Abstract: A gate valve and seat therefor, the valve including a valve body defining a longitudinal flowway and a valve element mounted in the valve body and movable transverse to the flowway between open and closed positions. A valve seat is mounted in the valve body for limited axial floating movement with respect to the valve body, the seat comprising a seat body having a generally axially facing contact face for engagement with one side of the valve element. The contact face has an annular groove therein intermediate its radially inner and outer extremities, and the seat body further has at least one vent communicating with the annular groove and extending outwardly therefrom to the radially outer extremity of the seat body.

Abstract: A connector for subsea wellhead bodies comprises a connector body adapted to be connected to a subsea wellhead body in generally coaxial alignment therewith. Latches carried by the connector body are engageable with the wellhead body to so connect the bodies. An actuator is operatively associated with the latches and longitudinally extendible for extending the latches into such engagement with the wellhead body. A lock assembly is provided for selectively locking the actuator in its longitudinally extended position. The lock assembly comprises inner and outer lock portions, the outer portion telescopically receiving the inner portion with a tight interference fit. The lock portions are oriented generally parallel to the path of movement of the actuator. One of the lock portions is connected to the connector body, while the other is connected to the actuator.

Abstract: The present invention provides novel pyridinyl-benzimidazoles and quinoxalines which are useful as thromboxane A.sub.2 (TXA.sub.2) synthetase inhibitors and as such represent potent pharmacological agents.

Abstract: A well casing hanger assembly for releasably connecting first and second well casings to and from each other in a well by longitudinal movement of the first member. The first member includes an annular recess in its peripheral surface and a stop shoulder is positioned at each end of the recess and a resiliently expandable and contractible locking ring is positioned in the recess for engagement with a locking notch on the second member. A protrusion is positioned in the recess and initially coacts with an opening in the locking ring. An improved releasable holding means is provided for initially preventing the locking ring from moving axially on the first member until the locking ring expands and engages the second member.

Abstract: A blowout preventer is disclosed as including a ram-type seal element which can be compressed and deformed to seal around a variety of pipe sizes. The seal element is molded from a resilient rubber material and includes a generally semicircular section to sealingly engage pipes. A plurality of metallic support elements are embedded in the seal to support the rubber material for deformation essentially only in a radial inward direction to conform to the drill string pipe size, when force is applied to the seal by the ram hydraulic system.

Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.

Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.

Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.

Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.

Abstract: The present invention relates to novel amido and sulfonamido derivatives of 2-decarboxy-2-amino-methyl-PG-type compounds. These analogs are useful as nasal decongestants, antifertility agents, and as cytoprotection agents.

Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

Abstract: This invention comprises 11-deoxy-17-phenyl-18,19,20-trinor-prostaglandin-type compounds which exhibit prostaglandin-type pharmacological activity, such as lowering blood pressure, inhibiting gastric secretion, regulating the reproductive cycle, and the like.

Abstract: A modular underwater support platform having interconnecting elements is lowered into position by a conductor pipe which in turn is connected to and supported from a drill pipe. Releasable hydraulic connections connect the platform to the conductor pipe and connect the conductor pipe to the drill pipe. After the hydraulic connection between the platform and the conductor pipe is released, the drill pipe drills a hole in the subsea floor for receiving the conductor pipe. The conductor pipe is positioned in the hole, and locked to the platform for supporting the platform. A base may be connected to the bottom of the support platform which includes hydraulic cylinder and piston assemblies for leveling the support platform. Hydraulic control lines are positioned on the support platform and adapted to be in communication with the hydraulic connections when the conductor pipe is locked to the platform for hydraulically releasing the connections allowing the removal of the drill pipe.

Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

Abstract: 5,6-Dihydro-prostacyclin (PGI.sub.1) analogs substituted with hydroxyphenyl groups, illustrated for example, by a compound of the formula ##STR1## i.e. 9-deoxy-6S,9.alpha.-epoxy-17-(o-hydroxyphenyl)-18,19,20-trinor-PGF.sub.1, said products having pharmacological utility.