Abstract: The present invention provides an agent which exhibits excellent antibacterial activity, low toxicity, improved bioavailability, and low binding rate to serum proteins. The present invention is directed to a pyridonecarboxylic acid derivative represented by formula (1): or a salt thereof, wherein R1 represents a methyl group, a fluorine atom, or a chlorine atom; R2 represents a hydrogen atom or a lower alkyl group; R3 represents an isopropyl group or a tert-butyl group; R4 represents a methyl group or a halogen atom; and R5 represents a fluorine atom or a chlorine atom. The present invention is also directed to an antibacterial agent and a medicament containing the derivative or the salt thereof as an active ingredient.

Abstract: A fuel feed apparatus includes a lid member, a sub-tank, first and second supporting members, a biasing structure, a supporting portion, and a guide portion. The first and second supporting members are arranged in substantially radially end portions of the cylindrical portion to be substantially radially opposed to each other. The lid member is capable of axially moving relative to the sub-tank via the first and second supporting members. The biasing structure is arranged on the outer periphery of the first supporting member, and is received in the guide portion to bias the lid member and the sub-tank to be apart from each other. The first supporting member defines a groove portion that circumferentially divides an inner wall thereof into at least two planes. The first supporting member is capable of axially reciprocating through the supporting portion.

Abstract: A fuel pump system for a fuel tank having a first and a second section has a fuel pump and a jet pump disposed in the first section. The jet pump draws fuel from the second section of the fuel tank through a transfer line and delivers it to the first section of the fuel tank. A check valve is located in the second section of the fuel tank to prohibit flow from the first section to the second section but to allow flow from the second section to the first. In this manner, the fluid is retained within transfer line so that a siphoning action can occur between the second section and the first section of the fuel tank.

Abstract: A fuel pump system for a fuel tank having a first and a second section has a fuel pump and a jet pump disposed in the first section. The jet pump draws fuel from the second section of the fuel tank through a transfer line and delivers it to the first section of the fuel tank. A check valve is located in the second section of the fuel tank to prohibit flow from the first section to the second section but to allow flow from the second section to the first. In this manner, the fluid is retained within transfer line so that a siphoning action can occur between the second section and the first section of the fuel tank.

Abstract: A fuel feed apparatus includes a sub-tank and a fuel pump that are received in the fuel tank. The sub-tank has an inner space that is partitioned into at least a first chamber and a second chamber. The fuel pump is arranged in the first chamber to discharge fuel received in the sub-tank to the outside of the fuel tank. The second chamber has an opening, through which the second chamber communicates with the outside of the sub-tank such that fuel accumulated in the second chamber is exhausted to the outside of the sub-tank through the opening. The fuel tank has a first tank space and a second tank space. The sub-tank is received in the first tank space. A first jet pump is disposed in the second chamber of the sub-tank. The first jet pump draws fuel accumulated in the second tank space into the first tank space.

Abstract: A fuel feed apparatus includes a sub-tank and a fuel pump that are received in the fuel tank. The sub-tank has an inner space that is partitioned into at least a first chamber and a second chamber. The fuel pump is arranged in the first chamber to discharge fuel received in the sub-tank to the outside of the fuel tank. The second chamber has an opening, through which the second chamber communicates with the outside of the sub-tank such that fuel accumulated in the second chamber is exhausted to the outside of the sub-tank through the opening. The fuel tank has a first tank space and a second tank space. The sub-tank is received in the first tank space. A first jet pump is disposed in the second chamber of the sub-tank. The first jet pump draws fuel accumulated in the second tank space into the first tank space.

Abstract: A fuel feed apparatus includes a lid member, a sub-tank, first and second supporting members, a biasing means, a supporting portion, and a guide portion. The first and second supporting members are arranged in substantially radially end portions of the cylindrical portion to be substantially radially opposed to each other. The lid member is capable of axially moving relative to the sub-tank via the first and second supporting members. The biasing means is arranged on the outer periphery of the first supporting member, and is received in the guide portion to bias the lid member and the sub-tank to be apart from each other. The first supporting member defines a groove portion that circumferentially divides an inner wall thereof into at least two planes. The first supporting member is capable of axially reciprocating through the supporting portion.

