Abstract: Embodiments include methods of managing network slices in a communications network by a domain manager of a Radio Access Network (RAN). Such methods include determining a change in cell composition of the RAN and determining neighbor cells within the RAN affected by the change in cell composition of the RAN. Such methods also include determining a set of RAN resource partitions affected by the change in cell composition of the RAN and adapting the configuration of RAN resource partitions of the set of RAN resource partitions by introducing changes corresponding to the change in cell composition of the RAN. Embodiments also include domain manager apparatus configured to perform operations corresponding to such methods.

Abstract: A network node in a telecommunications network stores information defining at least one network slice. For at least one defined network slice, information is stored identifying a plurality of cells that define at least a part of a boundary of a coverage area of the network slice. The operation of a cell is then adapted depending on whether or not the cell defines at least a part of the boundary of the coverage area of the network slice.

Abstract: Devices, systems, and methods for planning radiosurgical treatments for neuromodulating a portion of the renovascular system may be used to plan radiosurgical neuromodulation treatments for conditions or disease associated with elevated central sympathetic drive. The renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as preganglionic positions. Target regions include the renal plexus, celiac ganglion, the superior mesenteric ganglion, the aorticorenal ganglion and the aortic plexus. Planning of radiosurgical treatments will optionally employ a graphical representation of a blood/tissue interface adjacent these targets.

Abstract: A radiation treatment planning system includes a computing device; and an interface for a user to communicate with the computing device and plan delivery of at least one radiation beam, wherein the computing device is configured to: acquire a calculated position of each of the at least one radiation beam required to treat a target tissue in a patient, wherein each of the positions is a function of a phase of a physiological cycle of the patient; determine dosages in the target tissue to be irradiated, wherein timing of some or all of the at least one radiation beam is based on the phase of the physiological cycle of the patient.

Abstract: Devices, systems, and methods for planning radiosurgical treatments for neuromodulating a portion of the renovascular system may be used to plan radiosurgical neuromodulation treatments for conditions or disease associated with elevated central sympathetic drive. The renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as preganglionic positions. Target regions include the renal plexus, celiac ganglion, the superior mesenteric ganglion, the aorticorenal ganglion and the aortic plexus. Planning of radiosurgical treatments will optionally employ a graphical representation of a blood/tissue interface adjacent these targets.

Abstract: In one example aspect, a method performed by a network node for configuring a network slice is provided, the method comprising, in response to a request to configure a network slice, configuring network resources for providing the network slice, and configuring a state of the network slice to a first state, wherein in the first state the network slice is disabled.

Abstract: Methods and systems are disclosed for radiating a moving object. The method may comprise acquiring a plurality of indicators of the phase of a physiological cycle of a patient and a plurality of images of the patient that include a target. Each image may be taken at a different phase of the physiological cycle and may be registered to the phase at which the image was taken. The method may also include identifying the target in each of the plurality of images, calculating a dose of radiation required to treat the target, calculating the number, orientation, and dwell time of one or more radiation beams required to deliver the calculated required dose of radiation to the target, and calculating a position of each of the one or more radiation beams required to achieve the calculated orientation. Each position may be a function of the phase of the physiological cycle to which each of the plurality of images is registered.

Abstract: A machine learning system for evaluating at least one characteristic of myocardial tissue and its ablation or subset thereof, which includes a training mode and a production mode. The training mode is configured to train, assess and guide a computer and construct a transformation function to predict an anatomical, physiologic, electric, metabolomic, or genetic manifestation leading to alterations, including ablation, that predict and unknown structural or functional characteristic of myocardial tissue and a subsequent aberration that results in abnormal electrical signal and subsequently results in abnormal heart function. The production mode is programmed to use any transformational function to predict the unknown electroanatomic and metabolic characteristic that result in arrhythmia and abnormal myocardial function and guide subsequent ablation and elimination of arrhythmogenic foci.

Abstract: In one example aspect, a method of handover is provided. The method comprises determining a first handover candidate list for a first user equipment (UE). The first UE is connected to a first cell and is associated with a first network slice. In response to a determination that the first handover candidate list indicates no valid candidate target cells for handover of the first UE, the method comprises determining a second handover candidate list for a second UE, wherein the second UE is connected to the first cell, and causing the second UE to handover to a second cell indicated in the second handover candidate list.

Abstract: A method performed by a first network function. The method comprises receiving from a second network function a first message indicating that a core network needs to signal with a wireless device in delivering a service to said wireless device. The service is delivered via a network slice. The method also comprises determining an identifier of the network slice associated with the service and determining a connection management state, CM-state, of the wireless device. Further, the method comprises sending a second message in response to said first message, wherein said second message is based on said CM-state and said identifier of the network slice associated with the service.

