Patents by Inventor Nathaniel David

Nathaniel David has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Unit dose of an aryl sulfonamide that is effective for treating eye disease and averting potential vision loss
    Patent number: 10478433
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: November 19, 2019
    Assignees: Unity Biotechnology, Inc., Buck Institute for Research on Aging, Mayo Foundation for Medical Education and Research
    Inventors: Remi-Martin Laberge, Judith Campisi, Marco Demaria, Nathaniel David, Darren J. Baker, James L. Kirkland, Tamar Tchkonia, Yi Zhu, Jan M. A. van Deursen, Alain Philippe Vasserot, Bennett G. Childs
  • Transport Device with Chassis Mounted Battery
    Publication number: 20190344818
    Abstract: A transport device comprising a battery pack and a chassis member at least partially encased in the battery pack.
    Type: Application
    Filed: May 7, 2019
    Publication date: November 14, 2019
    Applicant: Ford Global Technologies, LLC
    Inventors: Nathaniel David McLean, Tharsika Nanthapalan
  • Personal mobility vehicle
    Publication number: 20190346859
    Abstract: A personal mobility vehicle comprising a control unit for controlling a steering function of the vehicle, wherein the control unit is adapted to receive route information from a personal smart device and to control the vehicle at least semi-autonomously based on the route information.
    Type: Application
    Filed: May 7, 2019
    Publication date: November 14, 2019
    Applicant: Ford Global Technologies, LLC
    Inventors: Nathaniel David McLean, Tharsika Nanthapalan
  • THERAPY FOR REMOVING SENESCENT CELLS AND TREATING SENESCENCE-ASSOCIATED DISEASE USING AN MDM2 INHIBITOR
    Publication number: 20190343832
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Application
    Filed: July 10, 2019
    Publication date: November 14, 2019
    Inventors: Remi-Martin Laberge, Judith Campisi, Albert Davalos, Marco Demaria, Nathaniel David, Alain Philippe Vasserot, James L. Kirkland, Tamar Tchkonia, Jennifer Elisseeff, Chaekyu Kim, Okhee Jeon, Yi Zhu
  • MICROSTRUCTURED AND PATTERNED LIGHT GUIDE PLATES AND DEVICES COMPRISING THE SAME
    Publication number: 20190339440
    Abstract: Disclosed herein are light guide plates (100, 100?, 100?) comprising a transparent substrate (110) having an edge surface in (150), a light emitting first major surface (160), and an opposing second major surface (170); and a polymeric film (120) disposed on at least one of the first (160) and second (170) major surfaces of the transparent substrate, wherein the polymeric film (120) comprises a plurality of microstructures (130) and/or a plurality of light extraction features. At least one light source (140) may be coupled to the edge surface (150) of the transparent substrate (110). Display and lighting devices comprising such light guide plates are further disclosed, as well as methods for manufacturing such light guide plates.
    Type: Application
    Filed: December 18, 2017
    Publication date: November 7, 2019
    Inventors: Dana Craig Bookbinder, Steven S Rosenblum, Natesan Venkataraman, Robert Stephen Wagner, James Andrew West, Nathaniel David Wetmore
  • ATM transaction with a mobile device
    Patent number: 10467604
    Abstract: A method for conducting financial transactions with an automated teller machine (ATM), including: receiving, by a mobile device, a first authentication credential from a user; authenticating, by the mobile device, the user for access to a financial account based on the first authentication credential; wirelessly transmitting, by the mobile device and to the ATM, a first request to establish a direct short range wireless connection with the ATM after authenticating the user; establishing, by the mobile device, the direct short range wireless connection with the ATM after transmitting the first request; and sending, over the direct short range wireless connection, an identifier of the user to the ATM, where the user makes a selection of a cash amount for withdrawal from the financial account, and where the ATM dispenses the cash amount to the user.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: November 5, 2019
    Assignee: Intuit Inc.
