Abstract: Systems and methods for storing and accessing healthcare data in blockchain managed digital filing cabinets are disclosed. The system can receive and store patient healthcare data from sources such as wearable devices, an implant, patient devices, healthcare provider devices, databases, cloud storage accounts, healthcare databases, or digital filing cabinets. The system can convert the healthcare into non-fungible tokens on a blockchain to protect the healthcare data from being accessed by nefarious actors. The system can manage access to the healthcare data based on authentication rules.

Abstract: Provided is a composition comprising: (a) a principal phase that is provided by a layered mixed metal oxide having a rocksalt structure belonging to the R-3m space group; the layered mixed metal oxide comprising the following component elements: 45 to 55 atomic % lithium; 20 to 55 atomic % of one or more transition metals selected from the group consisting of chromium, manganese, iron, nickel, cobalt, and combinations thereof; and 0 to 25 atomic % of one or more additional dopant elements selected from the group consisting of: magnesium, calcium, strontium, titanium, zirconium, vanadium, copper, ruthenium, zinc, molybdenum, boron, aluminium, gallium, tin, lead, bismuth, lanthanum, cerium, gadolinium and europium; wherein said atomic % is expressed as a % of total atoms of said layered oxide, excluding oxygen; (b) a minor phase that is provided by a metal oxide that does not have the crystal structure of the layered mixed metal oxide, the minor phase comprising one or more of the transition metals contai

Abstract: A computer-implemented method for designing a patient-specific orthopedic implant can include creating a user account associated with a patient. A patient-specific orthopedic implant can be designed based on patient data and imaging data. A healthcare provider can provide feedback for a design of the patient-specific orthopedic implant, treatment protocol, or other aspects of treatment. The patient can provide data and feedback.

Abstract: Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. In some embodiments, a method includes receiving intra-operative data during a surgical procedure to install a patient-specific implant in a patient. The system can compare the intra-operative data to a pre-operative plan to determine whether the implant is positioned and located according to the pre-operative plan.

Abstract: Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. In some embodiments, a method includes receiving a patient data set of a patient. The patient data set is compared to a plurality of reference patient data sets, wherein each of the plurality of reference patient data sets is associated with a corresponding reference patient. A subset of the plurality of reference patient data sets is selected based, at least partly, on similarity to the patient data set and treatment outcome of the corresponding reference patient. Based on the selected subset, at least one surgical procedure or medical device design for treating the patient is generated.

Abstract: A personalized fixation system includes a surgical planning software tool configured to adjust relationships of relevant anatomy of a subject, at least one bone anchor, a plate having a shape that does not conform to a single plane, the plate configured to accept the at least one bone anchor, wherein the shape of the plate is at least partially determined by the surgical planning software tool, and wherein the plate includes at least one node having a hole configured to receive the at least one bone anchor, and a locking element configured to connect the at least one bone anchor to the plate, wherein the plate is manufactured using additive manufacturing.

Abstract: A system and computer-implemented method for manufacturing an orthopedic implant involves segmenting features in an image of anatomy. Anatomic elements can be isolated. Spatial relationships between the isolated anatomic elements can be manipulated. Negative space between anatomic elements is mapped before and/or after manipulating the spatial relationships. At least a portion of the negative space can be filled with a virtual implant. The virtual implant can be used to design and manufacture a physical implant.

Abstract: A personalized fixation system includes a surgical planning software tool configured to adjust relationships of relevant anatomy of a subject, at least one bone anchor, a plate having a shape that does not conform to a single plane, the plate configured to accept the at least one bone anchor, wherein the shape of the plate is at least partially determined by the surgical planning software tool, and wherein the plate includes at least one node having a hole configured to receive the at least one bone anchor, and a locking element configured to connect the at least one bone anchor to the plate, wherein the plate is manufactured using additive manufacturing.

Abstract: A receptacle for containers has a rigid frame with a frame plate with a closed periphery and several recesses for receiving the containers. The frame has a closed circumferential collar extending from the periphery of the frame plate. The receptacle has a rigid cover that is fixed to the frame. The cover has a cover plate with a closed periphery with several through holes that are aligned with the recesses of the frame. The cover also has a closed circumferential collar extending from the periphery of the cover plate fitting the frame collar. A free space is provided between the frame plate and the cover plate in which the containers can be arranged so that each container is accessible from the outside.

Abstract: Systems and methods for modeling anatomical changes in a patient after installation of a patient-specific implant are disclosed. The system can model changes to a thoracic spine based on changes to the lumbar spine in a patient. The system can calculate and display reciprocal changes to nearby anatomy due to correction of index anatomy. For example, the system models the anatomical changes to the thoracic and cervical spines based on corrections to the lumbar spine.

