Patents by Inventor Palle Christophersen

Palle Christophersen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-(Phenylamino) Benzimidazole Derivatives and Their Use as Modulators of Small- Conductance Calcuim-Activated Potassium Channels
    Publication number: 20090076106
    Abstract: This invention relates to novel 2-(phenylamino)benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: June 21, 2006
    Publication date: March 19, 2009
    Applicant: NEUROSEARCH A/S
    Inventors: Ulrik Svane Sorensen, Lene Teuber, Dan Peters, Dorte Strobaek, Tina Holm Johansen, Karin Sandager Nielsen, Palle Christophersen
  • Novel Quinazoline-2,4-Diamine Derivatives and Their Use as Modulators of Small-Conductance Calcium-Activated Potassium Channels
    Publication number: 20090048278
    Abstract: This invention relates to novel quinazoline-2,4-diamine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: December 6, 2006
    Publication date: February 19, 2009
    Inventors: Ulrik Svane Sorensen, Birgitte L. Eriksen, Lene Teuber, Dan Peters, Dorte Strobaek, Tina Holm Johansen, Palle Christophersen
  • DIPHENYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS OR BKCa CHANNEL MODULATORS
    Publication number: 20090018172
    Abstract: The present invention relates to novel diphenylurea derivatives useful as chloride channel blockers or BKCa channel modulators. In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: March 9, 2007
    Publication date: January 15, 2009
    Inventors: Bjarne H. Dahl, Palle Christophersen, Lars Siim Madsen
  • Novel 2-Amino Benzimidazole Derivatives and Their Use As Modulators Of Small-Conductance Calcium-Activated Potassium Channels
    Publication number: 20080200529
    Abstract: This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: January 10, 2006
    Publication date: August 21, 2008
    Applicant: NEURO SEARCH A/S
    Inventors: Ulrik Svane Sorensen, Lene Teuber, Dan Peters, Dorte Strobaek, Tina Holm Johansen, Karin Sandager Nielsen, Palle Christophersen
  • Diphenylurea Derivatives Useful As Potassium Channel Activators
    Publication number: 20070293553
    Abstract: The present invention relates to the medical use of a certain group of diphenyl urea derivatives as potassium channel blockers for treating cardiovascular diseases, an obstructive or inflammatory airway disease, urinary incontinence, psychosis, epilepsy or pain, or for facilitating the blood-brain barrier permeability for other therapeutic substances. In other aspects the invention relates to the use of these compounds in a method of therapy.
    Type: Application
    Filed: December 14, 2005
    Publication date: December 20, 2007
    Inventors: Bjarne Dahl, Palle Christophersen, Joachim Demnitz
  • Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels
    Publication number: 20070197618
    Abstract: This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: August 3, 2005
    Publication date: August 23, 2007
    Applicant: NEUROSEARCH A/S
    Inventors: Ulrik Sorensen, Lene Teuber, Dan Peters, Dorte Strobaek, Tina Johansen, Karin Nielsen, Palle Christophersen
  • Erg channel openers for the treatment of cardiac arrhythmias
    Publication number: 20060281794
    Abstract: This invention relates to the use of ERG channel openers for the treatment of cardiac arrhythmias, and to the use of specific compounds for such treatment. In a separate aspect the invention provides novel compounds useful as ERG channel openers.
    Type: Application
    Filed: September 6, 2004
    Publication date: December 14, 2006
    Inventors: Soren Olesen, Morten Grunnet, Palle Christophersen, Dorte Strobaek, Joachim Demnitz, Rie Hansen
  • Diphenylurea derivatives and their use as chloride channel blockers
    Publication number: 20060178413
    Abstract: The present invention relates to novel diphenylurea derivatives useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: June 15, 2004
    Publication date: August 10, 2006
    Inventors: Bjarne Dahl, Palle Christophersen
  • Diarylurea derivatives and their use as chloride channel blockers
    Publication number: 20060160856
    Abstract: The present invention relates to novel diarylurea derivatives useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of bone metabolic diseases, diseases responsive to modulation of the mast cell or basophil activity, diseases responsive to inhibition of angiogenesis, or sickle cell anaemia, and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: September 4, 2003
    Publication date: July 20, 2006
    Inventors: Bjarne Dahl, Palle Christophersen, Michael En G Sig, Morten Karsdal, Niels Foged, Flemming Jensen
  • Compounds useful for the treatment of diseases responsive to antiangiogenetic therapy
    Publication number: 20060058395
    Abstract: This invention relates to the use of certain compounds for the treatment of diseases that are responsive to antiangiogenetic therapy. Excessive angiogenesis occurs in diseases such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis and psoriasis. The compounds are particularly useful for anti-metastatic treatment or for the treatment of age-related macular degeneration.
