Abstract: The present invention provides compositions and methods for the treatment of drug-tolerant glioblastoma, and in particular glioblastoma stem cells. Specifically, the methods comprise contacting a glioblastoma stem cell with a platelet-derived growth factor receptor alpha inhibitor and one or more of a histone lysine demethylase inhibitor and a Notch inhibitor.

Abstract: The invention provides noble metal-free electro-catalyst compositions for use in acidic media, e.g., acidic electrolyte. The noble metal-free electro-catalyst compositions include non-noble metal absent of noble metal. The non-noble metal is non-noble metal oxide, and typically in the form of any configuration of a solid or hollow nano-material, e.g., nano-particles, a nanocrystalline thin film, nanorods, nanoshells, nanoflakes, nanotubes, nanoplates, nanospheres and nanowhiskers or combinations of myriad nanoscale architecture embodiments. Optionally, the noble metal-free electro-catalyst compositions include dopant, such as, but not limited to halogen. Acidic media includes oxygen reduction reaction (ORR) in proton exchange membrane (PEM) fuel cells, and direct methanol fuel cells and oxygen evolution reaction (OER) in PEM-based water electrolysis and metal air batteries, and hydrogen generation from solar energy and electricity-driven water splitting.

Abstract: A proximal stent-graft retention system includes a stent-graft having a suture loop attached to a proximal end of the stent-graft and a delivery catheter having a distal tip that includes a retention feature. The retention feature can include a slot extending through a sidewall of the distal tip and a trigger wire. The slot of the distal tip exposes a portion of the trigger wire within the tip lumen such that the trigger wire may extend through the suture loop of the stent-graft at the slot of the distal tip of the delivery catheter and is configured to retain the proximal end of the stent-graft in the radially expanded configuration via the suture loop to prevent distal migration and compression of the stent-graft. Proximal retraction of the trigger wire releases the suture loop of the stent-graft such that the stent-graft is no longer coupled to the delivery catheter.

Abstract: A propulsion control system has an electric motor configured to generate an axle torque in response to a final torque command, and has a motor constraint that specifies a maximum torque. A motor controller is configured to generate the final torque command in response to an intermediate torque command and a distributed power limit command. An open-loop function in supervisory controller is configured to calculate an initial torque command vector in response to a driver torque command, calculate an intended operating vector by mapping the initial torque command vector into a multidimensional power space, generate the intermediate torque command by clipping the intended operating vector in response to the motor constraint, generate a constrained command vector by clipping the intended operating vector in response to the motor constraint and a plurality of energy storage constraints, and generate the distributed power limit command in response to the constrained command vector.

Abstract: The present disclosure provides metabolites of belumosudil and uses of the metabolites in of treating patients with ROCK2-mediated diseases including cGVHD.

Abstract: A detachable cap for measuring usage of an inhaler includes a hollow receiving portion adapted to removably receive the inhaler. A vent is formed in a roof portion of the cap to allow airflow through the cap to the inhaler. An extension portion is provided for containing electronic components, including an electronic circuit provided in the extension portion, the electronic circuit including a controller coupled to a storage device and a power source. A pressure sensor is provided adjacent to the vent, the pressure sensor communicatively coupled to the controller and adapted to detect an air pressure within the cap. The controller is programmed to calculate an air flow rate through the cap based on the detected air pressure and to store the calculated air flow rate in the storage device.

Abstract: An endovascular stent graft cover for delivering a stent graft to a target deployment site. The endovascular stent graft cover includes a tubular inner layer and a tubular outer layer. The stent graft cover also includes a tubular torsion layer disposed between the tubular inner layer and the tubular outer layer. The tubular torsion layer includes first wires and second wires. The first wires have a flat profile along a first longitudinal axis of the first wires. The second wires have a circular profile along a second longitudinal axis of the second wires. The tubular torsion layer is configured to radially align at the target deployment site the stent graft loaded into a distal portion of the stent graft cover.

Abstract: The present disclosure relates to the co-administration of Belumosudil with CYP3A Inducers and/or Proton Pump Inhibitors for use in the treatment of subjects with chronic graft-versus-host disease (cGVHD).

Abstract: The present disclosure provides metabolites of belumosudil and uses of the metabolites in of treating patients with ROCK2-mediated diseases including cGVHD.

Abstract: The present disclosure provides methods of administering belumosudil mesylate salt to certain subpopulations of patients with cGVHD.

