Abstract: A system and computer-implemented method for manufacturing an orthopedic implant involves segmenting features in an image of anatomy. Anatomic elements can be isolated. Spatial relationships between the isolated anatomic elements can be manipulated. Negative space between anatomic elements is mapped before and/or after manipulating the spatial relationships. At least a portion of the negative space can be filled with a virtual implant. The virtual implant can be used to design and manufacture a physical implant.

Abstract: Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. In some embodiments, a method includes receiving a patient data set of a patient. The patient data set is compared to a plurality of reference patient data sets, wherein each of the plurality of reference patient data sets is associated with a corresponding reference patient. A subset of the plurality of reference patient data sets is selected based, at least partly, on similarity to the patient data set and treatment outcome of the corresponding reference patient. Based on the selected subset, at least one surgical procedure or medical device design for treating the patient is generated.

Abstract: Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. In some embodiments, a method includes receiving a patient data set of a patient. The patient data set is compared to a plurality of reference patient data sets, wherein each of the plurality of reference patient data sets is associated with a corresponding reference patient. A subset of the plurality of reference patient data sets is selected based, at least partly, on similarity to the patient data set and treatment outcome of the corresponding reference patient. Based on the selected subset, at least one surgical procedure or medical device design for treating the patient is generated.

Abstract: Systems and methods for storing and accessing healthcare data in blockchain managed digital filing cabinets are disclosed. The system can receive and store patient healthcare data from sources such as wearable devices, an implant, patient devices, healthcare provider devices, databases, cloud storage accounts, healthcare databases, or digital filing cabinets. The system can convert the healthcare into non-fungible tokens on a blockchain to protect the healthcare data from being accessed by nefarious actors. The system can manage access to the healthcare data based on authentication rules.

Abstract: A computer-implemented method for designing a patient-specific orthopedic implant can include creating a user account associated with a patient. A patient-specific orthopedic implant can be designed based on patient data and imaging data. A healthcare provider can provide feedback for a design of the patient-specific orthopedic implant, treatment protocol, or other aspects of treatment. The patient can provide data and feedback.

Abstract: A patient-specific jig for confirming a correct contour of a fixation element in an operative setting, the patient-specific jig including a jig body having a top end and a bottom end provided at opposite ends of a longitudinal axis of the jig body, and an inner contour guide disposed in a front surface of the jig body, the inner contour guide having a shaped cross-section and being shaped in a contoured curve along the longitudinal axis of the jig body, wherein the contoured curve conforms to a set of patient-specific geometric parameters.

Abstract: A computer-implemented method for designing a patient-specific orthopedic implant can include creating a user account associated with a patient. A patient-specific orthopedic implant can be designed based on patient data and imaging data. A healthcare provider can provide feedback for a design of the patient-specific orthopedic implant, treatment protocol, or other aspects of treatment. The patient can provide data and feedback.

Abstract: A personalized fixation system includes a surgical planning software tool configured to adjust relationships of relevant anatomy of a subject, at least one bone anchor, a plate having a shape that does not conform to a single plane, the plate configured to accept the at least one bone anchor, wherein the shape of the plate is at least partially determined by the surgical planning software tool, and wherein the plate includes at least one node having a hole configured to receive the at least one bone anchor, and a locking element configured to connect the at least one bone anchor to the plate, wherein the plate is manufactured using additive manufacturing.

Abstract: Disclosed herein are acylated active agents and methods of their use, e.g., for modulating an autoimmunity marker or for treating an autoimmune disorder.

Abstract: Systems and methods for determining and implementing multi-stage, patient-specific surgical plans are described herein. The multi-stage treatment plans can include a comprehensive overview of specific surgical interventions to be performed over a period of time (e.g., 5 years, 10 years, 20 years, etc.). The surgical interventions can be specifically selected, timed, and sequenced to provide a higher likelihood of achieving favorable patient outcomes and improved quality of life.

