Patent number: 10975056
Abstract: The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Type:
Grant
Filed:
June 13, 2017
Date of Patent:
April 13, 2021
Assignees:
GlaxoSmithKline Intellectual Property Development Limited, Cancer Research Technology Ltd.
Inventors:
Nicholas David Adams, Andrew B. Benowitz, María Lourdes Rueda Benede, Karen Anderson Evans, David T Fosbenner, Bryan Wayne King, Mei Li, Juan Ignacio Luengo, William Henry Miller, Alexander Joseph Reif, Stuart Paul Romeril, Stanley J. Schmidt, Roger J. Butlin, Kristin M. Goldberg, Allan M. Jordan, Christopher S. Kershaw, Ali Raoof, Bohdan Waszkowycz
Patent number: 10842313
Abstract: Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid. A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage. The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home.
Type:
Grant
Filed:
January 16, 2018
Date of Patent:
November 24, 2020
Assignee:
BEDFORD SYSTEMS LLC
Inventors:
Thomas J. Novak, Ross Packard, Peter Peterson, Shawn Gulla, Jennifer Caitlin Huot Carlson, Camilla Schmitt, Mark Joseph Cohen, Ross Peter Jones, Nicolas Alejandro Martinez, Miles William Noel Hember, Fabien Yannick Schmitt, Gary Stacey, Niall Allan Mottram, Neil Lester Campbell, Cormac O'Prey, Wai Ting Chan, Nicholas David Rollings, Charles Frazer Kilby, Christopher Paul Richardson, Thomas Bates Jackson, Scott Grubb, Chris Covey, Barry Dobson, Paul Wilkins, Chris Roach, Peter David Cauwood, Keith Paul Thompson, James Hewitt, Marc Angotti, Ray Carroll, Richard Estabrook, Kevin Hartley, Frank Consoli