Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I? (I?) wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

Abstract: Provided herein is a nucleic acid extraction and the structure of a reaction chamber is improved such that a piston, a reaction chamber and a magnetic rod are independent of one another, magnetic beads are more concentrated, more sufficient adsorption, washing and elution are achieved, dead corners are eliminated, when the nucleic acid extraction and amplification device is used to perform nucleic acid extraction and amplification. The sensitivity and accuracy of nucleic acid detection can be further improved, and missing and wrong detection can be avoided.

Abstract: An application of a mitoxantrone preparation in preparation of a drug for diagnosing and treating a disease related to thyroidectomy, and use of mitoxantrone and/or a pharmaceutically acceptable salt thereof in preparation of a lymph tracer for preventing parathyroid gland staining in error, preventing parathyroid gland cutting in error, or reducing the rate of parathyroid gland cutting in error. Local injection of a mitoxantrone hydrochloride injection fluid would not cause parathyroid gland staining in error, and can reduce the rate of parathyroid gland cutting in error, thus protecting parathyroid glands well; moreover, no local or systemic toxic side effect is found after the local injection. The present invention has good tolerability, efficacy, and safety, and provides a new treatment idea in radically curing thyroid diseases thoroughly for patients suffering from diseases related to thyroidectomy.

Abstract: This application provides a positive electrode active material, a positive electrode plate, a secondary battery, a power consuming apparatus, and a preparation method. The positive electrode active material includes polycrystalline particles designated as the first active particles and monocrystalline or quasi-monocrystalline particles designated as second active particles. (Dv90?Dv10)/Dv50 of the first active particles and the second active particles are respectively designated as X1 and X2, where X1/X2 satisfies 0.2?X1/X2?0.7.

Abstract: The use of a mitoxantrone preparation in the preparation of a drug for diagnosing and treating breast cancer. Provided is the use of mitoxantrone and/or a pharmaceutically acceptable salt thereof in the preparation of a lymphatic tracer in a disease associated with breast resection. No local or systemic toxic and side effects are seen after local injection of the preparation, suggesting that the preparation has good tolerance, effectiveness and safety, which provides a new treatment idea for thoroughly curing breast cancer in a breast cancer patient.

Abstract: The present disclosure relates to a secondary battery and a battery module. The secondary battery includes a case including a receiving space with an opening; a cap assembly connected to the case and close the opening; an electrode assembly disposed in the receiving space and including two end faces opposite to each other in a first direction perpendicular to an axial direction of the receiving space, and tabs extending from the end faces and two or more electrode units stacked in the axial direction; and a current collecting unit, including a first piece extending in the axial direction and a first current collecting piece connected to the first piece, the tab extends in the first direction and is connected to the first current collecting piece, and a portion of the tab connected to the first current collecting piece and the first current collecting piece are stacked in the axial direction.

Abstract: A request to write host data to a memory device of a memory sub-system is received. Redundancy metadata associated with the host data is generated. A determination of a first status associated with the host data is made. The redundancy metadata associated with the host data is updated to indicate at least the first status associated with the host data. A memory access operation is performed to write the host data and the updated redundancy metadata to the memory device.

Abstract: The composite silicon material includes an inner core and a silicon-containing cladding layer cladded on the outer side of the inner core. The inner core comprises a silicon-carbon material, the silicon-carbon material includes a porous conductive material and a first silicon-based material, the outer surface of the porous conductive material has pores, and at least a portion of the first silicon-based material is distributed in the pores. The silicon-containing cladding layer contains an ion-conducting material and a second silicon-based material. The second silicon-based material is dispersed in the ion-conducting material.

Abstract: A secondary battery comprises a positive electrode plate and a negative electrode plate. The negative electrode plate comprises a negative electrode active material layer. The negative electrode active material layer comprises a negative electrode active material. The negative electrode active material comprises a silicon-based material. In the same charging and discharging cycle process, the volume ratio of the negative electrode plate during charging and discharging of the secondary battery is R, wherein R is less than or equal to 1.5; and the volume ratio of the positive electrode plate during charging and discharging of the secondary battery is Y, wherein Y is less than or equal to 0.98.

Abstract: [Object] To provide at least one of a beta zeolite having excellent catalytic activity and hydrothermal durability or a method for manufacturing it. [Solution]A beta zeolite having a total alkali metal content of 0.5% by mass or less, an SDA content of 4.0% by mass or less, a silica-to-alumina molar ratio of 20 or greater and 35 or less and a ratio of the height intensity of a peak having its peak top at 3735±10 cm?1 to the height intensity of a peak having its peak top at 1860±10 cm?1 in an IR spectrum of 1.90 or less.

