Abstract: Expansion and movement joints are disclosed. An example apparatus includes a collar having a first aperture extending therethrough to receive a conduit, and a guide to receive the collar, where the guide has a second aperture that defines an inner surface of the guide, and where the inner surface of the guide is larger than an outer surface of the collar to define a gap therebetween.

Abstract: According to various embodiments, an optoelectronic computer architecture is described herein for use as a convolutional neural network. The optoelectronic computer architecture includes a four-focal length (4F) optical subsystem that utilizes metasurfaces and lenses in conjunction with a digital electronic subsystem. Digital-to-analog converters and analog-to-digital converters are used to interface the optical subsystem and the digital subsystem. Various 4F lens and metasurface configurations are described herein, including various folded 4F lens configurations.

Abstract: The present invention relates to fluid pump assemblies in general, and in exemplary embodiments to fluid pump assemblies that are magnetically supported in position, and to related kits and methods useful to circulate water in aquariums. The fluid pump assembly comprises an outer mount, an inner mount, and a pump. The outer mount includes at least one outer permanent magnet; the inner mount includes at least one inner permanent magnet; and the pump includes at least one soft magnetic material. The outer permanent magnet, the inner permanent magnet, and the soft magnetic material collectively form a magnetic circuit.

Abstract: A lighting unit for illuminating a habitat is provided. The lighting unit includes a housing and a light emitter. The operating parameters of the lighting unit may be adjusted to mimic different natural conditions.

Abstract: The present invention relates to nucleic acid constructs comprising methyl CpG binding protein 2 (MeCP2) promoter sequences. The present invention further relates to vectors, viral vector host cells and pharmaceutical compositions comprising said nucleic acid constructs. The present invention also concerns the therapeutic use of said nucleic acid constructs, vectors, viral vectors and pharmaceutical compositions.

Abstract: A host device has a hardware-based remote control mode and a softwarebased remote control mode. The availability of each of the hardware- and software-based remote control modes is monitored. Client device remote control of the host device is selectively switched between the hardware- and softwarebased remote control modes, based on the monitored availability of each remote control mode.

Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

Abstract: A solar roof of a building includes a plurality of solar panels removably coupled to a roof of the building such that a first solar panel of the plurality of solar panels is configured to be removed from the roof without removing an adjacent solar panel.

Abstract: The present invention relates to fluid pump assemblies in general, and in exemplary embodiments to fluid pump assemblies that are magnetically supported in position, and to related kits and methods useful to circulate water in aquariums. The fluid pump assembly comprises an outer mount, an inner mount, and a pump. The outer mount includes at least one outer permanent magnet; the inner mount includes at least one inner permanent magnet; and the pump includes at least one soft magnetic material. The outer permanent magnet, the inner permanent magnet, and the soft magnetic material collectively form a magnetic circuit.

Abstract: A laser printhead assembly for a laser printhead is disclosed herein. The laser printhead assembly may include a laser containment door; and a laser containment housing that is configured to form a sealed enclosure with a label support of a label. The sealed enclosure may be configured to include the label and the laser printhead. The laser containment door, in a laser-enabled position, may be configured to permit the laser printhead, via a light beam, to modify the label and the laser containment door, in a laserdisabled position, may be configured to prevent a light beam from escaping the laser containment housing.

Abstract: The invention can provide compounds, analogs of blebbistatin, effective and selective inhibitors of nonmuscle myosin II relative to cardiac myosin II.

Abstract: In some embodiments, the system is directed to an autonomous inspection system for electrical grid components. In some embodiments, the system collects electrical grid component data using an autonomous drone and then transmits the inspection data to one or more computers. In some embodiments, the system includes artificial intelligence that analysis the data and identifies electrical grid components defects and provides a model highlighting the defects to a user. In some embodiments, the system enables a user to train the artificial intelligence by providing feedback for models where defects or components are not properly identified.

Abstract: The invention relates to new quinoline, pyridopyrazine, naphthyridine and quinazolinone derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: A foot spa tub includes a tub basin, a first magnetic drive member rotatably coupled to a drive motor, and a first casing supporting the magnetic drive member. The first casing is disposed against an exterior surface of a sidewall of the basin. A second magnetic drive member is rotatably coupled to a blade. The first and second magnetic drive members are magnetically coupled to each other so that the blade is drivingly coupled to the drive motor. A nozzle houses the second magnetic drive member and the blade. The nozzle is detachably securable to an interior surface of the sidewall by a magnetic attraction force between the first and second magnetic drive members. A method of circulating liquid in a foot tub spa is also provided.

Abstract: A method for providing an interactive interface for live event outcome selection and prediction may include generating a set of cells for an event. The set of cells may be provided to a client device to present in a user interface. A selection of a cell may be received from the client device. The selected cell may be assigned to a user account. The method may generate a coordinate for each cell in the set, wherein each cell coordinate includes a plurality of dimensions, each dimension corresponding to a different entity of the event, and wherein each cell coordinate is unique for the set of cells. The method may comprise calculating, prior to the start of the event, a probability that an event result represented by a cell coordinate will occur; and presenting the probability in association with the cell on the user interface. Other embodiments are described and claimed.

Abstract: Systems and methods for determining structural variation and phasing using variant call data obtained from nucleic acid of a biological sample are provided. Sequence reads are obtained, each comprising a portion corresponding to a subset of the test nucleic acid and a portion encoding a barcode independent of the sequencing data. Bin information is obtained. Each bin represents a different portion of the sample nucleic acid. Each bin corresponds to a set of sequence reads in a plurality of sets of sequence reads formed from the sequence reads such that each sequence read in a respective set of sequence reads corresponds to a subset of the nucleic acid represented by the bin corresponding to the respective set. Binomial tests identify bin pairs having more sequence reads with the same barcode in common than expected by chance. Probabilistic models determine structural variation likelihood from the sequence reads of these bin pairs.

Abstract: Described are computer-implemented methods, systems, and media for de novo phased diploid assembly of nucleic acid sequence data generated from a nucleic acid sample of an individual utilizing nucleic acid tags to preserve long-range sequence context for the individual such that a subset of short-read sequence data derived from a common starting sequence shares a common tag. The phased diploid assembly is achieved without alignment to a reference sequence derived from organisms other than the individual. The methods, systems, and media described are computer-resource efficient, allowing scale-up.

Abstract: A method of optimizing computer-implemented building design, includes the following: defining one or more options for each building component; providing an energy use intensity versus cost optimization value for each option for a plurality of metrics; selecting a subset of the plurality of metrics applicable to each option; defining a metric vector for each metric through connecting the energy use intensity versus cost optimization value for each option; arranging each metric vector on a coordinate grid with an equal angle between each metric vector; constructing a two-dimensional polygon on an XY-plane by interconnecting for all the metric vectors the energy use intensity versus cost optimization value for each option; providing a performance value for each option for each metric vector based on a percentage the metric vector the associated option represents; and representing a fitness factor for each option as a function of each of the plurality of metrics.

Abstract: Systems and methods for analyzing first and second strings against a ground truth string are provided. A construct representing a plurality of components is obtained, each component for a different portion of the truth string. The construct comprises a plurality of measurement string sampling pools each having an identifier and a corresponding plurality of measurement samplings corresponding to one or two of the components. Each sampling has the identifier and a portion of the first or second string. Samplings are assigned to first, second or third classes when coding a portion of the first string, second string, or both the first and second string. First and second positions are tested for sequence events by calculating a plurality of sequence event models using assumptions on the components having samplings encompassing the first and second positions and class assignments. These assumptions are updated using the calculated models and the models are recalculated.