Abstract: Methods (700,800,900), devices (12,20,30,40), and systems (500,540,560,570,600) for managing a federated network slice (602) providing an extension of one or more virtual network functions (620) from a first network domain (502,608) to a second network domain (504,610). One method (700), by a second orchestration manager (20,512) of the second network domain (504,610), includes accessing (702) a first virtual network function management component (514,562) for extension of the one or more virtual network functions (620) from the first network domain (502,608) to the second network domain (504,610). The method (700) further includes initiating registration (704) of the first virtual network function management component (514,562) with a look-up service (518) to generate a first association between a first name of the first virtual network function management component and a first location of the first virtual network function management component in the second network domain (504,610).

Abstract: A network node in a cellular communication network maintains a record of border cells of network slices. A change in the cells active in the network is then determined. The record of border cells of network slices is then updated based on said change in the cells active in the network.

Abstract: A domain manager (320) of a Radio Access Network, RAN, determines a configuration of a RAN resource partition of a network slice. The configuration defines which network elements of the RAN are assigned to the RAN resource partition of the network slice. The domain manager (320) receives at least one report (407, 408, 409) indicating, for at least one of the network elements assigned to the RAN resource partition, an amount of traffic of the network slice handled by the network element in an observation time window. Based on the at least one report (407, 408, 409), the domain manager (320) adapts the configuration of the RAN resource partition by removing one or more of the network elements from the RAN resource partition.

Abstract: Methods of treating a subject suffering from a brain tumor are described herein wherein said methods comprise administering a therapeutically effective amount of a crystalline polymorph of 1,6-dibromo-1,6-dideoxy-dulcitol (DBD) including combination therapies with synergistic second cancer treatments. Also disclosed are methods of screening subjects sensitive to a crystalline DBD polymorph and treating those subjects demonstrating sensitivity.

Abstract: Methods and systems are disclosed for radiating a moving object. The method may comprise acquiring a plurality of indicators of the phase of a physiological cycle of a patient and a plurality of images of the patient that include a target. Each image may be taken at a different phase of the physiological cycle and may be registered to the phase at which the image was taken. The method may also include identifying the target in each of the plurality of images, calculating a dose of radiation required to treat the target, calculating the number, orientation, and dwell time of one or more radiation beams required to deliver the calculated required dose of radiation to the target, and calculating a position of each of the one or more radiation beams required to achieve the calculated orientation. Each position may be a function of the phase of the physiological cycle to which each of the plurality of images is registered.

Abstract: A method in a domain manager for managing a wireless communications network operating at least one network slice. A network slice comprises a logically grouped subset of network resources and/or network functions. The method comprises populating (202) a first Information Object Class instance representing the network slice, adding (204) the populated first Information Object Class instance to a generic Network Resource Model and exposing (206) the modified generic Network Resource Model.

Abstract: Methods and systems are disclosed for radiating a moving object. The method may comprise acquiring a plurality of indicators of the phase of a physiological cycle of a patient and a plurality of images of the patient that include a target. Each image may be taken at a different phase of the physiological cycle and may be registered to the phase at which the image was taken. The method may also include identifying the target in each of the plurality of images, calculating a dose of radiation required to treat the target, calculating the number, orientation, and dwell time of one or more radiation beams required to deliver the calculated required dose of radiation to the target, and calculating a position of each of the one or more radiation beams required to achieve the calculated orientation. Each position may be a function of the phase of the physiological cycle to which each of the plurality of images is registered.

Abstract: A network node in a telecommunications network stores information defining at least one network slice. For at least one defined network slice, information is stored identifying a plurality of cells that define at least a part of a boundary of a coverage area of the network slice. The operation of a cell is then adapted depending on whether or not the cell defines at least a part of the boundary of the coverage area of the network slice.

Abstract: Devices, systems, and methods for planning radiosurgical treatments for neuromodulating a portion of the renovascular system may be used to plan radiosurgical neuromodulation treatments for conditions or disease associated with elevated central sympathetic drive. The renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as preganglionic positions. Target regions include the renal plexus, celiac ganglion, the superior mesenteric ganglion, the aorticorenal ganglion and the aortic plexus. Planning of radiosurgical treatments will optionally employ a graphical representation of a blood/tissue interface adjacent these targets.

Abstract: A system that generates a three-dimensional model of a tissue surface, for example the inner surface of the heart from two-dimensional image data slices. On this surface, one or more pattern lines are drawn, e.g., by a physician using a user interface, to designate desired lesion(s) on the surface. From the pattern lines, a three-dimensional volume for a lesion can be determined using known constraints. Advantageously, the series of boundaries generated by the three-dimensional volume may be projected back onto the individual CT scans, which then may be transferred to a standard radiosurgical planning tool. A dose cloud may also be projected on the model to aid in evaluating a plan.