    Type: Application
    Filed: July 31, 2003
    Publication date: March 16, 2006
    Applicant: NEUROSEARCH A/S
    Inventors: Jens Lichtenberg, Palle Christophersen, Bjarne Dahl
  • Ion channel modulating agents
    Patent number: 7012146
    Abstract: The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SK Ca, IK Ca and BK Ca channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, for methods of therapy, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: March 14, 2006
    Assignee: Poseidon Pharmaceuticals A/S
    Inventors: Bo Skaaning Jensen, Dorte Strobaek, Palle Christophersen, Lene Teuber, Jurgen Beyer
  • Use of isatin derivatives as ion channel activating agents
    Patent number: 6969729
    Abstract: The present invention relates to ion channel activating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as openers of SKCa and IKCa channels. In further aspects, the present invention relates to the use of these SK/IK channel activating agents for the manufacture of medicaments and pharmaceutical compositions comprising the SK/IK channel activating agents.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: November 29, 2005
    Assignee: Neurosearch A/S
    Inventors: Bo Skaaning Jensen, Tino Dyhring Jørgensen, Philip K. Ahring, Palle Christophersen, Dorte Strøbaek, Lene Teuber, Søren Peter Olesen
  • Method for screening compounds for activity in treating an osteoclast related bone disease
    Publication number: 20040224881
    Abstract: The present invention relates to methods for screening and identifying compounds which block chloride channels of the CIC family. In addition, the present invention relates to the use of chloride channel blockers of the CIC family for the treatment, prevention or alleviation of osteoclast related bone diseases.
    Type: Application
    Filed: July 18, 2003
    Publication date: November 11, 2004
    Inventors: Anne Marie Heegaard, Michael T. Engsig, Lars S. Madsen, Bo S. Jensen, Palle Christophersen, Martin Stahlhut, Morten A. Karsdal
  • Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction
    Patent number: 6797694
    Abstract: The present invention relates to chemical compounds having inhibitory activity on an intermediate conductance Ca2+ activated potassium channel (IKCa), and the use of such compounds for the treatment or alleviation of diseases or conditions relating to immune dysfunction.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: September 28, 2004
    Assignee: Poseidon Pharmaceuticals A/S
    Inventors: Bo Skaaning Jensen, Soren Peter Olsen, Palle Christophersen
  • Ion channel modulating agents
    Patent number: 6759422
    Abstract: The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds represented by general formula (I) that has proven useful as modulators of SKCa, IKCa and BKCa channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: July 6, 2004
    Assignee: Neurosearch A/S
    Inventors: Bo Skaaning Jensen, Lene Teuber, Dorte Strobaek, Palle Christophersen, Soren Peter Olesen
  • Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels
    Publication number: 20040055901
    Abstract: The present invention relates to a substrate and a method for obtaining an electrophysiological measuring configuration in which a cell forms a high resistive seal (giga-seal) around a measuring electrode making it suitable for determining and monitoring a current flow through the cell membrane. The substrate is typically part of an apparatus for studying electrical events in cell membranes, such as an apparatus for carrying out patch clamp techniques utilised to study ion transfer channels in biological membranes. The substrate has a plurality or an array of measuring sites with integrated measuring and reference electrodes formed by wafer processing technology. The electrodes are adapted to conduct a current between them by delivery of ions by one electrode and receipt of ions by the other electrode and are typically silver/silver halide electrodes.
    Type: Application
    Filed: October 23, 2003
    Publication date: March 25, 2004
    Applicant: Sophion Bioscience A/S
    Inventors: Jon Wulff Petersen, Pieter Telleman, Ole Hansen, Palle Christophersen, Morten Bech, Soren Peter Olesen, Jorgen Due, Lars Thomsen
  • Substituted phenyl derivatives, their preparation and use
    Patent number: 6706749
    Abstract: The present invention discloses compounds having formula (I) wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: March 16, 2004
    Assignee: NeuroSearch A/S
    Inventors: Bjarne H. Dahl, Palle Christophersen
  • Substituted phenyl derivatives, their preparation and use
    Patent number: 6696475
    Abstract: The present invention discloses compounds having the formula wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: February 24, 2004
    Assignee: NeuroSearch A/S
    Inventors: Bjarne H. Dahl, Palle Christophersen
  • Benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents
    Publication number: 20040029937
    Abstract: The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SKCa, IKCa and BKCa channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents.
    Type: Application
    Filed: July 1, 2003
    Publication date: February 12, 2004
    Applicant: NEUROSEARCH A/S.
    Inventors: Lene Teuber, Palle Christophersen, Dorte Strobaek, Bo Skaaning Jensen
  • Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels
    Patent number: 6682649
    Abstract: The present invention relates to a substrate and a method for obtaining an electrophysiological measuring configuration in which a cell forms a high resistive seal (giga-seal) around a measuring electrode making it suitable for determining and monitoring a current flow through the cell membrane. The substrate is typically part of an apparatus for studying electrical events in cell membranes, such as an apparatus for carrying out patch clamp techniques utilised to study ion transfer channels in biological membranes. The substrate has a plurality or an array of measuring sites with integrated measuring and reference electrodes formed by wafer processing technology. The electrodes are adapted to conduct a current between them by delivery of ions by one electrode and receipt of ions by the other electrode and are typically silver/silver halide electrodes.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: January 27, 2004
    Assignee: Sophion Bioscience A/S
    Inventors: Jon Wulff Petersen, Pieter Telleman, Ole Hansen, Palle Christophersen, Morten Bech, Soren Peter Olesen, Jorgen Due, Lars Thomsen