Abstract: A capsule containing a substance for the preparation of a potable beverage. The capsule comprises an aluminum capsule body having a side wall and an outwardly extending flange and a sealing member at the outwardly extending flange for providing a fluid sealing contact with an enclosing member of a beverage preparation device. The beverage preparation device comprises an annular element having a free contact end. The sealing member is integral with the outwardly extending flange and comprises at least one projection projecting from the outwardly extending flange. The projection comprising a projection top and is configured such that its projection top exerts a radial force on the free contact end of the annular element if the capsule is positioned in the enclosing member of the beverage preparation device and the enclosing member is closed using a closing member of the beverage preparation device.

Abstract: The present disclosure provides antibodies that bind to TNFR2 as well as uses of the antibodies and associated methods. The disclosure also provides processes for making, preparing, and producing antibodies that bind to TNFR2. Antibodies of the disclosure are useful in one or more of diagnosis, prophylaxis, or treatment of disorders or conditions mediated by, or associated with, TNFR2 activity.

Abstract: Methods and systems for selecting and presenting web resources (e.g. videos) are provided, the method includes: transmitting a first video to be played by a device associated with a user account; and during playback of the first video at the device: detecting an update to configuration data associated with the user account; determining, based on the update to the configuration data associated with the user account, a next video recommendation for the user account; and causing an indication of the next video recommendation to be displayed on the device.

Abstract: Described herein are compositions and methods for the treatment or prevention of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious diseases of the anterior surface of the eye(s). Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.

Abstract: A wake-up radio system in a wireless sensor network, the wake-up radio comprising: an analog front end configured to communicate with matching network; an analog to digital converter coupled to the analog front end; and a digital baseband coupled to the analog to digital converter, wherein the digital baseband outputs a fast wake-up signal and a secure wake-up signal, and wherein the wake-up radio listens to all channels simultaneously.

Abstract: A processor includes a first die, a second die connected to the first die with a microfluidic volume positioned between the first die and the second die, a wicking heat spreader positioned in the microfluidic volume; and a boiling enhancement surface feature positioned on at least one surface of the wicking heat spreader.

Abstract: A thermal management device includes a wicking heat spreader and a boiling enhancement surface feature positioned on at least one interior surface of the wicking heat spreader.

Abstract: The technology described in this application relates to a system and method for using an API for a video game application where the data from the API can be used in various processes and sub-processes. For example, the technology allows a system to create a tournament for a game (e.g., a multiplayer first person shooter game) where data obtained via an API can be used for measuring player participating in the tournament. The technology described herein can also utilize a technique for continuously making API calls without the risk of the API system denying a request (e.g., due to too many frequent API call attempts, due to too many requests made from a single network address).

Abstract: An immersion cooling system includes an immersion tank that is configured to retain dielectric working fluid and to hold a plurality of computing devices submerged in the dielectric working fluid. The immersion cooling system also includes a condenser that is configured to cause condensation of vaporized working fluid. The immersion cooling system also includes a subcooling heat exchanger that is in fluid communication with a coolant source. The coolant source provides coolant having a coolant temperature that is lower than a boiling point of the dielectric working fluid. The subcooling heat exchanger is positioned so that heat transfer can occur between the dielectric working fluid and the subcooling heat exchanger. The immersion cooling system also includes a control system that controls how much of the coolant flows into the subcooling heat exchanger based at least in part on a temperature of the dielectric working fluid.

Abstract: A beverage fluid dispensing head comprising a housing; and a fluid track, at least in part, arranged inside the housing. The fluid track comprises: an inlet channel arranged for receiving a beverage fluid, such as coffee, from a beverage apparatus; a collection chamber, fluidly connected to the inlet channel, for receiving the beverage fluid therefrom; and at least one outlet channel. The at least one outlet channel is fluidly connected to the collection chamber for receiving the beverage fluid from the collection chamber. A downstream part of the at least one outlet channel is formed as a tongue-shaped flow guide which is downwardly directed for, in use, guiding the received beverage fluid and submitting the received beverage fluid therefrom in the form of an integral fluid beam for dispensing.

Abstract: The present invention provides processes and key intermediates for the synthesis of (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoro-propane-2-yl)-1H-pyrazole-4-carboxamide:

Abstract: A data processing apparatus is provided. An A×B multiplier array has a group of logic gates clocked by a first clock signal, where A and B are both integers. A C×D multiplier array, separate from the A×B multiplier array, has second group of logic gates clocked by a second clock signal, where C and D are both integers. Addition circuitry performs an addition operation between a first at least partial product produced by the A×B multiplier array and a second at least partial product produced by the C×D multiplier array.

Abstract: A data processing apparatus is provided. Rename circuitry performs a register rename stage of a pipeline by storing, in storage circuitry, mappings between registers. Each of the mappings is associated with an elimination field value. Operation elimination circuitry replaces an operation that indicates an action is to be performed on data from a source register and stored in a destination register, with a new mapping in the storage circuitry that references the destination register and has the elimination field value set. Operation circuitry responds to a subsequent operation that accesses the destination register when the elimination field value is set; by obtaining contents of the source register, performing the action on the contents to obtain a result, and returning the result.

Abstract: A solar tracker system comprising a solar tracker. The solar tracker includes one or more solar panels and a first dampening assembly comprising a dampener that provides dampening of rotation of the one or more solar panels to provide for dampening of the solar tracker and the one or more solar panels, the dampener reducing undesirable oscillations of the one or more solar panels of the solar tracker.

Abstract: A wake-up radio system in a wireless sensor network, the wake-up radio comprising: an analog front end configured to communicate with matching network; an analog to digital converter coupled to the analog front end; and a digital baseband coupled to the analog to digital converter, wherein the digital baseband outputs a fast wake-up signal and a secure wake-up signal, and wherein the wake-up radio listens to all channels simultaneously.

Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to Cluster of Differentiation 1a (CD1a) are provided. Embodiments include uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

Abstract: A data processing apparatus is provided, which includes addition circuitry that performs a calculation of a sum of a first operand and a second operand. The addition circuitry produces an intermediate data prior to the calculation completing. Determination circuitry uses the intermediate data to produce the sum of the first operand and the second operand plus 1. Further determination circuitry configured to use the intermediate data to produce the sum of the first operand and the second operand plus 2.

Abstract: An immersion cooling system includes an immersion tank that is configured to retain dielectric working fluid and to hold a plurality of computing devices submerged in the dielectric working fluid. The immersion cooling system also includes a condenser that is configured to cause condensation of vaporized working fluid. The immersion cooling system also includes a subcooling heat exchanger that is in fluid communication with a coolant source. The coolant source provides coolant having a coolant temperature that is lower than a boiling point of the dielectric working fluid. The subcooling heat exchanger is positioned so that heat transfer can occur between the dielectric working fluid and the subcooling heat exchanger. The immersion cooling system also includes a control system that controls how much of the coolant flows into the subcooling heat exchanger based at least in part on a temperature of the dielectric working fluid.

Abstract: A missile for a hydraulic fracturing system can include a high-pressure (HP) missile manifold having a plurality of HP input channels, a HP output channel, and a main HP channel disposed between the plurality of HP input channels and the HP output channel, where each of the plurality of HP input channels is configured to couple to and receive a fracturing fluid from a pump truck, where the HP output channel is configured to couple to and send the fracturing fluid to a main manifold, and where the main HP channel has a widening section along its length that separates a first HP portion of the main HP channel having a first HP diameter and a second HP portion of the main HP channel having a second HP diameter.

Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.