Abstract: Provided herein are recombinant antibodies, antigen-binding fragments, and fusion proteins thereof useful for binding to and inhibiting programmed death 1 (PD-1), nucleic acid molecules encoding the same and therapeutic compositions thereof, as well as methods of using such antibodies, including the methods for enhancing T cell and NK cell function to increase cell and cytokine mediated immunity and methods of treatment of various immune dysfunction related disorders including cancer and infectious diseases.

Abstract: An example assembly includes: a tube having a first port and a second port; a sleeve fixedly disposed within the tube; a stem disposed, and axially movable, within the sleeve, wherein the stem has a rim formed at a proximal end thereof; a spring mounted around the stem and axially interposed between the sleeve and the rim of the stem; and a seal mounted to the stem. Refrigerant received at the first port pushes the stem in a distal direction, compressing the spring, thereby preventing the stem from moving in the distal direction beyond a particular axial position, while allowing refrigerant to flow to the second port. As pressure level at the first port is reduced, the spring pushes the stem in a proximal direction until the seal reaches the sleeve, thereby preventing the stem from moving further in the proximal direction, and blocking refrigerant flow to the first port.

Abstract: A bladeless fan including a housing, an impeller within the housing, a motor within the housing for rotatably driving the impeller, an outlet device having an at least partially circular outlet, and a diffuser configured to receive air from the impeller and direct the air into the outlet device, the diffuser at least partially changing a direction of the air being directed into the outlet device.

Abstract: A natural and organic composition for improving sleep problems and insomnia in human adults. The composition includes between 100 mg to 3000 mg of tart cherry (Prunus cerasus) extract and between 25 mg to 100 mg of Apocynum venetum leaf extract. The composition may also include between 10 mg to 100 mg of cannabidiol. The composition helps to improve sleep quality, daytime awareness, and sleep duration, while also decreasing sleep latency, insomnia severity scores, and generalized anxiety scores.

Abstract: An integrated development environment (IDE) for designing, programming, and configuring aspects of an industrial automation system uses a generative artificial intelligence (AI) model and associated neural networks to generate portions of an industrial automation project in accordance with functional requirements provided to the industrial IDE system in intuitive formats, such as spoken or written plain language text. The system uses generative AI to translate plain language requests or functional specifications into industrial control code, human-machine interface (HMI) applications, device configuration settings, or other aspects of an industrial control project.

Abstract: An integrated development environment (IDE) for designing, programming, and configuring aspects of an industrial automation system uses a generative artificial intelligence (AI) model and associated neural networks to generate portions of an industrial automation project in accordance with functional requirements provided to the industrial IDE system in intuitive formats, such as spoken or written plain language text. The system uses generative AI to translate plain language requests or functional specifications into industrial control code, human-machine interface (HMI) applications, device configuration settings, or other aspects of an industrial control project.

Abstract: An integrated development environment (IDE) for designing, programming, and configuring aspects of an industrial automation system uses a generative artificial intelligence (AI) model and associated neural networks to generate portions of an industrial automation project in accordance with functional requirements provided to the industrial IDE system in intuitive formats, such as spoken or written plain language text. The system uses generative AI to translate plain language requests or functional specifications into industrial control code, human-machine interface (HMI) applications, device configuration settings, or other aspects of an industrial control project.

Abstract: An integrated development environment (IDE) for designing, programming, and configuring aspects of an industrial automation system uses a generative artificial intelligence (AI) model and associated neural networks to generate portions of an industrial automation project in accordance with functional requirements provided to the industrial IDE system in intuitive formats, such as spoken or written plain language text. The system uses generative AI to translate plain language requests or functional specifications into industrial control code, human-machine interface (HMI) applications, device configuration settings, or other aspects of an industrial control project.

Abstract: Novel tools and techniques are provided for implementing protection of at least one tissue layer of a medical device or implant during crimping of the medical device or implant. In various embodiments, an implant tissue protection tool may include an outer portion configured to surround one or more outer segments of at least one tissue layer of a medical device to be implanted into a body of a subject and at least one protrusion (which may be affixed to a surface of the outer portion) configured to minimize or prevent occurrence (or likelihood of occurrence) of the at least one tissue layer (in some cases, leaflet material, or the like) of the medical device passing through at least one opening defined by a frame structure of the medical device during crimping of the medical device by a crimping device in preparation for implantation into the body of the subject.