    Inventors: William Michael Dorsch, Nathaniel David Anderson, Joseph Hikmet Guzel, Jonathan David Fasoli
  • Athletic shoe having a cross-training configuration and a weight-training configuration
    Patent number: 10455888
    Abstract: An athletic shoe is selectively configurable between a weight-training configuration and a cross-training configuration. The athletic shoe includes an upper portion configured to receive a foot and a first sole portion connected to the upper portion. The first sole portion has an inner surface and an outer surface opposite the inner surface. The outer surface is configured to contact a training surface when the athletic shoe is in the cross-training configuration. The athletic shoe also includes a second sole portion removably connected to the first sole portion when the athletic shoe is in the weight-training configuration. The second sole portion includes a first surface and a second surface. The first surface is configured to contact the training surface and the second surface is configured to contact the outer surface when the athletic shoe is in the weight-training configuration.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: October 29, 2019
    Inventor: Nathaniel David Davenport
  • COMPOSITION COMPRISING A GENE VECTOR THAT SELECTIVELY DEPLETES P16 POSITIVE SENESCENT CELLS
    Publication number: 20190316109
    Abstract: Polypeptides, viruses, methods and compositions provided herein are useful for the selective elimination of senescent cells. Method aspects include methods for inducing apoptosis in a senescent cell comprising administering to the cell a polynucleotide, virus, host cell, or pharmaceutical composition described herein. Other methods include expressing a pro-apoptotic gene in a senescent cell comprising administering to the cell the polynucleotide, virus, or pharmaceutical composition as described herein.
    Type: Application
    Filed: June 10, 2019
    Publication date: October 17, 2019
    Inventors: Serge Lichtsteiner, Nathaniel David
  • Chemical entities that kill senescent cells for use in treating age-related disease
    Patent number: 10426788
    Abstract: Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: October 1, 2019
    Assignee: Unity Biotechnology, Inc.
    Inventor: Nathaniel David
  • Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders using an inhibitor of Akt kinase
    Patent number: 10413542
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: September 17, 2019
    Assignees: Buck Institute for Research on Aging, Unity Biotechnology, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Remi-Martin Laberge, Nathaniel David, Alain Philippe Vasserot, Darren J. Baker, Bennett G. Childs, James L. Kirkland, Tamar Tchkonia, Jan M. A. van Deursen, Yi Zhu
  • System and method for providing alerts optimized for a user
    Patent number: 10406287
    Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: September 10, 2019
    Assignee: DexCom, Inc.
    Inventors: Anna Leigh Davis, Scott M. Belliveau, Naresh C. Bhavaraju, Leif N. Bowman, Rita M. Castillo, Alexandra Elena Constantin, Rian Draeger, Laura J. Dunn, Gary Brian Gable, Arturo Garcia, Thomas Hall, Hari Hampapuram, Christopher Robert Hannemann, Anna Claire Harley-Trochimczyk, Nathaniel David Heintzman, Andrea J. Jackson, Lauren Hruby Jepson, Apurv Ullas Kamath, Katherine Yerre Koehler, Aditya Sagar Mandapaka, Samuel Jere Marsh, Gary A. Morris, Subrai Girish Pai, Andrew Attila Pal, Nicholas Polytaridis, Philip Thomas Pupa, Eli Reihman, Ashley Anne Rindfleisch, Sofie Wells Schunk, Peter C. Simpson, Daniel Smith, Stephen J. Vanslyke, Matthew T. Vogel, Tomas C. Walker, Benjamin Elrod West, Atiim Joseph Wiley
  • TREATMENT OF PARKINSON'S DISEASE AND OTHER CONDITIONS CAUSED OR MEDIATED BY SENESCENT ASTROCYTES USING SMALL MOLECULE SENOLYTIC AGENTS
    Publication number: 20190269675
    Abstract: This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease.
    Type: Application
    Filed: May 3, 2019
    Publication date: September 5, 2019
    Inventors: Shankar J. Chinta, Judith Campisi, Julie K. Andersen, Remi-Martin Laberge, Nathaniel David, James L. Kirkland, Tamar Tchkonia, Yi Zhu
  • SYSTEM AND METHOD FOR DECISION SUPPORT
    Publication number: 20190251456
    Abstract: Systems and methods are provided to determine a time to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a model or pattern. The time to deliver guidance may be calculated to be useful to a user in the management of a glucose concentration level.
