Patents by Inventor Nathaniel David

Nathaniel David has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMS FOR A CRANKSHAFT DAMPER COVER
    Publication number: 20180023658
    Abstract: Systems are provided for a damper cover for an engine crankshaft damper. In one example, a damper cover may include a frame and an inset, with extensions of the frame adapted to couple to slots of an engine crankshaft damper, and with portions of the inset positioned between each extension and each corresponding slot. As one example, the frame may be comprised of metal and the inset may be comprised of a damping material such as foam or rubber.
    Type: Application
    Filed: July 25, 2016
    Publication date: January 25, 2018
    Inventors: Shashin Shah, Shaji Mathews, Chuck Raymond Kvasnicka, Nathaniel David Hansen, Tom Xu
  • Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions
    Publication number: 20180000816
    Abstract: A library of heterocyclic compounds has been screened to identify particular compounds that have high inhibitory capacity for the Bcl family of regulatory proteins. Compounds identified as Bcl antagonists have been further screened to select pharmaceutical agents with both high potency and high specificity for eliminating senescent cells in comparison with replicative or quiescent cells of the same tissue type. Particular structures are identified in this disclosure that eliminate senescent cells with an EC50 in the nanomole range and a specificity around or above 100-fold. In accordance with this invention, heterocyclic compounds provided in this disclosure can be formulated for the treatment of a range of age-related conditions caused or mediated by senescent cells. Such conditions are exemplified by ophthalmic conditions, pulmonary conditions, and osteoarthritis.
    Type: Application
    Filed: August 11, 2017
    Publication date: January 4, 2018
    Inventors: Nathaniel David, Remi-Martin Laberge
  • Treatment for osteoarthritis by intra-articular administration of a cis-imidazoline
    Patent number: 9855266
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: January 2, 2018
    Assignees: Unity Biotechnology, Inc., Buck Institute for Research on Aging, Mayo Foundation for Medical Education and Research, The John Hopkins University
    Inventors: Remi-Martin Laberge, Judith Campisi, Albert Davalos, Marco Demaria, Nathaniel David, Alain Philippe Vasserot, James L. Kirkland, Tamar Tchkonia, Jennifer Elisseeff, Chaekyu Kim, Okhee Jeon, Yi Zhu
  • COMMUNICATION MODE SELECTION
    Publication number: 20170373789
    Abstract: A device includes a memory, a processor, and a transceiver. The memory is configured to store capability data corresponding to a set of stations. The processor is configured to select, based at least in part on the capability data, one of a multi-user multiple-input multiple-output (MU-MIMO) mode or an orthogonal frequency-division multiple access (OFDMA) mode for wireless communication with a subset of the set of stations. The transceiver is configured to wirelessly communicate with the subset in the selected one of the MU-MIMO mode or the OFDMA mode.
    Type: Application
    Filed: May 12, 2017
    Publication date: December 28, 2017
    Inventors: Xiaolong HUANG, Hao ZHU, Srinivas KATAR, Naveen GANGADHARAN, Madhan JAGANATHAN, Nathaniel David HOUGHTON, Sabita NAHATA, Raja BANERJEA, Alireza RAISSINIA, James CHO, Chao CHENG
  • Unit dose of a cis-imidazoline for treating an osteoarthritic joint by removing senescent cells
    Patent number: 9849128
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: December 26, 2017
    Assignees: Unity Biotechnology, Inc., Buck Institute for Research on Aging, Mayo Foundation for Medical Education and Research, The John Hopkins University
    Inventors: Remi-Martin Laberge, Judith Campisi, Albert Davalos, Marco Demaria, Nathaniel David, Alain Philippe Vasserot, James L. Kirkland, Tamar Tchkonia, Yi Zhu, Jennifer Elisseeff, Chaekyu Kim, Okhee Jeon
  • System and method for rate adaptation based on total number of spatial streams in MU-MIMO transmissions
    Patent number: 9843411
    Abstract: Wireless node selects modulation coding schemes (MCS) and number of spatial streams for transmitting data to devices via a MU-MIMO transmission based on the total number of spatial streams. In one implementation, a wireless node selects first MCS, first number of spatial stream(s) for a first device, and total number of spatial streams to be used in the MU-MIMO transmission so as to maximize the data rate to the first device, then selects a second MCS and a second number of spatial stream(s) for a second device based on the selected total number of spatial streams. In another implementation, the wireless node toggles the first selection of the MCS and spatial stream(s) between the first and second devices for fairness purposes. In another implementation, a wireless selects the MCS and the spatial streams for the receiving nodes so as to maximize the aggregate data rate for the MU-MIMO transmission.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: December 12, 2017
    Assignee: QUALCOMM, Incorporated
    Inventors: Qinghai Gao, Nathaniel David Houghton, Ahmed Ragab Elsherif, Ehab Tahir
  • METHODS AND COMPOSITIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS
    Publication number: 20170348307
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Application
    Filed: July 12, 2017
    Publication date: December 7, 2017
    Inventors: Remi-Martin Laberge, Judith Campisi, Albert Davalos, Marco Demaria, Nathaniel David, Alain Philippe Vasserot, Darren J. Baker, Bennett G. Childs, James L. Kirkland, Tamar Tchkonia, Jan M.A. van Deursen, Jennifer Elisseeff, Chaekyu Kim, Okhee Jeon, Allyson K. Palmer
  • SYSTEM AND METHOD FOR PROVIDING ALERTS OPTIMIZED FOR A USER
    Publication number: 20170347971
    Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.