Abstract: An emergency LED lighting system maintains power to an LED lighting source based on measured voltages and currents provided to the LED lighting source; rolls back or decreases power provided to an LED lighting source over time in order to increase the amount of time the battery can power the LED lighting source; executes a soft start procedure, such that the power provided to the LED lighting source is gradually ramped up during activation of the LED lighting sources; identifies a type of battery coupled to the emergency LED lighting system; cycles the emergency LED lighting system between charging mode and standby mode to reduce power consumption over a window of time; detects AC power or an absence of AC power; and/or uses a status LED to communicate information about the emergency LED lighting system with a remote device.

Abstract: The present disclosure relates to the co-administration of Belumosudil with CYP3A Inducers and/or Proton Pump Inhibitors for use in the treatment of subjects with chronic graft-versus-host disease (cGVHD).

Abstract: A liquid ink composition includes a liquid phase and particles suspended in the liquid phase, the particles containing a target pharmaceutical or biological agent. The biological activity of the target pharmaceutical or biological agent is preserved upon suspension of the particles in the liquid phase. The liquid phase is capable of solidifying via a solidification process.

Abstract: A system and method for localizing an autonomous vehicle using mapped and real-time data. Mapped data and real-time data are scan matched. Characteristics of the autonomous vehicle such as, but not limited to, linear and angular velocities, heading, and motion prediction are provided to a Bayesian estimation algorithm, and a final pose is computed.

Abstract: Methods, systems, and computer programs are presented for generating a question for a group and prompting the user to post that question. One method includes determining, for one or more groups of a user network, at least one group skill associated with the groups. A prompt is generated based on one or more user skills of a first user, including inserting at least one user skill into a prompt template to generate the prompt, where the prompt template includes a request to generate questions for the respective group. The prompt is provided as input into a generative artificial intelligence (GAI) model, a question is selected from the output of the GAI model, and a group is selected for based on the user skill inserted into the prompt template and the group skills associated with the groups. The selected question and the selected group are presented on a user interface.

Abstract: The invention provides noble metal-free electro-catalyst compositions for use in acidic media, e.g., acidic electrolyte. The noble metal-free electro-catalyst compositions include non-noble metal absent of noble metal. The non-noble metal is non-noble metal oxide, and typically in the form of any configuration of a solid or hollow nano-material, e.g., nano-particles, a nanocrystalline thin film, nanorods, nanoshells, nanoflakes, nanotubes, nanoplates, nanospheres and nanowhiskers or combinations of myriad nanoscale architecture embodiments. Optionally, the noble metal-free electro-catalyst compositions include dopant, such as, but not limited to halogen. Acidic media includes oxygen reduction reaction (ORR) in proton exchange membrane (PEM) fuel cells, and direct methanol fuel cells and oxygen evolution reaction (OER) in PEM-based water electrolysis and metal air batteries, and hydrogen generation from solar energy and electricity-driven water splitting.

Abstract: The present disclosure provides methods of administering belumosudil mesylate salt to certain subpopulations of patients with cGVHD.

Abstract: Novel tools and techniques are provided for implementing protection of at least one tissue layer of a medical device or implant during crimping of the medical device or implant. In various embodiments, an implant tissue protection tool may include an outer portion configured to surround one or more outer segments of at least one tissue layer of a medical device to be implanted into a body of a subject and at least one protrusion (which may be affixed to a surface of the outer portion) configured to minimize or prevent occurrence (or likelihood of occurrence) of the at least one tissue layer (in some cases, leaflet material, or the like) of the medical device passing through at least one opening defined by a frame structure of the medical device during crimping of the medical device by a crimping device in preparation for implantation into the body of the subject.

Abstract: The present disclosure provides metabolites of belumosudil and uses of the metabolites in of treating patients with ROCK2-mediated diseases including cGVHD.

Abstract: A system configured to receive health data pertaining to a user; select a user health profile from a plurality of user health profiles based on the collected health data, each of the plurality of user health profiles being associated with a health and wellness program and a set of interventions; receive user activity data and updated health data pertaining to, or during the user's participation in the associated health and wellness program from health devices; select a new set of interventions based on the user activity data; and select a new user health profile from the plurality of user health profiles based on at least one of the user activity data and the updated health data.

Abstract: A proximal stent-graft retention system includes a stent-graft having a suture loop attached to a proximal end of the stent-graft and a delivery catheter having a distal tip that includes a retention feature. The retention feature can include a slot extending through a sidewall of the distal tip and a trigger wire. The slot of the distal tip exposes a portion of the trigger wire within the tip lumen such that the trigger wire may extend through the suture loop of the stent-graft at the slot of the distal tip of the delivery catheter and is configured to retain the proximal end of the stent-graft in the radially expanded configuration via the suture loop to prevent distal migration and compression of the stent-graft. Proximal retraction of the trigger wire releases the suture loop of the stent-graft such that the stent-graft is no longer coupled to the delivery catheter.