Abstract: This invention provides methods for treating a subject afflicted with cancer, comprising concurrently administering (i) an HDAC 6-selective inhibitor and (ii) a suitable cytotoxic agent such as SAHA, doxorubicin or etoposide. This invention also provides methods for inducing the death of a transformed cell such as a cancer cell, comprising concurrently contacting the cell with (i) an HDAC 6-selective inhibitor and (ii) a suitable cytotoxic agent such as SAHA, doxorubicin or etoposide.

Abstract: A dual-frequency ultrasound transducer, comprising a piezo-electric element bonded to a substrate, has two resonant vibration modes: a low frequency mechanical bending resonance mode and a relatively high frequency thickness resonance mode. The low frequency bending resonance mode occurs when the piezo-electric element is excited, in use, by a voltage which includes a low frequency oscillating component. The high frequency thickness resonance mode occurs when the piezo-electric element is excited, in use, by a voltage which includes a relatively high frequency oscillating component. The transducer may include a mounting arrangement, such as a support ring securing the periphery of the substrate to an underlying base layer that enhances the depth of penetration and focus of the ultrasound.

Abstract: An airbag assembly for a motor vehicle is disclosed having an airbag 110 that is inflated by an inflator when the airbag 110 is deployed in accordance with a control signal from an electronic controller. The airbag 110 has a main chamber 114 and at least one subsidiary chamber 116 fluidly connected to the main chamber 114 by a transfer vent 117. The main and subsidiary chambers 114 and 116 are vented to atmosphere by respective vents 115, 118 and the pressure in the subsidiary chamber 116 is arranged to be equal to or lower than the pressure in the main chamber 114. The subsidiary chamber 116 is produced in a simple manner by forming a depression in the main chamber 114 using a tether 124 and covering the depression so formed with a cover 125.

Abstract: A cleaner head for a cleaning appliance includes a rotatable agitator assembly, an agitator chamber housing the agitator assembly, and a sole plate defining a downwardly-directed opening through which debris energized by the agitator assembly enters the agitator chamber. A set of support members is located on a leading and trailing section of the sole plate, the support members extending downwardly beyond the sole plate to support the sole plate above a relatively hard floor surface. The lowermost extremities of the sets of support members are located in a first plane, and the edges of the opening are located in a second plane which is inclined upwardly relative to the first plane. The agitator assembly includes agitating members which extend outwardly from the opening beyond the second plane but within the first plane.

Abstract: A removable ink supply comprises an ink container including a coupler configured to removably engage a receiver of an ink supply station of an image forming apparatus. The coupler includes an end portion including an array of key holes with each key hole configured to removably receive a respective one key of an array of at least partially conductive keys of the receiver of the ink supply station. A conductive component of the coupler is positioned within the coupler and spaced apart from the end portion. The conductive component is in axial alignment with at least some of the respective key holes to be positioned for selective, removable contact with at least some of the respective keys of the receiver. An absence or a presence of removable contact between the conductive component and the key indicates an out-of-ink status of the image forming apparatus.

Abstract: A cleaner head for a vacuum cleaning appliance includes a first rotatable agitator and a second rotatable agitator for sweeping debris from a surface, each agitator comprising a disc-shaped body and a plurality of resilient members, preferably in the form of bristles, mounted on the body for engaging the surface. The agitators are housed within an agitator chamber which includes a downwardly-directed opening through which debris energized by the bristles enters the cleaner head. The opening is located in a plane, and each body is inclined relative to the plane of the opening so that, with rotation of the agitator, the bristles protrude through the opening. The bristles of the first agitator are angularly offset from the bristles of the second agitator.

Abstract: A cleaner head for a cleaning appliance includes a rotatable agitator and an agitator chamber housing the agitator. The agitator includes a flexible body and surface engaging members mounted on the body. The agitator chamber includes a downwardly-directed opening through which debris energized by the surface engaging members enters the cleaner head. The opening is located in a plane. The cleaner head includes a drive mechanism for rotating the agitator about a rotational axis which is inclined both relative to the plane of the opening and towards the rear of the opening so that, with rotation of the agitator, the surface engaging members protrude through the opening towards the front of the opening.

Abstract: A cleaner head for a cleaning appliance includes a rotatable agitator and an agitator chamber housing the agitator. The agitator includes a drive shaft, a flexible body connected to the drive shaft and surface engaging members mounted on the flexible body. The agitator chamber includes a downwardly-directed opening through which debris energized by the surface engaging members enters the cleaner head. The opening is located in a plane relative to which the flexible body is inclined so that, with rotation of the agitator, the surface engaging members protrude through the opening, preferably towards the front of the opening.

Abstract: A method of projecting liquid as jets or droplets from a nozzle provided on a transducer formed by a region of a material layer, the method comprising the steps of: supplying liquid to an inner end of the nozzle; exciting the nozzle to cause movement of the nozzle in a direction substantially aligned with the nozzle axis in order to project liquid as a droplet from an outer face of the nozzle; wherein the step of exciting the nozzle comprises sequentially driving the transducer with a first rising voltage change, a first falling voltage change, a second rising voltage change and a second falling voltage change; and wherein the first rising voltage change and the first falling voltage change are timed so that they enhance the movement of the material layer, and the second rising voltage change and the second falling voltage change are timed so that they substantially cancel the movement of the material layer.

