Abstract: A medical device, comprising a fastening assembly, wherein the fastening assembly includes an adapter defining an opening therethrough, a fastener releasably coupled to the adapter, wherein the fastener includes at least two jaws pivotable relative to one another, the fastener having a first configuration wherein the jaws are open and a second configuration wherein the jaws are closed, and at least one cable coupled to the fastener and the adapter, the at least one cable being configured to apply tension to the fastener to transition between the first configuration and the second configuration while the fastener is coupled to the adapter, and to control release of the fastener from the adapter.

Abstract: The present invention generally relates to a microjet array for use as a thermal management system for a heat generating device, such as an RF device. The microjet array is formed in a jet plate, which is attached directly to the substrate containing the heat generating device. Additional enhancing features are used to further improve the heat transfer coefficient above that inherently achieved by the array. Some of these enhancements may also have other functions, such as adding mechanical structure, electrical connectivity or pathways for waveguides. This technology enables higher duty cycles, higher power levels, increased component lifetime, and/or improved SWaP for RF devices operating in airborne, naval (surface and undersea), ground, and space environments. This technology serves as a replacement for existing RF device thermal management solutions, such as high-SWaP finned heat sinks and cold plates.

Abstract: A modular trailer comprising a base frame and a side-rail assembly configured to be secured to the base frame. The side-rail assembly comprises an elongated side rail and a plurality of uprights extending from the side rail. The modular trailer further comprises a plurality of connection assemblies configured to secure the side-rail assembly to the base frame. Each connection assembly comprises an outer connection plate rigidly secured to an associated upright of the plurality of uprights and one or more fasteners configured to extend through the base frame and into engagement with the outer connection plate.

Abstract: The present disclosure provides a cartridge and method to move fluids within the cartridge that simplifies the design and removes the need for any internal valves or metering devices. The design is amenable to injection molded manufacturing lowering cost for large volume manufacturing. The design can be adapted to carry out both sample preparation and detection of biological substances including nucleic acids and proteins.

Abstract: Peripheral devices such as wearables can link to mobile devices to access network elements. These peripheral devices can comprise a communication part and a processing part. Each of these parts, specially the processing part of the next item in a communication chain, can be multiple times larger and stronger than the previous linked item. For instance, the peripheral device can be connected to the mobile device which can be in line connected to an NodeB device. Because the processing power of mobile device can be several times stronger than the peripheral, a mobile edge computing platform and a multi-access application function facilitate sharing of processing power capabilities between the peripheral devices, mobile devices, and/or the NodeB devices.

Abstract: The present application provides methods of treating hidradenitis suppurativa in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound which inhibits JAK1 and/or JAK2, or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices that lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstructions for dissection tools. In particular, the present disclosure relates to devices that transition from a constrained to an unconstrained bowed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.

Abstract: In 6G, there are multiple radios that can cover the same location at any time, and yet radio failure can occur. However, a mobile edge computing (MEC) platform can increase the footprint of adjacent radios to compensate for a failed radio. To reduce the failure interruption and maintain a quality of experience for a subscriber, the MEC can utilize a virtual session capability to communicate radio change of service characteristics to a service provider. Consequently, the change in service characteristics can comprise an expanded coverage area for adjacent radios such that a mobile device of the subscriber can take advantage of the expanded coverage area without experiencing an interruption in service.

Abstract: The present disclosure, in its various aspects, is directed to expandable guide devices, implementation methods, and related systems. In one example, an expandable guide device is configured to receive an instrument through an instrument lumen of the device. Each of a plurality of expandable members are disposed circumferentially about a body of the device that defines the instrument lumen, and each expandable member is configured to be independently transitionable between an expanded configuration and an unexpanded configuration.

Abstract: The present disclosure relates to systems and methods for enhanced navigation and visualization of body passages. In particular, the systems and methods of the present disclosure provide enhanced navigation through the pulmonary peripheries, and enhanced visualization within larger pulmonary passages.

Abstract: Various embodiments are generally directed to fluid container adapters that couple with a fluid container, so to enable access to the contents of the fluid container, such as from an endoscopic system via a tubing set. Several embodiments are particularly directed to a fluid container adapter that can couple with an opening in a variety of fluid containers to place one or more tubes in fluid communication with an interior of any particular one of the variety of fluid containers.

