Abstract: Embodiments include semiconductor packages and methods to form the semiconductor packages. A semiconductor package includes a plurality of first dies on a substrate, an encapsulation layer over the first dies and the substrate, an interface layer over the first dies and the encapsulation layer, and a passive heat spreader on the interface layer, wherein the interface layer thermally couples the first dies to the passive heat spreader. The passive heat spreader includes a silicon (Si) or a silicon carbide (SiC). The interface layer includes a silicon nitride (SiN) material, a silicon monoxide (SiO) material, a silicon carbon nitride (SiCN) material, or a thermal adhesive material. The semiconductor package may include a plurality of second dies and the substrate on a package substrate, a thermal interface material (TIM) over the second dies, the passive heat spreader, and the package substrate, and a heat spreader over the TIM and the package substrate.

Abstract: Aspects of the present invention are directed to a nasal spray formulation comprising: at least one active pharmaceutical ingredient, glycerin, polyethylene glycol, and dextrose. Formulations of the present invention provide moisturizing benefits and retain at least about 3% water when exposed to about 80% relative humidity at a temperature of about 23° C. for about 750 minutes in a Dynamic Vapor Sorption (DVS) test.

Abstract: Provided herein are recombinant antibodies, antigen-binding fragments thereof, and fusion proteins thereof useful for binding to and inhibiting B7-H4. Also provided are nucleic acid molecules encoding the antibodies, antigen-binding fragments thereof, and fusion proteins thereof disclosed herein and therapeutic compositions thereof. Disclosed are further methods of using the disclosed antibodies, antigen-binding fragments thereof, and fusion proteins thereof for the treatment of disease.

Abstract: A method of operating a vehicle includes a vehicle controller receiving an operator-input vehicle control command with an associated torque request, and identifying any propulsion actuator constraints that limit a brake torque capacity available from the vehicle powertrain. Using the propulsion actuator constraint(s) and torque request, the controller determines a propulsion brake torque distribution for the vehicle's road wheels and a maximum brake torque capacity for the powertrain actuator(s). A first brake torque request is determined using the propulsion brake torque distribution and a vehicle control mode of the powertrain system, and a second brake torque request is determined using the maximum brake torque capacity and the vehicle control mode. A friction brake torque command is determined by arbitrating between the first and second brake torque requests.

Abstract: A luminaire includes a support positioned in a ceiling. A light module is connected to the support having a base, a light emitter, and an optic. The light modules allow different luminaire configurations to be formed out of similar components.

Abstract: An ion source with a target holder for holding a solid dopant material is disclosed. The ion source comprises a thermocouple disposed proximate the target holder to monitor the temperature of the solid dopant material. In certain embodiments, a controller uses this temperature information to vary one or more parameters of the ion source, such as arc voltage, cathode bias voltage, extracted beam current, or the position of the target holder within the arc chamber. Various embodiments showing the connections between the controller and the thermocouple are shown. Further, embodiments showing various placement of the thermocouple on the target holder are also presented.

Abstract: A method for distributing electrical power to electric motors in an electric powertrain, in which the electric motors are electrically connected to a shared power supply, includes receiving input signals via a supervisory controller. The input signals include a total torque request of the electric powertrain and electrical limits of the power supply. The method includes determining an open-loop torque command for each respective motor in response to the input signals. In response to the total torque request and the power supply limits, the controller also determines maximum and minimum power limits of motor, with the maximum and minimum power limits including a calibrated power reserve for executing a predetermined torque operation. The method includes transmitting the open-loop torque command and the power limits to a respective motor control processor of each motor to thereby control the torque operation.

Abstract: An endovascular delivery system for delivering a stent graft within a blood vessel. The delivery system includes a guide member configured to carry the stent graft into the blood vessel and a graft cover configured to cover at least a portion of the stent graft as the guide member is inserted into the blood vessel. The stent graft including a first end and a second end, the first end closer to a proximal end of the endovascular delivery system than the second end. The guide member includes a body having an elongated shape and a non-uniform outer periphery. The non-uniform outer periphery is configured to secure a first end of the stem graft in a first position, relative to a deployment location thin the blood vessel, to hold the first end of the stent graft in the first position as the graft cover is retracted to deploy the stent graft.

Abstract: An ion source with a target holder for holding a solid dopant material is disclosed. The ion source comprises a thermocouple disposed proximate the target holder to monitor the temperature of the solid dopant material. In certain embodiments, a controller uses this temperature information to vary one or more parameters of the ion source, such as arc voltage, cathode bias voltage, extracted beam current, or the position of the target holder within the arc chamber. Various embodiments showing the connections between the controller and the thermocouple are shown. Further, embodiments showing various placement of the thermocouple on the target holder are also presented.

Abstract: This disclosure relates to hydrogel compositions with isolated mitochondria suspended therein. The compositions are for providing protection to injured tissue, as well as tissue proximal to a site of injury. The hydrogel provides structural support while the mitochondria are able to prevent or slow cellular death. In some aspects, the compositions include N-acetylcysteine amide and/or acetyl-L-carnitine.

