Abstract: The present invention relates to the use of endocytosis inhibitors, including clathrin-dependent endocytosis inhibitors such as inhibitors of dynamin and antibodies, for enhancing the immune response to cancer, and thereby treating cancers including cancer associated receptor positive cancers.

Abstract: An apparatus that includes a conduit having a first end, a second end, and a longitudinal axis. The conduit may define an inner channel and may be configured to extend through a vane cavity of a vane. The apparatus may further include a damping finger that includes a first portion coupled to the conduit and a second portion diverging outward at an angled orientation from the conduit. The damping finger may be resiliently flexible and the second portion of the damping finger may be configured to contact an inner surface of the vane.

Abstract: The exercise performance monitoring apparatus consists of gloves and shoes that have embedded pressure sensor arrays to measure pressure applied to them during exercise. The gloves and shoes send the pressure data using wireless RF transmitters to a central display control unit located on each glove. The gloves have color LED strips which change color depending on whether the gloves or shoes are measuring equal pressures. The glove displays the state of balance between the glove and shoe pressures using separate LED displays on each glove. The pressure balance is adjustable as well as the selection of colors to display. The user can at a glance see if he or she is in balance when performing the specific exercise by observing the color shown on the glove display. The glove display for either glove or shoe pressure will flash the color representing unbalanced pressures if the pressures are unbalanced on the glove having the highest or lowest pressure depending on user preference.

Abstract: A process for the production of vinyl chloride comprises the step of passing a feed stream comprising ethylene dichloride (EDC) over a catalyst system comprising a dehydrochlorination catalyst and a hydrochlorination catalyst at a temperature, which may be in the range 150-350° C., sufficient to effect dehydrochlorination of the ethylene dichloride to produce vinyl chloride.

Abstract: A catalyst including gold, or a compound thereof, and sulphur, a compound of sulphur, trichloroisocyanuric acid or a metal dichloroisocyanurate on a support, together with a process for manufacturing the catalyst and its use in a chemical process are described.

Abstract: A system includes a support member and a hard disk drive interface connector, where a first side of the hard disk drive interface connector is disposed on a first side of the support member and a second side of the hard disk drive interface connector disposed on a second side of the support member. A conduit is coupled to the support member and to a fluid inlet disposed on the first side of the support member. A fluid outlet is disposed on the first side of the support member, and a housing is coupled to the first side of the support member and defines a volume with the support member, where an interface between the housing and the first side of the support member is leak-resistant, and where the fluid inlet and fluid outlet are in fluid communication with the volume.

Abstract: A tub is configured to contain a supply of water and is configured to be inserted into a chamber of a humidifier. The tub includes a tub base configured to contain the supply of water. The tub also includes a tub lid and a flow plate provided between the tub base and the tub lid. The flow plate includes a water level indicator configured to indicate a level of the supply of water in the tub base. In addition, the water level indicator includes a generally rectangular portion and a generally triangular portion.

Abstract: In an example, a cooling device is provided. The cooling device includes a connection block including a surface, an inlet passage, and an outlet passage. The cooling device includes a first membrane defining a first volume with a first opening at a first end thereof. The first membrane sealingly engages with the surface around the inlet passage. The cooling device includes a second membrane defining a second volume with a second opening at a second end thereof. The second membrane also defines a plurality of apertures and sealingly engages with the surface inside of the first membrane and around the outlet passage. The cooling device also includes a substrate arranged in the second membrane, is connected to the surface, and includes a heat-generating device. Coolant fluid flows into the first volume via the inlet passage, through the plurality of apertures into the second volume, and exits via the outlet passage.

Abstract: In an example, a server system is provided. The server system includes a frame including a support structure and a server supported by the support structure. The server system includes an actuator configured to cause the server to transition from a first position to a second position to increase exposure of the server to airflow to transfer heat away from the server via convection. The actuator is also configured to cause the server to transition from the second position to the first position to decrease exposure of the server to the airflow.

Abstract: A compound of formula (I) for use in the prevention or treatment of a bacterial infection wherein: PX is selected from the group consisting of (P1), (P2) and (P3).

Abstract: In an example, a cooling device is provided. The cooling device includes a connection block including a surface, an inlet passage, and an outlet passage. The cooling device includes a first membrane defining a first volume with a first opening at a first end thereof. The first membrane sealingly engages with the surface around the inlet passage. The cooling device includes a second membrane defining a second volume with a second opening at a second end thereof. The second membrane also defines a plurality of apertures and sealingly engages with the surface inside of the first membrane and around the outlet passage. The cooling device also includes a substrate arranged in the second membrane, is connected to the surface, and includes a heat-generating device. Coolant fluid flows into the first volume via the inlet passage, through the plurality of apertures into the second volume, and exits via the outlet passage.