    Type: Application
    Filed: August 23, 2017
    Publication date: December 7, 2017
    Inventors: Anna Leigh Davis, Scott M. Belliveau, Naresh C. Bhavaraju, Leif N. Bowman, Rita M. Castillo, Alexandra Elena Constantin, Rian Draeger, Laura J. Dunn, Gary Brian Gable, Arturo Garcia, Thomas Hall, Hari Hampapuram, Christopher Robert Hannemann, Anna Claire Harley-Trochimczyk, Nathaniel David Heintzman, Andrea J. Jackson, Lauren Hruby Jepson, Apurv Ullas Kamath, Katherine Yerre Koehler, Aditya Sagar Mandapaka, Samuel Jere Marsh, Gary A. Morris, Subrai Girish Pai, Andrew Attila Pal, Nicholas Polytaridis, Philip Thomas Pupa, Eli Reihman, Ashley Anne Rindfleisch, Sofie Wells Schunk, Peter C. Simpson, Daniel Smith, Stephen J. Vanslyke, Matthew T. Vogel, Tomas C. Walker, Benjamin Elrod West, Atiim Joseph Wiley
  • Treatment of Pain
    Publication number: 20170326136
    Abstract: This disclosure provides a technology for managing the sensation of pain in a subject in need thereof. Treatment methods according to this invention include administering to the subject a formulation that contains an effective amount of (4-[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone).
    Type: Application
    Filed: April 6, 2017
    Publication date: November 16, 2017
    Inventors: Nathaniel David, Albert Davalos, Remi-Martin Laberge, Judith Campisi, Marco Demaria, Alain Vasserot, Chaekyu Kim, Okhee Jeon, Jennifer Elisseeff
  • SYSTEM AND METHOD FOR PROVIDING ALERTS OPTIMIZED FOR A USER
    Publication number: 20170311904
    Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.
    Type: Application
    Filed: April 28, 2017
    Publication date: November 2, 2017
    Inventors: Anna Leigh Davis, Scott M. Belliveau, Naresh C. Bhavaraju, Leif N. Bowman, Rita M. Castillo, Alexandra Elena Constantin, Rian Draeger, Laura J. Dunn, Gary Brian Gable, Arturo Garcia, Thomas Hall, Hari Hampapuram, Christopher Robert Hannemann, Anna Claire Harley-Trochimczyk, Nathaniel David Heintzman, Andrea J. Jackson, Lauren Hruby Jepson, Apurv Ullas Kamath, Katherine Yerre Koehler, Aditya Sagar Mandapaka, Samuel Jere Marsh, Gary A. Morris, Subrai Girish Pai, Andrew Attila Pal, Nicholas Polytaridis, Philip Thomas Pupa, Eli Reihman, Ashley Anne Rindfleisch, Sofie Wells Schunk, Peter C. Simpson, Daniel Smith, Stephen J. Vanslyke, Matthew T. Vogel, Tomas C. Walker, Benjamin Elrod West, Atiim Joseph Wiley
  • SYSTEM AND METHOD FOR PROVIDING ALERTS OPTIMIZED FOR A USER
    Publication number: 20170311903
    Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.
