Abstract: A holder unit is movably provided in a tank body in such a manner that one end of the holder unit is movably connected to a rotation supporting portion formed on a bottom wall of the tank body. A manual lever is connected to the other end of the holder unit. When the manual lever is pulled up, the holder unit is rotated around the rotation supporting portion, so that the other end is located in an entrance space formed at a position adjacent to a tank opening. A pump module is inserted into the tank body through the tank opening and attached to the holder unit. Then, the holder unit is pushed down by the manual lever to a pump installation position, in which the other end of the holder unit is located in an installation space formed on the bottom wall. The holder unit is engaged with a holding portion formed in the tank body, so that the holder unit and the pump module are stably held at the pump installation position.

Abstract: A suction filter which filters fuel inside a fuel tank of a vehicle to let a fuel pump draw filtered fuel into an inlet port includes a filter element disposed inside the fuel tank and filtering stored fuel stored in the fuel tank by allowing the stored fuel to pass through to an inner space, and a partition wall element disposed in a posture with which to divide the inner space to a first space where filtered fuel filtered at the filter element flows in and a second space where the inlet port into which the filtered fuel is drawn opens, and allowing the filtered fuel in the first space to pass through to the second space. The partition wall element is provided in a form of a partition film dividing the inner space to the first space on an upper side and the second space on a lower side.

Abstract: A filter element is installed in an inside of a fuel tank to filter stored fuel by passing the stored fuel into an inside space through the filter element. A partition wall element is exposed in the inside space. The partitioning portion includes: a partitioning portion that is placed to partially partition the inside space into a first space, into which filtered fuel filtered through the filter element is supplied, and a second space, in which a suction inlet for suctioning the filtered fuel opens, wherein the partitioning portion conducts the filtered fuel from the first space to the second space; and a communication window that is formed in the partitioning portion at a location, which is offset to a side that is away from the suction inlet, wherein the communication window communicates between the first space and the second space while bypassing the partitioning portion.

Abstract: The present disclosure provides a suction filter that filters a fuel inside a fuel tank of a vehicle. The suction filter includes a filter element, a partitioning wall element, a passage element, and an open/close valve. The filter element is disposed in and exposed inside of the fuel tank. The filter element filters a stored fuel stored in the fuel tank. The partitioning wall element is arranged in the inside space to divide the inside space into a first space and a second space that is lower than the first space. The inlet to take in the filtered fuel is open in the second space. The passage element defines an inflow opening open in the first space, an outflow opening to which a negative suction pressure is applied through the inlet, and a flow passage through which the filtered fuel flows.

Abstract: A gasoline fuel supply system includes a feed pump part, an inline pump part, and a high-pressure pump part. The feed pump part includes a non-positive displacement electric pump, and pumps a gasoline fuel from a fuel tank and discharges at a feed pressure. The inline pump part includes a non-positive displacement mechanical pump, and pressurizes the gasoline fuel discharged from the feed pump part and discharges at a middle pressure. The high-pressure pump part includes a positive displacement mechanical pump, and pressurizes the gasoline fuel discharged from the inline pump part and discharges at a supply pressure to a fuel injection valve.

Abstract: A swirling wall structure-extends from a lower side toward an upper side in a sub-tank, and a fuel flow, which is outputted into an inside of the sub-tank from a flow outlet of a diffuser passage opened toward a lateral side, is swirled by the swirling wall structure. The swirling wall structure-includes a curved wall surface and a U-turn wall surface. The curved wall surface is curved about a longitudinal axis, which extends from the lower side toward the upper side in the sub-tank, to bend the fuel flow outputted from the flow outlet. The U-turn wall surface extends continuously from the curved wall surface to make a U-turn of the fuel flow, which is bent by the curved wall surface.

Abstract: A swirling wall structure-extends from a lower side toward an upper side in a sub-tank, and a fuel flow, which is outputted into an inside of the sub-tank from a flow outlet of a diffuser passage opened toward a lateral side, is swirled by the swirling wall structure. The swirling wall structure-includes a curved wall surface and a U-turn wall surface. The curved wall surface is curved about a longitudinal axis, which extends from the lower side toward the upper side in the sub-tank, to bend the fuel flow outputted from the flow outlet. The U-turn wall surface extends continuously from the curved wall surface to make a U-turn of the fuel flow, which is bent by the curved wall surface.

Abstract: The present disclosure provides a suction filter that filters a fuel inside a fuel tank of a vehicle. The suction filter includes a filter element, a partitioning wall element, a passage element, and an open/close valve. The filter element is disposed in and exposed inside of the fuel tank. The filter element filters a stored fuel stored in the fuel tank. The partitioning wall element is arranged in the inside space to divide the inside space into a first space and a second space that is lower than the first space. The inlet to take in the filtered fuel is open in the second space. The passage element defines an inflow opening open in the first space, an outflow opening to which a negative suction pressure is applied through the inlet, and a flow passage through which the filtered fuel flows.

Abstract: A common width direction, along which a passage width of a communication passage section and a passage width of a pressurizing passage are defined, is perpendicular to an extending direction of a flow restricting passage section. A first passage wall surface and a second passage wall surface, which define the communication passage section therebetween, are opposed to each other in the common width direction. The flow restricting passage section opens in the first passage wall surface. The second passage wall surface is concavely curved relative to the first passage wall surface toward the flow restricting passage section, so that the passage width of the communication passage section is progressively reduced toward the flow restricting passage section within a predetermined range that is equal to or smaller than the passage width of the pressurizing passage.

