Abstract: Disclosed are methods of making selective estrogen receptor degraders (SERDs) of Formula A, as well as intermediates thereof, salts thereof including a pharmaceutically acceptable salt, and pharmaceutical compositions thereof: wherein either R1 or R2 is independently Cl, F, —CF3, or —CH3, and the other is H; and R7 is H or PG.

Abstract: A thermal management system includes a boiler tank and at least one heat-generating component positioned in the boiler tank. The boiler tank is in fluid communication with a vapor return line and a liquid return line. A condenser is in fluid communication with the vapor return line and the liquid return line. The condenser is positioned between vapor return line and the liquid return line in the fluid communication.

Abstract: A system for thermal management of a computing device includes an immersion chamber, a cooling fluid, a plurality of heat-generating components, and a means for removing vapor from a cooling volume of the cooling fluid. The cooling fluid is positioned in the immersion chamber and fills at least a portion of the immersion chamber. The plurality of heat-generating components is positioned in the cooling fluid and arranged in a series. The series defines the cooling volume of the cooling fluid contacting the plurality of heat-generating components to cool the plurality of heat-generating components.

Abstract: A method for collecting information required for Bode plot creation of a UAV (Unmanned Aerial Vehicle) autopilot system is provided. The method comprises: creating a Bode plot generation input signal: adding the Bode plot generation input signal to control inputs; collecting data from multiple points within the control system; calculating magnitude and phase at the multiple points using the data collected; recording the magnitude and phase for the multiple points in a datalog; comparing the magnitude and phase for the multiple points to calculate the gain and phase margins for open loop responses in the control system; creating a Bode plot for at least one of the following: i) a closed loop response of the attitude and/or rate loops, ii) an open loop response of the attitude and/or rate loops and iii) a response of the UAV; and outputting the Bode plot.

Abstract: A tub is configured to contain a supply of water and is configured to be inserted into a chamber of a humidifier. The tub includes a tub base configured to contain the supply of water. The tub also includes a tub lid and a flow plate provided between the tub base and the tub lid. The flow plate includes a water level indicator configured to indicate a level of the supply of water in the tub base. In addition, the water level indicator includes a generally rectangular portion and a generally triangular portion.

Abstract: A liquid-submersible thermal management system includes a cylindrical outer shell and an inner shell positioned in an interior volume of the outer shell. The cylindrical outer shell has a longitudinal axis oriented vertically relative to a direction of gravity, and the inner shell defines an immersion chamber. The liquid-submersible thermal management system a spine positioned inside the immersion chamber and oriented at least partially in a direction of the longitudinal axis with a heat-generating component located in the immersion chamber. A working fluid is positioned in the immersion chamber and at least partially surrounding the heat-generating component. The working fluid receives heat from the heat-generating component.

Abstract: Fluid replacement structures used in immersion cooling tanks can include various enhancements to make them functional beyond simply taking up space. For example, the density of fluid replacement structures can be variable to assist with buoyancy control. As another example, fluid replacement structures can be designed to enable vaporized working fluid to be directed to a desired location. As another example, fluid replacement structures can include emergency cooling features, such as different substances that cause an endothermic reaction to occur when they are mixed together. The substances can be separated by a membrane that melts when the temperature reaches a certain point. As another example, a fluid replacement structure can provide structural support for an immersion cooling tank when negative pressure operations are performed. Fluid replacement structures can also include alignment features, lifting features, locking features, mating guides, fiducial markers, or the like.

Abstract: A predicated-loop-terminating branch instruction controls, based on whether a loop termination condition is satisfied, whether the processing circuitry should process a further iteration of a predicated loop body or process a following instruction. If at least one unnecessary iteration of the predicated loop body is processed following a mispredicted-non-termination branch misprediction when the loop termination condition is mispredicted as unsatisfied for a given iteration when it should have been satisfied, processing of the at least one unnecessary iteration of the predicated loop body is predicated to suppress an effect of the at least one unnecessary iteration.

Abstract: An immersion cooling system includes an immersion tank, a first fluid reservoir, a second fluid reservoir, and a mixing device. The first fluid reservoir contains a first working fluid having a first boiling temperature. The second fluid reservoir contains a second working fluid having a second boiling temperature. The mixing device mixes at least a portion of the first working fluid and at least a portion of the second working fluid into a mixed working fluid, and the mixing device directs the mixed working fluid to the immersion tank.

