Abstract: Protein enriched micro-vesicles and methods of making and using the same are provided. Aspects of the methods include maintaining a cell having a membrane-associated protein comprising a first dimerization domain and a target protein having a second dimerization domain under conditions sufficient to produce a micro-vesicle from the cell, wherein the micro-vesicle includes the target protein. Also provided are cells, reagents and kits that find use in making the micro-vesicles, as well as methods of using the micro-vesicles, e.g., in research and therapeutic applications.

Abstract: An extractor cleaning machine that includes a base movable along a surface to be cleaned, the base including a distribution nozzle and a suction nozzle. The extractor further includes a suction source in fluid communication with the suction nozzle. A recovery tank is in fluid communication with the suction source and the suction nozzle to receive the fluid drawn through the suction nozzle. The extractor further includes a supply tank including a first chamber for storing a first fluid, a second chamber for storing a second fluid, and a third chamber in fluid communication with the first chamber and the second chamber to receive the first and second fluids, the third chamber also in fluid communication with the distribution nozzle for supplying a mixture of the first and second fluids to the distribution nozzle.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, is directed toward an occlusive device that includes a first mesh having an expanded state in which it curves about a first axis to form a first band, and a second mesh having an expanded state in which it curves about a second axis different than the first axis to form a second band. The second band may be positioned radially inward of the first band such that the device includes first and second overlap regions in which the first band overlaps the second band.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, is directed toward an occlusive device that includes a first mesh having an expanded state in which it curves about a first axis to form a first band, and a second mesh having an expanded state in which it curves about a second axis different than the first axis to form a second band. The second band may be positioned radially inward of the first band such that the device includes first and second overlap regions in which the first band overlaps the second band.

Abstract: A floor cleaner including a vacuum source, a base movable over a surface to be cleaned, the base having a suction inlet in fluid communication with the vacuum source. The floor cleaner further includes a motor mounted to the base and a brushroll supported by the base rotatable about an axis and operably connected to the motor. The brushroll includes a cleaning medium configured to contact the surface to be cleaned and the cleaning medium includes a hydrophobic textile material.

Abstract: A method, computer system, and computer program product digitally manipulate a human resources workflow on a mobile device. A selection of a human resources operation is received from a mobile application executing on the mobile device; a business rule corresponding to the human resources operation is identified. The business rule comprises a plurality of linked metadata objects forming a syntax tree. The plurality of linked metadata objects is interpreted to implement the business rule, Interpreting comprises sending a first set of chat messages that request input for the plurality of linked metadata objects, and receiving a second set of chat messages that provide the requested input. The human resources operation is performed according to the business rule, generating a workflow stage notification, and publishing the workflow stage notification to a set of mobile devices for display on a timeline of the mobile application.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, is directed toward an occlusive device that includes a first mesh having an expanded state in which it curves about a first axis to form a first band, and a second mesh having an expanded state in which it curves about a second axis different than the first axis to form a second band. The second band may be positioned radially inward of the first band such that the device includes first and second overlap regions in which the first band overlaps the second band.

Abstract: An interface is processed for dynamically rendering an interactive geographical map. Custom-defined geographical boundaries are defined within the map. Customers currently geolocated within the geographical boundaries are identified. A custom-defined promotion is dynamically sent to devices operated by the customers and located within the geographical boundaries.

Abstract: An approach is provided for indirectly connecting a customer's mobile smart device to computers located at a business when the customer is making a purchase at the business. The customer's mobile smart device and the business's computers communicate over the Internet with a customer interaction manager executing on an Internet server. This provides an easy to use interface for the customer and allows the customer to receive information and send requests to the business without having to wait for personnel working at the business to be available.

Abstract: A drive mechanism for a vacuum cleaner having a motor and an agitator includes a belt coupled to the motor and the agitator to drive the agitator, and a belt tensioner operable to selectively tension the belt. The belt tensioner includes an arm movable relative to the belt, a shaft coupled to the arm, a pulley rotatably coupled to the shaft, a bearing positioned substantially within the pulley and around a portion of the shaft, and a member fixed to the pulley to retain the bearing within the pulley.

Abstract: An approach is provided for indirectly connecting a customer's mobile smart device to a point of sale computer located at a business when the customer is making a purchase at the business. The customer's mobile smart device and the POS computer communicate over the Internet with a customer interaction manager executing on an Internet server. This provides an easy to use interface for the customer and allows the customer to receive information and send requests to the business without having to wait for personnel working at the business to be available.

Abstract: An approach is provided for indirectly connecting a customer's mobile smart device to computers located at a business when the customer is making a purchase at the business. The customer's mobile smart device and the business's computers communicate over the Internet with a customer interaction manager executing on an Internet server. This provides an easy to use interface for the customer and allows the customer to receive information and send requests to the business without having to wait for personnel working at the business to be available.

Abstract: An approach is provided for indirectly connecting a customer's mobile smart defies to a point of sale computer located at a business when the customer is making a purchase at the business. The customer's mobile smart device and the POS computer communicate over the Internet with a customer interaction manager executing on an Internet server. This provides an easy to interface for the customer and allows the customer to receive information and send requests to the business without having to wait for personnel working at the business to be available.

Abstract: An approach is provided for indirectly connecting a customer's mobile smart device to a point of sale computer located at a business when the customer is making a purchase at the business. The customer's mobile smart device and the POS computer communicate over the Internet with a customer interaction manager executing on an Internet server. This provides an easy to use interface for the customer and allows the customer to receive information and send requests to the business without having to wait for personnel working at the business to be available.

Abstract: Private anonymous electronic messaging between a message originator and a message recipient within an organization encourages open communication which can provide information to the organization that might otherwise be secreted from the organization, and can allow the message originator to obtain desired help (e.g., counseling). By profiling of the message originator based on current and previous electronic messaging within the system as well as external organizational information (e.g., behavioral or financial information), the system can assess concerns yet act as a gateway to protect the message originator's true identity through escalating levels of concern unless a genuine concern about the health, well-being, and/or safety of the message originator, others, or the organization is indicated, in which case the system can reveal the true identity of the message originator as appropriate.