Abstract: A cleaning station for removing residual toner from a moving toner transfer surface includes a rotating brush and a scraper blade that is held away from the toner transfer surface when toner images are being transferred to recording media, such as sheets of paper. On a periodic basis, when toner images are not being transferred to the recording media, the scraper blade is moved into contact with the toner transfer surface to remove agglomerated toner therefrom, with continued operation of the rotating brush.

Abstract: The invention relates to the mda-7 gene, its encoded protein and fragments of the protein. Several of these fragments of the MDA-7 protein exhibit antiproliferative activity and/or inhibited the activity of intact MDA-7. Accordingly, the invention provides, among other things, for methods and compositions that may be used in the treatment of disorders of cell proliferation, including cancer.

Abstract: Many variables in processes such as those using turbocompressors and turbines must be limited or constrained. Limit control loops are provided for the purpose of limiting these variables. By using a combination of closed loop and open loop limit control schemes, excursions into unfavorable operation can be more effectively avoided. Transition between open loop and closed loop may be enhanced by testing the direction and magnitude of the rate at which the limit variable is changing. If the rate of change indicates recovery is imminent, control is passed back to the closed loop limit control function.

Abstract: An in-tank fuel supply unit self cleans the mesh filter of the primary fuel pump, thereby permitting smaller mesh sizes to decrease pump wear and increase the life of the pump. Generally, the in-tank fuel supply unit includes a reservoir, an auxiliary fuel pump, a primary fuel pump and a filter. Fuel exiting the auxiliary fuel pump outlet is directed towards the filter to wash debris from the filter. Preferably a swirling flow is generated within the reservoir, or the system in run in an overflow condition to assist in the self cleaning of the fuel filter.

Abstract: A method and system for obtaining motor current measurements from a DC bus current of an inverter that drives a pulse width modulated electric machine is disclosed. The method may include sensing a DC bus current in a sensor located on a bus of an inverter; sampling the DC bus current via an analog to digital converter wherein the sampling is controlled by sampling timing that is based on a pulse width modulation timing of the inverter; and determining three AC phase currents of the motor from the sampled DC bus current.

Abstract: A fuel pump includes a housing, and a motor. A single sided impeller has first and second impeller flow channels each including a plurality of vanes. The impeller defines a flow passageway extending therethrough. A cover is attached to the housing and has a cover surface that defines first and second cover flow channels. The cover flow channels receive fuel from inlets formed in the cover. The first and second cover flow channels are aligned with the first and second impeller flow channels and receive fuel through the inlets and deliver fuel to outlets. A body is positioned within the housing and defines an impeller chamber to receive the impeller, and a first outlet passageway fluidically connected to the first cover flow channel and impeller flow channel. A second outlet passageway formed within the cover is fluidically connected to the second cover flow channel and impeller flow channel.

Abstract: The present invention relates to chimeric molecules comprising portions of rat PEG-3 (“rPEG-3”) and human GADD34 (“hGADD34”) having apoptotic activity. It is based, at least in part, on the discovery that a chimeric protein comprising amino acids 1-347 of rat PEG-3 fused with residues 418-674 of human GADD34 exhibited anti-proliferative activity when expressed in transformed cells. The present invention provides for this and other rPEG3/hGADD34 chimeras, and the use of such proteins in inhibiting cell proliferation, angiogenesis, and tumor growth.

Abstract: The present invention relates to the discovery, identification and characterization of an eight genes that are differentially expressed as a consequence of metastatic progression in human melanoma cells. Six of the identified metastasis elevated genes (MEG genes), encode for known proteins (MEG-1 through MEG-6). However, two of the identified genes, referred to herein as MEG-7 and MEG-8, represent novel genes. The present invention relates to methods for inhibiting the metastatic potential of cancer cells through inhibition of the MEG genes/gene products, as well as diagnostic methods for determining the metastatic potential of cells. The invention further relates to novel MEG-7 and MEG-8 nucleotides, host cell expression systems, MEG-7 and MEG-8 proteins, fusion proteins, and antibodies to the MEG-7 and MEG-8.

Abstract: The present invention relates to the old-35 gene, its encoded protein, and its promoter sequence.

Abstract: The nucleic acid sequence of the human Excitatory Amino Acid Transporter-2 Gene (hEAAT2) promoter, a nucleic acid sequence that hybridizes to the hEAAT2 promoter nucleic acid sequence under stringent hybridization conditions, and a nucleic acid sequence that is functionally equivalent to the hEAAT2 promoter sequence are provided, as are vectors containing these nucleic acid sequences. In addition, methods for the use of these nucleic acids to achieve tissue- or cell-specific gene expression are provided, as are methods for the use of these hEAAT2 promoter nucleic acids to identify agents that can modulate glutamate transport or the activity of the glutamate promoter. Such agents may be useful in the prevention, palliation or treatment of neurodegenerative and/or cerebrovascular diseases.

Abstract: The present invention relates to methods of treating a cancer in a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. The present invention further relates to methods of inhibiting proliferation or promoting death in a cancer cell of a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. Generation of an effective amount of MDA-7 can occur by administering to the cancer cell an effective amount of an mda-7 nucleic acid, MDA-7 protein, functional equivalents of either of these molecules, by upregulation of the endogenous mda-7 gene, or by stabilization of the mda-7 mRNA.

