Abstract: A microporous substrate for detection of surface bound target analyte molecules includes a microporous substrate material having opposed surfaces and tapered micropores extending through the substrate with the micropores having wider openings on one side of the substrate compared to the other side. The micropores have bound therein analyte specific receptors complementary to the target molecules. When a liquid sample containing the target analyte molecules with optical probes attached to the target molecules is flowed through the substrate, they bind to their complementary analyte specific receptors and emit light. This microporous substrate structure gives an increase in the collection efficiency of light emitted from optical probes when the light is detected by a light detector spaced from the side of the microporous substrate facing the larger micropores openings compared to a light collection efficiency of light emitted from the optical probes when the micropores are straight and not tapered.

Abstract: A computing device includes a touch-sensitive area that is arranged and configured to receive one or more gestures, and a memory that is arranged and configured to store one or more device gestures, where the stored device gestures correspond to a selection of one or more remote devices and a processor that is operably coupled to the touch sensitive area and the memory. The processor is arranged and configured to compare the gestures received in the touch sensitive area to the stored device gestures, determine a selected remote device based on the comparison, and initiate contact with the selected remote device.

Abstract: A device for treating tissue includes a catheter including an elongated body extending from a proximal end to a distal end and including a lumen extending therethrough, a distal tip connected to the distal end of the elongated body and including a first electrode and a second electrode extending thereabout, the first electrode extending to a distal opening of the lumen and a first needle extending longitudinally from a proximal end to a distal end, the first needle slidably received within the lumen of the catheter to be moved between a retracted bipolar configuration, in which the distal end of the needle is proximal the distal opening of the catheter, and an extended monopolar configuration, in which the distal end of the first needle extends distally past the distal opening of the catheter so that the first needle contacts the first electrode and is configured to cut tissue.

Abstract: A framework for a 6th generation (6G) ubiquitous wireless communications network is provided. A system comprises: a memory that stores executable instructions; and a processor, coupled to the memory, that facilitates execution of the executable instructions to perform operations.

Abstract: A medical device includes a shaft including a central lumen configured to direct a flow of fluid through the shaft, and an electrode positioned at a distal portion of the shaft. The electrode includes an electrode lumen in fluid communication with the central lumen, and the electrode lumen is configured to receive the flow of fluid from the central lumen. The electrode also includes one or more channels angled relative to the electrode lumen, and the one or more channels are in fluid communication with the electrode lumen to receive the flow of fluid from the electrode lumen. The one or more channels are configured to divert the flow of fluid from the electrode lumen toward one or more outlets laterally offset from the electrode lumen.

Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices that lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstructions for dissection tools. In particular, the present disclosure relates to devices that transition from a constrained to an unconstrained bowed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.

Abstract: A locking pin system comprising: an actuator having an actuator body defining an axial bore along its length; a locking pin axially moveably mounted within the bore, and drive means for driving the locking pin axially along the bore between a locking position extending from the actuator body and an unlocking position relatively retracted into the actuator body; wherein the drive means comprises engagement means for releasably engaging the locking pin, the engagement means being biased to an open position where they are not in engagement with the locking pin, and wherein the bore comprises a first section having a first diameter and a second section having a second, wider diameter.

Abstract: Unlike smart devices, Internet of things (IoTs), such as meter readers, generate very low revenue per user. Traditional tunnel/bearer based connection-oriented architectures do not scale economically for billions of IoT devices due to the amount of signaling overhead associated with GTP tunnel setup/tear down and the states related to GTP tunnels maintained at various parts of the mobile network. However, the mobility network can efficiently support massive stationary and/or mobile IoTs by reducing the amount of signaling overhead, the state of the IoTs kept in network, and simplifying the data plane when possible.

Abstract: Sphincterotomes and methods for making and using sphincterotomes are disclosed. An example sphincterotome may include an elongate shaft having an outer surface and a distal end region. The sphincterotome may also include a sphincterotome wire assembly having a distal end coupled to the distal end region of the elongate shaft and a body portion extending along the outer surface of the elongate shaft. The sphincterotome wire assembly may be designed to shift the distal end region of the elongate shaft between a first configuration and a curved configuration. The body portion of the sphincterotome wire assembly may include a cutting region and a non-conductive region.

