Abstract: The present disclosure provides compositions that enable sustained release of a small molecule tyrosine kinase inhibitor, such as axitinib from a bioerodible polyester polymer implant for the treatment of disease. The composition is especially suitable for treating ophthalmic indications, such as neovascular age related macular degeneration and diabetic macular edema, by intravitreal injection of the implant. The implant is designed to be pre-loaded into a small diameter needle and injected via self-sealing scleral needle penetration at the pars plana. Small molecule tyrosine kinase inhibitors may be released from the implants over a period of one week to three years.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for unmanned aerial vehicle modular command priority determination and filtering system. One of the methods includes enabling control of the UAV by a first control source that provides modular commands to the UAV, each modular command being a command associated with performance of one or more actions by the UAV. Modular commands from a second control source requesting control of the UAV are received. The second control source is determined to be in control of the UAV based on priority information associated with each control source. Control of the UAV is enabled by the second control source, and modular commands are implemented.

Abstract: A pump can include a pump head, a body housing, a motor disposed within the body housing, and a motor shaft extending from the motor. The pump head can include a sensor, at least a first interface portion, and at least a first elongate conductor electrically connecting the sensor to the at least a first interface portion. The body housing can include at least a second interface portion and at least a second elongate conductor electrically connecting the at least a second interface portion to pump electronics. The sensor can be configured to sense when the at least a first interface portion does not contact the at least a second interface portion. When the at least a first interface portion does not contact the at least a second interface portion and the pump head is removed from the body housing, the pump head can be pivotable relative the motor shaft such that an orientation of the pump head can be changed with respect to the body housing.

Abstract: The invention relates to a method of treating a MEK-associated tumor by administering to a subject in need thereof a therapeutically effective amount of a solid form 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: The disclosed system may include a processor configured to detect that a data unit size for an instruction is smaller than a register. The processor may allocate a first portion of the register to the instruction in a manner that leaves a second portion of the register available for allocating to an additional instruction. The processor may also track the register as a split register. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A latch assembly includes a latch body having a longitudinal wall portion extending from a front wall portion to a rear hinge portion, first and second latch members assembled with the longitudinal wall portion and laterally movable between an extended position and a retracted position, and a hinge bracket. The hinge bracket defines a mounting surface and is hingedly attached to the rear hinge portion of the latch body for angular adjustment of the latch body with respect to the mounting surface. When the latch body is oriented at a first angle, first and second mounting apertures in the front wall portion align with first and second mounting apertures in the hinge bracket, such that installation of mounting fasteners through the corresponding first and second mounting apertures of the front wall portion and the hinge bracket secures the latch body at the first angle.

Abstract: Provided is a method for protocol parsing for network security. The method may include receiving, by a packet capture system, a plurality of packets, parsing lower layer data from each packet, and communicating a respective payload of each respective packet to at least one first queue. A routing system may route the respective payload of each respective packet to a respective second queue of a plurality of second queues based on a respective protocol of the respective packet. A respective protocol parser node of a parsing system may parse higher layer data from the respective payload of each respective packet from each respective second queue. The packet capture system may communicate the lower layer data for each packet to a third queue, and the parsing system may communicate the higher layer data for each packet to the third queue. A system and computer program product are also disclosed.

Abstract: Provided herein are populations of anti-CD20 antibody proteins with specified ranges of post-translational modifications. Also provided are methods of using and methods of making such populations of anti-CD20 antibody proteins.

Abstract: Provided herein are populations of anti-CD20 antibody proteins with specified ranges of post-translational modifications. Also provided are methods of using and methods of making such populations of anti-CD20 antibody proteins.

Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A conical inductively coupled plasma (ICP) torch (100) and a method for processing sample particles is disclosed. In this method raw, unprocessed, irregularly shaped sample particles (21) are injected into the conical torch, and pass through the plasma to form molten particles (22) and a spheroidization of the particles finally generates solid, smooth, spherical and dense processed particles (23) once cooled. The conical torch has a torch tube that has a conical section and an injector tube (2) that has a conical end. The conical section of the torch tube and the injector tube form an annular gap through which outer plasma gas is passed through. This conically exiting outer gas flow results in a rapid rise in gas temperatures and a short plasma region that rapidly melts any particles.