Abstract: A microphone is mounted to apparatus in order to receive sound from a sound source. The apparatus has a microphone clamp to secure different microphones to a variety of musical instruments and other sound sources and may be used to directly mount a microphone to a variety of clamping surfaces. The mounting apparatus incorporates a dual jaw design to allow for easy, fast, and secure mounting to the clamping surface. The apparatus supports a quick release mechanism for easy and fast engagement and disengagement of the dual jaws, consequently reducing time needed to securely clamp and remove the mounting apparatus with the clamping surface. The release mechanism may include a dowel release having a hole through which the jaw stud is situated. The hole has two curved surfaces so that one of jaws may be moved without turning the jaw stud when the dowel release is depressed.

Abstract: A pressure regulator apparatus usable with an aerosol supply device containing a fluid includes an inflatable diaphragm unit including an upper surface member, a lower surface member, and a diaphragm chamber formed between the upper surface member and the lower surface member, an output port member having an output cavity and an output port, at least a portion of the output port member is disposed within and in fluid communication with the diaphragm chamber, a valve actuator including an actuator cavity and one or more actuator openings in fluid communication with the output port, at least a portion of the valve actuator is moveably disposed within the output cavity, an input port member having an input port configured to allow the fluid to enter the actuator cavity, at least a portion of the input port member is disposed proximate to the actuator cavity, and an axial flow path extending between the input port and the output port, and configured to allow the fluid to selectively pass in a substantially axial

Abstract: The invention relates to a device that is always open for the pressure medium for reducing pressure pulsations and that can be switched between a pressure chamber of a slave cylinder and a pressure chamber of a master cylinder of a hydraulic force transmission system for motor vehicles. The device has an additional line section in the form of a channel having an opening on the slave cylinder side, an opening on the master cylinder side, and a channel length equaling a multiple of the direct distance between the two openings, and a volume receiver that can be elastically deformed under pressure, wherein the channel and the volume receiver are combined into an assembly in a housing. The result according to the invention is a device that not only has very good vibration dampening properties, but is also very compact and has a cost-effective design.

Abstract: A steering column assembly for a motor vehicle is disclosed having lower and upper steering column members that are slidingly interengaged. The upper column member is attached to a structural part of the motor vehicle by a ride down mechanism that allows the upper steering column to move in the event of a collision. A load transfer means is provided to bypass the ride down mechanism when an adjustment lever is moved to a position allowing the position of the upper steering column member to be adjusted thereby preventing accidental damage occurring to the ride down mechanism due to operator abuse.

Abstract: A steering column assembly for a motor vehicle is disclosed having lower and upper steering column members that are slidingly interengaged. The upper column member is attached to a structural part of the motor vehicle by a ride down mechanism that allows the upper steering column to move in the event of a collision. A load transfer means is provided to bypass the ride down mechanism when an adjustment lever is moved to a position allowing the position of the upper steering column member to be adjusted thereby preventing accidental damage occurring to the ride down mechanism due to operator abuse.

Abstract: A steering column assembly for a motor vehicle is disclosed having lower and upper steering column members that are slidingly interengaged. The upper column member is attached to a structural part of the motor vehicle by a ride down mechanism that allows the upper steering column to move in the event of a collision. A load transfer means is provided to bypass the ride down mechanism when an adjustment lever is moved to a position allowing the position of the upper steering column member to be adjusted thereby preventing accidental damage occurring to the ride down mechanism due to operator abuse.

Abstract: A method and device for installing an application to a device are provided. The method includes: receiving, at the device, application files associated with the application, the application files including computer readable instruction files and resource files; installing, by an installation manager, the computer readable instruction files to a first memory component associated with the device; and storing the resource files on a second memory component associated with the device.

Abstract: A method and system are provided for triggering a transmittal of an application to a device connected to a host computer. The method comprises: displaying in a web browser on the host computer a list of at least one application available for download to the device; receiving instructions through the web browser to download the application to the device; and in response to receiving instructions to download the application to the device: i) transmitting a request for the application to an application delivery server; ii) receiving the application from the application delivery server at the host computer; and iii) transmitting the application from the host computer to the device.

Abstract: A device for projecting liquid as jets or droplets from multiple nozzles, the device comprising: a plurality of transducers oriented substantially parallel to one another and each having an inner face and an outer face opposite said inner face, the transducers being arranged in a substantially planar array; a plurality of nozzles to project liquid therefrom; liquid supply means for supplying a liquid to the nozzles; each nozzle is associated with an adjacent respective transducer which is excitable to cause movement of the adjacent associated nozzle in a direction substantially aligned with the nozzle axis, to project liquid therefrom; the liquid supply means supplies liquid to an inner end of said nozzle; means for selectively exciting transducers as required, thereby to project liquid as jets or droplets from the respective outer face by movement of the liquid through the nozzle in response to the movement of the nozzle; wherein one or more pressure absorbing regions are disposed at a predetermined dista

Abstract: A toughening agent for use in making composites comprises an epoxy curing agent and a thermoplastic. Compositions, composites that comprise the toughening agent and associated methods of making and using the toughening agent are also disclosed.

Abstract: An airbag assembly for a motor vehicle has an airbag 10 that is inflated by an inflator 12 when the airbag 10 is deployed in accordance with a control signal from an electronic controller 6. A portion of the airbag 10 in a region where an expected head impact with the airbag 10 will occur is formed by a soft panel portion 25 which provides a softer or more compliant structure that can expand or stretch to an increased surface area condition to thereby reduce the risk of injury to an occupant. The soft panel portion 25 is constructed so as to provide increased give or stretch relative to the other parts of the fabric bag 9 when a head of an occupant impacts against it.