    Type: Application
    Filed: April 28, 2017
    Publication date: November 2, 2017
    Inventors: Anna Leigh Davis, Scott M. Belliveau, Naresh C. Bhavaraju, Leif N. Bowman, Rita M. Castillo, Alexandra Elena Constantin, Rian Draeger, Laura J. Dunn, Gary Brian Gable, Arturo Garcia, Thomas Hall, Hari Hampapuram, Christopher Robert Hannemann, Anna Claire Harley-Trochimczyk, Nathaniel David Heintzman, Andrea J. Jackson, Lauren Hruby Jepson, Apurv Ullas Kamath, Katherine Yerre Koehler, Aditya Sagar Mandapaka, Samuel Jere Marsh, Gary A. Morris, Subrai Girish Pai, Andrew Attila Pal, Nicholas Polytaridis, Philip Thomas Pupa, Eli Reihman, Ashley Anne Rindfleisch, Sofie Wells Schunk, Peter C. Simpson, Daniel Smith, Stephen J. Vanslyke, Matthew T. Vogel, Tomas C. Walker, Benjamin Elrod West, Atiim Joseph Wiley
  • SYSTEM AND METHOD FOR RATE ADAPTATION BASED ON TOTAL NUMBER OF SPATIAL STREAMS IN MU-MIMO TRANSMISSIONS
    Publication number: 20170302401
    Abstract: Wireless node selects modulation coding schemes (MCS) and number of spatial streams for transmitting data to devices via a MU-MIMO transmission based on the total number of spatial streams. In one implementation, a wireless node selects first MCS, first number of spatial stream(s) for a first device, and total number of spatial streams to be used in the MU-MIMO transmission so as to maximize the data rate to the first device, then selects a second MCS and a second number of spatial stream(s) for a second device based on the selected total number of spatial streams. In another implementation, the wireless node toggles the first selection of the MCS and spatial stream(s) between the first and second devices for fairness purposes. In another implementation, a wireless selects the MCS and the spatial streams for the receiving nodes so as to maximize the aggregate data rate for the MU-MIMO transmission.
    Type: Application
    Filed: April 19, 2016
    Publication date: October 19, 2017
    Inventors: Qinghai Gao, Nathaniel David Houghton, Ahmed Ragab Elsherif, Ehab tahir
  • DYNAMIC MEDIUM ACCESS CONTROL RECEPTION-REORDER TIMEOUT IN A CROWDED WIRELESS LOCAL AREA NETWORK
    Publication number: 20170295516
    Abstract: Methods, systems, and devices for wireless communication are described. A device may identify an indication of a station load in a wireless local area network (WLAN) and estimate a delay to fill a packet hole at the medium access control (MAC) layer based on the station load. The estimated time period may be used to adjust a reorder timeout value. In some cases the reorder timeout value may be increased when the station load is high to reduce the likelihood that packet holes will be flushed to higher layers before the device is served with the missing packets. In some cases, the station load may be determined based on a message received from a serving access point (AP).
    Type: Application
    Filed: April 8, 2016
    Publication date: October 12, 2017
    Inventors: Qinghai Gao, Nathaniel David Houghton, Ehab Tahir
  • COMPOUNDS AND THERAPEUTIC USES
    Publication number: 20170281649
    Abstract: Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.
    Type: Application
    Filed: March 14, 2016
    Publication date: October 5, 2017
    Inventor: Nathaniel David
  • USE OF A HETEROCYCLIC BCL-2 INHIBITOR FOR REMOVING SENESCENT CELLS AND TREATING SENESCENCE-ASSOCIATED CONDITIONS
    Publication number: 20170266211
    Abstract: Disclosed herein are compounds that are effective for treatment of various disease states. Dosing includes both single administration and regimens of cycling dosages.
    Type: Application
    Filed: June 1, 2017
    Publication date: September 21, 2017
    Inventors: Nathaniel David, Remi-Martin Laberge
  • METHOD AND APPARATUS FOR SIMULTANEOUS LOCALIZATION AND MAPPING OF MOBILE ROBOT ENVIRONMENT
    Publication number: 20170255203
    Abstract: Techniques that optimize performance of simultaneous localization and mapping (SLAM) processes for mobile devices, typically a mobile robot. In one embodiment, erroneous particles are introduced to the particle filtering process of localization. Monitoring the weights of the erroneous particles relative to the particles maintained for SLAM provides a verification that the robot is localized and detection that it is no longer localized. In another embodiment, cell-based grid mapping of a mobile robot's environment also monitors cells for changes in their probability of occupancy. Cells with a changing occupancy probability are marked as dynamic and updating of such cells to the map is suspended or modified until their individual occupancy probabilities have stabilized.