Abstract: A gas turbine engine comprises a turbomachine defining a core flow therethrough during operation. A flow tap is provided in fluid communication with the turbomachine, wherein the flow tap is configured to receive a portion of the core flow therethrough as a bleed flow. A bleed assembly includes a machine load, a bleed flow machine, and a bleed regulator. The bleed flow machine is disposed in fluid communication with the turbomachine through the flow tap, and is configured to drive the machine load. The bleed regulator is configured to regulate a bleed output provided to the bleed flow machine by controlling a capture rate of the bleed flow by the bleed flow machine.

Abstract: A method is provided of controlling a cooled cooling air system for an aeronautical gas turbine engine. The method includes: receiving data indicative of an ambient condition of the aeronautical gas turbine engine, data indicative of a deterioration parameter of the aeronautical gas turbine engine, data indicative of an operating condition of the aeronautical gas turbine engine, or a combination thereof; and modifying a cooling capacity of the cooled cooling air system in response to the received data indicative of the ambient condition of the aeronautical gas turbine engine, data indicative of the deterioration parameter of the aeronautical gas turbine engine, data indicative of an operating condition of the aeronautical gas turbine engine, or the combination thereof.

Abstract: A method of calibrating a pump system can include providing a pump, calibrating a pump input with an input device connected to the pump, and calibrating a pump output with an output device connected to the pump. Calibrating the pump input can include selecting a first input signal value, generating a transmitted input signal corresponding to the first input signal value, and setting a nominative pump input value to the first input signal value. Calibrating the pump output can include receiving a received output signal outputted from the pump, and setting a nominative pump output value to the first input signal value.

Abstract: Provided is a method for protocol parsing for network security. The method may include receiving, by a packet capture system, a plurality of packets, parsing lower layer data from each packet, and communicating a respective payload of each respective packet to at least one first queue. A routing system may route the respective payload of each respective packet to a respective second queue of a plurality of second queues based on a respective protocol of the respective packet. A respective protocol parser node of a parsing system may parse higher layer data from the respective payload of each respective packet from each respective second queue. The packet capture system may communicate the lower layer data for each packet to a third queue, and the parsing system may communicate the higher layer data for each packet to the third queue. A system and computer program product are also disclosed.

Abstract: A gas turbine engine includes a turbomachine defining a core flow therethrough during operation. A first flow tap is configured to receive a first bleed flow from upstream of the combustion section. A second flow tap is configured to receive a second bleed flow from downstream of the combustion section. A first flow outlet is provided in fluid communication with the first flow tap and a second flow outlet is provided in fluid communication with the second flow tap. The first flow outlet and the second flow outlet are configured to direct the first bleed flow and the second bleed flow to at least one aircraft flow assembly.

Abstract: A gas turbine engine comprises a turbomachine defining a core flow therethrough during operation. A flow tap is provided in fluid communication with the turbomachine, wherein the flow tap is configured to receive a portion of the core flow therethrough as a bleed flow. A bleed assembly includes a machine load, a bleed flow machine, and a bleed regulator. The bleed flow machine is disposed in fluid communication with the turbomachine through the flow tap, and is configured to drive the machine load. The bleed regulator is configured to regulate a bleed output provided to the bleed flow machine by controlling a capture rate of the bleed flow by the bleed flow machine.

Abstract: A gas turbine engine may include a turbomachine defining a core flow having a core mass flow rate therethrough during operation. A bleed assembly is provided to include a bleed flow machine and a machine load. The bleed flow machine is provided in fluid communication with the compressor section of the turbomachine and configured to drive the machine load. A machine outlet in fluid communication with the bleed assembly provides a bleed flow therethrough during operation of the gas turbine engine, the bleed flow defining a bleed mass flow rate. A compressor section of the turbomachine is configured to provide the bleed flow through the bleed flow machine and the machine outlet to an aircraft flow assembly, wherein the bleed mass flow rate is at least twelve percent (12%) of the core mass flow rate.

Abstract: A gas turbine engine includes a turbomachine, the turbomachine defining a core flow therethrough during operation. A first heat exchange assembly is in fluid communication with the turbomachine for receiving a first bleed flow from the turbomachine. A second heat exchange assembly is in fluid communication with the turbomachine for receiving a second bleed flow from the turbomachine. A first flow outlet is provided for receiving the first bleed flow from the first heat exchange assembly and providing the first bleed flow to a first aircraft flow assembly. A second flow outlet is provided for receiving the second bleed flow and providing the second bleed flow from the second heat exchange assembly to a second aircraft flow assembly.