Abstract: An inflatable structure includes a top end cap, a bottom end cap, a bladder, a nozzle, a loop, and a first tether. The bladder is attached to the top and bottom end caps and is configured to hold pressurized fluid therebetween. The nozzle is configured to allow fluid to enter and exit the bladder. The loop is attached to one of the top and bottom end caps. A tether is disposed within the bladder, coupled to the other one of the top and bottom end caps, and extends through the at least one loop. The top end cap assumes a first position when the bladder is inflated. When the top end cap is adjusted from the first position to a second position, the first tether is configured to maintain the top end cap in the second position.

Abstract: A method and computing apparatus for verifying an operability of a target device are provided. The method includes sequentially obtaining first image information of the target device, initiating a communication with the target device, obtaining second image information of the target device, comparing the first image information with the second image information; and determining whether the target device is operational based on a result of the comparing wherein the target device is determined as being operational when the first image information is different from the second image information, and the target device is determined as at least one of not receiving communications and not operational when the first image information is identical to the second image information.

Abstract: The disclosure provides crystalline forms for certain synthetic intermediates for making belzutifan, a HIF-2? inhibitor, useful for the treatment of cancer. The disclosure also provides processes for isolating the crystalline forms.

Abstract: Methods for the treatment of lung injury caused by chemical inhalation, smoke inhalation or microbial infection are described. The methods include administering a therapeutically effective amount of nitrite or a nitrite formulation. Nitrite formulations that include a nitrite salt and an anti-caking agent, such as sodium bicarbonate, and the use of such formulations, is also described.

Abstract: Novel tools and techniques are provided for implementing protection of at least one tissue layer of a medical device or implant during crimping of the medical device or implant. In various embodiments, an implant tissue protection tool may include an outer portion configured to surround one or more outer segments of at least one tissue layer of a medical device to be implanted into a body of a subject and at least one protrusion (which may be affixed to a surface of the outer portion) configured to minimize or prevent occurrence (or likelihood of occurrence) of the at least one tissue layer (in some cases, leaflet material, or the like) of the medical device passing through at least one opening defined by a frame structure of the medical device during crimping of the medical device by a crimping device in preparation for implantation into the body of the subject.

Abstract: A method for distributing electrical power to electric motors in an electric powertrain, in which the electric motors are electrically connected to a shared power supply, includes receiving input signals via a supervisory controller. The input signals include a total torque request of the electric powertrain and electrical limits of the power supply. The method includes determining an open-loop torque command for each respective motor in response to the input signals. In response to the total torque request and the power supply limits, the controller also determines maximum and minimum power limits of motor, with the maximum and minimum power limits including a calibrated power reserve for executing a predetermined torque operation. The method includes transmitting the open-loop torque command and the power limits to a respective motor control processor of each motor to thereby control the torque operation.

Abstract: A method of operating a vehicle includes a vehicle controller receiving an operator-input vehicle control command with an associated torque request, and identifying any propulsion actuator constraints that limit a brake torque capacity available from the vehicle powertrain. Using the propulsion actuator constraint(s) and torque request, the controller determines a propulsion brake torque distribution for the vehicle's road wheels and a maximum brake torque capacity for the powertrain actuator(s). A first brake torque request is determined using the propulsion brake torque distribution and a vehicle control mode of the powertrain system, and a second brake torque request is determined using the maximum brake torque capacity and the vehicle control mode. A friction brake torque command is determined by arbitrating between the first and second brake torque requests.

Abstract: A propulsion control system has an electric motor configured to generate an axle torque in response to a final torque command, and has a motor constraint that specifies a maximum torque. A motor controller is configured to generate the final torque command in response to an intermediate torque command and a distributed power limit command. An open-loop function in supervisory controller is configured to calculate an initial torque command vector in response to a driver torque command, calculate an intended operating vector by mapping the initial torque command vector into a multidimensional power space, generate the intermediate torque command by clipping the intended operating vector in response to the motor constraint, generate a constrained command vector by clipping the intended operating vector in response to the motor constraint and a plurality of energy storage constraints, and generate the distributed power limit command in response to the constrained command vector.

Abstract: A machine in a linear communication orbit receives a query, including a set of one or more rules, through the linear communication orbit. The machine, for each respective rule: identifies files that contain content that satisfies the respective rule, generates a first report identifying a count of files at the machine that contain content satisfying the rule, and sends the first report through the linear communication orbit to a server. The machine receives an instruction packet from an external machine that includes an instruction for establishing a direct duplex connection between the respective machine and the external machine. then sends a request to the external machine to establish the direct duplex connection. The machine sends to the external machine, via the direct duplex connection, a second report including information identifying files at the machine that contain file content satisfying each rule in the set of one or more rules.

Abstract: A liquid ink composition includes a liquid phase and particles suspended in the liquid phase, the particles containing a target pharmaceutical or biological agent. The biological activity of the target pharmaceutical or biological agent is preserved upon suspension of the particles in the liquid phase. The liquid phase is capable of solidifying via a solidification process.