Abstract: The present disclosure provides a method including positioning a first guidewire within a primary guidewire lumen of a multi-lumen tapered tip. A second guidewire is positioned within a secondary guidewire lumen and a shared guidewire lumen of the multi-lumen tapered tip, the second guidewire preventing the first guidewire from entering the shared guidewire lumen. A delivery system including the multi-lumen tapered tip is advanced over the second guidewire. By advancing the delivery system over a single guidewire, any possibility of entanglement of multiple guidewires during advancement of the delivery system is eliminated. The method further includes a guidewire exchange including releasing the second guidewire from the shared guidewire lumen, advancing the first guidewire through and out of the shared guidewire lumen, and advancing the delivery system over the first guidewire to a deployment location.

Abstract: A method and system for generating recommendations across multiple product or service domains are disclosed. The system includes a plurality of domain servers for handling user events and for interfacing with users via the Internet, a database for storing the user events, and a recommendation engine. The recommendation engine further includes one or more computer programs containing instructions for collecting the user events across a plurality of product or service domains in the database, receiving a triggering event for recommendations, analyzing the user events to formulate correlations between the user events in the database, and generating recommendations in response to the triggering event in accordance with the correlations between the user events in the database. The disclosure uses user input data from different domains for producing recommendations in any of those domains. The disclosure allows for access to a greater amount of user input data which in turn improves the quality of recommendations.

Abstract: A computer comprising one or more processors offering vector instructions may implement a direct convolution on a source data set. The source data set may be one-dimensional or multi-dimensional. For a given vector width, w, of the vector instructions, w consecutive data elements of the output data set are computed in parallel using vector instructions. For multi-dimensional data sets, multiple vectors of the output data set are computed for a single load of a set of vectors from the source data set. New vector instructions are disclosed to improve the performance of the convolution and to enable full utilization of the arithmetic logic units within the one or more processors.

Abstract: A method for evaluating a weld in a formed object includes performing a contact mechanics test of a first region that includes the weld and storing one or more corresponding weld surface mechanical property measurements, performing a contact mechanics test of a second region that excludes the weld and storing one or more corresponding base material surface mechanical property measurements, determining a relative difference in the weld surface mechanical property measurements and the base material surface mechanical property measurements, determining one or more weld width measurements on the exterior surface of the formed object, and evaluating the weld based on the determined relative difference in the weld surface mechanical property measurements and the base material surface mechanical property measurements in relation to the determined weld width measurements in order to provide an index of weld quality that is traditionally measured through a destructive test or examination.

Abstract: A battery-driver enclosure for a light fixture includes a first member and a second member. The first member and the second member together define the battery-driver enclosure, and the first member and the second member overlap at non-adjacent corners of the enclosure. A method of assembling a battery-driver enclosure includes engaging the first member with the second member to form the battery-driver enclosure and such that the first member and the second member overlap at non-adjacent corners of the battery-driver enclosure.

Abstract: Provided herein are recombinant antibodies, antigen-binding fragments, and fusion proteins thereof useful for binding to and inhibiting programmed death 1 (PD-1), nucleic acid molecules encoding the same and therapeutic compositions thereof, as well as methods of using such antibodies, including the methods for enhancing T cell and NK cell function to increase cell and cytokine mediated immunity and methods of treatment of various immune dysfunction related disorders including cancer and infectious diseases.

Abstract: The present disclosure relates generally to the treatment of patients with chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic stem cell transplantation by administering belumosudil at certain dosages.

Abstract: The disclosure provides crystalline forms for certain synthetic intermediates for making belzutifan, a HIF-2? inhibitor, useful for the treatment of cancer. The disclosure also provides processes for isolating the crystalline forms.

Abstract: A luminaire includes a support positioned in a ceiling. A light module is connected to the support having a base, a light emitter, and an optic. The light modules allow different luminaire configurations to be formed out of similar components.

Abstract: A computer comprising one or more processors offering vector instructions may implement a direct convolution on a source data set. The source data set may be one-dimensional or multi-dimensional. For a given vector width, w, of the vector instructions, w consecutive data elements of the output data set are computed in parallel using vector instructions. For multi-dimensional data sets, multiple vectors of the output data set are computed for a single load of a set of vectors from the source data set. New vector instructions are disclosed to improve the performance of the convolution and to enable full utilization of the arithmetic logic units within the one or more processors.