Abstract: A configurable system and method for automatically taking in streams of log data from various sources, dynamically parsing, normalizing the data and routing it to subsystems of an analytics engine. The routed data may undergo aggregating and other enrichment based on content, rules and data, so as to generate useful event observations, which may recursively be fed back into the system's data ingestion stream to further enhance the usefulness of the system's outputs, in real-time, in the context of computer system and data security.

Abstract: A method of enhancing delivery of an agent into tissue includes placing a housing that defines a chamber adjacent to a surface of the tissue, thereby locating the chamber adjacent to the injection site at which the agent was injected into the tissue, applying vacuum pressure to the chamber, thereby drawing a portion of the tissue through an opening of the chamber and into the chamber, and moving the housing relative to the tissue while the vacuum pressure is applied for enhancing agent delivery in the tissue.

Abstract: Example methods and apparatus can be used to reduce noise in motor assemblies, such as those used in architectural coverings. An example apparatus includes a first driver configured to be coupled to and rotated by an output shaft of a motor, a second driver, and a plurality of vibration-absorbers disposed between the first driver and the second driver. The second driver is configured to be coupled to a rotating member to transfer rotational motion from the first driver to the rotating member via the vibration-absorbers.

Abstract: A crankshaft for an internal combustion engine is provided and may include crank pins, crank journals, and webs extending between the crank pins and the crank journals. Each web further may include a web surface on each side of the web. On the web surface, a repair region is provided with an undercut formed in the web. Included in the crankshaft is a cladding deposit that is fused to the web surface in the repair region of the crankshaft.

Abstract: The efficiency of a solid fuel burning device can be increased and the emissions can be reduced with proper monitoring and guidance. At least one memory and processor can receive information related to operating conditions of a solid fuel burning device from at least one sensor and filter that information and determine a property related to usage of the solid fuel burning device based on fitting the filtered information to a set of reference conditions. The property can be compared to a lookup table comprising triggering events and when the property satisfies one of the triggering events appropriate guidance for operation of the solid fuel burning device can be retrieved and outputted so that alterations can be made to the operating conditions of the solid fuel burning device.

Abstract: A coated article includes: a substrate; a first dielectric layer including a metal oxide, metal alloy oxide, or a combination thereof and having a thickness of up to 40 nm over at least a portion of the substrate; a second dielectric layer having a thickness of up to 40 nm over at least a portion of the first dielectric layer; a third dielectric layer including a metal oxide, metal alloy oxide, or a combination thereof and having a thickness of at least 130 nm over at least a portion of the second dielectric layer; and a fourth dielectric layer having a thickness of at least 130 nm over at least a portion of the third dielectric layer; where the coated article, when contacted at 60° with light having a wavelength between 800 nm to 1,050 nm from a light source, transmits at least 75% of the light.

Abstract: Aspects of the invention described herein include a hydrogel prodrug and methods of making a hydrogel prodrug for drug delivery. Also contemplated are methods of treating, inhibiting, ameliorating or inhibiting a disease or disorder. Without being limiting, the methods for treatment can be directed to a cancer, HIV, a virus, pain, a bacterial infection, a neurological disorder, hemorrhaging, multiple sclerosis, diabetes, high blood pressure, Alzheimer's, or inhibiting a fungal growth in a subject in need.

Abstract: This disclosure describes, in part, techniques for sharing content associated with network applications. For instance, a user may want to share content for a network application, such as a game stream for a gaming application. As such, system(s) may launch a broadcasting session on a first virtual server and launch the network application on a second virtual server. The first virtual server may then receive content data representing states of the network application from the second virtual server. Additionally, the first virtual server may receive video data representing the user and/or audio data representing user speech from a user device. The first virtual server may then generate broadcasting data using the content data, the video data, and the audio data. After generating the broadcasting data, the system(s) may send the broadcasting data to one or more computing devices associated with a user account.

Abstract: A crankshaft for an internal combustion engine is provided and may include crank pins, crank journals, and webs extending between the crank pins and the crank journals. Each web further may include a web surface on each side of the web. On the web surface, a repair region is provided with an undercut formed in the web. Included in the crankshaft is a cladding deposit that is fused to the web surface in the repair region of the crankshaft.

Abstract: A device for vacuum-assisted in vivo delivery of an agent into cells of tissue includes a housing that defines a chamber and at least one opening into the chamber. A port extends through the housing, is remote from the at least one opening, and is connectable to a vacuum source. The port is configured to communicate vacuum pressure from the vacuum source to the chamber for drawing tissue through the opening and into the chamber.

