Patents by Inventor Norman A. Nelson

Norman A. Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-Decarboxy-2-hydroxymethyl-3,7-inter-m-phenylene-.omega.-phenyl-PGE.sub. 1 compounds
    Patent number: 4107215
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: August 15, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxy-methyl-5-oxa-.omega.-phenoxy-PGE.sub.1 compounds
    Patent number: 4107211
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: August 15, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxymethyl-.omega.-phenyl-PGA or 9-deoxy-9,10-didehydro-PGD analogs
    Patent number: 4107212
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: August 15, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxy-methyl-3,7-inter-m-phenylene-.omega.-phenoxy-PGD.sub. 1
    Patent number: 4107214
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: August 15, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxy-methyl-5-oxa-.omega.-phenoxy-PGD.sub.1 compounds
    Patent number: 4107213
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: August 15, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 3-(1'-Silyloxy-3'-hydroxyethyl)-4-hydroxy-6-silyloxyhexanoic acid .gamma. l a
    Patent number: 4102900
    Abstract: The present specification provides novel intermediates and novel processes for the synthesis of Thromboxane B.sub.2 (11a-homo-11a-oxa-PGF.sub.2.alpha.), its 15-epimer, and various carboxyl derivatives thereof. In particular, there are disclosed various bicyclic tetrahydrofuran-containing lactones useful in the above processes, and corresponding acyclic lactones.
    Type: Grant
    Filed: May 12, 1977
    Date of Patent: July 25, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 3-(1'-Silyloxy-2'-hydroxyethyl)-4-hydroxy-6-oxohexanoic acid .gamma. lactone derivatives
    Patent number: 4102899
    Abstract: The present specification provides novel intermediates and novel processes for the synthesis of Thromboxane B.sub.2 (11a-homo-11a-oxa-PGF.sub.2.alpha.), its 15-epimer, and various carboxyl derivatives thereof. In particular, there are disclosed various bicyclic tetrahydrofuran-containing lactones useful in the above processes, and corresponding acyclic lactones.
    Type: Grant
    Filed: May 12, 1977
    Date of Patent: July 25, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxymethyl-cis-4,5-didehydro-9-deoxy-PGD.sub.2 compounds
    Patent number: 4100198
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: March 17, 1977
    Date of Patent: July 11, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 4,5,6-Trinor-3,7-inter-m-phenylene prostaglandin E.sub.1 analogs
    Patent number: 4099013
    Abstract: This invention is a group of 4,5,6-trinor-3,7-inter-m-phenylene prostaglandin-type compounds and processes for making them. These compounds are useful for a variety of pharmacological purposes, including hypotensive control and inhibition of platelet aggregation.A typical formula for a PGE.sub.
    Type: Grant
    Filed: January 31, 1977
    Date of Patent: July 4, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxymethyl-3,7-inter-m-phenylene-PGF.sub.1.alpha. compounds
    Patent number: 4097537
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: March 17, 1977
    Date of Patent: June 27, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2,3,5.alpha.-Trihydroxy-2-hydroxymethyl-1.alpha.-cyclopentane acetic acid 5.gamma. -lactone derivatives
    Patent number: 4097493
    Abstract: The present specification provides novel intermediates and novel processes for the synthesis of Thromboxane B.sub.2 11a-homo-11a-oxa-PGF.sub.2.alpha.), its 15-epimer, and various carboxyl derivatives thereof. In particular, there are disclosed various bicyclic tetrahydrofuran-containing lactones useful in the above processes, and corresponding acyclic lactones.
    Type: Grant
    Filed: May 12, 1977
    Date of Patent: June 27, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxymethyl-11-deoxy-PGE.sub.1 analogs
    Patent number: 4097529
    Abstract: This invention comprises certain analogs of the prostraglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: April 6, 1977
    Date of Patent: June 27, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 13,14-Dihydro-16-phenoxy prostaglandin F.sub.1.alpha. analogs
    Patent number: 4096179
    Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 10, 1977
    Date of Patent: June 20, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 13,14-Dihydro-16-phenoxy prostaglandin E.sub.1 analogs
    Patent number: 4096178
    Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 10, 1977
    Date of Patent: June 20, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 16-Phenoxy prostaglandin B.sub.2 analogs
    Patent number: 4096335
    Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: February 7, 1977
    Date of Patent: June 20, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxymethyl-5-oxa-PGE.sub.1 compounds
    Patent number: 4093659
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: March 17, 1977
    Date of Patent: June 6, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxymethyl-cis-4,5-didehydro-11-deoxy-PGE.sub.1, compounds
    Patent number: 4088691
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: March 17, 1977
    Date of Patent: May 9, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxymethyl-5-oxa-11-deoxy-PGE.sub.1 compounds
    Patent number: 4088692
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmocological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: March 17, 1977
    Date of Patent: May 9, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxy methyl-cis-4,5-didehydro-9-deoxy-9,10-didehydro-PGD.sub.1 compounds
    Patent number: 4088690
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: March 17, 1977
    Date of Patent: May 9, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • 2-Decarboxy-2-hydroxymethyl-9-deoxy-9,10-didehydro-PGD.sub.1 analogs
    Patent number: 4088693
    Abstract: This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
    Type: Grant
    Filed: April 6, 1977
    Date of Patent: May 9, 1978
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson