Patents by Inventor Palle Christophersen

Palle Christophersen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of isatin derivatives as ion channel activating agents
    Publication number: 20020016354
    Abstract: The present invention relates to ion channel activating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as openers of SKCa and IKCa channels. In further aspects, the present invention relates to the use of these SK/IK channel activating agents for the manufacture of medicaments and pharmaceutical compositions comprising the SK/IK channel activating agents.
    Type: Application
    Filed: May 15, 2001
    Publication date: February 7, 2002
    Inventors: Bo Skaaning Jensen, Tino Dyhring Jorgensen, Philip K. Ahring, Palle Christophersen, Dorte Strobaek, Lene Teuber, Soren Peter Olesen
  • Diaminocyclobutene-3,4-dione derivatives, their preparation and use
    Publication number: 20010056092
    Abstract: The invention relates to compounds having the formula (I) or a pharmaceutically acceptable salt thereof. In the formula (I), X represents a group having the structural formula (II), and Y represents O or S. The compounds of the invention can be used a chloride channel blockers.
    Type: Application
    Filed: March 8, 2001
    Publication date: December 27, 2001
    Inventors: Bjarne H. Dahl, Palle Christophersen
  • Substituted phenyl derivatives, their preparation and use
    Patent number: 6297261
    Abstract: A compound having the formula (I) or a pharmaceutically acceptable salt thereof where the variables are defined in the specification are useful in the treatment of sickle-cell anemia.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: October 2, 2001
    Assignee: Neurosearch A/S
    Inventors: Palle Christophersen, Ove Pedersen
  • Microperfusion chamber assembly with base comprising silver chloride coated silver
    Patent number: 6117291
    Abstract: Apparatus for carrying out patch clamp technique utilized in studying the effect of certain materials on ion transfer channels in biological tissue, and more particularly patch clamp apparatus utilizing an autosampler, such as those utilized with HPLC apparatus, to provide high throughput, is disclosed. The invention additionally includes novel microperfusion chamber assemblies capable of utilizing only small amounts of material to be tested and only small amounts of liquid carrier, thereby enabling many tests to be completed in a short period of time. The invention more broadly relates to a novel electrophysiology drug handling and application set up for screening of chemical substances while providing high throughput and requiring only low volume of solutions and samples to be tested. The invention also comprises several novel procedures for utilizing the apparatus of the invention.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: September 12, 2000
    Assignee: NeuroSearch A/S
    Inventors: S.o slashed.ren-Peter Olesen, Palle Christophersen
  • Patch clamp apparatus and technique having high throughput and low fluid volume requirements
    Patent number: 6063260
    Abstract: Apparatus for carrying out patch clamp technique utilized in studying the effect of certain materials on ion transfer channels in biological tissue, and more particularly patch clamp apparatus utilizing an autosampler, such as those utilized with HPLC apparatus, to provide high throughput, is disclosed. The invention additionally includes novel microperfusion chamber assemblies capable of utilizing only small amounts of material to be tested and only small amounts of liquid carrier, thereby enabling many tests to be completed in a short period of time. The invention more broadly relates to a novel electrophysiology drug handling and application set up for screening of chemical substances while providing high throughput and requiring only low volume of solutions and samples to be tested. The invention also comprises several novel procedures for utilizing the apparatus of the invention.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: May 16, 2000
    Assignee: NeuroSearch A/S
    Inventors: S.o slashed.ren-Peter Olesen, Palle Christophersen
  • Piperidine compounds as calcium channel blockers
    Patent number: 5981539
    Abstract: The present invention discloses compounds of the formula ##STR1## any of its enantiomers or any mixture thereof, or a pharmaceutically-acceptable addition salt thereof, wherein X, Ar, R, R.sup.1, R.sup.2, n are as defined herein.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: November 9, 1999
    Assignee: Neurosearch A/S
    Inventors: Oskar Axelsson, Dan Peters, Nielsen Elsebet stergaard, Palle Christophersen
  • Imidazole compounds and their use as calcium channel blockers
    Patent number: 5360809
    Abstract: The present invention discloses compounds of the formula ##STR1## wherein X is C;Y is C;R.sup.4 to R.sup.7 and R.sup.11 to R.sup.13 are as defined herein; or a pharmaceutically-acceptable addition salt thereof. The compounds are useful as pharmaceuticals, for example, in the treatment of stroke, ischemia, anoxia, migraine and psychosis.
    Type: Grant
    Filed: March 24, 1993
    Date of Patent: November 1, 1994
    Assignee: NeuroSearch A/S
    Inventors: Oskar Axelsson, Dan Peters, Elsebet O. Nielsen, Palle Christophersen