Abstract: A laser-sustained broadband light source is disclosed. The light source may include a gas containment structure containing a mixture of a first noble gas and a second noble gas. The light source may include a laser pump source to generate an optical pump to sustain a plasma within the gas containment structure. The first noble gas absorbs broadband light within a first wavelength band and a second wavelength band. The light source may include a filter positioned within the gas containment structure and configured to absorb the broadband light emitted by the plasma having a wavelength below a selected wavelength threshold. The absorption of broadband light by the first noble gas and the filter provide long-pass filtering of broadband light below the selected wavelength to protect one or more downstream optical elements from damage.

Abstract: Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. In some embodiments, a method includes receiving intra-operative data during a surgical procedure to install a patient-specific implant in a patient. The system can compare the intra-operative data to a pre-operative plan to determine whether the implant is positioned and located according to the pre-operative plan.

Abstract: Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. An example method includes obtaining a first multi-dimensional image data of an anatomical region of a patient in a first loading state; determining, from the first multi-dimensional image data, regions corresponding to anatomical elements of a spine; identifying, in each region, a first set of landmarks; obtaining a second multi-dimensional image data of the anatomical region comprising the spine of the patient in a second loading state; identifying a second set of landmarks from the second multi-dimensional image data that map to the first set of landmarks; obtaining an aligned multi-dimensional image data of the patient's spine; generating a design for a medical implant based on spinopelvic parameters measured from the aligned multi-dimensional image data; and causing a medical implant to be manufactured by sending the design for the medical implant to a manufacturing device.

Abstract: Systems and methods for modeling anatomical changes in a patient after installation of a patient-specific implant are disclosed. The system can model changes to a thoracic spine based on changes to the lumbar spine in a patient. The system can calculate and display reciprocal changes to nearby anatomy due to correction of index anatomy. For example, the system models the anatomical changes to the thoracic and cervical spines based on corrections to the lumbar spine.

Abstract: Systems and methods for identifying edge case pathologies for inspection in a patient-specific orthopedic implant procedure are disclosed. A system can analyze patient data, such as implant data, pre-operative data, post-operative data, or implant manufactured data to identify edge case pathologies in the patient data that can affect installing an implant in the patient. Based on the type of edge case pathology, the system sends a notification for a human, such as a healthcare provider, to review the patient data prior to installing the patient-specific orthopedic implant in the patient.

Abstract: A medical implant can comprise a physical structure configured to secure the medical implant within a body of a patient, a proximity communication component physically coupled to the physical structure, and a memory operatively coupled to the proximity communication component. The memory can store a private key, wherein the memory is configured to provide the private key through the proximity communication component to an external device for enabling the external device to access one or more electronic medical records associated with a patient that is implanted with the implant from a distributed blockchain ledger of electronic medical records.

Abstract: Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. In some embodiments, a method includes receiving a patient data set of a patient. The patient data set is compared to a plurality of reference patient data sets, wherein each of the plurality of reference patient data sets is associated with a corresponding reference patient. A subset of the plurality of reference patient data sets is selected based, at least partly, on similarity to the patient data set and treatment outcome of the corresponding reference patient. Based on the selected subset, at least one surgical procedure or medical device design for treating the patient is generated.

Abstract: Disclosed are conjugates including a recognition element covalently bonded to or linked through a linker to a payload. The payload is a pharmaceutical agent (e.g., an antineoplastic agent, anti-infective agent, or anti-inflammatory agent) or a diagnostic agent. Also disclosed are methods of using the conjugates.

Abstract: Systems and methods for storing and accessing healthcare data in blockchain managed digital filing cabinets are disclosed. The system can receive and store patient healthcare data from sources such as wearable devices, an implant, patient devices, healthcare provider devices, databases, cloud storage accounts, healthcare databases, or digital filing cabinets. The system can convert the healthcare into non-fungible tokens on a blockchain to protect the healthcare data from being accessed by nefarious actors. The system can manage access to the healthcare data based on authentication rules.

Abstract: Data indicative of one or more user inputs directed to a user interface of a conversation designer tool is received. A conversation design is determined based on the data. The conversation design enables a conversation bot to provide a service using a conversation flow specified at least in part by the conversation design. The conversation design specifies in a first human language at least a portion of a message content to be provided by the conversation bot during an execution of the conversation flow. It is identified that an end-user of the conversation bot prefers to converse in a second human language different from the first human language. The message content of the conversation design in the first human language is dynamically translated for the end-user to the second human language.