    Type: Application
    Filed: February 6, 2019
    Publication date: August 15, 2019
    Inventors: Alexandra Elena Constantin, Scott M. Belliveau, Naresh C. Bhavaraju, Jennifer Blackwell, Eric Cohen, Basab Dattaray, Anna Leigh Davis, Rian Draeger, Arturo Garcia, John Michael Gray, Hari Hampapuram, Nathaniel David Heintzmann, Lauren Hruby Jepson, Matthew Lawrence Johnson, Apurv Ullas Kamath, Katherine Yerre Koehler, Phil Mayou, Patrick Wile McBride, Michael Robert Mensinger, Sumitaka Mikami, Andrew Attila Pal, Nicholas Polytaridis, Philip Thomas Pupa, Eli Reihman, Peter C. Simpson, Tomas C. Walker, Daniel Justin Wiedeback, Subrai Girish Pai, Matthew T. Vogel
  • SYSTEM AND METHOD FOR DECISION SUPPORT
    Publication number: 20190246973
    Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration level. The glucose concentration level may be provided to a stored model to determine a state. The guidance may be determined based at least in part on the determined state.
    Type: Application
    Filed: February 6, 2019
    Publication date: August 15, 2019
    Inventors: Alexandra Elena Constantin, Scott M. Belliveau, Naresh C. Bhavaraju, Jennifer Blackwell, Eric Cohen, Basab Dattaray, Anna Leigh Davis, Rian Draeger, Arturo Garcia, John Michael Gray, Hari Hampapuram, Nathaniel David Heintzmann, Lauren Hruby Jepson, Matthew Lawrence Johnson, Apurv Ullas Kamath, Katherine Yerre Koehler, Phil Mayou, Patrick Wile McBride, Michael Robert Mensinger, Sumitaka Mikami, Andrew Attila Pal, Nicholas Polytaridis, Philip Thomas Pupa, Eli Reihman, Peter C. Simpson, Tomas C. Walker, Daniel Justin Wiedeback, Subrai Girish Pai, Matthew T. Vogel
  • SYSTEM AND METHOD FOR DECISION SUPPORT
    Publication number: 20190252079
    Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration data sensed by a glucose concentration sensor. A host state change associated with the host glucose concentration data may be determined. A guidance message based at least in part on the host state change may also be determined. The guidance message may be delivered through a user interface.
    Type: Application
    Filed: February 6, 2019
    Publication date: August 15, 2019
    Inventors: Alexandra Elena Constantin, Scott M. Belliveau, Naresh C. Bhavaraju, Jennifer Blackwell, Eric Cohen, Basab Dattaray, Anna Leigh Davis, Rian Draeger, Arturo Garcia, John Michael Gray, Hari Hampapuram, Nathaniel David Heintzmann, Lauren Hruby Jepson, Matthew Lawrence Johnson, Apurv Ullas Kamath, Katherine Yerre Koehler, Phil Mayou, Patrick Wile McBride, Michael Robert Mensinger, Sumitaka Mikami, Andrew Attila Pal, Nicholas Polytaridis, Philip Thomas Pupa, Eli Reihman, Peter C. Simpson, Tomas C. Walker, Daniel Justin Wiedeback
  • SYSTEM AND METHOD FOR DECISION SUPPORT
    Publication number: 20190246914
    Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration level. The glucose concentration level may be provided to a stored model to determine a state. The guidance may be determined based at least in part on the determined state.
