Patents by Inventor Ofer Levy

Ofer Levy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12268739
    Abstract: Provided herein are Toll-like receptor 2 (TLR2) agonists for use in enhancing human immune response and/or as adjuvants in vaccines. The TLR2 agonists include thiophenes, imidazoles, or phenyl-containing compounds, which may be compounds of Formulae (I), (II), (III), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein are used as enhancers of an immune response (e.g., innate and/or adaptive immune response), and are useful in treating and/or preventing a disease, as adjuvants in a vaccine for the disease. (e.g., proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: April 8, 2025
    Assignees: Children's Medical Center Corporation, Dana-Farber Cancer Institute, Inc.
    Inventors: David J. Dowling, Ofer Levy, Francesco Borriello, David A. Scott, Spencer E. Brightman
  • Publication number: 20250077236
    Abstract: System, methods, and devices for initializing a system by loading drivers are provided. In one example, a system includes comprising one or more circuits to initiate a system initiation or a boot of the system, during the system initiation or the boot of the system, read data from a non-volatile memory, based on the data from the non-volatile memory, identify a plurality of hardware components, identify one or more drivers based on the plurality of hardware components, and load the one or more drivers during the system initiation or the boot of the system.
    Type: Application
    Filed: September 5, 2023
    Publication date: March 6, 2025
    Inventors: Ofer Levy, Nir Einati, Michael Shych, Vadim Pasternak, Layal Arkab, Keren Younger Hadad
  • Publication number: 20250048519
    Abstract: A network device includes a plurality of ports, a plurality of optical indicators, two or more packet processing circuits, and synchronization circuitry. The two or more packet processing circuits are to process packets communicated over the ports, each packet processing circuit to control a subset of the optical indicators to display status information relating to a subset of the ports. At least some of the status information is represented by blinking of the optical indicators. The synchronization circuitry is to synchronize at least one operational characteristic of the optical indicators among the two or more packet processing circuits.
    Type: Application
    Filed: July 31, 2023
    Publication date: February 6, 2025
    Inventors: Ofer Levy, Peled Dadosh, Zachy Haramaty, Avi Shalom, Shir Leibovitz
  • Publication number: 20250041278
    Abstract: Provided herein are uses for an immunostimulatory compound for stimulating an immune response when administered either alone or as an adjuvant in a vaccine. Also provided herein are kits, compositions, and methods of administration for the compound described for proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease, in a subject in need thereof. Using the compound as a vaccine adjuvant enables effective immunization in vulnerable populations.
    Type: Application
    Filed: September 29, 2022
    Publication date: February 6, 2025
    Applicant: The Children's Medical Center Corporation
    Inventors: David J. Dowling, Ofer Levy, Simon D. van Haren, Katherine Chew, Dheeraj Soni, Maria De Leon
  • Publication number: 20250000971
    Abstract: Provided herein are uses for an immunostimulatory compound for stimulating an immune response when administered either alone or as an adjuvant in a vaccine. Also provided herein are kits, compositions, and methods of administration for the compound described.
    Type: Application
    Filed: September 29, 2022
    Publication date: January 2, 2025
    Applicant: The Children's Medical Center Corporation
    Inventors: Ofer Levy, David J. Dowling, Simon D. van Haren, Katherine Chew, Yoshine Saito
  • Patent number: 12155979
    Abstract: A cable pillar is provided for use in a switch system. The cable pillar includes a cavity that enables a plurality of cables to pass from a first side to a second side of the cable pillar. For example, the cables may be routed from sets of access paths located in rails mounted on the sides of the cable pillar to enlarged access paths located near the top or bottom of the cable pillar. The enlarged access paths may be sized to receive every cable that passes through a set of access paths located on an opposing side of the cable pillar from a corresponding enlarged access path. Additionally, the cable pillar may be configured to releasably attach to a chassis of the switch system. In some examples, the plurality of cables accommodated by the cable pillar may serve as a cable backplane of the switch system.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: November 26, 2024
    Assignee: MELLANOX TECHNOLOGIES, LTD.
    Inventors: Ofer Levy, Avi Gibbs, Samer Khoury, Igor Loiferman
  • Publication number: 20240287174
    Abstract: According to at least some embodiments of the present invention is directed to anti-HIDE1 antibodies and polypeptides and methods of using same.
