Publication number: 20250381187
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
Type:
Application
Filed:
August 27, 2025
Publication date:
December 18, 2025
Applicant:
AMGEN INC.
Inventors:
John Gordon ALLEN, Jennifer Rebecca ALLEN, Ana Elena MINATTI, Qiufen XUE, Ryan Paul WURZ, Christopher M. TEGLEY, Alexander J. PICKRELL, Thomas T. NGUYEN, Vu Van MA, Patricia LOPEZ, Longbin LIU, David John KOPECKY, Michael J. FROHN, Ning CHEN, Jian Jeffrey CHEN, Aaron C. SIEGMUND, Albert K. AMEGADZIE, Shon BOOKER, Clifford GOODMAN, Nuria A. TAMAYO, Mary WALTON, Nobuko NISHIMURA, Youngsook SHIN, Jonathan Dante LOW, Victor J. CEE, Anthony B. REED, Hui-Ling WANG, Brian Alan LANMAN