Abstract: An exhaust nozzle assembly includes, but is not limited to, a nozzle body configured to be fluidly coupled with an engine and to receive a jet produced by the engine. An outer cover covers the nozzle body. A movable component is disposed and configured to have an effect on either the jet or an exhaust plume when the movable component moves. A linkage is coupled to the movable component and adapted for coupling to an actuator. The linkage transmits the force to the moveable component from the actuator. There is a gap between an inner surface of the outer cover and an outer surface of the nozzle body. The linkage is smaller than the actuator. The gap is smaller than a smallest dimension of the actuator and larger than the linkage. The linkage is partially disposed within the gap, and the exhaust nozzle assembly is free of the actuator.

Abstract: The present invention relates to a filler for a paint composition, wherein the filler comprises a calcinate having particles with an average particle size (d50, SediGraph III) in the range between 3 ?m and 50 ?m and a mullite content of 30-70 measured as mullite index. The invention is characterised in that the bulk density of the filler is >450 g/L. The invention also relates to a paint composition characterised in that it comprises a filler which has a bulk density>450 g/L and comprises a calcinate which has particles with a mean particle size (d50, SediGraph III) in the range between 3 ?m and 50 ?m and a mullite content of 30-70 measured as mullite index. Furthermore, the invention relates to uses of such a filler for the preparation of a paint composition.

Abstract: A hands-free shoe includes a heel assembly that allows a user to step into a shoe and tighten the shoe around the user's foot without the use of hands. The heel assembly includes a housing, a translating assembly including an inner frame and an outer frame, a plurality of translating pins, a plurality of stationary pins, a locking piece, a plurality of springs, and a heel button that work in conjunction to tighten the laces of the shoe and secure the shoe to a user's foot. The hands-free shoe can also be removed by depressing the heel button to loosen the laces of the shoe and release the shoe from a user's foot without the use of hands.

Abstract: This invention relates to broadly neutralizing and potent anti-HIV-1 antibodies, kits, and methods of use thereof.

Abstract: Systems, methods, devices and computer software for delivering electrical stimulation to biological tissue are described. In some implementations, an electrical lead for implantation in a patient can include a distal portion with electrodes that are configured to generate therapeutic energy for biological tissue of the patient, such as the heart or pericardium. The distal portion can include an electrode extension having a tip electrode, the electrode extension configured to facilitate contact of the tip electrode with biological tissue of the patient when the lead is in a deployed configuration. A distal part of the lead can be configured to include a heel portion, a bend in a proximal part, and/or a bend in a distal part, to facilitate contact of an electrode located on the heel portion with biological tissue of the patient when the lead is in a deployed configuration.

Abstract: The present disclosure relates to immunomodulatory compositions that selectively activate TLR7, comprising an RNA ligand and a pharmaceutically acceptable carrier, as well as to in vitro and therapeutic uses of such immunomodulatory compositions.

Abstract: A method for bioprocessing includes the steps of providing a bioprocessing system having a first bioreactor vessel and a second bioreactor vessel, activating a population of cells in the first bioreactor vessel, genetically modifying the population of cells to produce a population of genetically modified cells, and expanding the population of genetically modified cells within the first bioreactor vessel and the second bioreactor vessel.

Abstract: In a method for imaging a container holding a sample, the container is illuminated with a laser sheet of a first color, and one or more images of the container are capturing by a first imager configured to filter out colors other than the first color. Simultaneously with illuminating the container with the laser sheet of the first color, the container is illuminated with light of a second color different than the first color, wherein the light of the second color illuminates at least a majority of an entire volume of the container. One or more additional imagers of the container are captured by a second imager configured to filter out colors other than the second color. The one or more images and the one or more additional images are analyzed to detect particles within, and/or on an exterior surface of, the container.

Abstract: A mobile earth working machine includes a machine frame; a working apparatus; a functional apparatus connected to the machine frame pivotably; and a pivot joint between the machine frame and the functional apparatus, having a frame-associated joint element and an apparatus-associated joint element. A mechanical coupling includes a frame-side coupling configuration and an apparatus-side counterpart coupling configuration.

Abstract: A modular apparatus for extending a rod in an existing spinal construct comprises a modular rod connector for attachment to the existing rod and a modular rod extender that may be selectively attached to the rod connector. Each rod connector includes a spherical head that is formed to have the same size and configuration such that any selected modular rod extender may be attached to a selected rod connector. Each rod connector comprises an attachment portion having an opening for receipt of a portion of the rod of an existing spinal construct. Each modular rod extender comprises an extender body including a common modular attachment feature at one end for receipt of the spherical head of the selected rod connector, and an extension rod extending from an opposite end to extend the existing spinal rod.