Abstract: A clipping system includes an adapter mounted on an insertion device and a clip including first and second jaws connected via hinges so that the first and second jaws are movable between an insertion configuration and an initial deployed configuration. A deployment member is configured to move the clip distally over and off of the adapter so that, as the clip leaves the adapter, the clip moves from the insertion configuration to the initial deployed configuration. An extending member is releasably coupled to the clip and movably connected to the adapter, and is configured to permit the withdrawal of the adapter away from the clip while the extending member remains coupled to the clip to place the system in a review configuration. The extending member is operable to retract the clip over the adapter, freeing the clip from tissue on which it had been clipped.

Abstract: A clipping system includes an adapter configured to be mounted over an insertion device and a clip including first and second jaws movable between an insertion configuration and an initial deployed configuration. A first extending member is releasably coupled to the clip and movably connected to the adapter to permit a movement of the clip relative to the adapter from the insertion configuration to the initial deployed configuration. The first extending member is configured to permit withdrawal of the adapter away from the clip to place the system in a review configuration to enhance a visual observation of the clip. The first extending member is operable to retract the clip over the adapter so that the clip is forced open, freeing the clip from tissue on which it has been clipped. The first extending member is configured to release the clip therefrom in a final deployed configuration.

Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating prurigo nodularis.

Abstract: This invention is directed to a medical device having an elongate shaft having a distal end and a controller coupled to the shaft. A control member can extend through at least part of the elongate shaft and at least part of the controller, wherein the control member in a tensioned configuration can be moveable by the controller to control the distal end of the shaft and the control member can be slack in an untensioned configuration. A tensioning mechanism can be configured to move relative to at least one of the elongate shaft and the controller to tension the control member and automatically lock the control member in the tensioned configuration.

Abstract: A thermal management system includes a first heat source assembly including a first heat source exchanger, a first thermal fluid inlet line extending to the first heat source exchanger, and a first thermal fluid outlet line extending from the first heat source exchanger; a second heat source assembly including a second heat source exchanger, a second thermal fluid inlet line extending to the second heat source exchanger, and second a thermal fluid outlet line extending from the second heat source exchanger; a shared assembly including a thermal fluid line and a heat sink exchanger, the shared assembly defining an upstream junction in fluid communication with the first thermal fluid outlet line and second thermal fluid outlet line and a downstream junction in fluid communication with the first thermal fluid inlet line and second thermal fluid inlet line; and a controller configured to selectively fluidly connect the first heat source assembly or the second heat source assembly to the shared assembly.

Abstract: An integrated fracking system may include a substructure assembly including one or more frame rails. The integrated fracking system may include a variable frequency drive (VFD) coupled to the frame rails of the substructure assembly. The integrated fracking system may include a transformer coupled to the frame rails of the substructure assembly. The integrated fracking system may include a pump subsystem. The pump subsystem may include a first frac pump, a first motor operatively coupled to the first frac pump, a second frac pump, and a second motor operatively coupled to the second frac pump. The pump subsystem may be coupled to the frame rails of the substructure assembly.

Abstract: A service level-based integrity detection and self healing process can enable a better quality of service for an end user. For example, when an end user requests a service, a system can provide that service based upon a service level agreement and performance of the network. For example, a software defined network (SDN) component can provide intelligent functions and interfaces to create a service instance for the ordered the service. The SDN component can receive instructions from a detection and service healing component that generates instruction data to mitigate service outages based on historical data.

Abstract: The present disclosure relates generally to the field of medical devices and establishing fluid communication between body lumens. In particular, the present disclosure relates to devices and methods for placing the muscularis layers of first and second body lumens in contact to establish a long term or permanent open flow or access passage therebetween.

Abstract: This disclosure relates to ruxolitinib, or a pharmaceutically acceptable salt thereof, and its use in treating prurigo nodularis.

Abstract: A hydraulic system for a vehicle includes a hydraulic monitoring control unit configured to receive an operational signal from a sub-system of the vehicle and control flow of hydraulic fluid to actuators of components based on the operational signal. The hydraulic monitoring control unit is configured to bypass the flow of the hydraulic fluid in relation to a subset of the actuators in response to the operational signal indicating an altered operational state of the sub-system.

Abstract: This invention is directed to a medical device having a longitudinal axis, and including a handle and a catheter. The handle can include a body having a proximal end and a distal end, an actuator moveably coupled to the body, and a handle control member coupled to the actuator, wherein the actuator can be configured to move relative to the body to move the handle control member. The catheter can include a shaft having a proximal end and a distal end, wherein the proximal end of the shaft and the distal end of the body can be configured for releasable coupling. The catheter can also include a steering section located along the shaft and a catheter control member coupled to the steering section, wherein the catheter control member can be configured to move relative to the shaft to move the steering section relative to the longitudinal axis.