Abstract: This invention relates to 1-(6-amino-3,5-difluoropyridin-2-yl)-8-bromo-7-(3-ethylaminoazetidin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a salt thereof, and also to a medicine containing the same. This compound has characteristic features that, when administered orally, it has extremely high blood half-life and bioavailability while retaining properties that it has extremely high antimicrobial effects and has low toxicity. It can be used widely as preventives, therapeutics and the like for various infectious diseases of human and animals.

Abstract: The present invention relates a 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-hydroxyazetidin-1-yl)-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid or salt thereof; and drugs containing the same as the active ingredient. Since this compound or salt thereof is highly stable to light while sustaining the excellent properties inherent to quinolone antibacterial agents, an antibacterial agent comprising, as an active ingredient, the invention compound or salt thereof can be stored over a long period of time without suffering from any decrease in the drug effect and can therefore be supplied as stable preparations such as injections, eye drops and surgical medicines.

Abstract: A novel pyridonecarboxylic acid derivative or its salt exhibiting satisfactory antibacterial activities, intestinal absorption, metabolic stability, and reduced side effects, in particular, phototoxicity and cytotoxicity, as well as an antibacterial agent containing such pyridonecarboxylic acid derivative or its salt are provided. For such an object, a pyridonecarboxylic acid derivative represented by the following formula (1): (wherein R1 represents hydrogen atom, a halogen atom or a lower alkyl group; R2 represents hydrogen atom or a lower alkyl group; R3 represents substituted or unsubstituted amino group or hydroxyl group; and R4 represents hydrogen atom, a lower alkyl group, amino group or nitro group) or its salt is provided.

Abstract: A pyridonecarboxylic acid derivative represented by the following general formula (1): ##STR1## [wherein R.sup.1 represents hydrogen atom or a carboxyl protective group; R.sup.2 represents hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted amino group; R.sup.3 represents hydrogen atom or a halogen atom; R.sup.4 represents hydrogen atom or a halogen atom; R.sup.5 represents a halogen atom or an optionally substituted saturated cyclic amino group; R.sup.6 represents hydrogen atom, a halogen atom, nitro group, or an optionally protected amino group; X, Y and Z may be the same or different and respectively represent nitrogen atom, --CH.dbd. or --CR.sup.7 .dbd. (wherein R.sup.7 represents a lower alkyl group, a halogen atom, or cyano group) (with the proviso that at least one of X, Y and Z represent the nitrogen atom), and W represents nitrogen atom or --CR.sup.8 .dbd. (wherein R.sup.

Abstract: The invention relates to pyridonecarboxylic acid derivatives represented by the general formula (1): ##STR1## wherein R.sup.1 is --OH, a carboxy-protecting group or (alkyl)amino group, R.sup.2 is H, or --NO.sub.2, (protected) amino, (protected) hydroxyl, lower alkyl or lower alkoxyl group, R.sup.3 is a halogen atom, H, or --NO.sub.2, lower alkyl, lower alkoxyl or amino group, R.sup.4 is an azido, (substituted) hydrazino, (substituted) amino, lower alkoxyl or hydroxyl group, R.sup.5, R.sup.6 and R.sup.7 are independently H, --NO.sub.2, halogen atom or lower alkyl group, R.sup.8 is a --NO.sub.2, (substituted) amino, --OH or lower alkoxyl group, A is N or C--R.sup.12, in which R.sup.12 is H, halogen atom, or (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxyl, lower alkylthio or nitro group, and B is N or C--R.sup.13, in which R.sup.13 is H or halogen atom, or salts thereof, and medicine comprising such a compound as an active ingredient.

Abstract: A pyridonecarboxylic acid derivative represented by the following general formula (1): ##STR1## [wherein R.sup.1 represents hydrogen atom or a carboxyl protective group; R.sup.2 represents hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted amino group; R.sup.3 represents hydrogen atom or a halogen atom; R.sup.4 represents hydrogen atom or a halogen atom; R.sup.5 represents a halogen atom or an optionally substituted saturated cyclic amino group; R.sup.6 represents hydrogen atom, a halogen atom, nitro group, or an optionally protected amino group; X, Y and Z may be the same or different and respectively represent nitrogen atom, --CH.dbd. or --CR.sup.7 .dbd. (wherein R.sup.7 represents a lower alkyl group, a halogen atom, or cyano group) (with the proviso that at least one of X, Y and Z represent the nitrogen atom), and W represents nitrogen atom or --CR.sup.8 .dbd. (wherein R.sup.

