Abstract: A clipping system includes an adapter mounted on an insertion device and a clip including first and second jaws connected via hinges so that the first and second jaws are movable between an insertion configuration and an initial deployed configuration. A deployment member is configured to move the clip distally over and off of the adapter so that, as the clip leaves the adapter, the clip moves from the insertion configuration to the initial deployed configuration. An extending member is releasably coupled to the clip and movably connected to the adapter, and is configured to permit the withdrawal of the adapter away from the clip while the extending member remains coupled to the clip to place the system in a review configuration. The extending member is operable to retract the clip over the adapter, freeing the clip from tissue on which it had been clipped.

Abstract: A clipping system includes an adapter configured to be mounted over an insertion device and a clip including first and second jaws movable between an insertion configuration and an initial deployed configuration. A first extending member is releasably coupled to the clip and movably connected to the adapter to permit a movement of the clip relative to the adapter from the insertion configuration to the initial deployed configuration. The first extending member is configured to permit withdrawal of the adapter away from the clip to place the system in a review configuration to enhance a visual observation of the clip. The first extending member is operable to retract the clip over the adapter so that the clip is forced open, freeing the clip from tissue on which it has been clipped. The first extending member is configured to release the clip therefrom in a final deployed configuration.

Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating prurigo nodularis.

Abstract: This invention is directed to a medical device having an elongate shaft having a distal end and a controller coupled to the shaft. A control member can extend through at least part of the elongate shaft and at least part of the controller, wherein the control member in a tensioned configuration can be moveable by the controller to control the distal end of the shaft and the control member can be slack in an untensioned configuration. A tensioning mechanism can be configured to move relative to at least one of the elongate shaft and the controller to tension the control member and automatically lock the control member in the tensioned configuration.

Abstract: A thermal management system includes a first heat source assembly including a first heat source exchanger, a first thermal fluid inlet line extending to the first heat source exchanger, and a first thermal fluid outlet line extending from the first heat source exchanger; a second heat source assembly including a second heat source exchanger, a second thermal fluid inlet line extending to the second heat source exchanger, and second a thermal fluid outlet line extending from the second heat source exchanger; a shared assembly including a thermal fluid line and a heat sink exchanger, the shared assembly defining an upstream junction in fluid communication with the first thermal fluid outlet line and second thermal fluid outlet line and a downstream junction in fluid communication with the first thermal fluid inlet line and second thermal fluid inlet line; and a controller configured to selectively fluidly connect the first heat source assembly or the second heat source assembly to the shared assembly.

Abstract: An integrated fracking system may include a substructure assembly including one or more frame rails. The integrated fracking system may include a variable frequency drive (VFD) coupled to the frame rails of the substructure assembly. The integrated fracking system may include a transformer coupled to the frame rails of the substructure assembly. The integrated fracking system may include a pump subsystem. The pump subsystem may include a first frac pump, a first motor operatively coupled to the first frac pump, a second frac pump, and a second motor operatively coupled to the second frac pump. The pump subsystem may be coupled to the frame rails of the substructure assembly.

Abstract: A service level-based integrity detection and self healing process can enable a better quality of service for an end user. For example, when an end user requests a service, a system can provide that service based upon a service level agreement and performance of the network. For example, a software defined network (SDN) component can provide intelligent functions and interfaces to create a service instance for the ordered the service. The SDN component can receive instructions from a detection and service healing component that generates instruction data to mitigate service outages based on historical data.

Abstract: The present disclosure relates generally to the field of medical devices and establishing fluid communication between body lumens. In particular, the present disclosure relates to devices and methods for placing the muscularis layers of first and second body lumens in contact to establish a long term or permanent open flow or access passage therebetween.

Abstract: This disclosure relates to ruxolitinib, or a pharmaceutically acceptable salt thereof, and its use in treating prurigo nodularis.

