device includes a plurality of pathways for moving fluids from associated reservoirs to the microfluidic mixer chip. A mix controller controls the microfluidic pumps and valves so that the fluids, having different viscosities, can be accurately mixed at specified microfluidic amounts or volumes according to a specified microfluidic recipe, and the microfluidic mixture dispensed from the device. The device can be in communication with a software application implemented on a mobile compute device, such as a smartphone, and receive instructions for implementing the specified microfluidic recipe from the software application such that the operation of device components is at the direction of the software application executed on the mobile compute device.

Abstract: Within environments, such as audio-video environments, users may synchronize output of multiple media source(s). To synchronize the output of the media source(s), users may define setting(s) associated with outputting the media source(s) at one or more devices. For example, the user may delay or accelerate the output of audio and/or video sources. Interfaces presented on one or more of the devices may allow the user to change the settings. For environments including multiple users, each user may define setting(s) associated with each user to synchronize output of their associated media source(s). Recommendations may be provided to users, that when implemented, attempt to synchronize the media sources.

Abstract: A control system and method determine an energy demand associated with delivery of cargo in a trip. The energy demand represents how much electric energy is needed to move cargo vehicles that carry the cargo through the trip. Locations of energy tenders and states of charge of the energy tenders are determined. A schedule for the cargo vehicles to deliver the cargo to a delivery location within a delivery time slot is determined. This schedule is determined based on the energy demand, the locations of the energy tenders, and the states of charge of the energy tenders. The system and method direct which of the energy tenders that the cargo vehicles are to couple with, be powered by, and move with for powering the cargo along routes to the delivery location of the trip within the designated time slot.

Abstract: The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.

Abstract: The present invention relates to the unexpected discovery of novel methods of preparing nanodevices and/or microdevices with predetermined patterns. In one aspect, the methods of the invention allow for engineering structures and films with continuous thickness equal to or less than 50 nm.

Abstract: Methods, systems and devices for evaluating a product sampling event. The disclosed methods, systems and devices receive from a user a user identification specific to the user and compare the user identification to a user data set stored on a computer-readable medium. A sample is then delivered based on a predetermined condition, and a product value is changed after the step of causing delivery of the sample of the product. It can then be determined whether the user purchased the product after delivery of the sample of the product and, based on that determination, a sampling event value can be assigned. The user's preferences can also be used to provide a more custom sample with a user's order for example, with online or home delivery shopping.

Abstract: A system, method, and non-transitory computer-readable storage media programmed to create a pharmacy account based on primary information collected from a new customer when a prescription for purchase of a prescription drug is delivered by the customer, create an on-line account for the new customer based on the pharmacy account for the new customer, and link the pharmacy account and the on-line account together for the new customer.

Abstract: Disclosed herein are related to a system, a method, and a non-transitory computer readable medium for controlling a central plant. In one aspect, the system obtains a control envelope for a device controlled by the controller. The control envelope comprises boundaries of a plurality of control regions in a multidimensional operating space for the device. Each control region is enclosed by a corresponding boundary. The system counts a number of times that a ray of the device crosses the boundary of a control region. The system determines whether an operating point of the device is within the control region based on the counted number. The system operates the device according to a predetermined control technique corresponding to the control region, in response to determining that the operating point of the device is within the control region.

Abstract: A system includes a refrigerant compressor, an electric motor and configured to drive the refrigerant compressor, and a controller. The controller is configured to operate the compressor in a liquid clearing start mode where electrical current through the motor is prevented from exceeding a predetermined current limit for a period of time not to exceed a predetermined period of time, and is configured to operate the compressor in a run mode in response to determining the motor exceeds a predetermined speed threshold at or before expiration of the predetermined period of time, wherein the run mode does not prevent electrical current through the motor from exceeding said predetermined current limit.

Abstract: Methods, systems and devices for evaluating a product sampling event. The disclosed methods, systems and devices receive from a user a user identification specific to the user and compare the user identification to a user data set stored on a computer-readable medium. A sample is then delivered based on a predetermined condition, and a product value is changed after the step of causing delivery of the sample of the product. It can then be determined whether the user purchased the product after delivery of the sample of the product and, based on that determination, a sampling event value can be assigned. The user's preferences can also be used to provide a more custom sample with a user's order for example, with online or home delivery shopping.