Abstract: Methods and systems for obtaining address data, generating improved deliverable addresses, and generating an improved database of address information. Address data input to a graphical user interface (GUI) may be used to identify a location represented by an address entry in an address database. If the address entry is associated with supplemental address information, the GUI is modified to include a supplemental address information field to obtain additional address data, which is then combined with the address data to produce a complete deliverable address output. A history of delivery notifications, whether failures or successes, together with address data used in attempting the deliveries may be stored and used in determining whether to associate a location with supplemental address information, and to identify type or class of supplemental address information to associate with the location.

Abstract: A liquid-submersible thermal management system includes a shell, a heat-generating component, a working fluid, and at least one heat-dispersing element. The shell defines an immersion chamber where the heat-generating component is located in the immersion chamber. The working fluid is positioned in the immersion chamber and at least partially surrounds the heat-generating component so the working fluid receives heat from the heat-generating component. The at least one heat-dispersing element is positioned on exterior surface of the shell to conduct heat from the shell into the heat-dispersing element.

Abstract: A solar tracker system comprising one or more tracker rotation control systems that include: a curved gear plate; and a locking element configured to lock the solar tracker system in a first configuration.

Abstract: A method for collecting information required for Bode plot creation of a UAV (Unmanned Aerial Vehicle) autopilot system is provided. The method comprises: creating a Bode plot generation input signal: adding the Bode plot generation input signal to control inputs; collecting data from multiple points within the control system; calculating magnitude and phase at the multiple points using the data collected; recording the magnitude and phase for the multiple points in a datalog; comparing the magnitude and phase for the multiple points to calculate the gain and phase margins for open loop responses in the control system; creating a Bode plot for at least one of the following: i) a closed loop response of the attitude and/or rate loops, ii) an open loop response of the attitude and/or rate loops and iii) a response of the UAV; and outputting the Bode plot.

Abstract: A method of thermal management of a computing device includes immersing a first electronic component of the computing device in a first working fluid contained in a first volume, immersing a second electronic component of the computing device in a second working fluid contained in a second volume, and changing a pressure in the first volume to alter a boiling temperature of the first working fluid in the first volume.

Abstract: An electronics cooling system includes a printed circuit board (PCB) assembly having a heat generating component connected to a base. A plurality of thermally conductive microtubes are connected to the PCB assembly with a first spatial density. The plurality of thermally conductive microtubes are connected to a heat plate of a cooling system with a second spatial density to evenly spread the heat flux of the PCB assembly over the heat plate.

Abstract: A tub is configured to contain a supply of water and is configured to be inserted into a chamber of a humidifier. The tub includes a tub base configured to contain the supply of water. The tub also includes a tub lid and a flow plate provided between the tub base and the tub lid. The flow plate includes a water level indicator configured to indicate a level of the supply of water in the tub base. In addition, the water level indicator includes a generally rectangular portion and a generally triangular portion.

Abstract: A system for fracturing multiple wellbores on a multi-well pad can include a missile that receives high-pressure fracturing fluid from a plurality of pump truck. The system can also include a main manifold that receives the high-pressure fracturing fluid from the missile, where the main manifold includes multiple valves and multiple output channels, where each of the valves are operated between an open position and a closed position. The system can further include multiple wellbores including a first wellbore, a second wellbore, and a third wellbore, where the wellbores are connected to the output channels of the main manifold. The valves of the main manifold can be operated to enable simultaneous flow of the high-pressure fracturing fluid to the first wellbore, the second wellbore, and the third wellbore so that the first wellbore, the second wellbore, and the third wellbore are fractured simultaneously.

Abstract: A predicated-loop-terminating branch instruction controls, based on whether a loop termination condition is satisfied, whether the processing circuitry should process a further iteration of a predicated loop body or process a following instruction. If at least one unnecessary iteration of the predicated loop body is processed following a mispredicted-non-termination branch misprediction when the loop termination condition is mispredicted as unsatisfied for a given iteration when it should have been satisfied, processing of the at least one unnecessary iteration of the predicated loop body is predicated to suppress an effect of the at least one unnecessary iteration.

Abstract: The spring wire clip fastens fence wire to T-posts. The clip is constructed from hardened high carbon spring steel and has a geometry that allows the clip to be installed with no tools. The middle of the clip has a shape complementary to the T-post spine, typically a “V” shape, such that the clip wraps around the spine and the two ends extend laterally. Each end has a curl that can engage the fence wire on either side of the T-post. The clips can be installed five times faster than with standard twist-type clips and can be repositioned, or reused, as the attachment is not permanent.