Abstract: Aspects of the invention described herein include a hydrogel prodrug and methods of making a hydrogel prodrug for drug delivery. Also contemplated are methods of treating, inhibiting, ameliorating or inhibiting a disease or disorder. Without being limiting, the methods for treatment can be directed to a cancer, HIV, a virus, pain, a bacterial infection, a neurological disorder, hemorrhaging, multiple sclerosis, diabetes, high blood pressure, Alzheimer's, or inhibiting a fungal growth in a subject in need.

Abstract: Aspects of the invention described herein include a hydrogel prodrug and methods of making a hydrogel prodrug for drug delivery. Also contemplated are methods of treating, inhibiting, ameliorating or inhibiting a disease or disorder. Without being limiting, the methods for treatment can be directed to a cancer, HIV, a virus, pain, a bacterial infection, a neurological disorder, hemorrhaging, multiple sclerosis, diabetes, high blood pressure, Alzheimer's, or inhibiting a fungal growth in a subject in need.

Abstract: Techniques for treating subjects with an injected agent include applying vacuum pressure to tissue adjacent the injection and optionally electroporating said tissue. A device for applying such treatment includes a housing defining a receptacle and an opening into the receptacle. A port extends through the housing remote from the opening and is connectable to a vacuum source, such that the port can communicate vacuum pressure from the vacuum source to the receptacle. The device includes an insert that is receivable within the receptacle and that defines an internal chamber, which is in communication with the vacuum source when the insert resides in the receptacle. The insert includes at least one electrode positioned within the chamber and configured to deliver one or more electroporation pulses to a targeted portion of tissue extending through the at least one opening and at least momentarily held in the chamber responsive to the vacuum pressure.

Abstract: Aspects of the invention described herein include a hydrogel prodrug and methods of making a hydrogel prodrug for drug delivery. Also contemplated are methods of treating, inhibiting, ameliorating or inhibiting a disease or disorder. Without being limiting, the methods for treatment can be directed to a cancer, HIV, a virus, pain, a bacterial infection, a neurological disorder, hemorrhaging, multiple sclerosis, diabetes, high blood pressure, Alzheimer's, or inhibiting a fungal growth in a subject in need.

Abstract: A method and device for electroporating adipocytes in the adipose layer of tissue, where the device includes a frame, a first electrode coupled to the frame having a first contact surface, a second electrode coupled to the frame having a second contact surface, and where the first contact surface and the second contact surface define a treatment zone therebetween. The method including positioning a fold of tissue between the first and second electrodes such that the treatment zone formed between the two electrodes includes an adipose layer of tissue and no skeletal muscle.

Abstract: Aspects of the invention described herein include a hydrogel prodrug and methods of making a hydrogel prodrug for drug delivery. Also contemplated are methods of treating, inhibiting, ameliorating or inhibiting a disease or disorder. Without being limiting, the methods for treatment can be directed to a cancer, HIV, a virus, pain, a bacterial infection, a neurological disorder, hemorrhaging, multiple sclerosis, diabetes, high blood pressure, Alzheimer's, or inhibiting a fungal growth in a subject in need.

Abstract: A method and device for electroporating adipocytes in the adipose layer of tissue, where the device includes a frame, a first electrode coupled to the frame having a first contact surface, a second electrode coupled to the frame having a second contact surface, and where the first contact surf ace and the second contact surface define a treatment zone therebetween. The method including positioning a fold of tissue between the first and second electrodes such that the treatment zone formed between the two electrodes includes an adipose layer of tissue and no skeletal muscle.

Abstract: An injection device for in vivo delivery of an agent includes a tubular body defining a lumen that extends along a central axis that is oriented along a longitudinal direction. A distal end of the lumen is occluded and the tubular body defines at least one side-port extending from the lumen to an outer surface of the tubular body. The at least one side-port is elongated along the outer surface of the tubular body.

Abstract: An electrode array for use with an electroporation device includes a support member having a top surface and a bottom surface and defines a plurality of injection channels extending from the top surface to the bottom surface. A plurality of needle electrodes are coupled to the support member, such that distal ends of the plurality of needle electrodes extend to a needle depth below the bottom surface. The plurality of needle electrodes are arranged in a matrix pattern having rows of the needle electrodes and columns of the needle electrodes disposed along the support member. The plurality of injection channels are dispersed within the matrix pattern.

Abstract: Aspects of the invention described herein include a hydrogel prodrug and methods of making a hydrogel prodrug for drug delivery. Also contemplated are methods of treating, inhibiting, ameliorating or inhibiting a disease or disorder. Without being limiting, the methods for treatment can be directed to a cancer, HIV, a virus, pain, a bacterial infection, a neurological disorder, hemorrhaging, multiple sclerosis, diabetes, high blood pressure, Alzheimer's, or inhibiting a fungal growth in a subject in need.