Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.

Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

Abstract: A method of operating an electronic device including determining an initial charge level at a non-volatile charge storage structure of a radiation-sensitive device including a radiation-reactive material and determining if a first radiation event has occurred based upon the non-volatile charge storage device having a different charge level than the initial charge level. The method further includes identifying the first radiation event as associated with either a first type of radiation or a second type of radiation based upon the different charge level.

Abstract: Immuno-adjuvant photodynamic therapy to treat and prevent metastatic cancer is effected using photosensitizers in combination with immuno-adjuvants to destroy metastatic tumor cells.

Abstract: The present invention is generally directed to powerful and flexible methods and systems for consensus sequence determination from replicate biomolecule sequence data. It is an object of the present invention to improve the accuracy of consensus biomolecule sequence determination from replicate sequence data by providing methods for assimilating replicate sequence into a final consensus sequence more accurately than any one-pass sequence analysis system.

Abstract: A method of operating an electronic device including determining an initial charge level at a non-volatile charge storage structure of a radiation-sensitive device including a radiation-reactive material and determining if a first radiation event has occurred based upon the non-volatile charge storage device having a different charge level than the initial charge level. The method further includes identifying the first radiation event as associated with either a first type of radiation or a second type of radiation based upon the different charge level.

Abstract: A mobile device including a housing, a wireless signal transceiver contained within the housing, and a radiation-detecting structure comprising a charge storage structure contained within the housing to detect radiation.

Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.

Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.

Abstract: The present method involves the photodynamic treatment of acne vulgaris. The method involves the topical administration of a photosensitizer composition comprising hydrophobic green porphyrins such as lemuteporfin, polyethylene glycol and skin penetration enhancers such as oleyl alcohol and TRANSCUTOL™ to acne-affected skin and subsequent exposure of that skin to energy of a wavelength of activating the photosensitizer.

Abstract: An imaging device suitable for detecting certain imaging particles and recording the detection of imaging particles, and as such can include certain recording devices such as a charge storage structure.

Abstract: A dresser for dressing a grind stone including two concentric solid wheel dressing elements. The dressing elements include an abrasive material within a matrix material. The grind stones dressed with the dressers of the invention operate at high removal rates thereby grinding substrates quickly and at low cost. The grind stones dressed with the dressers of the invention also produce favorable mechanical surface characteristics such as low waviness and flatness.

Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.

Abstract: A new coolant for grinding the surface of the substrate of a magnetic recording medium is disclosed. The new coolant maintains the removal rate at about 1 mil/min even after 58 runs after dress. On the other hand, the removal rate using a commercially available coolant drops to less than 0.3 mil/min after only about 35 runs after dress.

Abstract: The present method involves the photodynamic treatment of hyperactive gland disorders. The method involves the topical administration of a photosensitizer composition comprising hydrophobic and/or lipophilic green porphyrins such as lemuteporfin, polyethylene glycol and skin penetration enhancers such as oleyl alcohol and TRANSCUTOL™ to affected skin and subsequent exposure of that skin to energy of a wavelength capable of activating the photosensitizer.

Abstract: A panel provided for use in an air handling unit includes a skin and a fixture, the fixture and the skin composed of a metal material. The fixture has a base, with an opening formed in the base. The base includes at least one riser extending substantially perpendicular to the base, the at least one riser being secured to the skin to form an enclosed chamber between the skin and the fixture. A perforated sheet is disposed over the opening, a layer of film disposed on a surface of the perforated sheet facing the skin. A first insulating material is disposed on a surface of the film layer opposite the perforated sheet. A second insulating material is disposed in the enclosed chamber between the first insulating material and the skin.

Abstract: A new coolant for grinding the surface of the substrate of a magnetic recording medium is disclosed. The new coolant maintains the removal rate at about 1 mil/min even after 58 runs after dress. On the other hand, the removal rate using a commercially available coolant drops to less than 0.3 mil/min after only about 35 runs after dress.

Abstract: To accurately axially position and/or seal between axially facing turbine parts, a groove having a cylindrical cross-section is formed in one surface with a centerline offset toward the one surface, the groove opening through the one surface. Rod segments having corresponding cylindrical cross-sections are inserted in the groove. The rod segments have flat surfaces coextensive therewith projecting a predetermined measured distance from the one surface, thereby accurately axially locating the turbine parts relative to one another and forming a seal therebetween. The rod segments have ends abutting one another to seal the segments one to the other.

Abstract: To accurately axially position and/or seal between axially facing turbine parts, a groove having a cylindrical cross-section is formed in one surface with a centerline offset toward the one surface, the groove opening through the one surface. Rod segments having corresponding cylindrical cross-sections are inserted in the groove. The rod segments have flat surfaces coextensive therewith projecting a predetermined measured distance from the one surface, thereby accurately axially locating the turbine parts relative to one another and forming a seal therebetween. The rod segments have ends abutting one another to seal the segments one to the other.

Abstract: A generator rotor jacking assembly includes a saddle secured to a generator end shield in the place of an outer oil deflector removed from the end shield. A yoke is located above the saddle and underlies the rotor end. Fluid-actuated cylinders are interposed between anvils on the saddle and flanges on the yoke to elevate the rotor end from the bearing, relieving the bearing from the weight of the rotor. A sling is then disposed about the rotor to support the rotor in an elevated position. The lower end shield is then lowered, carrying with it the associated parts for repair and maintenance.