Abstract: A rotary fuel pump employs pressure balancing features on the non-vaned side of the impeller to provide localized application of fluid forces so that the impeller is more precisely balanced within the pumping chamber. A generally disc-shaped impeller body has an impeller with a body-side surface and a cover-side surface. The cover-side surface defines an impeller flow channel extending circumferentially around the impeller. The impeller includes a plurality of vanes positioned at least partially within the impeller flow channel. The body-side surface has a plurality of discontinuous undercut regions each coaxially aligned with at least a portion of the impeller flow channel. The impeller has a plurality of apertures wherein each aperture connects the impeller flow channel with a respective undercut region, whereby pressure forces against the impeller from the fuel are substantially balanced in the axial direction.

Abstract: This invention provides isolated nucleic acid molecules encoding an OLD-35 protein, OLD-64 protein, OLD-137 protein, OLD-139 protein, OLD-142 protein or OLD-175 protein. This invention further provides a purified OLD-35 protein, OLD-64, OLD-137, OLD-139, OLD-142 and OLD-175. Finally, this invention provides different uses of the nucleic acids and proteins.

Abstract: Presented is a distributed computer network system and method for generating electronic title for commodities during international transit. The system populates data fields of a database with information from a shipper's letter of instruction concerning the commodity and identifying the title holder and the beneficial party. The data fields are transformed to create an electronic ocean bill of lading that associates title with a title holder identified therein. Encumbrance information from the titleholder and a third party, received through the network, is analyzed by a computer for any discrepancy. The computer authorizes an encumbrance on the title free of any paper documentation verifying the encumbrance, and updates the electronic ocean bill of lading to reflect the encumbrance. The electronic ocean bill of lading created by the computer is the sole determinant of the title to commodity, permitting the title holder to receive remuneration from the third party for the encumbrance.

Abstract: A remote art jurying system in which art jurors independently evaluate works of art at different locations, times and places. A central database presents information about each work of art and/or the artist to an individual juror. The database provides images of the artwork along with relevant information. Each juror can access the database independent of otherjurors in terms of location, or time. The system provides enhanced voting methods. The juror can review or change their votes at any time prior to final submission. They can review all works of art, by categories of art, or by scores. The juror reviews artwork thumbnail images, which can be used to select high resolution images with extended information. Selected categories of art can be enhanced by eliminating the lowest scores to balance artwork finalists across multiple categories of art.

Abstract: The present invention relates to viral vectors that are targeted to cancer cells. The viral vectors of the invention are adenoviruses having a PEG-3 promoter driving the expression of the viral genes E1A and E1B. The PEG-3 promoter exhibits increased activity in malignant cells. Adenoviruses of the invention show increased replication in malignant cells, thereby producing a cytopathic effect. The viral vectors of the invention may comprise additional genes of interest, and/or may have altered capsid proteins that may enhance infection of and/or target infection to cancer cells. Additional cell types derived from diseased states in which the PEG-3 promoter is selectively active are also therapeutic targets of the viral vectors of the instant invention including those generating allergic, autoimmune and inflammatory responses.

Abstract: A system for verifying the accuracy of an image generated by a display processor and rendering engine is disclosed. The system includes a correlator circuit. The correlator circuit is operable to capture image data produced by a rendering engine from a set of input data and determine a correlation value calculated using a comparison location within the image data and a template. The correlator is further operable to compare the correlation value against a threshold value to determine a match between the comparison location within the image data and the template. The system further includes a checking processor coupled to the correlator circuit. The checking processor is operable to receive data representative of the correlation from the correlator and is further operable to initiate a warning in the event of any error in the data representative of the correlation.

Abstract: This invention provides a method for preparing a hybridoma cell line which produces an antibody capable of specifically binding to a cell surface-expressed protein which expresses on the surface of one cell type but not the other. This invention also provides a method for preparing a hybridoma cell line which produces an antibody capable of specifically binding to a cell surface-expressed protein. This invention provides a method to prepare a hybridoma cell line which specifically recognizes and binds to a tumor associated antigen associated with a neoplastic, human cell. This invention also provides a method of preparing DNA encoding a cell surface antigen associated with a neoplastic, human cell. This invention further provides an isolated mammalian nucleic acid molecule having the sequence of Prostate Carcinoma Tumor Antigen Gene-1. This invention also provides an isolated mammalian nucleic acid molecule having the sequence of Prostate Tumor Inducing Gene-1.

Abstract: A fuel pump is provided having improved efficiency by lowering the wet circle index of the pump while maintaining robust axial clearances to meet the demands of an automotive application. One embodiment includes a fuel pump for pressurizing fuel for delivery to an engine of a motor vehicle. The fuel pump generally comprises a housing, a motor, a single sided impeller, a cover and a body. The provision of a single sided impeller greatly reduces the wet circle index and improves the pump efficiency. The cover, impeller, and body are structured to axially balance the impeller which is free floating on the shaft of the motor.

Abstract: The present invention relates to the discoveries that apoptotic effects of the melanoma differentiation associated gene mda-7 (also known as interleukin-24, “IL-24”) on malignant cells occur via the p38 MAPK pathway and members of the Growth Arrest and DNA Damage (“GADD”) gene family but are substantially independent of the JAK/STAT pathway. Accordingly, the invention provides for methods for identifying apoptosis-modulating agents using assay methods which determine the ability of a test agent to increase or decrease expression of constituents of the mda-7 apoptosis pathway, preferably in a JAK/STAT substantially independent manner. Such agents may be small molecules or may be fragments, variants and/or derivatives of native MDA-7.