Abstract: A closure device includes a first ring structure having a first distal portion and a first medial portion and a second ring structure having a second distal portion and a second medial portion. The first and second distal portions are movable between an open position, where the first and second distal portions form an angle relative to one another for receiving target tissue therebetween, and a closed position, where the first and second distal portions are drawn toward one another for gripping the target tissue. The device also includes an anvil about which the first and second medial portions are formed. Either one of proximal motion of the anvil relative to the first and second rings or proximal motion of the medial portions relative to the anvil causes the first and second distal portions to move into either one of the open position or the closed position.

Abstract: A medical device includes a shaft including a lumen configured to direct a flow of fluid through the shaft and an electrode. A proximal end of the electrode and a distal end of the shaft form a coupling configured to releasably couple the proximal end of the electrode with the distal end of the shaft. When the proximal end of the electrode is coupled to the distal end of the shaft, fluid delivered through the lumen is emitted from the electrode.

Abstract: Medical devices, assemblies and methods for guarding sharp tips of medical needles are disclosed herein. Some embodiments include an expandable device configured to be at least partially disposed within the needle lumen. The device may include an expandable distal portion that is designed to shift between a first configuration in which the expandable distal portion has an outer diameter that is the same as or less than the inner diameter of the needle lumen and a second configuration in which the expandable distal portion has an outer diameter that is greater than the inner diameter of the needle lumen. An elongated inner member may be used to shift the expandable distal portion from the first configuration to the second configuration.

Abstract: An agent delivery device comprises: one or more agent containers at a proximal end of the agent delivery device, wherein the one or more agent containers are configured to contain one or more fluids; an insertion section comprising a tube defining one or more lumens, the insertion section coupled to the agent containers such that the one or more fluids may flow from the agent containers to the one or more lumens and out of one or more outlets of the one or more lumens; and a distal impingement structure at the distal end of the insertion section, the distal impingement structure comprising an impingement surface arranged relative to one or more outlets to impinge the one or more fluids dispensed from the one or more outlets to cause mixing of the one or more fluids for application of the fluids at a treatment site.

Abstract: Provided is a downhole perforating device, a well system, and a method for perforating a well system. The downhole perforating device, in one aspect, includes a perforating structure for surrounding at least a portion of an outer surface of a wellbore casing. The downhole perforating device, according to this aspect, includes one or more perforation elements at least partially embodied within the perforating structure, the one or more perforation elements positioned to perforate the wellbore casing to an inside thereof, and electronics at least partially embodied within the perforating structure, the electronics for triggering the one or more perforation elements.

Abstract: Medical devices and methods of using medical devices are disclosed. An example tissue retraction delivery device includes a positioning assembly, the assembly including: a delivery catheter having a distal end region and a lumen extending therein, wherein the distal end region includes an engagement member orienting tip. The delivery device also includes an actuation catheter extending within at least a portion of the delivery catheter, the actuation catheter including a distal end region and a lumen extending therein. An actuation wire extends within the lumen of the actuation catheter, the actuation wire having a proximal end region and a distal end region. An end effector is coupled to the distal end region of the actuation wire, the end effector configured to capture an engagement member of a tissue retraction device, wherein manipulation of the actuation wire shifts the end effector from a first position to a second closed position.

Abstract: According to embodiments of the present disclosure, a stabilizer is configured to engage and stabilize a target tissue site so that a procedure may be performed on a target tissue independently of the stabilizer. A lever is associated with the stabilizer and coupled with the target tissue to leverage the target tissue. In some embodiments, the stabilizer is deployed proximal to the target tissue site, with the lever proximal to the target tissue site and proximal to the distal end of the delivery device used to deploy the stabilization and leverage device. In such embodiment, the lever includes a lever component which may extend through a passage in the stabilizer to be controlled at a proximal end of the delivery device.

Abstract: A method and apparatus for the separation of gas and liquid-solid slurry under pressure, and passage of the liquid-solid slurry to an atmospheric discharge.

Abstract: The present invention relates to a method for preparing a library of template polynucleotides and use thereof in methods of solid-phase nucleic acid amplification. More specifically, the invention relates to a method for preparing a library of template polynucleotides that have common sequences at their 5? ends and at their 3? ends.