Abstract: Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.

Abstract: Provided herein is a compound of the Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7 and L are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors.

Abstract: An illustrative example fuel cell assembly includes a plurality of fuel cells arranged in a stack including a first end fuel cell near a first end of the stack and a second end fuel cell near a second end of the stack. Each of the fuel cells includes a matrix containing an electrolyte, an anode and a cathode on opposite sides of the matrix, and respective flow fields adjacent the anode and the cathode. An electrolyte supply associated with the anode flow field of the first end fuel cell includes a porous material containing electrolyte. An electrolyte collector associated with the cathode flow field of the second end fuel cell includes a porous material configured to collect electrolyte from at least the cathode of the second end fuel cell.

Abstract: A medical marking device can produce visible temporary marks, including at least one of indentations or colorations, in a specified pattern on skin or tissue of a patient. The marking device can include a body, such as a cap, that can removably attach over an end of a surgical marker. The body can include marking features, such as blades, optionally positioned at a longitudinal end of the body. The marking features can be pressed against the skin or tissue of the patient to form the visible temporary marks. The marking features can optionally be inked, optionally by the surgical marker, before the marks are formed. The marking features can optionally be distributed between a first subset, positioned generally along a line, and a second subset, positioned asymmetrically with respect to the line. An optional inclinometer can attach to the body to allow alignment to a horizontal direction.

Abstract: The present invention relates to a communication system operative to provide a user interface for selecting content from at least a first content domain and a second different content domain, configured to drive a display device to display one or more content item identifiers (184) identifying content items of said first content domain and content item identifiers (192) identifying one or more content items of said second content domain in a common display arrangement (180). The invention also relates to an apparatus and method.

Abstract: A method is provided of controlling a cooled cooling air system for an aeronautical gas turbine engine. The method includes: receiving data indicative of an ambient condition of the aeronautical gas turbine engine, data indicative of a deterioration parameter of the aeronautical gas turbine engine, data indicative of an operating condition of the aeronautical gas turbine engine, or a combination thereof; and modifying a cooling capacity of the cooled cooling air system in response to the received data indicative of the ambient condition of the aeronautical gas turbine engine, data indicative of the deterioration parameter of the aeronautical gas turbine engine, data indicative of an operating condition of the aeronautical gas turbine engine, or the combination thereof.

Abstract: A system of creating a simulation to simulate behavior of an autonomous vehicle includes a simulation system having an electronic device and a computer-readable storage medium having one or more programming instructions. When executed, the one or more programming instructions cause the electronic device to identify an event that is to be analyzed, receive from an autonomous vehicle system a first data stream that includes event information from one or more vehicle event log files that corresponds to the event, receive from a vehicle dynamics model a second data stream that includes synthetic event information that corresponds to the event, until a switch point is detected operate in a pure log execution stage, upon detection of the switch point operate in a play-forward execution stage, and cause the new simulation to be executed.

Abstract: Disclosed herein are system, method, and computer program product embodiments for probabilistic search biasing and recommendations. A system including at least one processor may be configured to receive an input relating to an identified item, generate a database query based on the input, and receive a response to the database query. The response may include information on comparable items similar to the identified item, and corresponding metadata for the comparable items. The corresponding metadata may include a range of values corresponding to the comparable items. The system may be further configured to generate a probability score for at least two values of the range of values, based at least on the corresponding metadata for the comparable items. The system may be further configured to output at least a suggested value based on at least the generated probability score for the range of values and prompt for further input.

Abstract: A field effect transistor (FET) engager, for example, includes electrically coupling a gate driver to a gate of a FET for testing the FET. The FET engager further includes providing a probe pad for test instrument measurement of the FET without test instrument capacitance impacting operation of the FET. The FET engager can electrically couple to the gate of the FET hold the gate of the FET at a low voltage while the source and drains are stress tested. The FET engager provides fail-safe mechanisms against accidental turn-on of the FET during operation. The FET engager can provide a second probe pad for selective test instrument turn-on of a second FET. The FET engager can allow test instrument measurement of gate current of the FET without test instrument capacitance impacting operation of the FET.

