Abstract: A processor includes a front end, a decoder, a retirement unit, and a performance monitoring unit. The front end includes a decoder with logic to receive a tracking instruction to enable tracking of execution of a region of memory. The instruction is to define an address range of the region. The retirement includes logic to retire the tracking instruction and candidate instructions. The performance monitoring unit includes logic to determine that the candidate instructions are associated with an entrance and an exit to the address range, and to generate an alert based on the candidate instructions association with the entrance and the exit.

Abstract: A processing device implementing an elapsed cycle timer in last branch records (LBRs) is disclosed. A processing device of the disclosure includes a last branch record (LBR) counter to iterate with each cycle of the processing device and an LBR structure communicably coupled to the LBR counter. The LBR structure comprises a plurality of LBR entries. Furthermore, an LBR entry of the plurality of LBR entries comprises an address instruction pointer (IP) of a branch instruction executed by the processing device, an address IP of a target of the branch instruction, and an elapsed time field that stores a value of the LBR counter when the LBR entry is created.

Abstract: A composition of matter is disclosed which comprises crosslinked collagen, platelet rich plasma (PRP) and an inorganic salt. Methods of generating same and uses thereof are also disclosed.

Abstract: A method of an aspect includes generating real time instruction trace (RTIT) packets for a first logical processor of a processor. The RTIT packets indicate a flow of software executed by the first logical processor. The RTIT packets are stored in an RTIT queue corresponding to the first logical processor. The RTIT packets are transferred from the RTIT queue to memory predominantly with firmware of the processor. Other methods, apparatus, and systems are also disclosed.

Abstract: This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of KRTCAP3, FAM26F, MGC52498, FAM70A and TMEM154 proteins and variants, and therapeutic usages thereof.

Abstract: A method of an aspect includes generating real time instruction trace (RTIT) packets for a first logical processor of a processor. The RTIT packets indicate a flow of software executed by the first logical processor. The RTIT packets are stored in an RTIT queue corresponding to the first logical processor. The RTIT packets are transferred from the RTIT queue to memory predominantly with firmware of the processor. Other methods, apparatus, and systems are also disclosed.

Abstract: Provided are angiopoietin-derived peptides or homologs or derivatives thereof, pharmaceutical composition including them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins including them.

Abstract: In accordance with embodiments disclosed herein, there is provided systems and methods for using thresholds to gate timing packet generation in a tracing system (TS). For example, the method may include generating and outputting a trace data (TD) packet into a packet log. The method also includes generating and outputting a timing packet (TM) corresponding to the TD packet into the packet log when a number of clock cycles elapsed since an output of a previous TM packet exceeds a clock threshold value.

Abstract: A processor of an aspect includes a decode unit to decode a thread pause instruction from a first thread. A back-end portion of the processor is coupled with the decode unit. The back-end portion of the processor, in response to the thread pause instruction, is to pause processing of subsequent instructions of the first thread for execution. The subsequent instructions occur after the thread pause instruction in program order. The back-end portion, in response to the thread pause instruction, is also to keep at least a majority of the back-end portion of the processor, empty of instructions of the first thread, except for the thread pause instruction, for a predetermined period of time. The majority may include a plurality of execution units and an instruction queue unit.

Abstract: This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants which are suitable targets for immunotherapy, cancer therapy, and drug development.

Abstract: Artificial tissue constructs (TCs), methods of making the TCs, uses thereof, and kits comprising the TCs are provided. TCs are useful for vaccine evaluation for human adult, human non-newborn, and newborns.

Abstract: An expandable mold configured to be arthroscopically introduced into a joint for in-situ formation of a joint replacement prosthesis, and a flowable, curable substance configured for forming the joint replacement prosthesis inside said mold. In addition, a surgical kit for arthroscopic, in-situ formation of a joint replacement prosthesis, the surgical kit comprising: an expandable prosthesis mold configured to be arthroscopically introduced into a joint; at least one arthroscopic instrument configured to form an ellipsoidal cavity between two interfacing bones of the joint, for receiving said mold; and a first flowable, curable substance configured for forming the prosthesis inside said mold.

Abstract: In accordance with embodiments disclosed herein, there is provided systems and methods for tracking the mode of processing devices in an instruction tracing system. The method may include receiving an indication of a change in a current execution mode of the processing device. The method may also include determining that the current execution mode of the received indication is different than a value of an execution mode of a first execution mode (EM) packet previously-generated by the IT module. The method may also include generating, based on the determining that the current execution mode is different, a second EM packet that provides a value of the current execution mode of the processing device to indicate the change in the execution mode for an instruction in a trace generated by the IT module. The method may further include generating transactional memory (TMX) packets having n bit mode pattern in the packet log. The n is at least two and the n bit mode indicates transaction status of the TMX operation.

Abstract: A communicable drip irrigator including a housing formed with a fluid inlet for receiving irrigation fluid and a fluid outlet for emitting irrigation fluid, and a flow meter associated with the fluid inlet and/or the fluid outlet, configured for obtaining flow data. The irrigator also includes a communication unit associated with the flow meter and configured for providing to a controller, data regarding operation of the drip irrigator, the data including at least the flow data.

Abstract: A processing device implementing an elapsed cycle timer in last branch records (LBRs) is disclosed. A processing device of the disclosure includes a last branch record (LBR) counter to iterate with each cycle of the processing device and an LBR structure communicably coupled to the LBR counter. The LBR structure comprises a plurality of LBR entries. Furthermore, an LBR entry of the plurality of LBR entries comprises an address instruction pointer (IP) of a branch instruction executed by the processing device, an address IP of a target of the branch instruction, and an elapsed time field that stores a value of the LBR counter when the LBR entry is created.

Abstract: An error recovery unit that may include error logic to detect an error in a dispatch port and timestamp logic configured to generate a timestamp for the error. The error recovery unit may also include check logic to determine if an instruction associated with the error has been retired based on the timestamp. If the instruction has been retired, a machine check error logic may be initiated. If the instruction has not been retired, an error correction logic may be initiated to recover the error and to re-execute the instruction. Thus, speculative errors may be recovered without the need for calling the machine check error, which is undesirable because of its catastrophic nature. Therefore, machine check errors may be significantly reduced.

Abstract: In accordance with embodiments disclosed herein, there is provided systems and methods for providing status of a processing device with a periodic synchronization point in an instruction tracing system. For example, the method may include generating a boundary packet based on a unique byte pattern in a packet log. The boundary packet provides a starting point for packet decode. The method may also include generating a plurality of state packets based on status information of the processor. The plurality of state packets follows the boundary packet when outputted into the packet log.

Abstract: Stabilizing apparatus for inclined legs comprises a thigh engageable portion extending generally transversally along the width of the lap of a subject with which the apparatus is bodily engaged, two spaced appendage portions extending downwardly from the thigh engageable portion, a foot engageable portion positionable on an underlying surface, and a portion, such a connecting element and tensioning device, extending from each of the two appendage portions to a foot engageable portion. The two appendage portions are positionable to be substantially in contact with the lateral side of a thigh of the subject. A loop is defined such that each of the portions extending from an appendage portion to a foot engageable portion is suitably tensioned so as to apply forces to a foot engageable portion for resisting a forward foot sliding motion and to an appendage portion for resisting relative transversal motion of an inclined leg.

Abstract: This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants which are suitable targets for immunotherapy, cancer therapy, and drug development.

Abstract: This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants a which are suitable targets for immunotherapy, cancer therapy, and drug development.