Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: A negative electrode active material comprises a carbon-based material and a silicon-based material, wherein a first functional group exists on the surface of the carbon-based material, a second functional group exists on the surface of the silicon-based material, and the first functional group has a charge opposite to that of the second functional group.

Abstract: The present disclosure provides a page loading method, a device, and a storage medium. The method includes: preloading a preloaded resource of a first landing page into a memory cache of a first browser in response to a launch of a first application, where the first landing page is a third-party landing page; and in response to a load trigger operation on the first landing page, reading the preloaded resource of the first landing page from the memory cache through the first browser, and loading the first landing page based on the preloaded resource of the first landing page.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: A method for doping a two-dimensional material based on cluster ion implantation, including selecting a two-dimensional material sample to place same on a substrate; determining the selected implantation parameters by Monte Carlo particle tracing algorithm on the two-dimensional material sample; replacing the two-dimensional material sample, and placing a two-dimensional material thin film, wherein the thickness of the two-dimensional material thin film is ?10 nm; selecting a determined implantation parameter to form a cluster beam and acting on a two-dimensional material thin film; changing the implantation parameters to form different cluster beams and acting on the two-dimensional material thin film; performing annealing on the two-dimensional material thin film implanted with cluster ions to repair the damage caused by implantation.

Abstract: Disclosed in embodiments of the present application are a battery cell, a battery and an electric device. The battery cell comprises: an electrode assembly, the electrode assembly comprising a negative electrode sheet, the negative electrode sheet comprising a negative electrode active material from/into which metal ions can be reversibly deintercalated/intercalated, and the negative electrode active material comprising a silicon-based material; and a casing used for accommodating the electrode assembly, the tensile strength of at least partial area of the casing at the temperature of 25° C. being Rm, and Rm meeting: 250 MPa?Rm?2000 MPa. According to the battery cell, the battery and the electric device in the embodiments of the present application, the reliability of the battery cell can be improved.

Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I? (I?) wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

Abstract: Provided herein is a nucleic acid extraction and the structure of a reaction chamber is improved such that a piston, a reaction chamber and a magnetic rod are independent of one another, magnetic beads are more concentrated, more sufficient adsorption, washing and elution are achieved, dead corners are eliminated, when the nucleic acid extraction and amplification device is used to perform nucleic acid extraction and amplification. The sensitivity and accuracy of nucleic acid detection can be further improved, and missing and wrong detection can be avoided.

Abstract: An application of a mitoxantrone preparation in preparation of a drug for diagnosing and treating a disease related to thyroidectomy, and use of mitoxantrone and/or a pharmaceutically acceptable salt thereof in preparation of a lymph tracer for preventing parathyroid gland staining in error, preventing parathyroid gland cutting in error, or reducing the rate of parathyroid gland cutting in error. Local injection of a mitoxantrone hydrochloride injection fluid would not cause parathyroid gland staining in error, and can reduce the rate of parathyroid gland cutting in error, thus protecting parathyroid glands well; moreover, no local or systemic toxic side effect is found after the local injection. The present invention has good tolerability, efficacy, and safety, and provides a new treatment idea in radically curing thyroid diseases thoroughly for patients suffering from diseases related to thyroidectomy.

Abstract: This application provides a positive electrode active material, a positive electrode plate, a secondary battery, a power consuming apparatus, and a preparation method. The positive electrode active material includes polycrystalline particles designated as the first active particles and monocrystalline or quasi-monocrystalline particles designated as second active particles. (Dv90?Dv10)/Dv50 of the first active particles and the second active particles are respectively designated as X1 and X2, where X1/X2 satisfies 0.2?X1/X2?0.7.

Abstract: The use of a mitoxantrone preparation in the preparation of a drug for diagnosing and treating breast cancer. Provided is the use of mitoxantrone and/or a pharmaceutically acceptable salt thereof in the preparation of a lymphatic tracer in a disease associated with breast resection. No local or systemic toxic and side effects are seen after local injection of the preparation, suggesting that the preparation has good tolerance, effectiveness and safety, which provides a new treatment idea for thoroughly curing breast cancer in a breast cancer patient.

