Patents by Inventor Norman A. Nelson

Norman A. Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition and process
    Patent number: 4176236
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: April 6, 1977
    Date of Patent: November 27, 1979
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 4,5,6-Trinor-3,7,-inter-m-phenylene prostaglandin A.sub.1 analogs
    Patent number: 4175202
    Abstract: This invention is a group of 4,5,6-trinor-3,7-inter-m-phenylene prostaglandin-type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including hypotensive control and inhibition of platelet aggregation.A typical formula for a PGA.sub.
    Type: Grant
    Filed: June 29, 1978
    Date of Patent: November 20, 1979
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 11-Deoxy-2,2-difluoro-PGF compounds
    Patent number: 4172952
    Abstract: 11-Deoxy prostaglandin type compounds, i.e prostaglandin type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: October 30, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 2-Decarboxy-2-hydroxymethyl-PGF.sub.1 .alpha. analogs
    Patent number: 4171460
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: April 6, 1977
    Date of Patent: October 16, 1979
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 11-Deoxy-2,2-difluoro-PGE compounds
    Patent number: 4163110
    Abstract: 11-Deoxy prostaglandin type compounds, i.e. prostaglandin type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: July 31, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 15-Epi-15-methyl-16-phenoxy-PGE compounds
    Patent number: 4154950
    Abstract: Prostaglandin E-, F.sub..alpha. -, F.sub..beta. -, A-, and B-type compounds are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they are substituted at C-16 with a phenoxy or substituted phenoxy, and have a lower alkyl group in place of the hydrogen at C-15 and/or a lower alkoxy group in place of the hydroxy group at C-15. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.
    Type: Grant
    Filed: August 16, 1976
    Date of Patent: May 15, 1979
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 11-Deoxy-17-phenyl-13,14-dihydro-PGE.sub.1 compounds
    Patent number: 4152523
    Abstract: This invention comprises 11-deoxy-17-phenyl-18,19,20-trinor-prostaglandin-type compounds which exhibit prostaglandin-type pharmacological activity, such as lowering blood pressure, inhibiting gastric secretion, regulating the reproductive cycle, and the like.
    Type: Grant
    Filed: February 28, 1977
    Date of Patent: May 1, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 11-Deoxy-17-phenyl-13,14-dihydro-PGE.sub.2 compounds
    Patent number: 4151359
    Abstract: This invention comprises 11-deoxy-17-phenyl-18,19,20-trinor-prostaglandin-type compounds which exhibit prostaglandin-type pharmacological activity, such as lowering blood pressure, inhibiting gastric secretion, regulating the reproductive cycle, and the like.
    Type: Grant
    Filed: February 28, 1977
    Date of Patent: April 24, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 4-Hydroxy-3(2'-hydroxyacetyl)-6-oxohexanoic acid derivatives
    Patent number: 4143053
    Abstract: The present specification provides novel intermediates and novel processes for the synthesis of Thromboxane B.sub.2 lla-homo-lla-oxa-PGF.sub.2.alpha.), its 15-epimer, and various carboxyl derivatives thereof. In particular, there are disclosed various bicyclic tetrahydrofuran-containing lactones useful in the above processes, and corresponding acyclic lactones.
    Type: Grant
    Filed: May 12, 1977
    Date of Patent: March 6, 1979
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxymethyl)-16-fluoro-PGE.sub.2 compounds
    Patent number: 4139564
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: April 6, 1977
    Date of Patent: February 13, 1979
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 11-Deoxy-2,2-difluoro-.omega.-aryl-PGE compounds
    Patent number: 4138573
    Abstract: 11-Deoxy prostaglandin type compounds, i.e. prostaglandin type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: February 6, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 11-Deoxy-16-phenoxy-PGF compounds
    Patent number: 4138575
    Abstract: 11-Deoxy prostaglandin type compounds, i.e. prostaglandin type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: February 6, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 11-Deoxy-2,2-difluoro-.omega.-aryl-PGF compounds
    Patent number: 4138576
    Abstract: 11-Deoxy prostaglandin type compounds, i.e. prostaglandin type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: February 6, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 11-Deoxy-cis-4,5-didehydro-.omega.-aryl-PGF compounds
    Patent number: 4138577
    Abstract: 11-Deoxy prostaglandin type compounds, i.e. prostaglandin type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: February 6, 1979
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 11-Deoxy PGE.sub.2 compounds
    Patent number: 4130721
    Abstract: 11-Deoxyprostaglandin E and F type compounds, i.e. prostaglandin E and F type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: July 24, 1972
    Date of Patent: December 19, 1978
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 15-Methyl- and 16-phenoxy-PGF.sub.2 .alpha., amides
    Patent number: 4128577
    Abstract: The present invention relates to certain prostaglandin-type amides which are useful as intermediates in preparing corresponding 2-decarboxy-2-aminomethyl prostaglandin analogs. In addition to their use as chemical intermediates, these compounds are further useful for inducing prostaglandin-type physiological responses, especially being regulators of fertility.
    Type: Grant
    Filed: December 12, 1977
    Date of Patent: December 5, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxymethyl-17-phenyl-11-deoxy-PGF.sub.1 analogs
    Patent number: 4127733
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: November 28, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 11-Deoxy-cis-4,5-didehydro-.omega.-aryl-PGE compounds
    Patent number: 4126754
    Abstract: 11-Deoxy prostaglandin type compounds, i.e. prostaglandin type compounds in which the 11-hydroxy group is replaced by hydrogen, are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.This is a division of application Ser. No. 609,410, filed Sept. 2, 1975.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: November 21, 1978
    Assignee: The Upjohn Company
    Inventors: Gordon L. Bundy, Norman A. Nelson
  • 2-Decarboxy-2-hydroxy-methyl-16-fluoro-PGE.sub.1 compounds
    Patent number: RE29926
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: August 10, 1977
    Date of Patent: March 6, 1979
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Miniature light for dollhouses and the like
    Patent number: D251629
    Type: Grant
    Filed: April 7, 1977
    Date of Patent: April 17, 1979
    Assignee: Nelson Tool and Machine Company, Incorporated
    Inventor: Norman Nelson