    Type: Application
    Filed: September 1, 2023
    Publication date: August 29, 2024
    Inventors: Yosef Dicken, Liat Dassa, Amit Novik, Amir Toporik, Gad S. Cojocaru, Yossef Kliger, Yair Benita, Ofer Levy, Ilan Vaknin, Arthur Machlenkin, Iris Hecht, Jungmin Kim, Andrew Pow, Andrew W. Drake
  • Patent number: 12069829
    Abstract: A dual connect switch module may include a first set of pluggable panel connectors on a first side of a substrate of the switch and a second set of pluggable panel connectors on an opposing second side of the substrate. The switch module further includes a switch Integrated Circuit (IC) mounted between the first side and the second side, where the switch IC is connected to the first set of pluggable panel connectors and to the second set of pluggable panel connectors. A cable can be used to connect at least one pluggable panel connector of the first set of pluggable panel connectors and/or of the second set of pluggable panel connectors with a port of an external network device. In some examples, the switch and substrate may further include a management module that manages one or more on-board functions of the switch module.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: August 20, 2024
    Assignee: MELLANOX TECHNOLOGIES, LTD.
    Inventor: Ofer Levy
  • Publication number: 20240148864
    Abstract: Provided herein are adjuvantation systems comprising fungal polysaccharides for use in Beta coronavirus (e.g., MERS-CoV, SARS-CoV-1, or SARS-CoV-2) and influenza (influenza A virus and influenza B virus) vaccines and immunogenic compositions comprising the adjuvantation system and a Beta coronavirus or influenza virus antigen.
    Type: Application
    Filed: March 11, 2022
    Publication date: May 9, 2024
    Applicant: Children's Medical Center Corporation
    Inventors: Ivan Zanoni, Francesco Borriello, Ofer Levy, David J. Dowling
  • Publication number: 20240115693
    Abstract: Provided herein are nanoparticles which enhance the immunogenicity of antigens for use in Beta coronavirus (e.g., MERS-CoV, SARS-CoV-1, or SARS-CoV-2) vaccines, as well as immunogenic compositions comprising the antigen nanoparticles and additional adjuvants for further enhancing immunogenicity.
    Type: Application
    Filed: June 23, 2022
    Publication date: April 11, 2024
    Applicants: Children's Medical Center Corporation, Dana-Farber Cancer Institute, Inc.
    Inventors: Francesco Borriello, Ofer Levy, David J. Dowling, Sirano Dhe-Paganon, Hyuk-Soo Seo
  • Publication number: 20240025973
    Abstract: The present invention is directed to PVRIG polypeptides and their uses.
    Type: Application
    Filed: September 1, 2023
    Publication date: January 25, 2024
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Amir Toporik, Yossef Kliger, Ofer Levy, Arthur Machlenkin, Sergey Nemzer, Yair Benita, Amit Novik
  • Patent number: 11850026
    Abstract: Devices and methods are provided for performing remote physiological monitoring of vital signs from one or more subjects. Camera pairs including an intensity camera and a depth camera are used to obtain intensity image data and depth image data that are then processed using one or more ROIs for extracting heart rate and respiratory waveforms from which the heart rate and respiratory rate may be estimated. In other embodiments, multiple ROIs may be used to obtain several heart rate and respiratory rate values which are then fused together. In some embodiments motion compensation may be used prior to generating the heart rate and respiratory waveforms. In other embodiments, multiple camera pairs may be used to obtain intensity and depth data from multiple fields of view which may be used to obtain several heart rate and respiratory rate values which are then fused together.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: December 26, 2023
    Inventors: Ofer Levi, Eric Y. Zhu, Dene Alexander Adrian Ringuette, Ryan Chu
  • Publication number: 20230368944
    Abstract: A system for connecting cage-side connectors to PCB-side connectors. The system enables OSFP and QSFP pluggable modules to be connected to breakouts on PCBs within a networking device. The system includes one or more cage-side connectors connected via one or more cables to one or more PCB-side connectors. Keyed PCB-side connectors and unique lengths of cables ensure proper connections to headers on a PCB.