Abstract: Provided are methods, uses and pharmaceutical compositions for treatment of prostate cancer with a SEMA3C inhibitor in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the SEMA3C inhibitor may be selected from one or more of the following: an antibody, a SEMA3C peptide, an antisense RNA, a siRNA, a shRNA or a small molecule.

Abstract: A vehicle fuel system may employ a fuel pump module with a reservoir within a fuel tank. The system may also employ a fuel injection common rail, a fuel supply line leading from the fuel pump module reservoir to the fuel injection common rail, and a fuel return line leading from the fuel injection common rail through a fuel pump module flange. Additionally, the system may employ a first return fuel check valve to release fuel only into a reservoir jet pump and/or a transfer jet pump, while a second return fuel check valve may release fuel only directly into the fuel pump module reservoir. An electric fuel pump within the reservoir may have a fuel pump check valve and supply fuel only to the reservoir jet pump and/or the transfer jet pump, and not to an engine, when activated by a pressure sensor in the fuel return line.

Abstract: Provided are methods, uses and pharmaceutical compositions for treatment of prostate cancer with a SEMA3C inhibitor in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the SEMA3C inhibitor may be selected from one or more of the following: an antibody, a SEMA3C peptide, an antisense RNA, a siRNA, a shRNA or a small molecule.

Abstract: A support shaft connects between a flange and a pump unit. An intermediate member, which connects between the support shaft and pump unit, enables a relative positional change between the support shaft and the pump unit in an axial direction of the support shaft. The intermediate member limits a relative positional change between the support shaft and the pump unit in a circumferential direction of the support shaft. A resilient member is received in the support shaft and exerts a restoring force in an axial direction of the support shaft to urge the pump unit, which is movable relative to the support shaft in the axial direction, toward a bottom portion of the fuel tank.

Abstract: A fuel supply system includes a plurality of fuel pumps, and one suction filter. The suction filter includes connection portions that are connected to pump inlets of the fuel pumps, and an interval adjusting member that adjusts the interval between the connection portions in accordance with the interval between the fuel pumps. Thus, it is possible to fit the suction filter to the fuel pumps without changing the interval between the fuel pumps. Because the interval between pump outlets is not changed, it is possible to minimize the problems that are likely to occur when the suction filter is fitted to the fuel pumps.

Abstract: Provided are methods, uses and pharmaceutical compositions for treatment of prostate cancer with a SEMA3C inhibitor in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the SEMA3C inhibitor may be selected from one or more of the following: an antibody, a SEMA3C peptide, an antisense RNA, a siRNA, a shRNA or a small molecule.

Abstract: A support shaft connects between a flange and a pump unit. An intermediate member, which connects between the support shaft and pump unit, enables a relative positional change between the support shaft and the pump unit in an axial direction of the support shaft. The intermediate member limits a relative positional change between the support shaft and the pump unit in a circumferential direction of the support shaft. A resilient member is received in the support shaft and exerts a restoring force in an axial direction of the support shaft to urge the pump unit, which is movable relative to the support shaft in the axial direction, toward a bottom portion of the fuel tank.

Abstract: A vehicle fuel system may employ a fuel pump module with a reservoir within a fuel tank. The system may also employ a fuel injection common rail, a fuel supply line leading from the fuel pump module reservoir to the fuel injection common rail, and a fuel return line leading from the fuel injection common rail through a fuel pump module flange. Additionally, the system may employ a first return fuel check valve to release fuel only into a reservoir jet pump and/or a transfer jet pump, while a second return fuel check valve may release fuel only directly into the fuel pump module reservoir. An electric fuel pump within the reservoir may have a fuel pump check valve and supply fuel only to the reservoir jet pump and/or the transfer jet pump, and not to an engine, when activated by a pressure sensor in the fuel return line.

Abstract: The present invention provides an agent which exhibits excellent antibacterial activity, low toxicity, improved bioavailability, and low binding rate to serum proteins. The present invention is directed to a pyridonecarboxylic acid derivative represented by formula (1): or a salt thereof, wherein R1 represents a methyl group, a fluorine atom, or a chlorine atom; R2 represents a hydrogen atom or a lower alkyl group; R3 represents an isopropyl group or a tert-butyl group; R4 represents a methyl group or a halogen atom; and R5 represents a fluorine atom or a chlorine atom. The present invention is also directed to an antibacterial agent and a medicament containing the derivative or the salt thereof as an active ingredient.

Abstract: A cancer is evaluated for selection of appropriate therapy by evaluating a sample of cancerous tissue to determine an expression of level of phosphatase and tensin homologue deleted from chromosome 10 (PTEN); and in the case where the expression level of functional PTEN is below a threshold level, identifying the cancer as susceptible to an active agent that inhibits the expression of heat shock protein 27 (hsp27). The evaluation may be included as part of a method of treatment, in which an hsp27 inhibitor is selected as a therapeutic agent when the PTEN level is below the threshold.

Abstract: A fuel supply system includes a plurality of fuel pumps, and one suction filter. The suction filter includes connection portions that are connected to pump inlets of the fuel pumps, and an interval adjusting member that adjusts the interval between the connection portions in accordance with the interval between the fuel pumps. Thus, it is possible to fit the suction filter to the fuel pumps without changing the interval between the fuel pumps. Because the interval between pump outlets is not changed, it is possible to minimize the problems that are likely to occur when the suction filter is fitted to the fuel pumps.