    Type: Application
    Filed: February 6, 2019
    Publication date: August 15, 2019
    Inventors: Alexandra Elena Constantin, Scott M. Belliveau, Naresh C. Bhavaraju, Jennifer Blackwell, Eric Cohen, Basab Dattaray, Anna Leigh Davis, Rian Draeger, Arturo Garcia, John Michael Gray, Hari Hampapuram, Nathaniel David Heintzmann, Lauren Hruby Jepson, Matthew Lawrence Johnson, Apurv Ullas Kamath, Katherine Yerre Koehler, Phil Mayou, Patrick Wile McBride, Michael Robert Mensinger, Sumitaka Mikami, Andrew Attila Pal, Nicholas Polytaridis, Philip Thomas Pupa, Eli Reihman, Peter C. Simpson, Tomas C. Walker, Daniel Justin Wiedeback, Subrai Girish Pai, Matthew T. Vogel
  • Replication conditional virus that specifically kills senescent cells
    Patent number: 10378002
    Abstract: Polypeptides, viruses, methods and compositions provided herein are useful for the selective elimination of senescent cells. Method aspects include methods for inducing apoptosis in a senescent cell comprising administering to the cell a polynucleotide, virus, host cell, or pharmaceutical composition described herein. Other methods include expressing a pro-apoptotic gene in a senescent cell comprising administering to the cell the polynucleotide, virus, or pharmaceutical composition as described herein.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: August 13, 2019
    Assignees: Unity Biotechnology, Inc., Kythera Biopharmaceuticals, Inc.
    Inventors: Serge Lichtsteiner, Nathaniel David
  • SYSTEM AND METHOD FOR DYNAMIC AND CENTRALIZED INTERACTIVE RESOURCE MANAGEMENT
    Publication number: 20190238801
    Abstract: Systems and methods for interactive site resource management are disclosed. In certain embodiments, the system and method collects and accesses local geospatially-referenced landscape and site survey data in the field as facilitated by selectable content views, the gathered landscape and site survey data synthesized with baseline geospatially-referenced landscape and site survey data. In one aspect, the synthesized landscape and site geospatially-referenced survey data may be used by a project lead or authority agent, to create a landscape and/or site report, an authorized development plan, a master landscape and/or site survey, and/or as-built development plans. In certain embodiments, the synthesized landscape site survey data is presented as an augmented reality display.
    Type: Application
    Filed: January 25, 2019
    Publication date: August 1, 2019
    Inventors: Nathaniel David Boyless, Dante Lee Knapp
  • SCHEDULING AND GROUPING TRANSMISSION CONTROL PROTOCOL ACKNOWLEDGEMENT, TRANSMISSION CONTROL PROTOCOL DATA, AND USER DATAGRAM PROTOCOL DATA
    Publication number: 20190208041
    Abstract: In an aspect of the disclosure, a method, a computer-readable medium, and an apparatus are provided. The apparatus may determine a plurality of TCP ACKs, and at least one of TCP data or UDP data for a multi-user transmission to a set of STAs. The apparatus may allocate the plurality of TCP ACKs to a PPDU before allocating the at least one of the TCP data and the UDP data to the PPDU. In certain aspects, the plurality of TCP ACKs may be frequency division multiplexed in the PPDU. In certain other aspects, the apparatus may transmit, to the set of STAs, the multi-user transmission including at least the plurality of frequency division multiplexed TCP ACKs.
    Type: Application
    Filed: January 4, 2018
    Publication date: July 4, 2019
    Inventors: Madhan JAGANATHAN, Xiaolong HUANG, Srinivas KATAR, Nathaniel David HOUGHTON, Madhavan NAIR, Hao ZHU, Chao ZOU
  • Use of sulfonamide inhibitors of BCL-2 and BCL-xL to treat ophthalmic disease by selectively removing senescent cells
    Patent number: 10328073
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: June 25, 2019
    Assignees: Unity Biotechnology, Inc., Buck Institute for Research on Aging, Mayo Foundation for Medical Education and Research
    Inventors: Remi-Martin Laberge, Judith Campisi, Marco Demaria, Nathaniel David, Alain Philippe Vasserot, James L. Kirkland, Tamar Tchkonia, Yi Zhu, Darren J. Baker, Bennett G. Childs, Jan M. A. van Deursen