    Type: Application
    Filed: May 22, 2017
    Publication date: September 7, 2017
    Applicant: NEATO ROBOTICS, INC,
    Inventors: Boris SOFMAN, Vladimir ERMAKOV, Mark EMMERICH, Steven ALEXANDER, Nathaniel David MONSON
  • DAMPER COVER AND ATTACHMENT INTERFACE FOR A CRANKSHAFT DAMPER
    Publication number: 20170248219
    Abstract: Methods and systems are provided for a crankshaft damper cover for a crankshaft damper of a crankshaft in an engine. In one example, a crankshaft damper cover shaped to fit within a cavity of a crankshaft damper and including an inset and an annular ring embedded within the inset, where the annular ring includes tabs adapted to mate with an inner surface of the crankshaft damper. As one example, the inset may be comprised of a damping material, such as plastic or foam.
    Type: Application
    Filed: February 26, 2016
    Publication date: August 31, 2017
    Inventors: Chuck Raymond Kvasnicka, Shaji Mathews, Nathaniel David Hansen, Tom Xu, Shashin Shah
  • METHODS AND COMPOSITIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS
    Publication number: 20170224680
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Application
    Filed: January 28, 2015
    Publication date: August 10, 2017
    Inventors: Remi-Martin Laberge, Judith Campisi, Albert Davalos, Marco Demaria, Nathaniel David, Alain Philippe Vasserot, Darren J. Baker, Bennett G. Childs, James L. Kirkland, Tamar Tchkonia, Jan M.A. van Deursen, Jennifer Elisseeff, Chaekyu Kim, Okhee Jeon, Allyson K. Palmer
  • SYSTEM AND METHOD FOR DECISION SUPPORT USING LIFESTYLE FACTORS
    Publication number: 20170216518
    Abstract: Systems and methods are provided relating to open loop decision-making for management of diabetes. People with diabetes face many problems in controlling their glucose because of the complex interactions between food, insulin, exercise, stress, activity, and other physiological and environmental conditions. Established principles of management of glucose sometimes are not adequate because there is a significant amount of variability in how different conditions impact different individuals and what actions might be effective for them. Accordingly, systems and methods according to present principles minimize the impact of the vagaries of diabetes on individuals, i.e., by looking for patterns and tendencies of an individual and customizing the management to that individual. Consequently, the same reduces the uncertainty that diabetes typically is associated with and improves quality of life.
    Type: Application
    Filed: January 26, 2017
    Publication date: August 3, 2017
    Inventors: Anna Leigh Davis, Naresh C. Bhavaraju, Jennifer Blackwell, Leif N. Bowman, Esteban Cabrera, Jr., Alexandra Elena Constantin, Basab Dattaray, Rian Draeger, Nathaniel David Heintzman, Lauren Hruby Jepson, Apurv Ullas Kamath, Katherine Yerre Koehler, Andrew Attila Pal, Eli Reihman, Tomas C. Walker
  • SYSTEM AND METHOD FOR DECISION SUPPORT USING LIFESTYLE FACTORS
    Publication number: 20170220751
    Abstract: Systems and methods are provided relating to open loop decision-making for management of diabetes. People with diabetes face many problems in controlling their glucose because of the complex interactions between food, insulin, exercise, stress, activity, and other physiological and environmental conditions. Established principles of management of glucose sometimes are not adequate because there is a significant amount of variability in how different conditions impact different individuals and what actions might be effective for them. Accordingly, systems and methods according to present principles minimize the impact of the vagaries of diabetes on individuals, i.e., by looking for patterns and tendencies of an individual and customizing the management to that individual. Consequently, the same reduces the uncertainty that diabetes typically is associated with and improves quality of life.
    Type: Application
    Filed: January 26, 2017
    Publication date: August 3, 2017
    Inventors: Anna Leigh Davis, Naresh C. Bhavaraju, Jennifer Blackwell, Leif N. Bowman, Esteban Cabrera, JR., Alexandra Elena Constantin, Basab Dattaray, Rian Draeger, Nathaniel David Heintzman, Lauren Hruby Jepson, Apurv Ullas Kamath, Katherine Yerre Koehler, Andrew Attila Pal, Eli Reihman, Tomas C. Walker