Abstract: The present disclosure relates to a secondary battery and a battery module. The secondary battery includes a case including a receiving space with an opening; a cap assembly connected to the case and close the opening; an electrode assembly disposed in the receiving space and including two end faces opposite to each other in a first direction perpendicular to an axial direction of the receiving space, and tabs extending from the end faces and two or more electrode units stacked in the axial direction; and a current collecting unit, including a first piece extending in the axial direction and a first current collecting piece connected to the first piece, the tab extends in the first direction and is connected to the first current collecting piece, and a portion of the tab connected to the first current collecting piece and the first current collecting piece are stacked in the axial direction.

Abstract: A request to write host data to a memory device of a memory sub-system is received. Redundancy metadata associated with the host data is generated. A determination of a first status associated with the host data is made. The redundancy metadata associated with the host data is updated to indicate at least the first status associated with the host data. A memory access operation is performed to write the host data and the updated redundancy metadata to the memory device.

Abstract: The composite silicon material includes an inner core and a silicon-containing cladding layer cladded on the outer side of the inner core. The inner core comprises a silicon-carbon material, the silicon-carbon material includes a porous conductive material and a first silicon-based material, the outer surface of the porous conductive material has pores, and at least a portion of the first silicon-based material is distributed in the pores. The silicon-containing cladding layer contains an ion-conducting material and a second silicon-based material. The second silicon-based material is dispersed in the ion-conducting material.

Abstract: A secondary battery comprises a positive electrode plate and a negative electrode plate. The negative electrode plate comprises a negative electrode active material layer. The negative electrode active material layer comprises a negative electrode active material. The negative electrode active material comprises a silicon-based material. In the same charging and discharging cycle process, the volume ratio of the negative electrode plate during charging and discharging of the secondary battery is R, wherein R is less than or equal to 1.5; and the volume ratio of the positive electrode plate during charging and discharging of the secondary battery is Y, wherein Y is less than or equal to 0.98.

Abstract: [Object] To provide at least one of a beta zeolite having excellent catalytic activity and hydrothermal durability or a method for manufacturing it. [Solution]A beta zeolite having a total alkali metal content of 0.5% by mass or less, an SDA content of 4.0% by mass or less, a silica-to-alumina molar ratio of 20 or greater and 35 or less and a ratio of the height intensity of a peak having its peak top at 3735±10 cm?1 to the height intensity of a peak having its peak top at 1860±10 cm?1 in an IR spectrum of 1.90 or less.

Abstract: A negative electrode plate includes a current collector and a coating applied to at least one surface of the current collector, the coating comprising a negative electrode active material and a metal powder, wherein the electrode potential of the metal powder in the coating relative to lithium may be between 1.6 and 3.5 V, the negative electrode active material may be a silicon-based material, and relative to the total weight of the silicon-based material and the metal powder, the proportion by weight of the metal powder may be 5 to 20% and the proportion by weight of the silicon-based material may be 80 to 95%.

Abstract: This application discloses a data transmission method and system, and a related apparatus. An electronic device detects a first operation for a first control, and creates a first dragged object by using a view module. The first dragged object is used to carry dragging data of the first control, and the dragging data includes one or more of an image, a text, and a hyperlink. The electronic device transmits the first dragged object to a transfer station by using a drag framework, and transmits the first dragged object to a second application by using the transfer station. The electronic device displays, based on the first dragged object, the first control on a second interface by using the second application. In this way, cross-application data transmission can be implemented, an operation is simple, and no application adaptation is required.

Abstract: Disclosed is a mutually generative artificial intelligence system based on multi-dimensional spatiotemporal information vector graphics, relating to the field of artificial intelligence and engineering applications. Based on a geographic information system (GIS) or a computer-aided design (CAD) platform and a data source, a multi-dimensional vector spatiotemporal large model terminal, a multi-dimensional spatiotemporal information processing agent terminal, and an intelligent information system application terminal are constructed.

Abstract: A negative electrode sheet, a secondary battery, and an electric device. The negative electrode sheet includes a negative electrode current collector, a buffer layer, and an active layer, where the buffer layer is located between the negative electrode current collector and the active layer; the buffer layer includes a first binder; and an active material of the active layer includes silicon-carbon composite particles, and the silicon-carbon composite particles include a porous carbon material and a silicon material located in pores of the porous carbon material.