Abstract: A method of generating an internally consistent model of the state of a book captured in a video image is provided. The method comprises obtaining a plurality of pieces of evidence relating to the state of a corresponding plurality of aspects of the book in the video image, associating a quality score with each piece of evidence, generating an initial model of the state of the book wherein the state of the book is constrained by physical properties of the book and at least the highest scoring piece of evidence, and sequentially constraining the model in response to one or more successive pieces of evidence whose scores meet a respective predetermined first threshold value.

Abstract: A physical structure is created at least partially utilizing one or more materials from soil of a site upon which the physical structure is to be created. A plurality of metrics associated with the physical structure is identified. The plurality of metrics includes a shape of available physical space, a size of available physical space, materials included within the soil of a location of the physical structure, a context of use of the physical structure, a climate of the location, or availability of resources associated with the location. The plurality of metrics is analyzed to determine a material from the materials included within the soil of the location of the physical structure to be used in creating the physical structure. Growth of the physical structure is generated in a downward direction utilizing the material. Utilizing the determined material comprises using the determined material as a portion of the physical structure.

Abstract: A continuously growing physical structure may be generated by identifying a plurality of metrics associated with the physical structure. The plurality of metrics may include at least one of a shape of available physical space, a size of available physical space, a type of soil/earth of a location of the physical structure, a context of use of the physical structure, a climate of the location, or availability of resources associated with the location. The plurality of metrics may be analyzed to determine at least one of a rate of growth of the physical structure or a most suitable shape of the physical structure. Growth of the physical structure may then be generated according to at least one of the determined rate of growth of the physical structure or the determined most suitable shape of the physical structure. The identified plurality of metrics may then be monitored periodically.

Abstract: A capsule containing a substance for the preparation of a potable beverage. The capsule comprises an aluminum capsule body having a side wall and an outwardly extending flange and a sealing member at the outwardly extending flange for providing a fluid sealing contact with an enclosing member of a beverage preparation device. The beverage preparation device comprises an annular element having a free contact end which may be provided with a plurality of radially extending open grooves. The sealing member is integral with the outwardly extending flange and comprises at least one projection projecting from the outwardly extending flange. The projection comprising a projection top and is configured such that its projection top exerts a radial force on the free contact end of the annular element if the capsule is positioned in the enclosing member of the beverage preparation device and the enclosing member is closed by means of a closing member of the beverage preparation device.

Abstract: A capsule containing a substance for the preparation of a potable beverage. The capsule comprises an aluminum capsule body having a side wall and an outwardly extending flange and a sealing member at the outwardly extending flange for providing a fluid sealing contact with an enclosing member of a beverage preparation device. The beverage preparation device comprises an annular element having a free contact end which may be provided with a plurality of radially extending open grooves. The sealing member is integral with the outwardly extending flange and comprises at least one projection projecting from the outwardly extending flange. The projection comprising a projection top and is configured such that its projection top exerts a radial force on the free contact end of the annular element if the capsule is positioned in the enclosing member of the beverage preparation device and the enclosing member is closed by means of a closing member of the beverage preparation device.

Abstract: The present invention relates to a method of reducing total gas production and/or methane production in a ruminant animal.

Abstract: A cooled electronics module (CEM) includes a cooling device and a server blade or other electronic device that is operationally enclosed in a container of the cooling device by a closure secured to a connection block. Each CEM is pluggable for electronic communication and coolant fluid flow. The connection block has electronics connectors to connect the contained electronic device, which is submerged in coolant, with external networks, power, and other infrastructure. CEMs may be installed in an initial deployment of electronic devices, or later to rapidly replace or supplement an operating electronic device. Installation may include placing the CEM on a rail which has coolant lines and electrical lines and connectors, putting coolant in the CEM before or after placement, and making connections for power, data signal, and coolant flow. CEMs may be constrained as to the number of motherboards or volume or thermal energy per CEM pool of coolant.

Abstract: In a described example method, semiconductor wafer with a backside silicon nitride layer is encapsulated with a diffusion barrier layer prior to a high temperature anneal greater than about 1000 degrees Celsius. After the high temperature anneal the diffusion barrier layer and the backside silicon nitride layers are stripped.