Abstract: A negative electrode plate includes a current collector and a coating applied to at least one surface of the current collector, the coating comprising a negative electrode active material and a metal powder, wherein the electrode potential of the metal powder in the coating relative to lithium may be between 1.6 and 3.5 V, the negative electrode active material may be a silicon-based material, and relative to the total weight of the silicon-based material and the metal powder, the proportion by weight of the metal powder may be 5 to 20% and the proportion by weight of the silicon-based material may be 80 to 95%.

Abstract: This application discloses a data transmission method and system, and a related apparatus. An electronic device detects a first operation for a first control, and creates a first dragged object by using a view module. The first dragged object is used to carry dragging data of the first control, and the dragging data includes one or more of an image, a text, and a hyperlink. The electronic device transmits the first dragged object to a transfer station by using a drag framework, and transmits the first dragged object to a second application by using the transfer station. The electronic device displays, based on the first dragged object, the first control on a second interface by using the second application. In this way, cross-application data transmission can be implemented, an operation is simple, and no application adaptation is required.

Abstract: Disclosed is a mutually generative artificial intelligence system based on multi-dimensional spatiotemporal information vector graphics, relating to the field of artificial intelligence and engineering applications. Based on a geographic information system (GIS) or a computer-aided design (CAD) platform and a data source, a multi-dimensional vector spatiotemporal large model terminal, a multi-dimensional spatiotemporal information processing agent terminal, and an intelligent information system application terminal are constructed.

Abstract: A negative electrode sheet, a secondary battery, and an electric device. The negative electrode sheet includes a negative electrode current collector, a buffer layer, and an active layer, where the buffer layer is located between the negative electrode current collector and the active layer; the buffer layer includes a first binder; and an active material of the active layer includes silicon-carbon composite particles, and the silicon-carbon composite particles include a porous carbon material and a silicon material located in pores of the porous carbon material.

Abstract: The composite silicon material includes an inner core and a silicon-containing cladding layer cladded on the outer side of the inner core. The inner core comprises a silicon-carbon material, the silicon-carbon material includes a porous conductive material and a first silicon-based material, the outer surface of the porous conductive material has pores, and at least a portion of the first silicon-based material is distributed in the pores. The silicon-containing cladding layer contains an ion-conducting material and a second silicon-based material. The second silicon-based material is dispersed in the ion-conducting material.

Abstract: The present application relates to a silicon-carbon composite material and a preparation method therefor, a negative electrode sheet, a secondary battery, and an electrical device. The silicon-carbon composite material comprises a porous carbon matrix and a silicon-based material layer located in pores of the porous carbon matrix, the silicon-based material layer comprises a sub-nano silicon cluster and a sub-nano silicon carbide cluster, and the surface of the sub-nano silicon carbide cluster is in contact with the surface of the sub-nano silicon cluster. The silicon-carbon composite material has small expansibility, good cycle performance and fast charging performance and high energy density.

Abstract: A silicon composite material and a preparation method therefor, a negative electrode sheet, a secondary battery, and an electrical apparatus. The silicon composite material comprises a one-dimensional conductive material, an inner core, and a coating layer, the outer surface of the inner core is coated with the coating layer, the one-dimensional conductive material is arranged on the outer surface of the coating layer, and the inner core comprises a silicon-based material. The silicon composite material has good cycle performance and fast charging performance.

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: A silicon composite material and a preparation method, a negative electrode plate, a battery, and an electrical apparatus. The silicon composite material comprises a silicon-based material and a flexible material, wherein the hardness of the flexible material is less than the hardness of the silicon-based material. The silicon-based material comprises at least one of elemental silicon, a silicon-oxygen compound, a silicon-carbon composite, a silicon-nitrogen composite, and a silicon alloy. The flexible material is located on at least part of the surface of the silicon-based material. By means of the combination of the flexible material and the silicon-based material, the risk of a current collector being crushed during the preparation of an electrode plate can be reduced, and the compacted density of the electrode plate can be improved, thus increasing the energy density of a battery.

Abstract: A silicon composite material and a preparation method therefor, a negative electrode sheet, a secondary battery, and an electric device. The silicon composite material comprises a core and a first coating layer covering the surface of the core; the core comprises a first core and a second core; the first core comprises a first conductive material; the first conductive material comprises a flexible conductive material; the second core comprises a silicon-based material of which the surface is coated with a second coating layer; and the second coating layer contains a second conductive material. The silicon composite material has the characteristics of good cycle performance and fast charging performance.