Abstract: A portable microfluidic mixer system includes a blend application to issue blend instructions, and a microfluidic mixer device. The microfluidic mixer device includes a housing, microfluidic pumps and valves within the device housing, a microfluidic dispenser, a microfluidic mixer chip, and a mix controller. The microfluidic mixer chip receives and meters microfluidic amounts of one or more fluids. The mix controller electronically communicates with the blend application to receives blend application blend instructions. The microfluidic mixer device includes fluid pathways for fluid communication between one or more fluid canisters and the microfluidic mixer chip, and between the microfluidic mixer chip and the microfluidic dispenser.

Abstract: A bumper sized to fit a cylinder of a fastener driving tool includes a side profile of the bumper defined by a plurality of flat regions and a plurality of convex regions around an outer periphery of the bumper. Included in the bumper are an inner peripheral surface and an outer peripheral surface. The flat and convex regions are disposed on the outer peripheral surface of the bumper in an alternating pattern.

Abstract: The present disclosure envisages an on-board battery state monitoring system for monitoring state of charge of a battery of an electric vehicle. The system comprises an onboard processor in data communication with a central server of a transit agency; at least one CAN network for monitoring different parameters of the electric vehicle; a recharge module configured to analyze Parameter Group Numbers (PGNs) in messages broadcasted by the at least one CAN network and filter out PGNs that provide state of charge of the battery, wherein the filtered out PGNs are transmitted to the on-board processor for the state of charge analysis of the battery to determine if an electric vehicle block can be completed.

Abstract: A dispensing device, comprising a plurality of microfluidic pumps, microfluidic valves, and a microfluidic mixer chip, for receiving and mixing microfluidic amounts of a plurality of fluids having differing viscosities, is disclosed. The device includes a plurality of pathways for moving fluids from associated reservoirs to the microfluidic mixer chip. A mix controller controls the microfluidic pumps and valves so that the fluids, having different viscosities, can be accurately mixed at specified microfluidic amounts or volumes according to a specified microfluidic recipe, and the microfluidic mixture dispensed from the device. The device can be in communication with a software application implemented on a mobile compute device, such as a smartphone, and receive instructions for implementing the specified microfluidic recipe from the software application such that the operation of device components is at the direction of the software application executed on the mobile compute device.

Abstract: A control system and method determine an energy demand associated with delivery of cargo in a trip. The energy demand represents how much electric energy is needed to move cargo vehicles that carry the cargo through the trip. Locations of energy tenders and states of charge of the energy tenders are determined. A schedule for the cargo vehicles to deliver the cargo to a delivery location within a delivery time slot is determined. This schedule is determined based on the energy demand, the locations of the energy tenders, and the states of charge of the energy tenders. The system and method direct which of the energy tenders that the cargo vehicles are to couple with, be powered by, and move with for powering the cargo along routes to the delivery location of the trip within the designated time slot.

Abstract: Temperature value determination of at least one variable frequency drive component is provided. In one form, a method includes providing a variable frequency drive that includes a first component in thermal communication with a second component in thermal communication with a switching device. A temperature value of the second component is determined using a temperature value of the first component, a power loss characteristic of the drive, and a first characteristic of heat transfer between the first and second components. The method further includes sensing a temperature value of the second component and determining a temperature value for the switching device using the power loss characteristic, a second characteristic of heat transfer between the second component and the switching device, and the greater of the sensed and determined temperature values of the second component. Further embodiments, forms, features, and aspects shall become apparent from the description and drawings.

Abstract: Systems and methods including one or more processing modules and one or more non-transitory storage modules storing computing instructions configured to run on the one or more processing modules and perform acts of determining a prospective product for a user to add to an cart, identifying a prospective cart merchant group that includes prospective merchants that offer the prospective product, determining a prospectively-unlocked product group that includes a plurality of products offered by the prospective merchants that are discounted if the prospective product is added to the electronic cart, determining a savings score for the prospectively-unlocked product group, and coordinating displaying to the user on the website of the online retailer (1) the prospective product and (2) the savings score of the prospectively-unlocked product group.

Abstract: Systems and methods including one or more processors and one or more non-transitory storage devices storing computing instructions configured to run on the one or more processors and perform acts of storing, in a pharmacy database of a computer system, pharmacy account information, wherein the pharmacy account information comprises: a unique patient ID associated with a customer; a pharmaceutical drug record indicating a pharmaceutical drug prescribed to the customer; and an action record indicating triggering actions of the pharmaceutical drug; determining, by the computer system, that the customer is entering or has entered a retail store; after determining that the customer is entering or has entered a retail store: confirming, by the computer system, that the customer has at least one prescription fill order pending with a pharmacy of the retail store; prioritizing, by the computer system, the at least one prescription fill order to a top of a workflow of a pharmacist in the pharmacy of the retail store;