Abstract: A bioreactor vessel includes a base having a plurality of through openings, a lid connected to the base via a plurality of heat stakes, and a gas-permeable, liquid impermeable membrane sandwiched between the base and the lid and held in position by the plurality heat stakes.

Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.

Abstract: The present disclosure provides pumped thermal energy storage systems that can be used to store and extract electrical energy. A pumped thermal energy storage system of the present disclosure can store energy by operating as a heat pump or refrigerator, whereby net work input can be used to transfer heat from the cold side to the hot side. A working fluid of the system is capable of efficient heat exchange with heat storage fluids on a hot side of the system and on a cold side of the system. The system can extract energy by operating as a heat engine transferring heat from the hot side to the cold side, which can result in net work output.

Abstract: This invention relates to a laundry care composition comprising a laundry care ingredient and a polymeric thiophene hueing agent.

Abstract: A transitive closure data structure is constructed for a pair of features represented in a vector space corresponding to an input dataset. The data structure includes a set of entries corresponding to a set of all possible paths between a first feature in the pair and a second feature in the pair in a graph of the vector space. The data structure is reduced by removing a subset of the set of entries such that only a single entry corresponding to a single path remains in the transitive closure data structure. A feature cross is formed from a cluster of features remaining in a reduced ontology graph resulting from the reducing the transitive closure data structure. A layer is configured in a neural network to represent the feature cross, which causes the neural network to produce a prediction that is within a defined accuracy relative to the dataset.

Abstract: A robotic inspection platform comprises a robotic arm, an imager, and a controller. The controller causes the robotic arm to retrieve, using its end effector, a container, and to manipulate the container such that the container is sequentially placed in a plurality of orientations while in view of the imager. The controller also causes the imager to capture images, with each of the images being captured while the container is in a respective one of the orientations. The controller also determines one or more attributes of the container, and/or a sample within the container, by analyzing the images using a pattern recognition model and, based on the attribute(s), determines whether the container and/or sample satisfies one or more criteria. If the container and/or sample fails to satisfy the criteria, the controller causes the robotic arm to place the container in an area (e.g., bin) reserved for rejected containers and/or samples.

Abstract: An exhaust nozzle assembly includes, but is not limited to, a nozzle body configured to be fluidly coupled with an engine and to receive a jet produced by the engine. An outer cover covers the nozzle body. A movable component is disposed and configured to have an effect on either the jet or an exhaust plume when the movable component moves. A linkage is coupled to the movable component and adapted for coupling to an actuator. The linkage transmits the force to the moveable component from the actuator. There is a gap between an inner surface of the outer cover and an outer surface of the nozzle body. The linkage is smaller than the actuator. The gap is smaller than a smallest dimension of the actuator and larger than the linkage. The linkage is partially disposed within the gap, and the exhaust nozzle assembly is free of the actuator.

Abstract: Orbital debris removal (ODR) systems under the present approach may use a ground- or surface-based FEL and mirror system with sufficient power and both spatial and temporal resolution to both locate Category II OD (1 cm to 10 cm diameter) in low Earth orbit (LEO, 160 to 2000 km altitude) and remove these objects from orbit. Locating the Category II OD is performed by having the light beam from an FEL and its beam director scan a volume of space of interest and then observing the light reflected from the OD. Removing the OD may include heating the OD to a sufficiently high temperature to evaporate the OD, changing the orbit of the OD such as to lower the perigee, or both. Megawatt-class MOPA FELs for, inter alia, removing OD, are described.

Abstract: The present disclosure relates to a brake fluid device comprising a brake fluid reservoir having a storage space, having a fastening device for fastening to a pressure generator unit of a motor vehicle brake system and/or to a mounting interface in a motor vehicle. The brake fluid interface has an outlet interface for transporting brake fluid into such a pressure generator unit, and having an inlet interface (15) for brake fluid. The brake fluid device further includes a filling adapter having a filling opening, having a receiving space, and having an outlet interface for brake fluid. A brake fluid line connects the outlet interface of the filling adapter and the inlet interface of the brake fluid reservoir and through which brake fluid is able to flow from the filling adapter into the brake fluid reservoir.

Abstract: An elastomeric laminate material having resolution and image clarity includes an underlying ink graphic fabric material which is receptive to a SEBS like material, the underlying ink graphic fabric material layer having an image thereon having interstitial areas residing in the fabric and a SEBS like transparent polymeric material which is formed as a layer on the fabric layer and penetrating the interstitial areas in a manner to substantially remove all air therefrom and which is compressed and consolidated bonded to the ink graphic layer to form a substantially uniform laminate configuration and retain a transparent and elastic cushion characteristic through the exterior polymeric film layer enabling resolution and clarity of the image, wherein the exterior polymeric film layer imparts a nonslip tactile surface to the laminate.