Abstract: Systems and methods for designing patient-specific medical devices are described herein. In some embodiments, a method includes obtaining patient data that includes image data and kinematic data of a patient's spine. A virtual model of the patient's spine is generated and can be manipulated until a target anatomical configuration is achieved. A patient-specific implant can then be designed based at least in part on the target anatomical configuration and the kinematics such that, when the patient-specific implant is implanted in the patient, the patient-specific implant provides the target anatomical correction while maintaining or improving the kinematics of the patient's spine.

Abstract: A computer-implemented method for designing a patient-specific orthopedic implant can include creating a user account associated with a patient. A patient-specific orthopedic implant can be designed based on patient data and imaging data. A healthcare provider can provide feedback for a design of the patient-specific orthopedic implant, treatment protocol, or other aspects of treatment. The patient can provide data and feedback.

Abstract: A patient-specific jig for confirming a correct contour of a fixation element in an operative setting, the patient-specific jig including a jig body having a top end and a bottom end provided at opposite ends of a longitudinal axis of the jig body, and an inner contour guide disposed in a front surface of the jig body, the inner contour guide having a shaped cross-section and being shaped in a contoured curve along the longitudinal axis of the jig body, wherein the contoured curve conforms to a set of patient-specific geometric parameters.

Abstract: Provided is a composition comprising: (a)a principal phase that is provided by a layered mixed metal oxide having a rocksalt structure belonging to the R-3m space group; the layered mixed metal oxide comprising the following component elements: 45 to 55 atomic % lithium; 20 to 55 atomic % of one or more transition metals selected from the group consisting of chromium, manganese, iron, nickel, cobalt, and combinations thereof; and 0 to 25 atomic % of one or more additional dopant elements selected from the group consisting of: magnesium, calcium, strontium, titanium, zirconium, vanadium, copper, ruthenium, zinc, molybdenum, boron, aluminium, gallium, tin, lead, bismuth, lanthanum, cerium, gadolinium and europium; wherein said atomic % is expressed as a % of total atoms of said layered oxide, excluding oxygen; (b)a minor phase that is provided by a metal oxide that does not have the crystal structure of the layered mixed metal oxide, the minor phase comprising one or more of the transition metals contained in t

Abstract: Persistent storage contains a parent table and one or more child tables, the parent table containing: a class field specifying types, and one or more filter fields. One or more processors may: receive a first request to read first information of a first type for a first entity; determine that, in a first entry of the parent table for the first entity, the first type is specified in the class field; obtain the first information from a child table associated with the first type; receive a second request to read second information of a second type for a second entity; determine that, in a second entry of the parent table for the second entity, the second type is indicated as present by a filter field that is associated with the second type; and obtain the second information from a set of additional fields in the second entry.

Abstract: The present technology includes systems and methods for generating and implementing patient-specific diagnostic plans. The diagnostic plans include one or more specific diagnostic tests that should be performed on a particular patient based on the patient's demographics and/or health complaints. The diagnostic tests can be selected to determine specific diagnostic information that is expected to be useful in determining patient-specific surgical plans for the particular patient.

Abstract: Disclosed herein are plant messenger packs (PMPs) encapsulating one or more exogenous polypeptides. Also disclosed are methods of producing a PMP comprising an exogenous polypeptide.

Abstract: Disclosed are conjugates including a recognition element covalently bonded to or linked through a linker to a payload. The payload is a pharmaceutical agent (e.g., an antineoplastic agent, anti-infective agent, or anti-inflammatory agent) or a diagnostic agent. Also disclosed are methods of using the conjugates.

Abstract: A system and computer-implemented method for manufacturing an orthopedic implant involves segmenting features in an image of anatomy. Anatomic elements can be isolated. Spatial relationships between the isolated anatomic elements can be manipulated. Negative space between anatomic elements is mapped before and/or after manipulating the spatial relationships. At least a portion of the negative space can be filled with a virtual implant. The virtual implant can be used to design and manufacture a physical implant.

Abstract: Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. In some embodiments, a method includes receiving a patient data set of a patient. The patient data set is compared to a plurality of reference patient data sets, wherein each of the plurality of reference patient data sets is associated with a corresponding reference patient. A subset of the plurality of reference patient data sets is selected based, at least partly, on similarity to the patient data set and treatment outcome of the corresponding reference patient. Based on the selected subset, at least one surgical procedure or medical device design for treating the patient is generated.