    Type: Application
    Filed: May 12, 2022
    Publication date: November 16, 2023
    Inventor: Ofer Levy
  • Patent number: 11795209
    Abstract: The present invention is directed to PVRIG polypeptides and their uses.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: October 24, 2023
    Assignee: COMPUGEN LTD.
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Amir Toporik, Yossef Kliger, Ofer Levy, Arthur Machlenkin, Sergey Nemzer, Yair Benita, Amit Novik
  • Publication number: 20230310438
    Abstract: Provided herein are TLR7/8 agonists to enhance immune responses or for use as adjuvants in fentanyl vaccines in opioid-using individuals.
    Type: Application
    Filed: October 16, 2020
    Publication date: October 5, 2023
    Applicants: Children's Medical Center Corporation, the University of Montana, Regents of the University of Minnesota
    Inventors: David J. Dowling, Ofer Levy, Dheeraj Soni, Sharon Levy, Jay Evans, Marco Pravetoni, David Burkhart, Shannon Miller
  • Publication number: 20230308785
    Abstract: A cable pillar is provided for use in a switch system. The cable pillar includes a cavity that enables a plurality of cables to pass from a first side to a second side of the cable pillar. For example, the cables may be routed from sets of access paths located in rails mounted on the sides of the cable pillar to enlarged access paths located near the top or bottom of the cable pillar. The enlarged access paths may be sized to receive every cable that passes through a set of access paths located on an opposing side of the cable pillar from a corresponding enlarged access path. Additionally, the cable pillar may be configured to releasably attach to a chassis of the switch system. In some examples, the plurality of cables accommodated by the cable pillar may serve as a cable backplane of the switch system.
    Type: Application
    Filed: March 28, 2022
    Publication date: September 28, 2023
    Inventors: Ofer Levy, Avi Gibbs, Samer Khoury, Igor Loiferman
  • Patent number: 11730810
    Abstract: Provided herein are imidazopyrimidine compounds, such as compounds of Formula (I), for use in enhancing human immune response and/or as adjuvants in vaccines.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: August 22, 2023
    Assignees: Children's Medical Center Corporation, Dana-Farber Cancer Institute, Inc.
    Inventors: Ofer Levy, David J. Dowling, Francesco Borriello, David A. Scott, Spencer E. Brightman, Frederic Feru
  • Publication number: 20230201340
    Abstract: Provided herein are adjuvantation systems for use in Beta coronavirus (e.g., MERS-CoV, SARS-CoV-1, or SARS-CoV-2) vaccines and immunogenic compositions comprising the adjuvantation system and a Beta coronavirus antigen.
    Type: Application
    Filed: May 28, 2021
    Publication date: June 29, 2023
    Applicant: Children's Medical Center Corporation
    Inventors: David J. Dowling, Ofer Levy, Francesco Borriello, Etsuro Nanishi, Timothy O'Meara, Yoshine Saito, Simon D. van Haren
  • Publication number: 20230201339
    Abstract: Provided herein are thiazole amide compounds (e.g., Formula (I)) for use in enhancing human immune response and/or as adjuvants in vaccines. The compounds described herein are used as enhancers of an immune response (e.g., innate and/or adaptive immune response), and are useful in treating and/or preventing a disease, as adjuvants in a vaccine for the disease, (e.g., proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease). Also provided in the present disclosure are compositions (e.g., pharmaceutical composition), kits, methods, and uses including or using compounds described herein.
    Type: Application
    Filed: September 16, 2020
    Publication date: June 29, 2023
    Applicant: Children's Medical Center Corporation
    Inventors: David J. Dowling, Ofer Levy, Francesco Borriello
  • Patent number: 11673891
    Abstract: The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein are used as enhancers and/or modifiers of an immune response (e.g., innate and/or adaptive immune response), and are useful in treating and/or preventing a disease, as adjuvants in a vaccine for the disease, (e.g., proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease), or as stand alone anti-infective or immune response modifying agents. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: June 13, 2023
    Assignees: Dana-Farber Cancer Institute, Inc., Children's Medical Center Corporation
    Inventors: Ofer Levy, David J. Dowling, Francesco Borriello, David A. Scott, Spencer E. Brightman, Frederic Feru