Abstract: A hydraulic system for a vehicle includes a hydraulic monitoring control unit configured to receive an operational signal from a sub-system of the vehicle and control flow of hydraulic fluid to actuators of components based on the operational signal. The hydraulic monitoring control unit is configured to bypass the flow of the hydraulic fluid in relation to a subset of the actuators in response to the operational signal indicating an altered operational state of the sub-system.

Abstract: This invention is directed to a medical device having a longitudinal axis, and including a handle and a catheter. The handle can include a body having a proximal end and a distal end, an actuator moveably coupled to the body, and a handle control member coupled to the actuator, wherein the actuator can be configured to move relative to the body to move the handle control member. The catheter can include a shaft having a proximal end and a distal end, wherein the proximal end of the shaft and the distal end of the body can be configured for releasable coupling. The catheter can also include a steering section located along the shaft and a catheter control member coupled to the steering section, wherein the catheter control member can be configured to move relative to the shaft to move the steering section relative to the longitudinal axis.

Abstract: The present disclosure relates to the field of tissue dissection. Specifically, the present disclosure relates to medical devices which lift and retract tissue during a dissection procedure to improve visualization of the target tissue and mitigate obstruction of dissection tools. In particular, the present disclosure relates to a tissue retraction device which moves from a constrained to relaxed configuration to immobilize and retract the dissected portion of target tissue during a dissection procedure.

Abstract: A device includes a processor. The processor is configured to execute instructions to receive first operator input and generate layers for a map based on the first operator input. The layers include features to indicate whether an Uncrewed Aerial Vehicle (UAV) operator should or could fly a UAV in an airspace corresponding to an area within the map. The processor is also configured to receive second operator input that specifies a path on the map, for a UAV flight.

Abstract: Automatic neighbor relationships (ANR) can be implemented within a radio access network intelligent controller (RIC), which receives load information from network nodes and user equipment measurements from user equipment. The RIC can create and maintain real-time load information and leverage slicing knowledge of neighbor cells during mobility to direct the user equipment to various network slices. Thus, an enhanced radio access network (RAN) neighbor relationship that utilizes slicing information can provide slice level RAN neighbor visibility on top of physical ANR relationships to enable enhancements for mobility management optimization.

Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.

Abstract: An apparatus includes a body and an actuator is coupled to the body. A needle is mounted to the actuator. The needle comprises a slot along a length to a tip. A sensor is coupled to a plurality of wires. A base is configured to be moveable by the actuator and includes a cutout, a circuit board having a microprocessor, and a plurality of contacts. Each contact is coupled to a wire of the plurality of wires. A power source is connected to the circuit board and to the base. A bracket is coupled to the bottom surface of the body and configured to receive the base. A patch is coupled to the bracket and has an adhesive. A needle is configured to be moveable by the actuator. The plurality of wires extend from the circuit board of the base, through the needle and out of the slot.

Abstract: A device for treating hemorrhoids includes a housing sized and shaped for insertion to a target site within a rectum. The device also includes an inner member received within the housing such that the member may move longitudinally relative to the housing. In addition, the device includes a ligating mechanism at a distal end of the member which includes grasping arms movable between a receiving configuration in which distal ends of the arms are separated from one another and a grasping configuration in which the distal ends are drawn together to grasp tissue. The mechanism includes a ligating band received around the arms that is movable distally off of the arms to constrict around tissue grasped by the arms.

Abstract: An inductive position sensor may be configured to detect relative position between a first member and a second member. The inductive position sensor may include a transmit aerial configured to be disposed on the first member. The inductive position sensor may include a receive aerial configured to be disposed on the first member. The inductive position sensor may include processing circuitry configured to provide one or more signals indicative of the relative position between the first member and the second member based on a receive signal induced in the receive aerial resulting from a signal provided to the transmit aerial. One or more of the transmit aerial and the receive aerial may include one or more windings. A shape of the one or more windings can be a combination of a sinusoidal waveform and one or more scaled harmonics of the sinusoidal waveform.