Abstract: A pyridonecarboxylic acid derivative represented by the following general formula (1): ##STR1## [wherein R.sup.1 represents hydrogen atom or a carboxyl protective group; R.sup.2 represents hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted amino group; R.sup.3 represents hydrogen atom or a halogen atom; R.sup.4 represents hydrogen atom or a halogen atom; R.sup.5 represents a halogen atom or an optionally substituted saturated cyclic amino group; R.sup.6 represents hydrogen atom, a halogen atom, nitro group, or an optionally protected amino group; X, Y and Z may be the same or different and respectively represent nitrogen atom, --CH.dbd. or --CR.sup.7 .dbd. (wherein R.sup.7 represents a lower alkyl group, a halogen atom, or cyano group) (with the proviso that at least one of X, Y and Z represent the nitrogen atom), and W represents nitrogen atom or --CR.sup.8 .dbd. (wherein R.sup.

Abstract: The invention provides a pyridonecarboxylic acid derivative of the following general formula (1): ##STR1## wherein R.sup.1 is a hydrogen atom or carboxy protecting group, R.sup.2 is a nitro or substituted or unsubstituted amino group, R.sup.3 is a halogen atom, each of R.sup.4 and R.sup.5, which may be the same or different, is a hydrogen atom, halogen atom, lower alkyl group or lower alkoxy group, A is a nitrogen atom or --CX.dbd. wherein X is a hydrogen atom, halogen atom, lower alkyl group or lower alkoxy group, and Z is a halogen atom or a saturated cyclic amino group which may have a substituent, or a salt thereof and an antibacterial agent comprising the same.

Abstract: The present invention is directed to a toner composition containing a polyester resin having an OHV/AV value of 1.2 or more as a major component of a binder resin wherein AV is an acid value of said polyester and OHV is a hydroxyl value thereof and hydrophobic silica having a degree of hydrophobic property of 80 or more or having a pH value of 5.5 to 8 in water-methanol solution. A toner composition of the present invention exhibits no decrease in electric charge retainability and fluidity of a toner and a visible image with good quality for a long period with no black spots occurring.

Abstract: A tricyclic compound represented by the general formula (1) and salts thereof are disclosed. ##STR1## A method for producing the tricyclic compound and salts thereof, and an antimicrobial agent containing the tricyclic compound and salts thereof as an active ingredient are also disclosed.

Abstract: The present invention is directed to a toner composition containing a polyester resin as a major component of a binder resin and 0.01 to 1.5 parts by weight of hydrophobic silica having a degree of hydrophobic property of not less than 80, and/or having a pH value of 5.5 to 8 when 4% by weight of hydrophobic silica is dispersed in water-methanol solution (1:1) to 100 parts by weight of the toner.

Abstract: A tricyclic compound represented by the general formula (1) and salts thereof. ##STR1## A method for producing the tricyclic compound and salts thereof, and an antimicrobial agent containing the tricyclic compound and salts thereof as an active ingredient are also disclosed.

Abstract: A novel resin is produced by the step of polymerizing (a) styrene and/or a derivative thereof, (b) a monomer component selected, alone or in combination of two or more, from the group consisting of methacrylic acid, acrylic acid, a methacrylic ester and an acrylic ester, and (c) 0.05 to 10 percent by weight, based on the total weight of the monomers, of a polybasic acid having 7 to 40 carbon atoms, an anhydride thereof or a lower (C1 to C6) alkyl ester thereof, the monomer component (b) containing at least one acrylic or methacrylic ester having hydroxyl or epoxy group in at least equimolar amount to the component (c) and has a softening point of 100.degree. to 160.degree. C. and a glass transition temperature of 50.degree. C. or higher. It is useful as a binder resin for a toner composition.