Abstract: Systems and methods for verifying the quality of patient specific implants are disclosed. A system can generate implant data, such as design files or fabrication instructions, for manufacturing the implant. The system can manage access to the implant data based on authentication levels. Based on the determined authentication level of the user requesting access to the implant data, the system can permit the user to access some or all of the implant data. The system can perform a quality check on a manufactured implant by scanning the manufactured implant to identify any errors in the manufactured implant.

Abstract: Systems and methods for reviewing and analyzing proposed patient-specific surgical plans are described herein. In some embodiments, a surgical plan review program provides a user-friendly interface for a surgeon to review various aspects of a proposed surgical plan. The program enables the surgeon to approve the surgical plan and/or provide feedback on the surgical plan to prompt revisions to the surgical plan.

Abstract: Systems and methods for storing and accessing healthcare data in blockchain managed digital filing cabinets are disclosed. The system can receive and store patient healthcare data from sources such as wearable devices, an implant, patient devices, healthcare provider devices, databases, cloud storage accounts, healthcare databases, or digital filing cabinets. The system can convert the healthcare into non-fungible tokens on a blockchain to protect the healthcare data from being accessed by nefarious actors. The system can manage access to the healthcare data based on authentication rules.

Abstract: The disclosure relates to improvements in methods for efficient editing of two or more endogenous tomato genes by insertion of one or more single stranded DNA donor molecules that are not homologous to the insertion sites in the tomato genome.

Abstract: Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. In some embodiments, a method includes receiving a patient data set of a patient. The patient data set is compared to a plurality of reference patient data sets, wherein each of the plurality of reference patient data sets is associated with a corresponding reference patient. A subset of the plurality of reference patient data sets is selected based, at least partly, on similarity to the patient data set and treatment outcome of the corresponding reference patient. Based on the selected subset, at least one surgical procedure or medical device design for treating the patient is generated.

Abstract: Systems and methods for planning and implementing medical procedures and/or devices are disclosed. For example, many embodiments include generating multiple patient-specific surgical plans, with each of the multiple patient-specific surgical plans providing a different recommended treatment protocol for a patient. Each patient-specific surgical plan can also provide predicted post-operative data associated with the treatment protocol.

Abstract: A conversation design is received for a conversation bot that enables the conversation bot to provide a service using a conversation flow specified at least in part by the conversation design. The conversation design specifies in a first human language at least a portion of a message content to be provided by the conversation bot. It is identified that an end-user of the conversation bot prefers to converse in a second human language different from the first human language. In response to a determination that the message content is to be provided by the conversation bot to the end-user, the message content of the conversation design is dynamically translated for the end-user from the first human language to the second human language. The translated message content is provided to the end-user in a message from the conversation bot.

Abstract: A system and computer-implemented method for manufacturing an orthopedic implant involves segmenting features in an image of anatomy. Anatomic elements can be isolated. Spatial relationships between the isolated anatomic elements can be manipulated. Negative space between anatomic elements is mapped before and/or after manipulating the spatial relationships. At least a portion of the negative space can be filled with a virtual implant. The virtual implant can be used to design and manufacture a physical implant.

Abstract: Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. In some embodiments, a method includes receiving a patient data set of a patient. The patient data set is compared to a plurality of reference patient data sets, wherein each of the plurality of reference patient data sets is associated with a corresponding reference patient. A subset of the plurality of reference patient data sets is selected based, at least partly, on similarity to the patient data set and treatment outcome of the corresponding reference patient. Based on the selected subset, at least one surgical procedure or medical device design for treating the patient is generated.

Abstract: Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. In some embodiments, a method includes receiving a patient data set of a patient. The patient data set is compared to a plurality of reference patient data sets, wherein each of the plurality of reference patient data sets is associated with a corresponding reference patient. A subset of the plurality of reference patient data sets is selected based, at least partly, on similarity to the patient data set and treatment outcome of the corresponding reference patient. Based on the selected subset, at least one surgical procedure or medical device design for treating the patient is generated.

Abstract: Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.

Abstract: Systems and methods for verifying the quality of patient specific implants are disclosed. A system can generate implant data, such as design files or fabrication instructions, for manufacturing the implant. The system can manage access to the implant data based on authentication levels. Based on the determined authentication level of the user requesting access to the implant data, the system can permit the user to access some or all of the implant data. The system can perform a quality check on a manufactured implant by scanning the manufactured implant to identify any errors in the manufactured implant.

Abstract: Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. An example method includes obtaining, first multi-dimensional image data of an anatomical region of a patient in a first loading state; determining, from the first multi-dimensional image data, regions corresponding to anatomic elements of a spine; identifying, in each region, a first set landmarks; obtaining, a second multi-dimensional image data of the anatomical region comprising the spine of the patient in a second loading state; identifying a second set of landmarks from the second multi-dimensional image data that map to the first set of landmarks; obtaining an aligned multi-dimensional image data of the patient's spine; generating a design for a medical implant based on spinopelvic parameters measured from the aligned multi-dimensional image data; and causing a medical implant to be manufactured by sending the design for the medical implement to a manufacturing device.

Abstract: The disclosure relates to gene edited wheat plants, seeds, and compositions, as well as improvements to wheat plant breeding and methods for creating modifications in wheat plant genomes.

Abstract: Systems and methods for providing patient-specific medical devices and patient-specific surgical plans are described herein. In some embodiments, a patient-specific implant is provided that includes an implant body configured to interface with one or more identified anatomical structures at and/or proximate a target position. The patient-specific implant also includes a data storage element positioned on and/or within the implant body. The data storage element can include memory storing data that is accessible after the patient-specific implant is implanted in the patient. The data can include (i) first data specifying at least one step of a patient-specific surgical plan for implanting the patient-specific implant at the target position, and (ii) second data specifying one or more characteristics of the patient-specific implant.

Abstract: Systems and methods for storing and accessing healthcare data in digital filing cabinets are disclosed. The system can receive and store patient healthcare data from sources and manage access to the healthcare data based on authentication levels. The system can analyze healthcare data collected from wearable devices, an implant, patient devices, healthcare provider devices, databases, cloud storage accounts, healthcare databases, or digital filing cabinets. The system can manage patient healthcare data by collecting and analyzing patient healthcare data and generating health goals for the patient based on the healthcare data. The system can generate viewable versions of the healthcare data for the patient to view on a user interface.

Abstract: The invention relates to novel soybean plants, seeds and compositions, as well as improvements to plant breeding and methods for creating modifications in plant genomes.

Abstract: Systems and methods for storing and accessing healthcare data in blockchain managed digital filing cabinets are disclosed. The system can receive and store patient healthcare data from sources such as wearable devices, an implant, patient devices, healthcare provider devices, databases, cloud storage accounts, healthcare databases, or digital filing cabinets. The system can convert the healthcare into non-fungible tokens on a blockchain to protect the healthcare data from being accessed by nefarious actors. The system can manage access to the healthcare data based on authentication rules.

Abstract: A system and computer-implemented method for manufacturing an orthopedic implant involves segmenting features in an image of anatomy. Anatomic elements can be isolated. Spatial relationships between the isolated anatomic elements can be manipulated. Negative space between anatomic elements is mapped before and/or after manipulating the spatial relationships. At least a portion of the negative space can be filled with a virtual implant. The virtual implant can be used to design and manufacture a physical implant.