Abstract: A cutting device 1 for cutting leaves from flowers of plants has a rotating drum 7 into which the flowers to be treated can be placed. The drum 7 has two spaced rings 9 and 11 between which a number of elongate wall elements 13 extend. During operation, the leaves to be cut protrude through the openings 17 between the wall elements and are cut off there by revolving knives 21. Tensioning means 29 are integrated in the drum 7 for keeping the wall elements 13 taut. The tensioning means 29 have an elongated tensioning element 31 that at one end is connected to one of the rings 9 and at the other end is connected to the other ring 11. The tensioning means 29 can move the rings away from each other and thereby bring the wall elements 13 under tension.

Abstract: Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.

Abstract: An apparatus includes a reconfigurable optical add/drop multiplexer (ROADM) having an input port to receive a first optical signal from a second device. The ROADM also includes a first wavelength selective switch (WSS), in optical communication with the input port, to convert the first optical signal into a second optical signal, a loopback, in optical communication with the first WSS, to transmit the second optical signal, and a second WSS, in optical communication with the loopback, to convert the second optical signal to a third optical signal and direct the third optical signal back to the second device via the input port.

Abstract: Baluster connectors and railing systems utilizing baluster connectors. The baluster connectors can include a baluster engaging portion, a support engaging portion, and a flange.

Abstract: A flow rate assembly can include a fluid flow interface portion having a front facing wall and a back facing wall. The flow interface portion can include an inlet passage within the fluid flow interface portion, an outlet passage within the fluid flow interface portion, at least one inlet aperture extending through the front facing wall of the fluid flow interface portion into the inlet passage, and at least one outlet aperture extending through the back facing wall of the fluid flow interface portion into the outlet passage. In some cases, the fluid flow interface portion includes a plug forming at least a portion of the inlet passage.

Abstract: The disclosure describes an adaptive and optimal imaging of individual quantum emitters within a lattice or optical field of view for quantum computing. Advanced image processing techniques are described to identify individual optically active quantum bits (qubits) with an imager. Images of individual and optically-resolved quantum emitters fluorescing as a lattice are decomposed and recognized based on fluorescence. Expected spatial distributions of the quantum emitters guides the processing, which uses adaptive fitting of peak distribution functions to determine the number of quantum emitters in real time. These techniques can be used for the loading process, where atoms or ions enter the trap one-by-one, for the identification of solid-state emitters, and for internal state-detection of the quantum emitters, where each emitter can be fluorescent or dark depending on its internal state.

Abstract: The present disclosure is directed to a composite implant for the sustained release of a therapeutic agent from a hydrogel matrix. The hydrogel matrix may be a cross-linked bioerodible polyethylene glycol (PEG) hydrogel with a therapeutic complex dispersed within the cross-linked bioerodible PEG hydrogel. The therapeutic complex may include a therapeutic agent in association with mesoporous silica particles. The composite implant is configured to be delivered to or implanted into an eye of a subject or patient. The composite implant may be used treat ocular disease in a subject or patient. Ocular diseases may be selected from at least one of neovascular age related macular degeneration (AMD), diabetic macular edema, or macular edema following retinal vein occlusion.

Abstract: A protective cover to cover an opening of an electrical box having a threaded bore on inwardly projecting protrusions. In one approach the protective cover may have a back panel and four side panels together defining an interior cavity; a flange connected to a free edge of the side panels; wherein the flange has a pair of keyhole shaped bores defining a pair of openings along a center longitudinal axis of the flange; and wherein the keyhole openings are configured to allow a head of a screw to extend from the threaded bore and through a rounded portion of the keyhole opening and to allow a threaded shaft of the screw to slide along the length of an elongated narrow portion of the keyhole opening, the narrow portion being narrower than the diameter of the screw head.

Abstract: It is provided a chemical compound according to general formula (1)

Abstract: A testing system includes: a substrate having a probe pad and having a supply input; driver circuitry having a driver output; a transistor having a gate, a source, and a drain; and a field effect transistor (FET) engager. The gate of the transistor is coupled to the driver output, and the drain of the transistor is coupled to the supply input. The FET engager is configured to couple the probe pad to the gate of the transistor and provide test instrument measurement of gate current of the transistor without test instrument probe capacitance impacting operation of the transistor.

Abstract: A method for charge-induced functionalized nanofluid heat transfer includes preparing a nanofluid so that a first type of nanoparticles in the nanofluid have a surface charge with a first polarity, and attracting the first type of nanoparticles in the nanofluid to one of a heat sink or a heat source by applying a first voltage to the one of the heat sink or the heat source, the first voltage having a second polarity opposite to the first polarity. A system, for charge-induced functionalized nanofluid heat transfer is also provided.